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Diabetes Mellitus (DM) is a chronic disease that requires long-term adherence to treatment. One of the main challenges in managing type 2 DM is the low level of patient adherence to medication. This literature review aims to analyze the effect of health education on improving patients’ knowledge and medication adherence. The review is based on selected scientific articles that discuss the relationship between education, knowledge, and adherence in patients with DM. Findings indicate that health education-delivered through counseling, printed media, self-instructional modules, or home visits—generally improves patients’ understanding of the disease and the importance of regular treatment. This increase in knowledge contributes to better health behavior, particularly in terms of medication compliance. Interactive educational methods that involve healthcare providers and patient families are more effective than one-way communication approaches. Structured and continuous education tailored to patient characteristics has the potential to significantly enhance disease management. Therefore, health education should be prioritized as a key strategy to improve treatment adherence and prevent long-term complications in patients with diabetes mellitus.

Indonesia is also known to have many cultural diversities, one of which is the culture of traditional medicine that has been passed down from generation to generation from ancestors. The use of animals as traditional medicine is still carried out by the people of Kangae Village. The purpose of this study is to find out how the knowledge of vertebrate animals, especially reptiles and mammals, is used as traditional medicine in Kangae Village and how the use of vertebrate animals, especially reptiles and mammals, as medicine in Kangae Village. This study uses a qualitative method. This study was conducted in Kangae Village, Mekeng Detung Village, Kangae District. Data collection techniques were carried out by observation, interviews, and documentation. The results of this study indicate that the people of Kangae Village use vertebrate animals as medicine, namely there are 5 types of animals that are used as medicine. Among the 5 types of animals, there are 3 types of reptiles and 2 types of mammals. These animals are Geckos (Teke), Monitor Lizards (Oti), Snakes (Ular), Dogs (Ahu), and Bats (Ni’i). The knowledge of the Kangae Village community regarding the use of animals as medicine is obtained in two ways, namely, traditions passed down from ancestors and finding out for themselves (through relatives, neighbors and friends) and the method of processing medicinal animals consists of roasting, chopping, and making it into a dish according to the taste of the person consuming it.

Pulmonary tuberculosis (TB) is a public health problem of concern because of its contagious nature. Success in treating pulmonary TB, which is very important to prevent drug resistance, is largely determined by patient compliance in taking medication regularly. However, the most important factor in the diagnosis of this disorder is the extent to which recommendations are followed. Therefore, the task of the family exercise monitor (PMO) is very important in helping the patient accept the forced teaching. The aim of this research is to analyze family members on the health status of pulmonary tuberculosis patients who come to take medication at the Tlogosari Kulon Health Center. The design in this research analysis is cross-sectional correlation, specifically to test the relationship between two variables at the same time. This sample consisted of 71 cases of pulmonary tuberculosis registered at Balai Tlogosari Kulon. At this institution, a cross-sectional correlation analysis design is used to analyze the relationship between two variables over a period of time. The sample in this study was 71 TB patients registered at the Tlogosari Kulon Health Center. Purposive sampling is a sample collection technique used, where respondents are carefully selected based on predetermined criteria to ensure they meet the research objectives. The tool used to accumulate data is a questionnaire, which is designed to collect information about the variables studied. The data obtained from the questionnaire was then analyzed using the Chi-square test to analyze whether there was a significant relationship between these variables. The results of the study explained that the majority of respondents, namely 40 people (56.3%), rated the family's role as Medication Monitoring Supervisor (PMO) in the good category, while 28 respondents (39.4%) showed good compliance in taking medication. The Chi-square test results show that the significance value is p = 0.003, (<0.05). This shows that the null hypothesis (H0) is rejected. This research can be concluded that there is a relationship between the role of the family and compliance with taking medication for pulmonary TB clients at the Tlogosari Kulon Community Health Center.

