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Sensory Integration Therapy is an approach that focuses on sensory stimulation to improve sensory processing and adaptive responses in individuals with sensory disorders, one of which is children with autism. Sensory integration therapy makes it easier for autistic children to communicate to be better understood and to create good social interactions. Therefore, the Yasmin Autism Therapy Center carries out Sensory Integration Therapy to improve social interaction in autistic children. This research aims to determine the application of sensory integration therapy at the Yasmin Autism Therapy Center to improve social interaction in autistic children and determine the obstacles in implementing sensory integration therapy. Data collection techniques include documentation, observation and interviews. The results of the research show that the stages of Sensory Integration Therapy at the Yasmin Autism Therapy Center are providing simple instructions, a series of sequential activities and honing concentration, consistency and endurance in activities through play. Supporting factors for sensory therapy activities include good collaboration between therapists and parents. Meanwhile, the obstacles to children's communication are difficult factors, limited therapy tools, and limited therapy time.

Banyuanyar Village is located in Banjarsari District, Surakarta City. Banyuanyar Village is included in the status of urban areas and has a Puskesmas which plays an important role in public health. Patient visits at the Banyuanyar Health Center physiotherapy clinic for shoulder pain cases from 2022 were 25 patients while in 2023 they increased to 50 patients. The most common case is shoulder pain with the third highest case. Characterized by complaints of pain in the shoulder that hinder daily activities. The purpose of this program is to provide education and demonstrate exercises in cases of shoulder pain in order to reduce and prevent complaints. The method used was education in the form of counseling and distributing leaflets to the elderly at the Banyuanyar RW 03 elderly post. The results obtained from measuring the increase in understanding using the pre-test and post-test questionnaires were a significant increase in understanding regarding exercise with a pre-test average value of 10 and a post-test average value of 85.5

In November 2022, Cianjur experienced an earthquake with a magnitude of 5.6 on the SR, which was followed by several aftershocks. As a result, the people of Cianjur experienced material and non-material losses such as houses being damaged or even collapsed, the loss of family members, or post-disaster trauma, especially for children. One of the communities working to help survivors is KM Cianjur, which focuses on trauma healing activities for children. This research uses descriptive-qualitative methods by collecting data through interviews and documentation. The total research population was 380 children in 4 villages, and the research subjects used random sampling techniques, namely 100 children in Kp Cirumput. The results of this research are trauma healing carried out by the KM Cianjur community using play therapy such as fun games, singing, and games with elements of knowledge. As a result of trauma healing, there are positive changes in children, as evidenced by the return of their functioning and their lifestyles starting to improve.

This article aims to explain and describe social work in handling cases of bullying in children through cognitive behavioral therapy. The discussion in this article was obtained through literature studies from various reading sources such as journals and books which were used to explain theories related to bullying and cognitive behavioral therapy. The current lack of education and handling of bullying is the trigger for the increasing number of bullying cases that occur every year, this shows the importance of handling bullying cases. In this case, the role of social work includes, among others, as a broker, enabler, advocate and motivator. Apart from that, in cases of child bullying through cognitive behavioral therapy, social work as a counselor plays a role in helping the learning process to create conventions in such a way that clients can change their behavior and solve their problems. By looking at the benefits of behavioral counseling mentioned above, researchers hope to minimize bullying.    

Death is an event that can have a traumatic impact on the family left behind. It is hoped that the peace process with oneself will come out of the traumatic period experienced. A healing process that has an impact also involves other people in resolving the trauma, using various trauma healing models. This aims to find out more about the trauma healing model using a play therapy approach. The method then used was a qualitative research method by taking a case study approach of the trauma felt by children due to the death of their lover's mother and a father who was required to be able to accompany his lover's children. This research will provide awareness to arrive at the ability to clearly find solutions and methods in overcoming perceived trauma.

