Publication Search

Trigona sp. propolis simplicia is widely used by the community as a traditional medicine that has many benefits so that this propolis can treat sore throats, flu, and support the immune system. Propolis cultivation is increasingly developing, but there is no scientific data regarding the standardization of raw propolis simplicia. This study aims to determine the standard parameters of Trigona sp. propolis simplicia from Balikpapan. Specific parameters measured on Trigona sp. propolis simplicia include organoleptic tests, identification of chemical compounds, and tests of water-soluble and ethanol extract levels. Non-specific parameters include water content tests, total ash content tests, and acid-insoluble ash content tests. Trigona sp. propolis simplicia in organoleptic tests has a solid form, a distinctive aromatic odor, a blackish brown color, and a slightly bitter sour taste. Trigona sp. propolis simplicia was positively identified as containing compounds of the alkaloid, flavonoid, triterpenoid/steroid, and tannin groups, while saponins were identified negatively. Trigona sp propolis simplicia has ethanol and water soluble extract content values ​​of 10% ± 0.008 and 14.4% ± 0.003 respectively, the water content value obtained is 1.3% ± 0.002, the total ash content and acid insoluble ash content values ​​are 3.67% ± 0.008 and 1.5% ± 0.005 respectively.

Enteric bacterial infectious diseases such as Escherichia coli are still a serious health problem in many countries, mainly due to the increasing cases of antibiotic resistance that cause the effectiveness of conventional therapies to decline. This condition encourages the search for safer and more effective natural alternatives, one of which is propolis produced by the Trigona sp. bee Trigona sp. Propolis is known to contain a variety of bioactive compounds, including flavonoids and phenolic acid, which act as antimicrobials. This study aims to test the antibacterial activity of propolis extract against E. coli by the sumpray diffusion method. The results of the study showed that there was an inhibition zone that varied according to the concentration of the extract. At a concentration of 10%, an average inhibition zone of 19.85 mm (strong category), a 20% concentration of 22.35 mm (very strong), and a concentration of 30% reaches 26.62 mm (very strong). In comparison, the positive control of ciprofloxacin produced 21.25 mm of resistance, while the negative control (DMSO) showed no activity. ANOVA analysis confirmed significant differences between treatments (p < 0.05). These findings confirm that propolis extract has the potential to be developed as an effective natural antimicrobial agent.

Bajakah tampala (Spatholobus littoralis Hassk.) is a medicinal plant that is traditionally used by the Dayak people to overcome various diseases, including indigestion such as diarrhea and dysentery. This plant is known to contain secondary metabolites, including flavonoids, tannins, saponins, alkaloids, and phenolics, which have the potential to have antibacterial activity. This study aims to evaluate the antibacterial activity of pulp extract of patchy bajakah with n-hexane solvent against Escherichia coli ATCC 25922. The extract was obtained through the maceration method and tested using the well diffusion method at concentrations of 10%, 20%, and 30%. The results showed a relatively low yield of the extract (0.10–0.14%) with a reddish-orange color. The inhibition zones formed ranged from 4.28–5.55 mm with significant differences between concentrations (p = 0.000), but the antibacterial activity was relatively low. These findings indicate that the active compounds of the patch stalk are likely to be more polar or semi-polar, so they are less optimally extracted using the nonpolar solvent n-hexane. Therefore, further research with different solvent variations, particularly those that are polar, is urgently needed to uncover the greater antibacterial potential of these plants.

The development of information technology has encouraged institutions, including hospitals, to adopt digital systems to improve operational efficiency. One important aspect is the employee attendance system, which previously relied on fingerprints. This method has limitations, such as difficulty detecting when fingers are not in ideal condition and causing queues during peak hours. This research aims to design and implement an Android-based attendance system using the Eigenface facial recognition method as a faster, safer, and more accurate alternative. Eigenface works by extracting facial features using Principal Component Analysis (PCA), thus being able to efficiently recognize individual identities. The system was developed with MySQL database integration and tested on employees of Khalishah General Hospital. The implementation results showed that the system can recognize faces with a good level of accuracy and increase the effectiveness of attendance recording. Furthermore, the use of facial-based attendance can minimize the potential for fraud and increase user comfort because it does not require physical contact. Thus, the Eigenface method has proven feasible to be implemented as a modern attendance solution to support employee attendance management in hospital work environments and other institutions.

