Publication Search

Arabica coffee (Coffea arabica) contains various bioactive compounds such as caffeine, polyphenols, flavonoids, and alkaloids that have the potential to produce diverse pharmacological effects on both the autonomic and central nervous systems. The variation in its chemical composition is influenced by factors such as cultivar, post-harvest processing, and preparation methods, resulting in biological responses that are dose-dependent and not always linear. This study aimed to evaluate the pharmacological activity of arabica coffee simplicia powder at three concentrations (1%, 2%, and 4%) by observing parasympathomimetic, parasympatholytic, sympathomimetic, sympatholytic, analeptic, central nervous system stimulation and depression, as well as muscle relaxation parameters. The research was conducted using a laboratory experimental design with test animals administered orally according to the designated concentrations. The results showed that some parameters increased at higher concentrations, such as parasympathomimetic activity (51.85%) and central nervous system stimulation (63.74%), while other parameters demonstrated decreasing or biphasic patterns, such as sympatholytic activity, which was high at 1% and 4% but low at 2%, and analeptic activity, which dropped sharply at 2% and increased again at 4%. These response patterns align with literature indicating that caffeine and polyphenols such as chlorogenic acid may interact synergistically or antagonistically, generating complex pharmacological effects through mechanisms involving adenosine modulation, excitatory neurotransmitters, the enteric nervous system, as well as antioxidant and anti-inflammatory pathways. Overall, this study demonstrates that arabica coffee simplicia exhibits multipotential pharmacological activity, with responses strongly influenced by concentration and the composition of its bioactive compounds, thereby providing a basis for further research on the phytopharmaceutical potential of arabica coffee.

The extract of Carica papaya L. leaves contains phytochemical compounds such as flavonoids, alkaloids, phenolics, and saponins that play a role in biological activities, including antioxidants, anti-inflammatory, analgesic, and modulation of the nervous system. This study aims to evaluate the effects of fresh papaya leaf extract on the central nervous system (CNS) and autonomic nervous system based on varying extract concentrations. The study used test animals with treatment groups consisting of negative control, positive control, and extracts at concentrations of 4%, 8%, and 16%. Parameters observed included parasympathomimetic (PSM), parasympatholytic (PSL), sympathomimetic (SM), sympatholytic (SL), analeptic effects (ANA), CNS stimulation (SSSP), CNS depression (DSSP), and muscle relaxation (RO). The results showed that the 16% concentration produced the highest PSM activity (46.82%) and dominant CNS stimulation (38.59%), while DSSP and RO decreased at higher concentrations. This phenomenon indicates that increasing the extract concentration does not always enhance CNS depression, but rather leads to stimulation. These findings support the potential of papaya leaf extract as a neuroprotective and multifunctional agent. Further research is needed to confirm its molecular mechanisms and clinical effectiveness as a phytotherapy candidate.

The Hospital Management Information Sistem (SIMRS) is a key component in the digital transformation of healthcare services, aiming to enhance efficiency and service quality. This study evaluates the implementation of SIMRS at Mutiara Bunda Mother and Child Hospital and explores the challenges and opportunities for improvement. A qualitative case study approach was employed, with data collected through in-depth interviews, observations, and document reviews involving five key informants, including the medical records head, medical service manager, registration officers, and IT staff. The results show that the SIMRS covers registration, procedure input, laboratory, and pharmacy functions. However, issues such as delayed data entry by medical staff, limited equipment, lack of integration across service units, and absence of written user guidelines and regular training persist. The study concludes that although the SIMRS is in use at RSIA Mutiara Bunda, sistem optimization, staff capacity building, and stronger managerial support are crucial to fully realize its potential in improving service quality.

