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Herpes zoster and crusted scabies are dermatological conditions that pose a higher risk and clinical severity in immunocompromised patients, particularly those with chronic comorbidities such as diabetes mellitus and hypertension. This case report presents a 55-year-old woman with painful vesicular eruptions on the right neck and generalized thick, crusted, itchy plaques across the body. She had a longstanding history of type 2 diabetes mellitus and hypertension. Clinical diagnosis of herpes zoster and crusted scabies was confirmed through physical examination and KOH microscopic testing, which identified Sarcoptes scabiei. The patient was treated with oral acyclovir, topical permethrin, and supportive therapy to manage pain and prevent secondary infections. The coexistence of herpes zoster and crusted scabies in a diabetic patient highlights the role of impaired immunity in disease severity and presentation. Early recognition and integrated management are essential to improve prognosis and prevent complications.

Mrs. Km visited the Integrated Health Post (Posbindu) in Alue Keureunyai Village with complaints of throbbing neck pain that had occurred intermittently over the past two weeks and worsened in the last day. The pain intensified after consuming fatty or coconut milk-based foods and improved with rest or cholesterol-lowering medication. She also experienced a persistent, heavy, throbbing headache for two weeks and ongoing fatigue for the past three weeks, despite minimal physical activity. These symptoms led to reduced motivation in daily activities. Physical examination showed: BP 160/100 mmHg, HR 88 bpm, RR 20 breaths/min, T 36.8°C. Laboratory results revealed a total cholesterol level of 250 mg/dL. Data were gathered through auto-anamnesis, physical and laboratory examinations, home visits, completion of the family folder, and patient documentation. Assessment was based on holistic diagnosis at the initial, ongoing, and final stages of the visit, using both qualitative and quantitative approaches. Interventions included education on the causes of hypercholesterolemia, the importance of taking medication regularly, and awareness of complications due to high cholesterol levels.

A 55-year-old female patient came to the Non-Communicable Diseases Polyclinic of Banda Baro Health Center with complaints of headaches that had been felt since ± 7 days ago. The headache was felt as if it was throbbing all over the head. The headache was felt to be worse when the patient was active and stressed and reduced when the patient rested. This headache complaint had disrupted the patient's daily activities. The patient also complained of a stiff neck accompanied by weakness. The patient had been diagnosed with hypertension since 5 years ago but did not take medication regularly. The therapy received by the patient was Amlodipine 1 x 5 mg. From the results of the examination, BP was 145/90 mmHg, HR: 82 x / i, RR: 19 x / i, temperature: 36.5 ° C. Primary data was obtained through anamnesis and physical examination by conducting home visits, filling out family folders, and filling out patient files. The assessment is carried out based on the initial holistic diagnosis, process, and end of visit. Interventions carried out include education on the importance of a healthy lifestyle, taking medication regularly to control blood pressure and complications that can occur due to high blood pressure.

The patient came with complaints of frequent tingling in both legs for 2 months. These complaints were accompanied by a body that continuously felt weak even though the patient did not do heavy activities. The patient also complained of nausea but no vomiting, frequent urination especially at night, and often felt thirsty. Other complaints such as fever and bowel disorders were denied by the patient. The patient also did not routinely use insulin medication. Primary data were obtained through autoanamnesis and physical examination by conducting home visits, filling out family folders, and filling out patient files. The assessment was carried out based on the initial holistic diagnosis, process, and end of the visit quantitatively and qualitatively. The interventions carried out included education about the causes of diabetes mellitus to his family, education about lifestyle modification and management of the disease, and explaining complications that may arise from the patient's disease so that the patient takes regular treatment and makes preventive efforts.

