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Afrizal Bagaskara; Ni Made Laksmi Devi Jayanti; I Komang Aditya Negara

Jurnal Ilmu Kesehatan dan Gizi 2026 Pusat Riset dan Inovasi Nasional

Regular physical activity is known to play an important role in maintaining overall health, including improving immune system function and mental health. Lack of physical activity remains a public health issue, making it important to understand the impact of physical activity on the immune system and mental health. This study aimed to review the effect of regular physical activity on the immune system and mental health using a literature review method. The literature sources were obtained from publications within the last five years using databases such as Google Scholar, PubMed, and ScienceDirect. The articles were then screened and selected based on inclusion and exclusion criteria, resulting in nine relevant articles for analysis. The selection results indicate that regular physical activity can increase the mobilization and activity of immune cells such as lymphocytes, neutrophils, and natural killer cells, and also modify the adaptive immune system through changes in T cells and B cells. In addition, physical activity also improves mental health through neurobiological mechanisms such as increased endorphin, dopamine, and serotonin levels, which can reduce stress, anxiety, and depression, as well as improve sleep quality and psychological well-being. Therefore, regular physical activity has a positive effect on the immune system and mental health and can be used as a promotive and preventive strategy to maintain overall health.

Muhammad Farhan; Fury Maulina

Jurnal Kesehatan dan Kedokteran 2026 Lembaga Pengembangan Kinerja Dosen

Leprosy remains a significant public health problem in various developing countries, including Indonesia. This disease is caused by Mycobacterium leprae, which attacks the skin and peripheral nerves and can cause long-term physical, psychological, and social impacts if not treated early and adequately. Health-seeking behavior in leprosy patients is also influenced by structural factors such as the availability of health facilities, distance, transportation costs, and the quality of communication between health workers and patients. Research in various endemic countries confirms that friendly, accessible primary health care services that provide comprehensive education can improve early detection and therapy adherence. Patient SA, an 11-year-old child diagnosed with multibacillary (MB) leprosy and has been undergoing treatment for four months. The progression of the disease to MB indicates limitations in early symptom recognition and the family's health-seeking behavior, which may be influenced by low perceptions of disease susceptibility and severity, lack of knowledge, and barriers to accessing health services. However, after the diagnosis was confirmed and education provided by health workers, positive behavioral changes occurred, indicated by the patient's adherence to routine therapy as recommended.

Muhammad Al Ghifari; Muhammad Adjie Ar Rauuf Mikail; Muhammad Ichlas Ramadhan; Andrian Jeremy Marulitua Sigalingging

Jurnal Riset Rumpun Ilmu Sosial, Politik dan Humaniora 2026 Pusat Riset dan Inovasi Nasional

This study examines in depth the responsibility of the Pangkalpinang City Government in maintaining environmental cleanliness. Such responsibility is not merely an administrative obligation but a constitutional mandate as stated in the 1945 Constitution of the Republic of Indonesia. Every citizen, including the people of Pangkalpinang, has the right to live in a clean and healthy environment, while the local government is obliged to ensure the fulfillment of this right. This research analyzes the extent to which the local government has carried out its responsibilities through preventive measures (such as formulating regulations and supervising permits) and enforcement actions (including imposing sanctions and restoring the environment). The findings reveal several obstacles, such as limited budget, weak inter-agency coordination, and low public awareness regarding environmental cleanliness. Therefore, although the legal framework is well established, strong commitment, synergy, and continuous efforts from all stakeholders are required to realize a clean and sustainable Pangkalpinang City.

Ritha Mariati Sembiring; Eka Permata Sari Br. Sihombing; Indah Juni Florida Daeli; Maria Aloysia O. W. L. Masa; Grace Krishna Angelica Gea +1 more

Jurnal Riset Rumpun Ilmu Kesehatan 2026 Pusat riset dan Inovasi Nasional

Gout arthritis is a disease characterized by sudden inflammation of the joints due to high levels of uric acid in the body (hyperuricemia). This condition is marked by acute episodes of joint inflammation, often affecting a single joint and preceded by asymptomatic periods of varying duration. Older adults represent the final stage in the human lifespan and experience the natural aging process. This study employed an analytic survey design with a cross-sectional approach. The purpose of this study was to determine the relationship between gout arthritis pain and the level of independence in activities of daily living among patients at the Helvetia Public Health Center. The results showed that the majority of older adults in the working area of UPT Puskesmas Helvetia experienced high levels of pain, with 73 respondents reporting severe pain. Meanwhile, most respondents demonstrated independence in their daily activities, with 72 categorized as independent. The findings indicate a significant relationship between gout arthritis and the level of independence in activities of daily living among older patients at the Helvetia Public Health Center.