Abdominal pain is one of the main complaints frequently encountered in patients in emergency departments and inpatient wards. This condition may be caused by various factors, ranging from gastrointestinal disorders and inflammation to reproductive system problems. Poorly managed pain can affect the patient’s quality of life, reduce daily activities, and increase anxiety. This case study aims to describe nursing care for Mrs. U, who presented with abdominal pain at dr. Soeselo Hospital, Tegal Regency. The research method applied was a case study with a nursing process approach, including assessment, diagnosis, intervention, implementation, and evaluation. The assessment revealed that the patient complained of lower abdominal pain with a pain scale of 5 (moderate), accompanied by nausea, weakness, and intermittent fever. The primary nursing diagnosis established was acute pain related to physiological injury agents. Interventions included pain management education, relaxation techniques, application of warm compresses, and collaboration in administering analgesics. The evaluation showed a decrease in pain intensity from a scale of 5 to 3, with the patient appearing calmer and showing improved sleep quality. This study emphasizes the crucial role of nurses in providing comprehensive care to reduce abdominal pain through both independent and the collaborative interventions with the medical team.

Febrile illnesses can be caused by a wide variety of viruses, bacteria, and other pathogenic microbes, and their production originates from outside the body. These substances, known as exogenous pyrogens, can enter the human system through contaminated water, food, or direct human-to-human transmission. Once inside the body, exogenous pyrogens stimulate the immune system by triggering the release of endogenous pyrogens such as cytokines, which in turn act on the hypothalamus to increase body temperature as a defense mechanism. This physiological response, while protective, can also indicate an underlying infection that may need prompt medical treatment. According to the World Health Organization (WHO) in 2020, the number of fever cases worldwide reached approximately 11–20 million people annually, with an estimated 128,000–161,000 deaths each year due to complications from febrile illnesses (Meirita et al., 2024). The global burden of fever varies by region; for example, in the United States, South America, and Western Europe, the incidence of fever is estimated to reach 4–5% of the population. In contrast, several Asian countries report higher prevalence rates, such as Japan with 6–9%, India with 5–10%, and Guam with 14% (Ulum et al., 2024). These statistics highlight the ongoing public health challenge posed by febrile illnesses, emphasizing the need for improved surveillance, prevention strategies, and treatment protocols worldwide.

Hypertension is one of the most common non-communicable diseases, with a high incidence rate that has become a major global health concern. It is often referred to as a “silent killer” because many patients are unaware of their condition until serious complications arise. In Indonesia, the prevalence of hypertension is relatively high, yet many sufferers remain undiagnosed or do not receive proper medical treatment. Several risk factors contribute to hypertension, including age, heredity, high-salt diet, obesity, lack of physical activity, and unhealthy lifestyles such as smoking and alcohol consumption. Without proper management, hypertension may lead to severe complications such as stroke, heart failure, and chronic kidney disease. Management of hypertension generally involves pharmacological therapy, such as the administration of antihypertensive drugs, as well as non-pharmacological interventions through lifestyle modifications. Nurses play a crucial role in patient education, monitoring, and preventing complications through comprehensive nursing care. The purpose of this study is to describe the nursing care provided to Mr. R, who experienced a cardiovascular system disorder, namely hypertension, in the Dahlia Ward of RSUD dr. Soeselo, Tegal Regency. The research method used was descriptive with a case study approach, allowing for a systematic and clear presentation of the patient’s condition. The case findings showed that the patient’s main complaint was a headache radiating to the nape of the neck. Based on nursing assessment, two nursing diagnoses were identified: acute pain and lack of knowledge regarding the disease and its management. Interventions were determined using national standards such as SDKI, SLKI, and SIKI, which are expected to reduce symptoms and improve the patient’s understanding of hypertension.