Digital transformation and sustainability demands are driving the need for the integration of E-HRM and Green HRM to achieve sustainable organizational performance. This integration serves as a solution to the challenges of resource efficiency, carbon footprint reduction, and enhanced employee engagement in the digital era. This research aims to analyse the role of E-HRM in enhancing Green HRM practices and its impact on sustainable organizational performance. The research methodology employs a Systematic Literature Review (SLR), utilising the Scopus database, with selection based on inclusion-exclusion criteria, data extraction, and thematic analysis of selected journals. The anticipated impact of E-HRM is its support for Green HRM through the digitalization of HR processes that reduce resource usage, the establishment of digital platforms for environmental awareness, and data-driven impact measurement. The integration of both significantly enhances sustainable performance across three dimensions: environmental (a 20-30% reduction in carbon footprint), economic (15-25% cost savings), and social (30-40% increase in employee engagement). Key implementation factors include technological readiness, management commitment, and alignment with ESG strategies. This research contributes a conceptual framework for the integration of E-HRM and Green HRM, along with practical recommendations for achieving sustainable competitive advantage in the digital age.

Chicken and processed products like dimsum are susceptible to rapid spoilage due to their high water and nutrient content. This makes it difficult for consumers to directly assess a packaged product's freshness. To address this, a novel smart packaging solution using a biodegradable film infused with anthocyanin extract from butterfly pea flowers (Clitoria ternatea) as a visual freshness indicator was developed. The primary objective of this research was to evaluate the effect of three different anthocyanin concentrations (3%, 5%, and 7%) on the film's physical properties and its ability to change color in response to spoilage over a three-day storage period. The research results showed that the film with a 7% anthocyanin concentration had the best physical properties, with a thickness of 0.092 mm, a tensile strength of 8.66 MPa, 14.99% elongation, 62.59% water resistance, and 100% biodegradation. The anthocyanins successfully changed color in response to the freshness level of both chicken meat and dimsum throughout the storage period.

Leaves of Etlingera walang (Blume) RMSm have been empirically used in traditional medicine to relieve stomach disorders and are known to contain secondary metabolites with potential antimicrobial properties. Salmonella typhi infection can cause typhoid fever with symptoms such as diarrhea and abdominal pain, while Candida tropicalis is a fungus that can infect the gastrointestinal tract and lead to digestive disturbances. This study aimed to evaluate the antibacterial and antifungal activities of the ethanolic extract of E. walang leaves against S. typhi and C. tropicalis. The antimicrobial assay was carried out using the disk diffusion method at extract concentrations of 25%, 50%, and 100%, with chloramphenicol and ketoconazole as positive controls, and DMSO as the negative control. Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, and tannins. However, the results showed that the extract did not produce inhibition zones against either test microorganism. Extract evaluation indicated a moisture content of 12.23%, total ash 13.39% (above the standard), acid-insoluble ash 1.25%, total plate count 1.8 × 10 ⁴ , and mold and yeast count 1.0 × 10 ³. The findings suggest that although the ethanolic extract of E. walang leaves contains secondary metabolites and is traditionally used for stomach ailments, it does not exhibit antimicrobial activity against S. typhi or C. tropicalis.

Citrus hystrix DC., commonly known as kaffir lime, is a citrus plant widely distributed in Southeast Asia including Indonesia, Thailand, India, and China. Its leaves are traditionally used as food flavoring and herbal medicine due to their distinctive aroma and therapeutic potential. This study was conducted to identify the presence of secondary metabolite compounds in kaffir lime leaves through qualitative phytochemical screening. Fresh leaves were extracted and tested using standard phytochemical methods with specific reagents to detect alkaloids, flavonoids, phenolics, tannins, saponins, steroids, and terpenoids. The screening process was carried out through colorimetric reactions that indicate the presence of specific metabolite groups. The results showed that kaffir lime leaves positively contain several classes of secondary metabolites, including alkaloids (brownish-black precipitate with Bouchardat reagent), flavonoids (red color with Mg and concentrated HCl), saponins (stable foam formation after shaking with HCl), steroids (green color with acetic anhydride), terpenoids (reddish-purple color with concentrated H2SO4), and tannins (greenish-black color with FeCl3). The findings confirm that kaffir lime leaves are rich in bioactive compounds that may contribute to pharmacological activities such as antimicrobial, antioxidant, anti-inflammatory, and therapeutic properties. These results support the traditional use of kaffir lime leaves as natural medicine and highlight their potential as a source of natural bioactive compounds for further pharmaceutical and nutraceutical development. This study provides preliminary scientific evidence and encourages more detailed quantitative and isolation studies on the active components of Citrus hystrix.