Fanita Oktavia; Rani Safitri

Jurnal Siti Rufaidah 2026 PPNI UNIMMAN

Immunization is a vital public health strategy to prevent infectious diseases and reduce morbidity and mortality. In Indonesia, the Pentabio vaccine protects against diphtheria, pertussis, tetanus, hepatitis B, and Haemophilus influenzae type b. Despite its effectiveness, post-immunization reactions such as fever and local pain are common, potentially affecting caregiver perceptions and immunization adherence. A descriptive observational study with a cross-sectional design was conducted among infants receiving Pentabio immunization at Posyandu in the UPT Timpah Community Health Center, Central Kalimantan. Data were collected through structured observation and caregiver interviews for infants aged 2–11 months. Fever (≥37.5°C) and local pain (tenderness, redness, or swelling) were assessed. Of the 30 infants, 40% were aged 2–3 months, 33.33% were 4–6 months, and 26.67% were 7–11 months, with slightly more males (53.33%). Post-immunization fever occurred in 60%, and local pain in 70%, with both reactions being mild, transient, and appearing within 24–48 hours. These findings highlight the commonality of mild adverse events, especially in early infancy, and underscore the need for clear caregiver education to maintain confidence in immunization services and ensure adherence to vaccination schedules.

Ayyi Afifah; Devi Novita Sari; Siti Nurlaila; Dilla Erlianti

Jurnal Media Administrasi 2026 Universitas 17 Agustus 1945 Semarang, Indonesia

Food security is a complex issue closely related to various aspects such as agriculture, nutrition, health, and the environment. In the context of global development, food security is an integral part of the Sustainable Development Goals (SDGs), particularly Goal 2: Zero Hunger. This study aims to analyze the implementation of food security policies in supporting the achievement of the SDGs and to identify the factors that hinder the successful implementation of these policies. This research uses a qualitative approach with a literature study method, examining various secondary data sources including books, journal articles, laws and regulations, official government reports, mass media, and relevant online publications. The results show that the Indonesian government has undertaken various efforts to achieve food security through strengthening regulations, starting from Law Number 18 of 2012, Government Regulation Number 17 of 2015, and Presidential Regulation Number 125 of 2022. These efforts are supported by increased budget allocation, local wisdom-based food diversification programs, food estate programs, and strengthening national food reserves through cross-sectoral coordination. However, the implementation of these policies still faces four structural constraints, namely high population growth, the conversion of agricultural land, the impact of climate change on agricultural productivity, and low interest among the younger generation, which threatens farmer regeneration. The implications of this study indicate that the successful implementation of food security policies in supporting the achievement of the SDGs requires comprehensive, sustainable strategies and effective cross-sector collaboration.

Intan Kumalasari; M. Tri Riansyah; Ayu Febri Wulanda

DIAGNOSA: Jurnal Ilmu Kesehatan dan Keperawatan 2026 International Forum of Researchers and Lecturers

Undernutrition among children under five remains a significant public health challenge in Indonesia, including in Ogan Ilir District. This condition can adversely affect growth, cognitive development, and immune function. This study aimed to determine the risk factors associated with undernutrition among children under five in the working area of Seri Tanjung Public Health Center, Ogan Ilir District, in 2025. This was an analytical study with a cross-sectional design. A total of 95 children under five were selected using cluster sampling. Data were collected through structured interviews using a questionnaire and anthropometric measurements of weight-for-age (W/A), then analyzed using the Chi-Square test with a significance level of 0.05. The results showed that economic status (p=0.012; OR=3.25; 95%CI=1.29–8.20), environmental sanitation (p=0.021; OR=2.98; 95%CI=1.18–7.53), infectious diseases (p=0.004; OR=3.85; 95%CI=1.55–9.58), and maternal health history (p=0.037; OR=2.67; 95%CI=1.06–6.74) were significantly associated with undernutrition. The strongest influencing factor was infectious diseases. This study recommends strengthening infection prevention efforts, improving environmental sanitation, providing nutrition education for families, and monitoring maternal health during pregnancy to reduce the prevalence of undernutrition among children under five.