Background: Atherosclerosis is a chronic inflammatory cardiovascular disorder strongly associated with elevated low-density lipoprotein cholesterol (LDL-C) levels and serves as a major predictor of adverse cardiovascular events. This study aimed to investigate the relationship between inflammatory markers (adiponectin and TNF-α) and key biochemical parameters in atherosclerosis patients. Methods:  A case-control study was conducted on 60 participants (aged 40–65 years) recruited from private cardiac clinics in Fallujah, Iraq, between October and December 2024. Subjects were stratified into two groups: 30 atherosclerosis patients (diagnosed by specialists) and 30 age-matched healthy controls. Blood samples were collected, centrifuged, and analyzed for CRP, TNF-α, adiponectin, PAI-1, MDA, GSH, sodium (Na), and magnesium (Mg) levels using standardized biochemical assays. Statistical analysis was performed using SPSS, with significance set at *p* ≤ 0.001. Results: Atherosclerosis patients exhibited significantly elevated serum levels of CRP (2.21 ± 14.46 vs. 1.07 ± 7.76 mg/dL), TNF-α (15.14 ± 120.86 vs. 4.27 ± 65.16 pg/mL), PAI-1 (6.52 ± 0.82 vs. 2.02 ± 0.42 ng/dL), MDA (590.26 ± 29.64 vs. 155.52 ± 25.19 ng/mL), and Na (140.16 ± 1.18 vs. 125.46 ± 6.17 nmol/L) compared to controls (*p* ≤ 0.001). Conversely, adiponectin (0.18 ± 1.81 vs. 0.67 ± 4.18 mg/dL), GSH (22.79 ± 1.37 vs. 40.81 ± 3.05 μg/mL), and Mg (1.46 ± 0.175 vs. 1.84 ± 0.67 nmol/L) were markedly reduced in patients. ROC curve analysis demonstrated perfect diagnostic accuracy (AUC = 1.0) for CRP, TNF-α, and adiponectin in distinguishing patients from controls. Conclusion: The study highlights pronounced dysregulation of inflammatory, oxidative, and metabolic pathways in atherosclerosis, with CRP, TNF-α, and adiponectin serving as robust discriminative biomarkers. These findings underscore the potential of targeting these pathways for therapeutic intervention and early diagnosis.

Thyroid crisis is an acute, life-threatening form of thyrotoxicosis and represents one of the severe complications of hyperthyroidism. During pregnancy, thyroid disorders have unique characteristics due to structural and functional changes in the thyroid gland that occur throughout gestation. Pregnancy can influence the course of thyroid disease, and conversely, thyroid disorders may also impact pregnancy outcomes. In this case report, we present a 30-year-old patient, Mrs. F, gravida 5, abortus 4, para 0, who presented with palpitations, fever, restlessness, and a history of uncontrolled hyperthyroidism. The diagnosis of thyroid crisis was made clinically using the Burch & Wartofsky score instrument. Management of thyroid crisis in pregnant women requires a multidisciplinary approach, close monitoring, administration of antithyroid drugs, β-blockers, and other supportive therapies, while also considering fetal safety.

Approximately 35.4% of the Asian population suffers from Tinea corporis, a superficial dermatophyte fungal infection that attacks hairless skin such as the face, arms, and legs. This dermatophyte causes symptoms in the form of circular lesions with active red and scaly edges and a calmer center. This case involved a 12-year-old girl who came to the Dermatology and Venereology Polyclinic of Fauziah Bireun Hospital with complaints of reddish spots on her body that had lasted for eight months. The lesions were accompanied by itching, especially when sweating or in hot conditions, but improved after bathing. The clinical diagnosis showed Tinea corporis. The therapy given was 2% ketoconazole cream applied twice a day and systemic treatment with 200 mg itraconazole and 10 mg cetirizine. This management aims to overcome fungal infections, reduce symptoms, and prevent recurrence. Patient education regarding personal hygiene and prevention of skin moisture is an important part of therapy.

Breast cancer is the most prevalent cancer among women worldwide, requiring early and accurate diagnosis to reduce mortality. This study proposes a hybrid classification pipeline that integrates Hybrid Statistical Feature Selection (HSFS) with unsupervised LSTM-guided feature extraction for breast cancer detection using the Wisconsin Diagnostic Breast Cancer (WDBC) dataset. Initially, 20 features were selected using HSFS based on Mutual Information, Chi-square, and Pearson Correlation. To address class imbalance, the training set was balanced using the Synthetic Minority Over-sampling Technique (SMOTE). Subsequently, an LSTM encoder extracted non-linear latent features from the selected features. A fusion strategy was applied by concatenating the statistical and latent features, followed by re-selection of the top 30 features. The final classification was performed using a Support Vector Machine (SVM) with RBF kernel and evaluated using 5-fold cross-validation and a held-out test set. Experimental results showed that the proposed method achieved an average training accuracy of 98.13%, F1-score of 98.13%, and AUC-ROC of 99.55%. On the held-out test set, the model reached an accuracy of 99.30%, precision of 100%, and F1-score of 99.05%, with an AUC-ROC of 0.9973. The proposed pipeline demonstrates improved generalization and interpretability compared to existing methods such as LightGBM-PSO, DHH-GRU, and ensemble deep networks. These results highlight the effectiveness of combining statistical selection and LSTM-based latent feature encoding in a balanced classification framework.