Fungal infections are a common health problem in tropical regions, including Indonesia, since humid conditions support microbial growth. Candida tropicalis is a pathogenic species frequently identified as the cause of both superficial and systemic candidiasis. The rising resistance to synthetic antifungal agents such as fluconazole and ketoconazole highlights the need for safer and more effective alternative therapies. Propolis, a resinous substance produced by Trigona sp. bees from various plant sources, contains flavonoids, phenolics, and terpenoids with important biological activities, including antimicrobial and antifungal effects. This study aimed to evaluate the effectiveness of ethanol extract of propolis from Balikpapan against the growth of Candida tropicalis using the disk diffusion method. Phytochemical screening revealed the presence of alkaloids, flavonoids, phenolics, tannins, and terpenoids in the extract. Antifungal activity testing showed that concentrations of 80%, 90%, and 100% significantly inhibited fungal growth, with the largest inhibition zone of 27.93 mm observed at 100% concentration. Statistical analysis using ANOVA confirmed significant differences among treatments. Thus, ethanol extract of Trigona sp. propolis from Balikpapan demonstrates strong potential as a natural antifungal agent. These findings support the use of propolis as a natural-based therapeutic alternative for fungal infections and contribute to the development of herbal pharmaceutical products.

Natural Science (IPA) learning is an important foundation in developing students' scientific literacy, critical thinking skills, and scientific attitudes. However, the learning process still faces many challenges related to low learning interest, the dominance of conventional methods, and limited use of technology. This article aims to analyze the effectiveness of innovative approaches in science learning through a systematic review of 25 national and international journal articles published in 2020–2025. The systematic review method was carried out through the stages of identification, selection, data extraction, and thematic analysis. The results of the analysis show that the Problem-Based Learning (PBL), Inquiry-Based Learning (IBL), STEM Learning, and digital technology integration (PhET Simulation, mobile learning, gamification, blended learning) approaches have been proven to have a positive impact on learning outcomes, critical thinking skills, creativity, and student motivation. The thematic analysis resulted in four main themes: (1) strengthening critical thinking skills through PBL, (2) developing creativity and scientific literacy through IBL, (3) STEM integration to improve collaboration and scientific attitudes, and (4) utilizing digital technology for motivation and understanding abstract concepts. This study concludes that a combination of various innovative approaches is needed to make science learning more relevant to the demands of the 21st century.

In facing the digital era, there is a change in conventional broadcasting to digital broadcasting with a focus on multiplatform content distribution. This encourages TVMU to adapt to digital broadcasting. This study aims to understand how media, especially TVMU, formulates strategies, chooses the right approach, implements, and conducts monitoring and evaluation to increase the relevance and reach of its broadcasts. The Media Management Strategy Theory that became the focus of the research from Media Strategy Formulation, Media Strategy Selection, Media Strategy Implementation, Monitoring and Evaluation. A qualitative approach with a case study method was used to extract data through observation and in-depth interviews with relevant informants. The results show that multiplatform content distribution is the main strategy in facing the challenges of digital broadcasting. Social media is utilized for promotion, interaction, and distribution of program excerpts, while the website serves as an additional channel for live streaming and information provision. Television remains the main focus, but digital platforms are used to expand audience reach and attract the younger generation. Monitoring and evaluation processes are conducted regularly to assess the effectiveness of the strategies implemented, with adjustments based on analysis of audience data and digital trends. Key challenges include copyright issues on digital platforms and the difficulty of attracting audiences to educational and da'wah content amidst the dominance of entertainment content. The study concludes that implementing an integrated and adaptive content distribution strategy is an important step to support media sustainability in the digital era. The findings provide guidance for other media in effectively managing content distribution to reach a wider audience.