Disorders of the musculoskeletal system encompass a wide range of conditions affecting the bones, joints, and muscles. Bone-related disorders include osteoporosis, fractures, spinal deformities, osteopenia, osteomalacia, Paget’s disease of bone, osteopetrosis, achondroplasia, osteogenesis imperfecta, and osteomyelitis. Joint-related disorders consist of arthritis, bursitis, tendinitis, tendon injuries, tennis elbow, and carpal tunnel syndrome, while muscle disorders include myalgia, fibromyalgia, muscle injuries, muscular dystrophy, muscle atrophy, cramps, and spasms (Astuti et al., 2024). Fractures may lead to complications in surrounding tissues, such as soft tissue edema, bleeding into muscles and joints, joint dislocation, nerve damage, vascular injury, and tendon rupture (Rumapea, 2024). A patellar tendon rupture occurs when the fibrous tissue connecting the patella to the quadriceps muscle tears, and complete ruptures typically require surgical repair. The objective of this study was to design and implement a nursing care plan for patient A, who underwent post-operative management of a patellar tendon rupture in Mawar Ward 2 at RSUD dr. Soeselo, Tegal Regency, in 2025. This study applied a descriptive case study method. The findings revealed that the main complaint reported by the patient was pain in the left knee. Three nursing diagnoses were identified: acute pain, impaired physical mobility, and risk of infection. Nursing interventions were structured based on standardized guidelines from SDKI, SLKI, and SIKI, enabling systematic implementation. The results highlight the importance of comprehensive and evidence-based nursing care to optimize recovery outcomes for patients with post-operative tendon rupture.

This study aims to analyze the implementation of the Unit Dose Drugs Dispensing Sistem (UDDDS) based on the SERVQUAL theory at the Inpatient Pharmacy Installation of RS “X”. The research method used a quantitative design with SERVQUAL questionnaires given to pharmacists and nurses, supplemented by in-depth interviews to explore perceptions of the UDDDS implementation. Data analysis was conducted using univariate, bivariate, and multivariate methods. The results of the study indicate that all SERVQUAL dimensions significantly influence the quality of UDDDS services. Based on multiple linear regression analysis, the dimension of Assurance had the most dominant influence on service quality, with a B value of 8.464 and a contribution of 35%. This was followed by Empathy (B = 7.475, 31%), Tangibles (B = 7.547, 28%), Responsiveness (B = 4.847, 20%), and Reliability (B = 3.475, 16%). These findings suggest that the Assurance dimension, which includes trust and confidence in healthcare professionals, plays a crucial role in improving service quality at the Inpatient Pharmacy Installation. Overall, the findings indicate a significant relationship between the implementation of UDDDS and improvements in hospital service quality, particularly in terms of timely medication administration, reduced medication returns, and increased healthcare worker satisfaction. The reduction in medication returns reflects the efficiency of the drug distribution sistem, while the increased satisfaction of healthcare workers shows that UDDDS contributes to better service quality. These findings emphasize the importance of strengthening the Assurance dimension through improving the competence, ethics, and professionalism of healthcare workers. Additionally, integrating UDDDS into the hospital's quality indicators is essential for establishing a sustainable quality culture. This will support the overall improvement of service quality at the hospital.

Non-Communicable Diseases (NCDs) remain the leading cause of global morbidity and mortality, and one of the chronic conditions included in this group is rheumatoid arthritis (RA). RA is an autoimmune disease that affects the synovial joints, resulting in persistent inflammation, chronic pain, stiffness, and eventual deformities if left untreated. In Indonesia, the burden of RA continues to grow; the prevalence reaches 11.9% based on clinical diagnosis and rises to 24.7% when measured using symptom-based diagnosis. This case study aimed to describe family nursing care for a client with RA through a structured nursing process approach to improve quality of life and family involvement. The study took place in Purwodadi Village, Tonjong Subdistrict, Brebes Regency, focusing on the family of Mr. AS with Mrs. W as the client diagnosed with RA. Data collection involved comprehensive interviews, direct observation, physical examination, and documentation review. Assessment findings included chronic pain with an intensity score of 4, limited mobility, and inadequate family knowledge regarding RA management. Nursing interventions implemented were family education on RA, simple rheumatic exercises tailored to the client’s ability, and the application of warm ginger compresses as a non-pharmacological pain relief method. Post-intervention evaluation showed pain reduction to a score of 2, improved independence in performing light daily activities, and enhanced family understanding and support. In conclusion, family-centered nursing care combined with non-pharmacological interventions can effectively reduce pain, improve mobility, and strengthen the family’s role in supporting RA management.