Psoriasis is a chronic inflammatory disease that attacks the skin and can occur at any age with various clinical variations. The diagnosis is generally made clinically, but in atypical cases a biopsy is required for confirmation. The combination of clinical and histopathological examination provides more accurate diagnosis results. This study aims to assess the suitability of clinical diagnosis and histopathological examination results in psoriasis vulgaris in Semarang Regency. This cross-sectional observational study was conducted by the department of dermatology, venereology and aesthetics at Diponegoro University. A total of 10 samples were clinically diagnosed as psoriasis vulgaris or other morphological types of psoriasis vulgaris at a Dermatology Polyclinic in Semarang Regency, over a period of 2 years. The clinical manifestations of 10 cases with a clinical diagnosis of psoriasis vulgaris assessed from the typical predilection and the presence of scaly plaques tended to be consistent with the histopathological diagnosis but were not statistically significant. Concordance between clinical diagnosis and histopathological diagnosis was observed in 8 (80%) cases and discordance in 2 (20%) cases. Based on the research results, it can be concluded that there is a high level of agreement (80%) between clinical diagnosis and histopathological features in cases of psoriasis vulgaris.

Neurocognitive disorders, particularly dementia, affect various cognitive functions such as memory, attention, language, learning, and problem-solving, with the elderly population being the most impacted. The prevalence of dementia is projected to rise to 131 million cases by 2050, posing significant social and economic implications. This study employed a cross-sectional method to evaluate the role of Apolipoprotein A (APOA) and Apolipoprotein B (APOB) in the diagnosis and prevention of dementia in older adults. The results showed that Apolipoprotein A was not significantly correlated with MMSE scores, indicating no clear relationship between APOA and cognitive function. In contrast, Apolipoprotein B demonstrated a significant negative correlation with MMSE, suggesting that increased APOB levels are associated with cognitive decline. Elevated ApoB, linked to increased LDL and oxidative stress, correlated with reduced cognitive function, whereas ApoA, the main component of HDL, is associated with neuroprotective effects. These findings underscore the importance of monitoring lipid profiles, including ApoA and ApoB, in the prevention and management of dementia in the elderly.    

Vergence movement is an important mechanism in eye coordination to maintain visual focus. The neural pathways controlling vergence involve complex interactions between various brain structures, such as the mesencephalic nucleus of the oculomotor nerve (CN III), the abducens nucleus (CN VI), the reticular pontine formation (PRF), and the visual and motor cortices. Disorders in this system can lead to convergence insufficiency, esotropia, exotropia, as well as diplopia which impacts the quality of binocular vision. This study aims to conduct a systematic review of the neural pathways that play a role in the vergence system. This research design is a study that uses the Systematic Literature Review (SLR) method. 5 articles were obtained using a method of secondary analysis of literature review through scientific database portals such as SINTA, Scopus and Google Scholar published in 2015-2025 both national and international articles. The results of the analysis show that vergence disorders are common in children and the elderly, with various causes ranging from benign factors to more serious neurological conditions. Studies show that activities in the parietal eye field (PEF), frontal eye field (FEF), superior colliculus (SC), and PRF have important roles in vergence coordination. In addition, vergence deficits were also found in Parkinson's patients, who showed prolonged latency and reduced vergence gain. In the context of technology, research on virtual reality (VR) shows that vergence errors often occur when users interact with virtual environments, leading to visual fatigue and incorrect depth perception. This study also highlights that neurotransmitters such as GABA, glutamate, and dopamine have a role in the modulation of neural signals that control vergence. A deeper understanding of the neural pathways of vergence is crucial in ophthalmology and neurology, especially in the diagnosis and therapy of binocular vision disorders. In addition, research on vergence also contributes to the development of visual technologies, such as VR and eye tracking systems, that are more adaptive to human physiological characteristics.