Acute Coronary Syndrome (ACS) is a major cardiovascular problem because it causes high rates of hospitalization and mortality. The clinical manifestations of ACS are that the patient feels pain and discomfort that is not specific in the chest and legs radiating to the neck, left shoulder and arms and back then accompanied by cold sweat, nausea, vomiting, weakness and dizziness and can faint which occurs suddenly with high intensity.  Objective: To find out the results of applying Thermotherapy therapy to relieve chest pain in patients with Acute Coronary Syndrome. Moewardi Surakarta. Method: This type of research is a descriptive case study. The application was carried out on 2 patients selected by purposive sampling method with inclusion and exclusion criteria. Thermotherapy is carried out for 10-20 minutes 1x/day for 3 days. The research instrument used SOP foot massage, hemodynamic status observation sheets, and informed consent. Results: After being given the application to both respondents for 1 time a day for 3 consecutive days, a decrease in the level of the chest pain scale was found in the patient Mr. S with a pain scale level before being carried out by Thermotherapy therapy, severe pain and after being carried out by Thermotherapy therapy for 1 time in 3 consecutive days to mild pain. Meanwhile, in the patient Mr. A with the level of pain scale before the Thermotherapy therapy is severe pain and after the Thermotherapy therapy is done for 1 time in 3 consecutive days it becomes mild pain. Conclusion: there is a reduction in the chest pain scale in patients with Acute Coronary Syndrome at RSUD Dr. Moewardi Surakarta after being given thermotherapy.

Health is a state of health, both physically, mentally, spiritually and socially, which enables everyone to live a productive life socially and economically. Public health is a condition that describes the level of health that occurs in society. Society is a group of individuals who live together, work together to obtain common interests and have an order of life, norms and customs that are adhered to in their environment. Public Health is a part of science that discusses and studies the prevention and treatment of disease in each individual. Physiotherapy as a health worker plays a very important role and must have the ability to maximize the potential for movement and function within the promotive, preventive, curative and rehabilitative scope. Therefore, it is proof that physiotherapy not only plays a curative and rehabilitative role but also plays a big preventive role. Nape pain or neck pain is generally not a serious condition that needs to be watched out for. This condition can heal in a few days or weeks without special treatment. However, neck pain can also occur due to certain diseases. Bending over, looking down for too long, often gritting your teeth, or reading in bed, using a cell phone for a long time can cause the neck muscles to become tense. Over time, this condition will cause Kornik's neck pain, which is a myofascial condition. Smartphones are a real manifestation of technological progress and are devices that work very complexly with access to the internet, social media and games. Excessive smartphone use can cause musculoskeletal disorders. Musculoskeletal disorders associated with smartphone use cause neck muscle fatigue caused by poor posture. Using smartphones for a long time can cause muscle tension. Apart from using smartphones, household activities can also cause neck pain such as ironing and washing. Providing exercise therapy in the form of Free Active Movement can reduce complaints of neck pain.

Drug-resistant tuberculosis (TB) is an escalating global health issue, particularly with the rise of multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB), which complicate treatment and control efforts. Resistance to both first-line and second-line drugs weakens the effectiveness of standard WHO-recommended therapies, while alternative drugs can cause severe side effects and reduce patient adherence. This study aims to explore the integration of bioinformatics and pharmacogenomics in supporting personalized TB treatment to improve therapeutic success and reduce the risk of further resistance. The research employed a laboratory-based experimental design with a bioinformatics approach, involving TB patients with clinical evidence of drug resistance. Clinical samples were analyzed through whole genome sequencing to identify gene mutations associated with resistance, followed by pharmacogenomic mapping to predict pharmacological responses based on patients’ genetic variations. The results revealed several specific gene mutations consistently linked to resistance and produced individualized therapeutic recommendations that were more targeted than standard protocols. Effectiveness evaluation demonstrated that genome-based personalized therapy yielded higher treatment success rates, faster recovery times, and lower rates of subsequent resistance. These findings highlight the significant potential of precision medicine in TB management, particularly for resistant cases that are difficult to treat with conventional approaches. In conclusion, the integration of bioinformatics and pharmacogenomics plays an essential role in strengthening TB treatment strategies through a personalized, adaptive, effective, and sustainable approach. Nevertheless, its implementation still faces challenges such as high costs, limited infrastructure, and the need for clear regulations regarding the use of patients’ genomic data.