Liver cirrhosis is a chronic disease characterized by progressive fibrosis, altered liver architecture, and the formation of regenerative nodules. Although it develops slowly, cirrhosis often leads to serious complications such as ascites, variceal bleeding, jaundice, and hepatic encephalopathy. According to the Global Burden of Disease Study 2019, cirrhosis is among the leading causes of death worldwide, with more than 1.4 million deaths annually. In Indonesia, the prevalence of cirrhosis is reported at 0.4% (Riskesdas, 2021) and shows an increasing trend over the years. This case study aims to describe the application of comprehensive nursing care in a patient diagnosed with liver cirrhosis using the nursing process approach. The research design was a case study conducted on Mr. R, who was admitted to Dahlia Ward at RSUD dr. Soeselo, Tegal. Data collection was carried out through interviews, observations, physical examinations, and medical record reviews. The results revealed that the main nursing problems identified were ineffective peripheral perfusion, ineffective breathing pattern, and knowledge deficit. Nursing interventions provided included positioning the patient in semi-fowler, monitoring vital signs, educating the patient about low-sodium diet and fluid restriction, and collaborating in the administration of diuretics and albumin. After three days of nursing care, the evaluation indicated clinical improvement, evidenced by reduced edema, decreased shortness of breath, and increased patient understanding of his disease and treatment plan. In conclusion, nursing care with a comprehensive process approach has a significant positive impact on the condition of patients with liver cirrhosis. Nurses play an essential role in assessment, planning, implementation, evaluation, and providing health education to prevent complications and improve patients’ quality of life.

The digestive system plays a role in processing food into nutrients so that they can be absorbed and utilized by the body, but it is often found that the digestive system experiences disorders that can be caused by various factors such as infection, inflammation, motility disorders, or even neoplasms (Suryati et al., 2025).One of the diseases caused by digestive system disorders is ileus obstruction, which is a disorder of the digestive system that occurs due to a mechanical blockage in the intestine and is often found in patients with intestinal obstruction. One of the diseases resulting from digestive system disorders isileus obstruction, which is a disorder of the digestive system caused by a mechanical obstruction in the intestines and is commonly found in patients who visit the emergency room. It is estimated that approximately 2-8% and 15% of patients require treatment in the surgical unit (Andi Nailah et al., 2024). Obstructive ileus occurs in the small intestine and can be caused by incarcerated hernia, intussusception, intestinal adhesions or adhesions, ascariasis, volvulus, tumors, or gallstones entering the ileum (Su’un, Gani, & Purnama, 2024). The purpose of this writing is to understand and provide nursing intervention  for Mrs. T with a digestive system disorders: a case of ileus obstruction in Mawar 2 ward dr. Soeselo Regional General Hospital, Tegal Regency. The method used in this writing is a descriptive method. From the case review, it was found that the patient's main complaint was pain in the lower right abdomen. Three diagnoses emerged: acute pain, anxiety, and knowledge deficit. Interventions were developed based on SDKI, SLKI, and SIKI, which can be implemented.

The endocrine system is a ductless body control system that produces hormones to regulate various organs and physiological processes. Hormones act as important biological messengers in the human body. One of the most essential hormones is insulin, which plays a key role in blood sugar regulation. Insufficient insulin production or impaired insulin action can cause disruption of blood glucose control, leading to diabetes mellitus. Diabetes mellitus is a chronic metabolic disorder characterized by persistently high blood glucose levels caused by impaired insulin secretion, insulin action, or both. The purpose of this paper is to apply nursing care to Mr. N, a patient with endocrine system disorders: diabetes mellitus, treated in the Dahlia Ward of Dr. Soeselo Regional Hospital, Tegal Regency. This descriptive case study method was used to explain the nursing process in a structured manner. The main complaint presented by the client was pain in the wound on the left foot. Four nursing diagnoses were identified during the assessment, namely unstable blood glucose levels, acute pain, impaired skin/tissue integrity, and knowledge deficit. Nursing interventions were developed and implemented based on the Standar Diagnosis Keperawatan Indonesia (SDKI), Standar Luaran Keperawatan Indonesia (SLKI), and Standar Intervensi Keperawatan Indonesia (SIKI). The case highlights the importance of comprehensive nursing care in diabetes management, with a focus on blood glucose stabilization, pain management, wound care, and patient education. The results of this study are expected to provide additional references for clinical practice and strengthen the role of nurses in preventing complications of diabetes mellitus.