Dengue fever is an acute infectious disease caused by the dengue virus and transmitted primarily by the Aedes aegypti mosquito in urban environments and Aedes albopictus in rural settings. This disease is endemic in many tropical and subtropical regions and is a significant public health concern due to its potentially severe clinical manifestations. This case study presents an 8-year-old boy who was admitted to the hospital with complaints of a high-grade fever lasting for approximately three days. The fever was intermittent and accompanied by chills, which raised suspicions of a viral infection. In addition to fever, the patient also experienced dizziness with a spinning sensation, occasional cough, and flatulence. A thorough clinical evaluation was conducted, including history taking, physical examination, and supporting laboratory tests. Based on the clinical findings and laboratory results, the patient was diagnosed with dengue hemorrhagic fever (DHF) grade I. DHF grade I is characterized by fever, positive tourniquet test, and evidence of plasma leakage without spontaneous bleeding. The patient was managed with supportive therapy, including fluid replacement and close monitoring of vital signs and hematocrit levels to prevent the progression to more severe stages of dengue. No significant complications occurred during the hospital stay. After a period of observation and clinical improvement, the patient was discharged in good condition. This case highlights the importance of early recognition and accurate diagnosis of DHF in pediatric patients, especially in endemic areas. Prompt and appropriate management is essential to prevent complications and ensure recovery. Continuous public health education and vector control remain key strategies in reducing dengue incidence and severity.

In the art and science of dermatology, ridge patterns and surface markings are studied on the finger’s skin, palm, foot toes, and soles. It is helpful for research into illnesses that may have a hereditary component. Dermatoglyphics has developed into a practical instrument in the fields of biology, anthropology, genetics, medicine, and dentistry over the past few centuries. The state of medical dermatoglyphics today is such that different systemic illnesses are linked to fingerprint patterns. Breast cancer, smokeing tobacco, bronchial asthma, diabetes mellitus, and several others were maintained. The sophisticated and contemporary uses of dermatoglyphics in the diagnosis of various oral, systemic, and dental conditions are covered in this article. It also emphasizes how beneficial dermatoglyphics is as a medical diagnostic tool for a variety of systemic illnesses. An approach to investigating the genetic relationships of oral, craniofacial, and systemic illnesses that is easily accessible, affordable, practical, trustworthy, and noninvasive is dermatoglyphics. Therefore, dermatoglyphics is a great tool for screening the population for numerous medical and dental conditions in addition to providing personal identification.

The potential of cardiac markers in predicting preeclampsia, such as Creatinine Kinase (CK) and Tyrosine Kinase 1 (TK1), has emerged as promising due to their involvement in the pathophysiology of this pregnancy complication. Preeclampsia is characterized by hypertension and organ dysfunction, and it can lead to significant maternal and fetal morbidity if not detected early. Early identification of preeclampsia is critical for preventing severe complications, and biomarkers like CK and TK1 can provide valuable insights. This study aimed to investigate the role of CK and TK1 as potential predictors of preeclampsia in the third trimester of pregnancy. Forty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Participants were divided into two groups: twenty (20) normotensive pregnant women and twenty (20) preeclamptic pregnant women in their third trimester. Blood samples were collected and processed using a bucket centrifuge at 2500 RPM for 10 minutes, and plasma was stored frozen for further analysis. Tyrosine Kinase 1 was analyzed by fluorescence immunoassay, and Creatinine Kinase was measured using a spectrophotometric method. Data obtained were analyzed using GraphPad Prism 9, with results expressed as mean ± SEM. Statistical significance was set at a P-value of ≤ 0.05. The study found a statistically significant increase in the levels of both CK and TK1 in preeclamptic women compared to normotensive controls. These findings suggest that CK and TK1 could serve as predictive biomarkers for identifying and monitoring preeclampsia, aiding in early diagnosis and timely interventions

Pulmonary tuberculosis (TB) is a public health problem of concern because of its contagious nature. Success in treating pulmonary TB, which is very important to prevent drug resistance, is largely determined by patient compliance in taking medication regularly. However, the most important factor in the diagnosis of this disorder is the extent to which recommendations are followed. Therefore, the task of the family exercise monitor (PMO) is very important in helping the patient accept the forced teaching. The aim of this research is to analyze family members on the health status of pulmonary tuberculosis patients who come to take medication at the Tlogosari Kulon Health Center. The design in this research analysis is cross-sectional correlation, specifically to test the relationship between two variables at the same time. This sample consisted of 71 cases of pulmonary tuberculosis registered at Balai Tlogosari Kulon. At this institution, a cross-sectional correlation analysis design is used to analyze the relationship between two variables over a period of time. The sample in this study was 71 TB patients registered at the Tlogosari Kulon Health Center. Purposive sampling is a sample collection technique used, where respondents are carefully selected based on predetermined criteria to ensure they meet the research objectives. The tool used to accumulate data is a questionnaire, which is designed to collect information about the variables studied. The data obtained from the questionnaire was then analyzed using the Chi-square test to analyze whether there was a significant relationship between these variables. The results of the study explained that the majority of respondents, namely 40 people (56.3%), rated the family's role as Medication Monitoring Supervisor (PMO) in the good category, while 28 respondents (39.4%) showed good compliance in taking medication. The Chi-square test results show that the significance value is p = 0.003, (<0.05). This shows that the null hypothesis (H0) is rejected. This research can be concluded that there is a relationship between the role of the family and compliance with taking medication for pulmonary TB clients at the Tlogosari Kulon Community Health Center.