White Feces Disease (WFD), which infects Pacific white shrimp (Litopenaeus vannamei), poses a serious challenge in aquaculture due to its potential to cause mass mortality and substantial economic losses. One of the main causes of this disease is bacterial infection from the genus Vibrio. The use of natural substances, such as garlic (Allium sativum) extract, is considered a more environmentally friendly and sustainable alternative for disease control. This study aimed to examine the effect and determine the optimal concentration of garlic extract in inhibiting the growth of Vibrio sp. isolated from WFD-infected L. vannamei ponds, cultured on TCBS media. The study was conducted in vitro using the disc diffusion method with four extract concentrations (25%, 50%, 75%, and 100%) against two bacterial isolates, designated as isolate A and isolate B. The results showed that garlic extract was able to inhibit the growth of Vibrio sp., with the largest inhibition zone observed in isolate A at 75% concentration (14.8 mm) and in isolate B at 100% concentration (19.3 mm). These findings indicate the potential of garlic as a natural antibacterial agent to inhibit pathogenic bacteria and support the sustainability of shrimp aquaculture.

Diabetes Mellitus is a metabolic disorder caused by the pancreas failing to produce insulin hormone adequately. Based on the cause, diabetes mellitus is classified into three types, including type 1 DM, type 2 Diabetes Mellitus, and gestational diabetes mellitus. Hyperglycemia can also occur due to food consumed that is not balanced with physical activity carried out so that fat accumulates in the body and causes blood to be unable to enter the body's cells, ultimately increasing blood sugar levels. Signs and symptoms that often appear in Diabetes Mellitus patients are polydipsia (excessive thirst), polyuria (frequent urination due to excessive urine production), polyphagia (quickly feeling hungry even though you eat a lot and want to eat continuously) and weight loss without a clear cause. Symptoms of diabetes mellitus can be controlled by increasing physical activity, following a healthy diet, and getting enough rest. Several studies have proven that bay leaves have the potential as an antidiabetic. This study aims to determine the content of secondary metabolic compounds and the antidiabetic activity of bay leaf extract using α-amylase enzyme inhibition in vitro. This research method uses laboratory experiments. This study uses α-amylase enzyme inhibition to determine the antidiabetic activity contained in bay leaf extract. The method used is DNSA. The results of this study obtained a yield of bay leaf extract of 30%, water content of simplicia of 6.24%, drying loss of simplicia of 5.3%, ash content test of 5.6%, water content test of extract of 6.34%, drying loss test of extract of 7.03%. Bay leaf extract positively contains secondary metabolite compounds, namely saponins, tannins, flavonoids, and alkaloids. The results of IC50 in bay leaf extract of 66.705 ppm are classified as strong antidiabetic. The results of acarbose of 56.818 ppm are classified as strong antidiabetic.

Eleutherine bulbosa (Mill.) and Allium cepa L. (including garlic and onion peel) are medicinal plants that have long been traditionally used to treat cancer, diabetes, hypertension, infectious diseases, and inflammation. Recent scientific studies emphasize the importance of extract standardization to ensure consistent quality, safety, and efficacy. Standardization includes specific parameters—such as organoleptic identification, water- and ethanol-soluble extract values, phytochemical profiles, and determination of marker compounds—and nonspecific parameters such as moisture content, loss on drying, total ash, and acid-insoluble ash. Ethanol extract of E. bulbosa showed moisture and drying loss values below 10%, total flavonoid content of around 1.2%, and positive phytochemical tests for alkaloids, flavonoids, saponins, and quinones. Onion peel extract contains a high flavonoid content (7.84 mg QE/g) with moderate antioxidant capacity (DPPH IC₅₀ 152.65 µg/mL), while fermented garlic (black garlic) contains more than 12% polyphenols and more than 2% flavonoids, as well as a high level of S-allyl-L-cysteine (SAC) as a stable bioactive compound. The pharmacological activities of these standardized extracts include strong antioxidant effects, α-glucosidase inhibition for antidiabetic activity, induction of apoptosis and anti-angiogenesis as anticancer potential, membrane disruption and enzyme inhibition for antimicrobial activity, as well as COX/LOX modulation for anti-inflammatory effects. These activities are directly correlated with the secondary metabolite composition of each material. With their phytochemical richness and diverse biological activities, E. bulbosa and A. cepa have great potential as raw materials for standardized herbal products. Further in vivo studies and clinical trials are needed to validate their therapeutic efficacy and to support the development of evidence-based phytopharmaceuticals.