Post-operative care is a critical phase in the recovery process, beginning immediately after the completion of surgery until the patient is stabilized and transferred to the inpatient ward. Among various surgical procedures, lumpectomy is a common intervention performed to manage mammary tumors, aiming to preserve breast tissue while removing the tumor (Arif et al., 2021). This paper presents a case study of Mrs. D, a patient with an endocrine disorder who underwent a right breast lumpectomy at Mawar 2 Ward, Dr. Soeselo Regional General Hospital, Tegal Regency. The study employed a descriptive method to explore the patient’s condition and nursing interventions. Upon assessment, the main complaint reported by the patient was pain localized in the post-operative area. Based on the findings, two primary nursing diagnoses were established: acute pain related to surgical trauma and knowledge deficit related to post-operative care and self-management. Nursing interventions were designed and implemented according to the Indonesian Nursing Diagnosis Standard (SDKI), the Indonesian Nursing Outcomes Standard (SLKI), and the Indonesian Nursing Interventions Standard (SIKI). Interventions included pain management strategies, such as pharmacological support and non-pharmacological relaxation techniques, as well as health education to improve patient knowledge and self-care ability. The case highlights the importance of comprehensive nursing care that addresses both physical discomfort and the patient’s understanding of recovery, thereby promoting optimal health outcomes after breast surgery.

Heart failure or congestive heart failure (CHF) is a condition where the heart is unable to pump blood optimally to meet the body's metabolic needs, resulting in symptoms such as shortness of breath, excessive fatigue, and edema (Majid, 2017). According to WHO data in 2023, CHF is one of the main causes of death with a total of 17.5 million deaths from a total of 58 million cases recorded worldwide. This paper aims to describe and provide an overview of nursing care for patient Mr. H who experiences cardiovascular system disorders in the form of CHF in the Dahlia room of Dr. Soeselo Regional Hospital, Tegal Regency in accordance with nursing practice standards. The method used is a descriptive method through a case study with data collection techniques using interviews and observations. From the results of the case review, the main complaint experienced by the patient was shortness of breath which was quite disruptive to daily activities. Based on this condition, four main nursing diagnoses were found, namely ineffective airway clearance, hypervolemia, activity intolerance, and knowledge deficits related to the disease and self-care. The interventions provided are based on theoretical references in the Indonesian Nursing Diagnosis Standards (IDHS) and the Indonesian Nursing Outcome Standards (SLHS), and are tailored to the patient's actual condition. The implemented action plan is expected to help reduce symptoms, improve the patient's ability to function, and provide a better understanding of CHF so that the patient can actively participate in the care process.

Introduction the management of expired drugs is an important part of the hospital's pharmaceutical logistics system to ensure the safety of patients, staff, and to protect the environment. The purpose of this study is to evaluate the implementation of procedures for returning expired drugs to the manufacturer or pharmaceutical company, as well as to examine the expired drug disposal system, particularly the methods of direct disposal to the Final Disposal Site (TPA) and open burning at RSUD Mohammad Natsir Solok. However, the implementation in the field has not been entirely effective. The method used in this study is a qualitative descriptive approach, with data collection techniques including observation, interviews, and documentation. The approach involved several informants who were directly involved in pharmaceutical logistics management in order to obtain in-depth and relevant data. The results of the study show that the hospital has not carried out expired drug destruction using the methods of direct disposal to the TPA or open burning. No clear information or official documentation was found regarding the use of these two methods. Informants stated that even if such methods were used, they occurred in the past and were not formally documented. The conclusion of this study is that open burning and direct disposal to the TPA have not become part of the expired drug management system at RSUD Mohammad Natsir Solok. The recommendation of this research is the development of clear operational procedures and increased staff awareness regarding the importance of safe and standard-compliant pharmaceutical waste managemen