The purpose of this study was to investigate how dhikr therapy can lessen psychopathological symptoms. Eighteen hypertension patients in all were chosen as volunteers and divided into two groups: experimental and control. While the control group (n = 9) was placed on a waiting list, the experimental group (n = 9) received the therapy. The Brief Symptoms Inventory (BSI), which measures psychopathological symptoms before therapy (pretest), after therapy (posttest), and during a two-week follow-up test, was administered to all participants. With Z = -3.339 and p = 0.000, data analysis using the Mann-Whitney U revealed a significant decrease in symptoms. The findings confirmed the theory that psychopathological symptoms were alleviated by dhikr treatment. This study concluded that spiritual therapy plays a significant influence in lowering psychological symptoms.

Children are the younger generation who have an important role in maintaining and continuing the ideals of the nation. Several cases of serious health complaints experienced by children require more than just outpatient treatment. If a child is hospitalized, then the child will easily experience a crisis because the child experiences anxiety due to the changes he is experiencing. Children need media that can overcome anxiety due to hospitalization and be able to work with health workers while in treatment. One of the media so that children can overcome anxiety is the skill of playing coloring pictures. Intervention play therapy coloring pictures is done 15-20 minutes every day for 2 days in a row. The level of anxiety before being given play therapy coloring pictures in subject I was 11 (severe anxiety) and subject II was 6 (moderate anxiety). The level of anxiety after being given play therapy coloring pictures in subject I is a score of 9 (moderate anxiety) and subject II a score of 4 (mild anxiety). The conclusion from the discussion of this case study is that there is a decrease in anxiety levels after the application of coloring pictures play therapy in preschool-aged children.

Hospitalization or inpatient care has an impact on anxiety in children. Anxiety or a condition of excessive fear caused by certain situations often occurs in almost every child who is hospitalized or hospitalized. Play activity therapy is a good activity to deal with anxiety in children who experience hospitalization, so that it can accelerate the healing process of pain in children. Determine changes in anxiety levels in preschool aged 3-5 years at RSUD Pandan Arang Boyolali hospital. This study used a descriptive design on two male respondents which was conducted from 4 to 6 July 2023 ar Pandan Arang Boyolali Hospital with each respondent being given intervention for 3 consecutive days. The instrument used was the Spence Children Anxiety Scale SCAS observation sheet to measure the level of anxiety before and after giving therapy. Before the two respondents were put into action, the level of anxiety was moderate (first respondent scored 18; second respondent scored 20), and after the two respondents were put into action, the level of anxiety was mild (first respondent scored 12; second respondent scored 13). The application of play therapy to coloring pictures with color sand is able to reduce anxiety levels in preschool aged 3-5 years at Pandan Arang Boyolali Hospital.

Afterpains are a common physiological complaint experienced by mothers during the postpartum period due to uterine contractions that occur after childbirth. This pain can disrupt comfort, inhibit the involution process, and affect the mother's physical and psychological well-being. Non-pharmacological treatment efforts such as the Effleurage Massage technique are an effective alternative because they can increase relaxation and stimulate the release of endorphins that play a role in reducing pain perception. This study aims to determine the effect of the Effleurage Massage technique on the level of afterpains in postpartum mothers at Midwife Sulastri, Percut Sei Tuan District, Deli Serdang Regency in 2022. The research design used was a quasi-experimental design with a one-group pretest-posttest without a control group. The study sample consisted of 45 postpartum mothers selected using the total sampling technique. Data were collected through observations with a numeric pain scale and analyzed using the Wilcoxon Signed Rank Test. The results showed that there was a significant decrease in pain levels after Effleurage Massage with a p value = 0.000 (<0.05). These findings demonstrate that the Effleurage Massage technique is effective in reducing the intensity of postpartum afterpains. Consequently, this massage can be used as a complementary therapy in postpartum midwifery care to increase comfort and accelerate the mother's recovery process.