Roslina Roslina; Nila Widya Keswara

Jurnal Siti Rufaidah 2026 PPNI UNIMMAN

Anemia during pregnancy is a major public health issue, especially in developing countries like Indonesia, contributing to maternal morbidity and adverse pregnancy outcomes. The second trimester, marked by increased iron needs due to plasma volume expansion and fetal growth, is critical for preventing anemia. Moringa leaves (Moringa oleifera), rich in micronutrients, may serve as an effective nutritional intervention to enhance hemoglobin levels in pregnant women. This study aimed to assess the impact of moringa leaf supplementation on hemoglobin levels in second-trimester pregnant women. Using a one-group pretest-posttest quasi-experimental design, the study was conducted at the Tadoy Community Health Center in Bolaang Mongondow Regency from October to November 2025, involving 25 pregnant women selected via purposive sampling. Hemoglobin levels were measured before and after the supplementation. Data analysis, including the Shapiro-Wilk test and Wilcoxon Signed Rank Test, indicated significant changes in hemoglobin levels (p = 0.000). The results showed a notable increase in hemoglobin levels post-supplementation, supporting the potential of moringa leaves as a safe, affordable, and effective intervention. This finding suggests that moringa leaves could be integrated into antenatal care and nutrition education to help prevent anemia in pregnant women.  

Faramayla Adinda Rinaldy; Andarita Rolalisasi; Febby Rahmatullah Masruchin

Konstruksi: Publikasi Ilmu Teknik, Perencanaan Tata Ruang dan Teknik Sipil 2026 Asosiasi Riset Ilmu Teknik Indonesia

Surabaya is one of the metropolitan cities in Indonesia with significant potential for the development of sports performance and the improvement of public health quality. The advancement of modern sports requires a sport science–based approach that integrates training, health, technology, and research aspects. However, the lack of integrated sport science facilities remains a major challenge. Therefore, proper site selection is a crucial factor in the design of a Sport Science Center. This study aims to formulate appropriate site selection criteria for the design of a Sport Science Center in Surabaya. The research method used is descriptive qualitative, employing literature studies, site observations, and comparative analysis of alternative sites based on predetermined criteria. The results indicate that the main site selection criteria include accessibility, proximity to supporting facilities, compliance with spatial planning regulations, environmental conditions, land area, and future development potential. Based on the analysis, the Middle East Ring Road (MERR) area in Surabaya is considered the most suitable location for the development of a Sport Science Center.

Risca Manoppo; Greita Marsya Selina Timpal

Sevaka : Hasil Kegiatan Layanan Masyarakat 2026 STIKES Columbia Asia Medan

Risky sexual behavior among adolescents is an increasingly concerning public health issue, particularly due to the lack of comprehensive sexual education in school and family environments. This community service activity aimed to improve the knowledge, awareness, and preventive attitudes of students at SMA Negeri 2 Tomohon regarding the dangers of free sex and the importance of maintaining reproductive health. The method used was educational socialization through interactive lectures, demonstrations, and open discussions involving 60 students as participants. Evaluation was conducted using pre-test and post-test instruments to measure improvements in participants' knowledge. The results showed a significant increase in knowledge, with the average pre-test score of 52.3 increasing to 80.7 in the post-test (a 54.3% improvement). A total of 91.7% of participants reached the good knowledge category after the activity, compared to only 18.3% before the activity. Participants also demonstrated more positive and critical attitudes toward the risks of free association. This activity affirms that interactive education-based socialization on reproductive health is effective in improving adolescent understanding. It is recommended that schools integrate reproductive health content regularly in counseling guidance programs to strengthen the sustainability of this activity's impact.

Isak Klafle; Dian Ferriswara; Ulul Albab; Sapto Pramono

International Journal of Humanities and Social Sciences Reviews 2026 Asosiasi Penelitian dan Pengajar Ilmu Sosial Indonesia

This study aims to analyze the effectiveness of the Papua Special Autonomy policy in improving the welfare of indigenous communities by reviewing the achievement of policy objectives, integration and coordination between institutions, and policy adaptation to the socio-cultural conditions of the local community. The approach used is qualitative with the Qualitative Secondary Analysis (QSA) method, utilizing various secondary data sources such as policy documents, government reports, and relevant research and academic journals. The results of the study indicate that the Papua Special Autonomy policy was designed as an affirmative policy aimed at accelerating regional development, improving community welfare, and recognizing the rights of indigenous communities. This policy has produced several positive results, especially in increasing regional fiscal allocations, developing infrastructure, and expanding community access to education and health services. In addition, the establishment of special institutions such as the Papuan People's Assembly provides space for the representation of indigenous people's culture in the regional government system. However, the study also shows that the Special Autonomy policy faces several challenges, including suboptimal inter-institutional coordination, limited institutional capacity of local governments in managing Special Autonomy funds, and the incomplete integration of indigenous socio-cultural values ​​in the planning and implementation of development programs. Therefore, strengthening policy governance, increasing accountability in fund management, and expanding indigenous community participation are crucial factors in enhancing the effectiveness of Papua's Special Autonomy policy. This research provides theoretical contributions to public policy development, particularly in the context of implementing asymmetric decentralization and culture-based development policies.