Gangguan Psikotik Akut merupakan timbulnya gangguan psikotik secara tiba-tiba yang berlangsung kurang dari satu bulan yang ditandai dengan munculnya satu atau lebih dari gejala psikotik yaitu delusi,halusinasi,berbicara tidak teratur serta prilaku yang sangat tidak tertatur atau prilaku katatonik. Tujuan dari penelitian ini untuk mengetahui faktor-faktor apa saja yang berhubungan dengan kejadian Gangguan Psikotik Akut di Rumah Sakit Jiwa dr. Samsi Jacobalis Provinsi Kepulauan Bangka Belitung Tahun 2024. Penelitian ini adalah penelitian kuantitatif dengan pendekatan cross-sectional. Sampel dalam penelitian ini adalah keluarga dengan orang gangguan psikotik akut dan orang dengan ganggua psikotik yang terdaftar berkunjung di Poliklinik Rumah Sakit Jiwa Daerah dr. Samsi Jacobalis Provinsi Kepulauan Bangka Belitung sebanyak 78 orang. Analisa data menggunakan uji chisquare dengan derajat kepercayaan 95%. Hasil penelitian ini menyimpulkan faktor-faktor yang berhubungan dengan ganguan psiktoik akut adalah dukungan keluarga (p=0,000), pengalaman traumatis (p=0,001), penyalahgunaan napza (p=0,000 dan POR=323.000). Kesimpulan dalam penelitian ini adalah bahwa dukungan keluarga, pengalaman traumatis dan penyalahgunaan napza memiliki hubungan kejadian Gangguan Psikotik Akut di Rumah Sakit Jiwa Daerah dr. Samsi Jacobalis Provinsi Kepulauan Bangka Belitung Tahun 2024. Saran dari penelitian ini diharapkan dapat meningkatkan edukasi kepada keluarga untuk orang dengan gangguan jiwa agar dapat mengelola stress dengan baik serta menjauhkan obat-obatan terlarang. Meningkatkan literasi serta referensi pembelajaran dengan media edukasi lainnya mengenai gangguan jiwa terutama terkait pada gangguan psikotik akut.

Hypertension is one of the non-communicable diseases that can cause death. This disease is called the silent disease because sufferers do not know they have hypertension. One of the absolute requirements for achieving effective therapy and improving the quality of life of patients is compliance, while patient non-compliance in taking medication is one of the main factors causing therapy failure. The role of nurses as educators helps patients increase their knowledge about medical care and actions so that patients get information to improve drug compliance for hypertension. This study was conducted to determine the relationship between the role of nurses as educators and medication adherence in patients with hypertension at the Larangan Utara Health Center. The study design was a correlational design with a cross-sectional approach. The study population was all patients with hypertension who came for treatment at the Larangan Utara Health Center in Tangerang City. The sampling technique was Non Probability Sampling using the Purposive Sampling approach, namely 96 respondents. Data analysis of univariate and bivariate analysis using the chi-Square test. The results showed that out of 96 respondents, 44 people chose the role of nurses with a moderate level of compliance (45.8%) and 28 respondents had high compliance (38.9%). The conclusion is that there is an influence between the role of nurses as educators and medication adherence. So the better the role of nurses as educators, the more patient compliance in taking medication

Background: Hypertension has a high prevalence of 43.11%, which is even higher among the elderly in Indonesia. The treatment of hypertension requires long-term therapy, making medication adherence crucial for controlling blood pressure and preventing complications. Sample: The sample in this study consisted of 76 pregnant women in Tangkil Tengah and Rengas villages. After screening according to inclusion and exclusion criteria, 62 pregnant women were selected as respondents. Method: This study employed a correlational analytical method using a quantitative approach. The sampling technique used was non-probability sampling. The research instrument was a questionnaire that included the variables to be studied. The analysis used was univariate analysis with frequency distribution and percentages, and bivariate analysis using the Statistical Program for Social Science (SPSS). Results: The knowledge of elderly individuals with hypertension about hypertension was categorized as high (9%), moderate (35%), and low (57%), while adherence to antihypertensive medication was categorized as high (24%), moderate (7%), and low (70%). The correlation analysis in this study, using the Chi-square test, showed a significant relationship between the level of knowledge and the level of adherence to antihypertensive medication among the elderly, with a p-value of 0.00. Conclusion: There is a significant relationship between the level of knowledge and the level of adherence to antihypertensive medication among the elderly at RSU Bhakti Asih Ciledug.