Cough Becomes Non-Physiological When Felt As A Disturbance. Such Cough Is Often A Sign Of Disease In Or Outside The Lungs And Sometimes Is An Early Symptom Of A Disease. Transmission Of Cough Disease Through The Air (Air Borne Infection). The Causes Are Various And Recognition Of The Pathophysiology Of Cough Will Be Very Helpful In Establishing A Diagnosis And Management Of Cough. The purpose of the community service activity is to implement the ethics of coughing, sneezing and washing hands for the community so that the community can live healthily in their households/families. From the results of the counseling activities on Coughing, Sneezing and Washing Hands Ethics, it is hoped that the community will be able to maintain a clean and healthy lifestyle. Always bring a handkerchief or tissue when coughing or sneezing and always wash your hands every day with clean running water

Osteoarthritis is a type of arthritis that occurs in the area around the joints because the cartilage that protects the ends of the bones begins to break down accompanied by reactive changes at the edges of the joints which can cause pain and difficulty moving. Drug use is said to be rational if the patient receives treatment that is in accordance with clinical needs, namely correct diagnosis, correct drug selection, correct indication, correct dose, correct method of administration, and correct patient. This research aims to use a descriptive analysis design for observational research. The research design used was quantitative research to determine the rationality of using NSAIDs anti-pain medication in osteoarthritis patients undergoing treatment at the Klinik Teluk Banten. The rationality results in this research are, 100% correct diagnosis, 100% correct indication. 100% correct choice of drug, 89% correct dose, 100% correct method of administration, 94% correct patient for Osteoarthritis at Klinik Teluk Banten.

X-ray radiation has been widely used in the medical field for both diagnosis and cancer therapy. However, its biological impact on healthy and cancerous tissues remains a major concern in clinical practice. This study aims to evaluate the biological effects of X-ray exposure, including DNA damage mechanisms, cellular responses, and long-term effects on healthy tissues, as well as its effectiveness in killing cancer cells. A meta-analysis was conducted on studies investigating the effects of X-ray radiation on various tissue types. The findings indicate that while X-rays are effective in destroying cancer cells, uncontrolled exposure can lead to genetic mutations and carcinogenesis in healthy tissues. Therefore, the use of X-rays in cancer therapy must consider optimal dosage to maximize therapeutic effects while minimizing risks to healthy tissues.

This case report discusses a 54-year-old female patient diagnosed with Stage V Chronic Kidney Disease (CKD) undergoing Continuous Ambulatory Peritoneal Dialysis (CAPD). The patient presented with clinical symptoms such as nausea, vomiting, abdominal pain, and reduced ultrafiltration volume, raising suspicion of Encapsulated Peritoneal Sclerosis (EPS). EPS is a rare but serious complication in long-term CAPD patients. Management includes discontinuation of CAPD, adequate nutritional support, and symptomatic therapy. This report aims to enhance understanding of the diagnosis and management of EPS in Stage V CKD patients.

Thalassemia is an inherited blood disorder characterized by a deficiency of globin chain products in hemoglobin which results in low Hb levels. Blood transfusion is a treatment used in thalassemia patients. The purpose of this study was to determine the level of blood transfusion compliance in pediatric thalassemia patients at Cut Meutia General Hospital, North Aceh. The research method used a descriptive observational design, with 95 respondents and data collection using medical records and questionnaires. The results showed that 43.2% of respondents were predominantly early adolescents, 54.7% of respondents were predominantly male, 42.1% of respondents were predominantly blood type O, 58.9% of respondents had hemoglobin levels ≥7 g/dl, 87.4% of respondents had a blood transfusion frequency of 2-4 weeks. 53.7% of respondents had high compliance. Based on this, it can be concluded that the level of blood transfusion compliance in pediatric thalassemia patients at Cut Meutia General Hospital, North Aceh, mostly had high compliance.