Karmanis Karmanis; Ainun Ganisia

Jurnal Media Administrasi 2026 Universitas 17 Agustus 1945 Semarang, Indonesia

Stunting is one of the chronic nutritional problems that remains a major challenge in health development in Indonesia. This condition not only affects children’s physical growth but also influences cognitive development, productivity, and the quality of human resources in the future. The government has developed various policies to accelerate the reduction of stunting through specific and sensitive intervention approaches implemented in an integrated manner across sectors. Semarang, as one of the urban areas in Indonesia, has also implemented these policies through various health, nutrition, sanitation, and community empowerment programs. This study aims to analyze the policies of specific and sensitive interventions in addressing stunting in Semarang and to identify factors influencing the effectiveness of their implementation. This research uses a qualitative approach with a policy study method through document analysis, observation, and interviews with relevant stakeholders such as the health office, community health centers, and other local government agencies. Data analysis was conducted descriptively by examining program integration, inter-agency coordination, and community participation in policy implementation. The results show that the implementation of specific and sensitive intervention policies in Semarang has been carried out through various programs such as maternal and child nutrition services, improved access to sanitation, health education, and family empowerment. However, several challenges remain, including suboptimal cross-sector coordination, limited resources, and varying levels of public understanding regarding stunting prevention. Therefore, strengthening policy governance, improving synergy among institutions, and enhancing community participation are necessary to ensure that efforts to accelerate stunting reduction can be implemented more effectively and sustainably.

Soni Kurnia Pebriyanto; Linda Barus; Bambang Murwanto

VitaMedica : Jurnal Rumpun Kesehatan Umum 2026 STIKES Columbia Asia Medan

Dengue Hemorrhagic Fever (DHF) is a disease caused by the dengue virus and transmitted through the bite of the Aedes aegypti mosquito. According to the WHO, 40% of the world's population is at risk of dengue fever, with a significant increase in cases in the last two decades, especially in 2019. After declining during the Covid-19 pandemic, cases surged again in 2023, including in previously unaffected areas. In Indonesia, Ministry of Health data shows an increasing trend in cases, with 186,324 cases and 1,120 deaths by week 35 of 2024. Environmental factors and community behavior influence the spread of dengue-causing mosquitoes. This study aims to determine the relationship between these factors and the incidence of dengue fever in Central Lampung Regency. This study aims to determine the relationship between environmental factors and community behavior with the incidence of Dengue Hemorrhagic Fever (DHF) in Central Lampung Regency. This study is an observational analytical study using a case control study design. The research instruments used were questionnaires and observation sheets. The data analysis technique used the chi square test. From the results of the study it is known that out of 9 variables, 4 variables have a relationship with the incidence of DHF, namely the availability of container covers (p value = 0.023 <0.05), frequency of container drainage (p value = 0.001 <0.05), the presence of larvae in containers (p value = 0.006 <0.05), and respondent attitudes (p value = 0.023 <0.05). Based on research in Central Lampung Regency, of the nine variables examined, four were shown to be associated with the incidence of Dengue Hemorrhagic Fever (DHF). Therefore, it is crucial to raise public awareness and routinely implement Dengue Prevention (PSN) or 3M, both independently and collectively. Dengue prevention needs to be carried out not only through sanctions (punishment), but also through a promotive and preventive approach involving individuals, communities, environmental policies, and supervision from relevant agencies. These efforts must be comprehensive and sustainable, involving all levels of society.

Ainun Ganisia; Karmanis Karmanis; Ruri Fintayana

Jurnal Media Administrasi 2026 Universitas 17 Agustus 1945 Semarang, Indonesia

This study aims to analyze the governance of health service policies in improving the quality of public services in Semarang City. Health services are one of the essential sectors in public service delivery that require policies which are effective, transparent, and responsive to community needs. This research employs a qualitative approach with a descriptive method to understand the processes of policy formulation, implementation, and coordination among actors in the governance of health service policies. Data were collected through literature review, policy documentation, and analysis of health service delivery practices at the local government level. The results indicate that the governance of health service policies in Semarang City has undergone several improvement efforts through the strengthening of regulations, enhanced inter-agency coordination, and the utilization of health service innovations. However, several challenges remain, such as limited resources, inequality in service access, and the need to improve the quality of human resources in the health sector. Therefore, strengthening policy governance that is more collaborative, accountable, and community-oriented is necessary to sustainably improve the quality of health services. This study is expected to contribute to the development of public policy, particularly in the field of regional health service delivery.