Burn injuries are a significant health problem because they damage the skin’s protective barrier, increase the risk of infection, and may cause severe complications if not treated properly. The healing process is complex and involves several cellular events, in which fibroblasts play a key role by producing collagen and forming granulation tissue. Recently, there has been growing interest in natural, herbal-based therapies for wound care. Tamarind leaves (Tamarindus indica) were chosen in this study because they contain flavonoids, polyphenols, tannins, and saponins, all of which have anti-inflammatory, antioxidant, and tissue-regenerating properties. The aim was to evaluate the effectiveness of ethanol extract gel of tamarind leaves at concentrations of 2.5%, 5%, and 10% in promoting fibroblast proliferation and healing of burn wounds in male rats (Rattus norvegicus). An experimental randomized design was used with six groups: normal control, neative control, positive control, and three treatment groups. Clinical observation and histopathological analysis showed that the extract gel accelerated wound closure significantly compared to the negative control. Fibroblast proliferation was higher in all treatment groups, with the 10% extract giving the best result, similar to Bioplacenton. These findings highlight tamarind leaves’ potential as a safe and affordable alternative for burn wound therapy.

Tonic is a preparation thats can stqrengsthen the body and improve stamina. Curcuma zedoaria and Curcuma aeruginosa are known to have phytochemical compunds such as flavonoids, alkaloids, saponins, tannin, triterpenoids, curcuminoid and polyphenols that can function as stimulant and tonics. This studiy aimed to investigate tonic effects of ethanolic extracts of Curcuma zedoaria, ethanolic extract of Curcuma aeruginosa, and their combinations on male white mice (Mus musculus). Curcuma zedoaria rhizome and Curcuma aeruginosa rhizome were extracted using the maceration method for 3 days using 70% ethanol solvent which was then thickened in a waterbath. A total of 35 male mice were divided into 7 groups with different treatments, including negative control (aquadest), positive control (caffeine 100 mg/kgBB), ethanolic exctract of Curcuma zedoaria (600 mg/kgBB), ethanolic extract of Curcuma aeruginosa (600 mg/kgBB), and combination ethanolic extract of Curcuma zedoaria and Curcuma aeruginosa at dosage of 150:450 mg/kgBB, 300:300 mg/kgBB, and 450:150 mg/kgBB. Tonic effect were evaluated using natatory exhaustion and rotarod tests. The natatory exhaustion test is carried out by observing how long the mice swim, while the rotarod test is carried out by observing how long the mice stay on the rotarod apparatus. The data analyzed using ANOVA and Tukey’s test. The results of One Way Anova showed a there were significansts differensce in each groups (p<0,05) with combination of Curcuma zedoaria : Curcuma aeruginosa (150:450 mg/kgBB) yielding the best tonic effect. From the result of Tukey’s followsup test, it showed that the highers the dosae of Curcuma aeruginosa rhizome extracts the better the tonics effects giiven. This suggest that Curcuma aeruginosa has a dominant role in enhancing phsycal endurance in male white mice.

Indonesia, as an archipelagic nation, faces considerable challenges in meeting its food requirements in accordance with Law No. 18 of 2012 on Food Security. The country’s heavy reliance on wheat imports, ranking as the largest wheat importer globally, highlights the urgency of diversifying local food sources. This study aims to explore the utilization of jali flour (Coix lacryma-jobi L.), mocaf flour (Modified Cassava Flour), and soybean flour as raw materials for producing fettucini pasta, with the addition of green spinach extract for natural coloring and nutritional enhancement. A quantitative experimental method was employed, testing three formulations of jali and mocaf flour combined with soybean flour. Sensory evaluations were conducted with 35 panelists—comprising trained, semi-trained, and untrained participants—to assess color, aroma, taste, texture, and overall acceptability. The findings revealed that flour composition significantly influenced pasta’s sensory attributes. The F2 formulation (50% jali flour, 50% mocaf flour, 20% soybean flour) achieved the highest acceptance, with average scores across all parameters rated as “liked” to “highly liked.” The incorporation of spinach extract not only imparted an appealing natural green hue but also enhanced the product’s nutritional profile, particularly in iron and dietary fiber content. These results underscore the potential of combining jali and mocaf flours as a nutritious, gluten-free pasta alternative that supports local food diversification and reduces reliance on imported wheat.