The implementation of health information systems such as SIMKES (Sistem Informasi Manajemen Kesehatan) plays a crucial role in enhancing administrative efficiency and service delivery in primary healthcare centers. However, user satisfaction remains a key indicator of system effectiveness, especially in outpatient service units. This study aims to evaluate the satisfaction level of health personnel toward the implementation of SIMKES at the outpatient unit of Teguhan Health Center, Ngawi, Indonesia. Employing a descriptive quantitative method, this research involved a census of 17 respondents using a validated questionnaire based on the End-User Computing Satisfaction (EUCS) model, which comprises five dimensions: content, accuracy, format, ease of use, and timeliness. The data were analyzed using frequency distribution and mean scoring to categorize satisfaction levels. Results showed that the overall satisfaction score was 73.58, indicating that users were generally satisfied with the system. All five EUCS dimensions were categorized as satisfactory, with the highest rating in the format dimension and the lowest in timeliness. Despite the overall positive assessment, users reported issues related to system speed, technical bugs, and limited guidance for system navigation. The findings suggest that while SIMKES supports outpatient service delivery effectively, improvements are needed in system responsiveness and user support to enhance satisfaction and usability. This study contributes to the ongoing evaluation and development of health information systems in resource-limited primary care settings.

Loneliness is a problem that is often experienced by adolescents. Many factors can influence the occurrence of loneliness in adolescents. This systematic literature review aims to explore what factors influence adolescent loneliness. Journal searches were conducted using Scopus and Google Scholar databases with the keywords “loneliness in adolescents and young adulthood”. A total of 6 studies that fit the inclusion and exclusion criteria were then analyzed to identify the factors that cause loneliness in adolescents. These factors included gender, friendship quality, social media use, social relationships with peers, self-esteem and social acceptance. The results of this study are expected to provide a deeper understanding of the factors that cause loneliness in adolescents so that its negative impact can be anticipated and prevented.

Pneumonia is an acute respiratory infection that remains a major public health issue in Indonesia, particularly among infants and children. West Java is among the provinces with a high number of cases, and in 2024, Tasikmalaya City reported 2,178 cases, with Cilembang Public Health Center (Puskesmas Cilembang) recording the highest number. This study aims to evaluate the P2 ISPA (pneumonia) surveillance system at UPTD Puskesmas Cilembang. A descriptive-evaluative method was used, involving interviews, document reviews, and observations with surveillance and P2 ISPA program officers at the Tasikmalaya City Health Office and Puskesmas Cilembang. The findings indicate that the pneumonia surveillance implementation at Puskesmas Cilembang is fairly adequate, although improvements are needed to better align with current guidelines and government regulations.

The Autonomic Nervous System (ANS) is a part of the peripheral nervous system that plays a role in controlling bodily functions unconsciously. The ANS consists of two main divisions, namely the sympathetic and parasympathetic nervous systems, which work antagonistically to maintain the body's homeostasis. This article discusses the structure, function, and working mechanisms of the ANS under various physiological and pathological conditions. Understanding the ANS is crucial in the medical field, especially in managing diseases related to autonomic nervous system dysfunction.

This research was conducted to describe the impact of fatherlessness on children's socio-emotional conditions. This topic was chosen because the presence of a father in a child's life has a very important role in shaping the child's socio-emotional aspects. However, the phenomenon of fatherlessness is increasing in society, whether due to divorce, problems in marriage, father's death, or fathers working outside the city. This research uses a systematic literature review to analyze data obtained from various sources. Based on the data findings, it can be seen that children who experience fatherlessness tend to have low self-confidence, have difficulty adapting to the social environment, and experience socio-emotional problems such as loneliness and loss. These impacts can be seen from various phases of development starting from early childhood, adolescence, even to early adulthood.