Harianto Sitepu; Risnita Risnita; Hermanto Harun; Abdul Halim

International Journal of Sociology and Law 2026 Asosiasi Penelitian dan Pengajar Ilmu Hukum Indonesia

Drug misuse continues to be a complicated social and legal issue that has an impact on societal stability, public health, and personal wellbeing. Many criminal justice systems have moved away from punitive tactics in favor of rehabilitation-focused ones in recent years, especially for drug users who are frequently viewed as sufferers of addiction rather than serious criminals. The National Narcotics Agency (BNN) in Indonesia is implementing rehabilitation programs and restorative justice processes as a result of this change. This study investigates the efficacy of restorative justice in drug rehabilitation at Jambi Province's National Narcotics Agency and evaluates its applicability from the standpoint of Islamic law, specifically the framework of maqāṣid al-sharīʿah. The study uses a case study design and a qualitative methodology. Participant observation, document analysis, and in-depth interviews with BNN officials, rehabilitation counselors, medical staff, and ex-drug users were used to gather data. The results show that an integrated evaluation system that assesses drug users' physical, psychological, and social states in order to determine their eligibility for recovery is used to institutionally apply restorative justice principles. Combining medical care, psychological counseling, and social reintegration programs, the rehabilitation programs greatly aid in participants' recuperation, enhance psychological stability, and fortify familial ties. Additionally, by promoting individual responsibility, family support, and community involvement, restorative justice-based rehabilitation lowers the risk of recidivism. From the standpoint of Islamic legal philosophy, these actions are consistent with the goals of maqāṣid al-sharīʿah, specifically the defense of human dignity, life (ḥifḍ al-nafs), and intellect (ḥifḍ al-ʿaql). According to the study's findings, restorative justice-based rehabilitation is a compassionate and successful method of treating drug dependency while encouraging social reintegration and long-term recovery.

Nike Handayani

Presidensial : Jurnal Hukum, Administrasi Negara, dan Kebijakan Publik 2026 Asosiasi Peneliti dan Pengajar Ilmu Hukum Indonesia

The National Health Insurance Program (JKN) is a government policy aimed at providing health protection for all Indonesians through fair, equitable, and sustainable healthcare services. However, its implementation still faces various challenges and issues. This study aims to analyze the implementation of the JKN program in Indonesia using a systematic literature review and the CIPP (Context, Input, Process, Product) evaluation model. Ten scientific articles published between 2021 and 2025 were selected and analyzed based on established inclusion and exclusion criteria. The results indicate that in the context aspect, there are still problems, such as a large number of participants with inactive membership status and a low level of public understanding of their rights and obligations as JKN participants. In the input aspect, obstacles faced include limited health workers, uneven distribution, and inadequate facilities and infrastructure. Furthermore, in the process aspect, various obstacles were found, such as long service queues, complex administrative procedures, disruptions in the medical record system, and the suboptimal use of digital-based services. Meanwhile, in terms of products, the National Health Insurance (JKN) program has proven effective in improving public access to healthcare services, although service quality remains uneven, drug availability remains unstable, and the BPJS Kesehatan financing system still faces several challenges. Overall, the JKN program has had a positive impact on the community, but comprehensive improvements are still needed, particularly in strengthening governance, equitable access to services, and improving the quality of healthcare services.

Mardin, Nur Muhardiana; Muzakkir Muzakkir; Asriyanti Asriyanti

Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan 2026 Asosiasi Riset Ilmu Kesehatan Indonesia

Stroke is one of the leading causes of death and long-term disability worldwide. Early detection and prompt first aid during the golden period are essential to improve patient outcomes, yet family knowledge regarding stroke management is often limited. This study aimed to analyze the effect of health education media, specifically audio-visual and leaflet, on family knowledge of early detection and first aid for stroke patients in the working area of Tamamaung Public Health Center, Makassar. This study used a quasi-experimental design with a two-group pre-test post-test approach. A total of 64 respondents were selected using purposive sampling and divided into audio-visual and leaflet groups. Data were collected using a structured questionnaire and analyzed using the Wilcoxon and Mann-Whitney tests. The results showed a significant increase in knowledge in both groups after the intervention (p = 0.000), with a significant difference between groups (p = 0.016), where audio-visual media was more effective than leaflets. These findings indicate that both media improve family knowledge, but audio-visual media is more effective and can be recommended as a primary educational tool to improve family preparedness in stroke emergencies.