Sappan wood (Caesalpinia sappan L.) is known to contain various bioactive compounds such as saponins, tannins, flavonoids, phenols, brazilin, and gallic acid. These compounds play an important role as antioxidants that can ward off free radicals and absorb UVA and UVB radiation that are harmful to the skin. Ultraviolet radiation is known to accelerate premature aging and cause tissue damage, so a topical formulation is needed that can provide protection while maintaining skin health. This study aims to determine the antioxidant activity and sunscreen ability of sappan wood extract in the form of lip balm with varying extract concentrations. Antioxidant activity was evaluated using the DPPH (1,1-Diphenyl-2-Picrylhydrazyl) method, while the Sun Protection Factor (SPF) value was determined by the Mansyur method using UV-Vis spectrophotometry. Sappan wood extract was formulated into four lip balm preparations, namely F0 (control without extract), F1 (5%), F2 (10%), and F3 (15%). Physical tests including homogeneity, pH, spreadability, adhesiveness, and organoleptic were conducted to ensure the quality of the preparation. The results showed that sappanwood extract had an IC50 value of 23.62 ppm which was categorized as very strong antioxidant activity. In the lip balm formulation, the IC50 values ​​obtained were F0 = 246.76 ppm (very weak), F1 = 92.68 ppm (strong), F2 = 78.03 ppm (strong), and F3 = 63.58 ppm (strong). The SPF test showed a protection value of F0 = 2.11 (minimum), F1 = 13.64 (maximum), F2 = 14.25 (maximum), and F3 = 18.28 (ultra). Thus, lip balm made from sappanwood extract has the potential as a cosmetic preparation that not only meets physical criteria, but also provides high antioxidant activity and effective sunscreen protection.

Memory is a vital biological system in the body that plays a role in storing, processing, and recalling information. Over time, due to aging or external factors, memory function may decline. One possible effort to maintain and improve cognitive performance is through the use of bioactive compounds with antioxidant properties. Avocado (Persea americana Mill.) leaves contain flavonoids, which act as antioxidants and possess neuroprotective effects that may enhance cognitive function, including memory. This study aimed to determine the effect of avocado leaf extract on the memory of male mice and to identify the most effective dose in improving cognitive performance. The extract was obtained using the maceration method with 70% ethanol as the solvent. Memory activity was tested on male mice, which were divided into five groups: negative control, positive control, and three treatment groups given avocado leaf extract at doses of 50, 100, and 200 mg/kgBW. The Y-Maze method was employed to assess memory through two parameters: latency time and error numbers. The results demonstrated that avocado leaf extract significantly improved memory in the test animals. Mice induced with 10% ethanol showed an increase in latency time and error numbers, while the groups treated with avocado leaf extract experienced reductions in both parameters. The most effective dose was 200 mg/kgBW, which produced a latency time difference of 19.5 seconds and an error number difference of 3.57. Therefore, avocado leaf extract shows potential as a natural agent to support and enhance cognitive function.

This study aims to analyze the differences between various extraction techniques and their relationship to the yield and biological activity of phytochemical compounds derived from natural materials. A systematic literature review was conducted by analyzing relevant and reliable scientific publications published within the last five years. The findings indicate that extraction methods such as maceration, soxhletation, microwave-assisted extraction (MAE), and ultrasound-assisted extraction (UAE) demonstrate varying levels of effectiveness depending on the type of material, solvent polarity, extraction temperature, and duration of the process. Modern extraction methods, particularly sonication, MAE, and UAE, have been shown to produce higher yields with enhanced biological activity while offering greater efficiency in terms of reduced time and solvent consumption. On the other hand, conventional techniques such as maceration and soxhletation remain relevant, particularly for thermolabile compounds that are sensitive to high temperatures. The selection of an appropriate extraction method plays a crucial role in obtaining high-quality extracts that can serve as potential raw materials for phytopharmaceuticals, functional foods, dietary supplements, and other natural products. This review not only highlights the advantages and limitations of each technique but also emphasizes the importance of aligning method selection with specific research objectives and compound characteristics. Overall, this study provides a theoretical foundation for future experimental research and serves as an initial guideline for determining extraction strategies based on efficiency, effectiveness, and sustainability.