Self-medication is a common practice among the public in managing health complaints, including coughs. This study aims to assess the level of knowledge regarding self-medication for cough medicine among patients at Sehati Bina Cakrawala Pharmacy in Karawang during the June–July 2024 period. A descriptive research method was employed, with a sample of 132 respondents selected using purposive sampling. Data were collected through questionnaires and analyzed using univariate analysis with IBM SPSS 26 and Microsoft Excel. The findings indicate that out of 132 respondents, 93% had a good level of knowledge, 6% had a moderate level of knowledge, and 1% had a low level of knowledge regarding self-medication for cough medicine.

Masalah kesehatan internasional adalah hipertensi, penyebab utama gagal ginjal, stroke, dan penyakit jantung. Diperkirakan 34,1% orang di Indonesia menderita hipertensi, dan sebagian besar dari mereka tidak mendapatkan pengobatan. Meskipun Puskesmas Welahan 1 menangani hipertensi, pasien sering mengalami kesulitan mengontrol tekanan darah mereka karena berbagai macam obat yang tersedia. Tujuan dari penelitian ini adalah untuk mengetahui seberapa efektif terapi monoterapi dan kombinasi untuk mencapai target tekanan darah pasien hipertensi di Puskesmas Welahan 1 dan bagaimana berbagai obat mempengaruhi kontrol tekanan darah. Data dari 60 pasien hipertensi yang memenuhi kriteria inklusi dianalisis selama tiga bulan menggunakan pendekatan cross-sectional. Digunakan statistik inferensial dan deskriptif, seperti uji chi-square. Tidak ada korelasi signifikan antara kontrol tekanan darah sistolik dan diastolik dan jenis terapi obat (p > 0,05). Namun, pasien yang menerima amlodipine atau amlodipine + captopril lebih mampu mengontrol tekanan darah mereka, dengan rasio kemungkinan 0,857 untuk tekanan sistolik dan 6,429 untuk tekanan diastolik, masing-masing.  Hasilnya menunjukkan bahwa terapi kombinasi mungkin membantu mengontrol tekanan darah diastolik, meskipun jenis obat tidak mempengaruhi tekanan darah secara langsung

Human Immunodeficiency Virus (HIV) is a disease that attacks the body's immune system so that it is unable to fight various diseases. Communities with low levels of health literacy will face more problems. According to the Central Java Provincial Health Service, the number of HIV sufferers has also increased rapidly to Central Java, Semarang City with 331 cases, and the majority of those infected are men. The general aim of this research is to determine the relationship between health literacy and adherence to taking antiretroviral drugs (ARV) in people living with HIV (PLHIV). This research is a type of non-experimental descriptive analytical research with a cross-sectional approach. The samples taken were all patients with HIV (PLHIV) who took ARV drugs in the work area of ​​the Poncol Health Center, Semarang City. The technique used was consecutive sampling of 83 people. The correlation test used in this research is the chi-square test. From the results of the analysis, it was found that of the 83 research respondents, there was a relationship between the health literacy of people living with HIV (PLHIV) and the use of antiretroviral drugs (p value 0.003). The research results showed that the majority of respondents had high health literacy and were compliant with medication consumption with a total of 55 respondents (96.5%).