Fine motor development is a movement that only involves small muscles in the body, such as skills in using fingers and wrist movements. Delays in fine motor development are caused by the lack of opportunities for children to play, the stimulation that children receive is good by parents. This study aims to determine the effectiveness of playing collage and plasticine therapy on fine motor development in children 4-5 years old at Zainul Hasan Genggong Kindergarten, ProbolinggoThis type of research is pre-experimental with a two group pretest-posttest research design. The population was 46 respondents who met the inclusion requirements of the study were selected using a total sampling technique. Children's fine motor development was measured using an observation sheet, and information was gathered using editing, coding, scoring, and tabulating procedures. In both groups, the data were evaluated using the Wilcoxon test hypothesis.The results showed that the value of ρ Value α = 0.000 in the collage playing group and the value of ρ Value α = 0000 in the plasticine playing group. The significant level of ρ Value < α 0.05, it is stated that both therapies are effective in developing children's fine motor development. However, judging by the results of the observation, the post-test value of playing plasticine therapy was more with the results of the BSB category being 20 children. Due to the age characteristics in group 2, there were more 4 years of age at that age, children's fine motor development was more rapid.Collage and plasticine games are a series of therapies to develop fine motor development in children. For further researchers, it is recommended to add variety of images in collage play therapy, to approach children more when given play therapy.    

Hospitalization is a form of stressor in children that lasts as long as the child is hospitalized, hospitalization becomes a crisis that must be faced by children. Feelings of anxiety are the impact of hospitalization experienced by pre-school children. This impact has the risk of interfering with child development and the healing process in children. To reduce children's anxiety, we need a media that can express anxiety, one of which is play therapy. Forms of games that are suitable for children aged 3-6 years are coloring pictures. The purpose of this application is to find out the results of applying play therapy to reducing anxiety due to hospitalization. The application method was carried out using a case study descriptive method to 3 respondents and the coloring play therapy was carried out once in 30 minutes. The results of the application that has been carried out are a decrease in anxiety due to hospitalization. The conclusion in this study is that coloring play therapy can be used as a technique to reduce feelings of anxiety in preschool children due to hospitalization.

Elderly is someone who is over 65 years old and the elderly are also a risk group whose population is increasing. Elderly is not a disease, but an advanced stage of a life process which is marked by a decrease in the body's ability to adapt to environmental stress. The purpose of doing perceptual stimulation group activity therapy is that the client can reduce the depression he is experiencing and follow the treatment program optimally. Health counseling was held on Wednesday, June 7 2023. The population in this counseling were officers and the elderly in the Wisma Durian Room Tresna Werdha Budi Mulia 2 Social Institution. After carrying out group activity therapy "ball relay" the results (100%) were officers and the elderly understand, understand and be able to exemplify how to play the ball relay.  

Insulin plays an important role in metabolism. miR-Let-7b-5p has an important role in the regulation of genes that play a role in the insulin signaling pathway. This study aims to look at the role of hsa-miR-Let-7b-5p in the insulin signaling pathway and the genes related. This research method is an in silico study using DIANA MiRPath v3.0. Pathway analysis was performed using DIANA MiRPath v3.0 web-based software to analyze miRNA regulation. This research uses data on the regulatory pathways of the Homo sapiens species. The results showed that there were 10 target genes from hsa-miR-Let-7b-5p in the insulin signaling pathway. The metabolic processes involved in the insulin signaling pathway are related to glucose uptake, lipogenesis, glycolysis, glycogenensis, antiapoptosis, protein synthesis, proliferation and differentiation. The NRAS, MAP2K2 and KRAS genes affect the process of proliferation, differentiation and protein synthesis. The CRKL gene influences the process of glucose uptake. The ACACA gene influences the process of lipogenesis. The GYS1 gene influences the process of glycogenesis. The PRKAR2A gene influences the antilipolysis process. The INPPL1 gene influences the inhibition of the PI3K gene into aPKC, PDKI2 and mTOR in various pathways in the insulin signaling pathway. Other pathway processes related to the insulin signaling pathway are the phosphatidyl signaling system and the MAPK signaling pathway. So that miR-Let-7b-5p as an indicator of examination or can be a target of therapy related to the role of insulin.