Fajar Abdul Aziz; Sartika Dewi; Muhamad Abas

Birokrasi: JURNAL ILMU HUKUM DAN TATA NEGARA 2026 Sekolah Tinggi Ilmu Administrasi (STIA) Yappi Makassar

This study aims to determine the effectiveness of supervision conducted by the Environmental and Sanitation Agency (DLHK) of Karawang Regency regarding the mining activities of PT Mas Putih Belitung based on Law Number 32 of 2009 concerning Environmental Protection and Management. The study also examines the obstacles faced in monitoring the impacts of mining activities on public health and the environment. The research used an empirical juridical method with legislative and empirical approaches. Data were collected through interviews, observations, and literature studies, then analyzed qualitatively using Soerjono Soekanto’s theory of legal effectiveness. The findings show that DLHK supervision has been implemented but has not yet operated effectively. Several factors contribute to this condition, including limited human resources, inadequate facilities and infrastructure, weak administrative law enforcement, low community participation, and insufficient compliance by the company in environmental management practices. Therefore, stronger supervision, improved law enforcement, and greater collaboration between government, companies, and communities are necessary to ensure environmental protection and public health sustainability.

Dwi Puspitasari Anggita Anggraeni; Duta Liana; Ratna Indrawati

International Journal of Management Science and Business 2026 International Forum of Researchers and Lecturers

Digital transformation in healthcare services is a strategic approach to improve access, efficiency, and service quality, particularly within Indonesia’s National Health Insurance (JKN) system. BPJS Kesehatan has introduced an online queue feature through the Mobile JKN application to minimize manual queuing and reduce waiting times in outpatient services. However, despite the widespread ownership of the application, its actual utilization for online queuing remains relatively low, including in a regional public hospital (RSUD) in West Bandung. This condition reflects a gap between the availability of digital health technology and patients’ actual usage behavior, highlighting the need to examine factors influencing adoption.This study aims to analyze the effects of perceived ease of use, social influence, and facilitating conditions on the actual use of the Mobile JKN online queue, with behavioral intention as an intervening variable among outpatients. A quantitative cross-sectional design was applied, involving 255 JKN outpatient participants selected through purposive sampling. Data were collected using structured questionnaires and analyzed using Structural Equation Modeling (SEM) with AMOS version 24, based on the Technology Acceptance Model (TAM) and the Unified Theory of Acceptance and Use of Technology (UTAUT). Data analysis included descriptive statistics, validity and reliability testing, normality assessment, goodness-of-fit evaluation, Three Box Method, and hypothesis testing.

Hadjriatun Sundari; Anik Sri Purwanti

Journal of Health Sciences, Public Health and Pharmacy 2026 International Forum of Researchers and Lecturers

Background: Anemia in pregnancy is a significant public health problem that can increase the risk of maternal and fetal complications. One of the main strategies to prevent anemia is the administration of Multiple Micronutrient Supplements (MMS), which provide essential vitamins and minerals during pregnancy. However, the effectiveness of MMS in preventing anemia is closely related to the level of knowledge pregnant women have about its use. Therefore, understanding the relationship between knowledge about MMS and anemia incidence is crucial to improving maternal health outcomes (Rahmawati et al., 2023). Objective: This study aims to determine the relationship between pregnant women’s knowledge level about Multiple Micronutrient Supplements (MMS) and the incidence of anemia among pregnant women in the working area of Dr. Hi. Zainal Umar Sidiki Hospital, North Gorontalo. Methods: This research employed an analytical observational design with a cross-sectional approach. A total of 30 pregnant women were selected as the sample using purposive sampling techniquesResults: The study found that the majority of participants who had high knowledge levels about MMS had a lower incidence of anemia, while those with low knowledge levels had a higher incidence. These results highlight that knowledge about MMS strongly influences pregnant women’s adherence and effectiveness in preventing anemia. Conclusion: There is a significant relationship between pregnant women’s knowledge level about Multiple Micronutrient Supplements (MMS) and the incidence of anemia. Improving maternal knowledge about MMS through health education, counseling, and guidance from healthcare providers is essential to prevent anemia and support optimal pregnancy outcomes.