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Tuberculosis (TB) is a disease that is ranked 10th with the highest number of deaths. Side effects caused by Anti-Tuberculosis Drugs (OAT) are often experienced by TB patients and result in physical disorders that reduce the quality of life of TB patients. This study aims to analyze the relationship between OAT side effects and the quality of life of TB patients at the Banyuglugur Community Health Center The research design in the study used a cross sectional approach. The population of this study was all TB patients in the Banyuglugur health center working area who underwent treatment for <6 months according to the inclusion criteria in January 2022 - May 2023, totaling 40 people using the Total Sampling sampling technique. Data were collected using a questionnaire on OAT side effects and quality of life. The analytical test used was the Spearman Rank test. The results of this study showed that the side effects of OAT in 27 TB patients (67.5%) were severe and the quality of life of 31 TB patients (77.5%) was poor. The results of the analysis show a p value of .001 (smaller than 0.05), so there is a significant linear relationship between the OAT side effect variable and the quality of life of TB patients at the Banyuglugur Community Health Center. This research shows that the side effects experienced by TB sufferers, both mild and severe, greatly affect the quality of life of TB patients. Health workers must always carry out routine monitoring of OAT side effects experienced by TB sufferers and treat them as soon as possible so that they do not affect the quality of life of TB patients in terms of physical, nutritional or psychological aspects in order to prevent them from dropping out of treatment.

Nonparametric regression is used to determine the relationship between the response variable and the predictor variable whose shape of the regression curve is not known. This study examines the factors that affect the number of tuberculosis cases in Central Java in 2021. The number of berculosis cases in Central Java reached 117 cases per 115,000 residents with a mean of 110,35 and a variance of 1360.74. Tuberculosis case rates and their affecting factors are modeled using a spline truncated nonparametric regression method. The relationship between tuberculosis case rates in Central Java and the factors that are thought to affect it does not form a specific plot. . Based on the research results, the best model of the minimum Mean Square Error (MSE) value is obtained at the knot point combination (1, 3, 2, 3, 3), with a MSE value of 0.57. The model, it is known that all factors have a significant effect on tuberculosis cases in Central Java, with a coefficient of determination of 93.41%. That is, the model can explain the diversity of tuberculosis cases in Central Java by 93.41%.

Introduction. Tuberculosis (TB) is one of the oldest diseases known to attack humans, caused by the bacterium Mycobacterium tuberculosis. Multi-drug-resistant TB (MDR-TB) is a stage or condition in which Mycobacterium tuberculosis becomes minimally resistant to rifampicin administration and also insonicotinylhydrazine (INH). Extensive-drug-resistant TB (XDR-TB) is an MDR-TB with Mycobacterium tuberculosis immune characteristics against one of the fluoroquinolone class drugs and one of the second-line injection OAT (capreomycin, kanamycin, and amikacin). The aim of this study was to find out the description of variation in laboratory costs of MDR-TB/XDR patients on one treatment cycle. Method. The inclusion criteria were patients who had been diagnosed with MDR-TB/XDR and performed laboratory tests. The design of this study was a cross-sectional retrospective analytics using medical records of MDR-TB/XDR patients in MDR division. Results. There were 30 MDR-TB research subjects and 2 XDR-TB research subjects examined for laboratory examination. Comparison of laboratory mean of MDR-TB/XDR (p = 0,018). Discussion. There was a significant difference in the total cost of MDR-TB/XDR laboratory examinations in one treatment cycle. Conclusion. Laboratory examination of MDR-TB/XDR patients requires considerable cost, this is due to the side effects of OAT that require patient clinical monitoring.