This article discusses the maintenance of Family Medicinal Plants (TOGA) in Mata Wawatu Village as an effort to improve public health. The aim of this program is to provide information to the public regarding the benefits and cultivation techniques of medicinal plants. The methods employed include qualitative research with a descriptive approach, encompassing observations, interviews, and documentation collection. The findings of this study indicate that this initiative has successfully enhanced the community's understanding of TOGA and encouraged them to utilize medicinal plants in their daily lives. This program is expected to improve the health and well-being of the community and reduce dependence on chemical medications

This study aims to analyze the legal review of legal protection for consumers related to the circulation of drugs that do not have a distribution permit in Indonesia. The research method used in this study is the normative legal research method. The main data source in this study is a secondary legal source, consisting of laws and regulations governing the circulation of drugs. The results of this study indicate that legal protection for consumers related to the circulation of drugs without a distribution permit in Indonesia has been strictly regulated in various regulations. Law Number 8 of 1999 concerning Consumer Protection, Law Number 36 of 2009 concerning Health, and Regulation of the Head of BPOM Number 26 of 2017 provide a strong legal basis to ensure that drug products circulating in the market are safe and have obtained a valid distribution permit from BPOM. This aims to protect consumer rights so that they are not exposed to health risks caused by drugs that are not guaranteed to be safe. However, a major challenge faced is the high number of illegal drugs circulating, both on the black market and online platforms that are difficult to monitor. In addition, the lack of awareness from consumers also exacerbates this problem. Suboptimal supervision is also another challenge in this legal protection. The lack of utilization of technology in supervision is also a significant obstacle. Although there are regulations and supervisory authority from BPOM and pharmaceutical personnel, the distribution of drugs without a distribution permit remains a complex problem

Jurang Hamlet is one of the hamlets located in Girirejo Village, Tempuran District, Magelang Regency. In general, people in Jurang Hamlet have a fairly large yard land. The land can be used and optimized, one of which is by planting family medicinal plants (TOGA). TOGA is a plant that is usually used as a traditional medicine to treat various diseases and is usually grown in the yard of the house. There are problems that occur in Jurang Hamlet, namely the lack of understanding and knowledge related to the planting and utilization of TOGA. In addition to increasing public knowledge and understanding, this activity is also intended to empower the PKK women of Jurang Hamlet in terms of managing medicinal plants in the yard of the house. This community empowerment activity uses three methods: (1) Preparation of TOGA seeds, (2) Socialization of effective TOGA planting methods, (3) Socialization of the benefits of each TOGA to be planted, (4) The distribution of TOGA seedlings and the planting of TOGA together. From the results of the TOGA planting activities that have been carried out by the residents of Jurang Hamlet, it is known that the residents of Jurang Hamlet have become more aware of how to plant TOGA well and also some of the benefits of each plant seed that has been distributed.

School Health Business (UKS) is a program that aims to promote a healthy lifestyle among students. Health services at UKS include providing medicine for students who experience minor illnesses. However, a shortage of pharmacists in schools can increase the risk of errors in medication management and threaten patient safety. Teachers play an important role in providing first aid and coordinating medical emergencies at school. Teachers also play a role in providing education about health to students, including correct medication management. This activity aims to increase the understanding and awareness of UKS managers about the importance of correct medication management, as well as encouraging behavioral changes in obtaining, using, storing and disposing of medication (DAGUSIBU) correctly. The activities were carried out using counseling, outreach and mentoring methods for Teachers and students at SD Muhammadiyah 16 and 52.The results of the activity showed that there was an increase in teachers' and students' understanding of drug management, especially drug storage.

One cardiovascular condition known as venous thromboembolism (VTE) is believed to be brought on by hormonal medications like oral contraceptives. Women taking oral contraceptives are more likely to develop VTE over the age of 40 due to a genetic predisposition that can trigger the risk from the cytochrome gene. One of the genes associated with VTE and contraception is the CYP2C19, CYP3A4, CYP1A2, and CYP345 genes. Methods: A quality assessment of the method and risk was conducted using The Joanna Briggs Institute (JBI) Instrument after a number of articles collected from Scopus, Crossref, Ebsco, Pubmed, Science Direct, and Google Scholar were selected by the inclusion criteria. Results:Articles or journals on the JBI instrument showed good quality in the number of 10 research particles. From the results of the journal analysis, several cytochrome genes were obtained, namely the CYP2C19, CYP3A4, CYP1A2, and CYP345 genes. Conclusion: Several types of cytochrome genes that affect oral use as well as VTE. The cytochrome CYP2C19 gene may decrease the effects of clopidogrel. The use of CYP3A4 gene-inducing drugs should be considered at the same time as contraception and it is advisable to use other drug alternatives. Concomitant use of CYP1A2 gene-inducing drugs with contraception should be avoided because they may decrease the contraceptive effect. The use of cyclosporine drugs needs to be monitored because cyclosporine can increase estrogen levels in the liver.