Anxiety is the most common feeling experienced by pediatric patients who experience hospitalization, anxiety that is often felt by children such as crying, fear of the environment and new people. The number of stressors experienced by children when undergoing hospitalization can have a negative impact on the child's development. This aim is to determine the effect of coloring play therapy on the anxiety level of preschool-aged children who experience hospitalization at the Banda Aceh Mother and Child Hospital. This study used a quantitative research design with a sample size approach of 5 respondents. The sampling technique used is purposive sampling. Data collection instruments were carried out before and after carrying out coloring play therapy using observation sheets with a percentage calculation assessment scale. The results showed that before being given coloring play therapy, there were 2 respondents who experienced moderate anxiety (40%) and 3 child respondents who experienced severe anxiety (60%). And after being given coloring play therapy there were 4 child respondents who experienced mild anxiety (80%) and 1 person who was in the moderate category (20%). It is suggested that the results of this study can be used as a reference for coloring play therapy in preschool-age child patients who experience hospitalization anxiety in the children's room at the Banda Aceh mother and child hospital in 2021.

The challenges of the 21st century nursing world demand that nursing educators be able to prepare future nurses who can adapt to changes in the health care system, new technologies, changes in information systems (computerized), changes in pharmacological therapy, increased workload for nurses, increased infectious diseases in the community. , increasing cases of antibiotic-resistant infections, increasing aging population, and increasing number of chronic and co-morbid conditions (Aiken, Clarke, Cheung, Sloane, & Silber, 2003). Nurse educators are responsible for preparing graduates who can adapt to this rapidly changing health system. The simulation learning strategy is proposed as a suitable method to overcome this problem and can bridge the gap between education and clinical practice in hospitals. This literature search aims to analyze the results of related research that focuses on the effect of Simulation-Based Learning on the critical thinking of nursing students. This study was conducted using the review method of research results from 2010 – 2020 which have been published in electronic media such as ProQuest, Pubmed, and CINAHL. The number of journals obtained was 10 journals and 6 of them met the criteria. The conclusion of the research results obtained was that simulation is an interactive teaching-learning process, learning knowledge about critical care from a simulation of real patient situations, learning clinical skills and presenting holistic patient care by playing a role , and bridging the theory-practice gap to enhance critical thinking. In addition, simulations can hone critical thinking skills through feedback from simulators and monitor displays, develop communication skills through teamwork, and improve task delegation skills in complex situations.

Hospitalization is a process that requires children to undergo treatment and therapy at the hospital until they return home. The impact of hospitalization that is most often experienced by children is anxiety. Anxiety experienced by children during hospitalization can be overcome by playing therapy. The purpose of this study was to determine the effect of giving playing ball therapy to hospitalized children with anxiety before examining vital signs. This research method is a descriptive study, with a sample of 2 people in the Hospital of Temanggung Regency. The instrument used to measure anxiety levels is the Spence Children's Anxiety Scale (SCAS). Respondents were given play therapy 3 times in 3 days. The results of this study indicate that the anxiety level of hospitalized children decreased from an average score of 36, namely the moderate anxiety category, to an average score of 20, mild anxiety category.    

Language is the primary tool humans use to convey thoughts and messages, both verbally and in writing. According to experts, language is a system of sound symbols used for communication and interaction, consisting of phonology, lexicon, and grammar. Phonology studies the sounds of language and is a crucial aspect of linguistics, divided into phonetics and phonemics. Language plays an important role in daily life, not only as a communication tool but also as a reflection of individual or group identity. Language preserves cultural heritage and strengthens social relationships within a community. Proper use of language facilitates communication and influences the understanding of the interlocutor. The development of globalization makes language a means of cross-cultural connection, aiding in collaboration and participation between countries. However, every language faces challenges in pronunciation, word formation, writing, and sentence usage. Phonological disorders, such as in individuals with cleft lip and stuttering, affect speaking ability and language comprehension. A cleft lip causes difficulties in producing certain consonants, while stuttering causes disruptions in speech flow. Phonological error analysis helps to understand the patterns of sound production errors and design interventions to improve speaking abilities. This research is essential for identifying phonological disorders and developing effective therapy methods. The study titled "Phonological Disorders in Mustofa in the Wkwk Project Podcast by Genflik" aims to gain a deeper understanding of phonological disorders in individuals with cleft lip and stuttering, and to find solutions to improve their communication abilities.