One cardiovascular condition known as venous thromboembolism (VTE) is believed to be brought on by hormonal medications like oral contraceptives. Women taking oral contraceptives are more likely to develop VTE over the age of 40 due to a genetic predisposition that can trigger the risk from the cytochrome gene. One of the genes associated with VTE and contraception is the CYP2C19, CYP3A4, CYP1A2, and CYP345 genes. Methods: A quality assessment of the method and risk was conducted using The Joanna Briggs Institute (JBI) Instrument after a number of articles collected from Scopus, Crossref, Ebsco, Pubmed, Science Direct, and Google Scholar were selected by the inclusion criteria. Results:Articles or journals on the JBI instrument showed good quality in the number of 10 research particles. From the results of the journal analysis, several cytochrome genes were obtained, namely the CYP2C19, CYP3A4, CYP1A2, and CYP345 genes. Conclusion: Several types of cytochrome genes that affect oral use as well as VTE. The cytochrome CYP2C19 gene may decrease the effects of clopidogrel. The use of CYP3A4 gene-inducing drugs should be considered at the same time as contraception and it is advisable to use other drug alternatives. Concomitant use of CYP1A2 gene-inducing drugs with contraception should be avoided because they may decrease the contraceptive effect. The use of cyclosporine drugs needs to be monitored because cyclosporine can increase estrogen levels in the liver.

Traditional medicine is currently developing rapidly, especially those based on plants. Active plant compounds are the main basis for the development of new drugs, which after further research, can be commercialized and used in pharmaceutical treatment. This review was conducted to identify the pharmacological effects of active drug compounds isolated from medicinal plants by conducting a literature study. The results of the literature review contained 37 articles that met the inclusion criteria. Until now, there are several active drug compounds from plants that are sold commercially in the form of modern drugs. Some of the pharmacological effects found are cardiac glycosides, anticholinergics, antiplatelets, analgesics, anticancer, sympathomimetics and antimalarials. This search shows that natural materials are still used as a potential source of active drug compounds, thus encouraging research to find new active compounds from medicinal plants to overcome diseases in the future.

Dengue fever, malaria, and other mosquito-borne diseases remain significant health problems and challenges in various regions, especially in rural areas. Dengue fever (DBD) is caused by the dengue virus types 1-4, which are transmitted through the bites of Aedes aegypti and Aedes albopictus mosquitoes. The majority of the residents of Karya Mukti Village work as rubber tappers. They usually start their activities early in the morning or even before dawn. However, mosquitoes are most active in the morning and late afternoon, making the local community highly vulnerable to mosquito bites. To address this issue, the people of Karya Mukti Village still widely use mosquito repellents available on the market, which contain harmful chemicals that pose risks to both health and the environment if used over the long term. Therefore, this community service initiative aims to conduct outreach and hands-on training on the use of citronella (Cymbopogon nardus) as a natural mosquito repellent alternative. This program is carried out using a socialization and product-making approach through participatory engagement, where Dasawisma (women's community groups) are encouraged to identify their needs and challenges, as well as appropriate solutions to address them. By involving Dasawisma members in the learning and production process of natural mosquito repellents, it is hoped that they will gain better knowledge and skills in making natural mosquito repellents.

Gout arthritis (gout) is a disease that occurs suddenly and repeatedly, characterized by the formation of monosodium uric acid crystal deposits that attack the joints, due to high levels of uric acid in the blood (hyperuricemia). The aim of this activity is to be able to understand gouty arthritis and the practice of making non-pharmacological drugs from pineapple juice and honey to reduce uric acid levels in the body. This health education can increase the knowledge of Purwodadi village residents to do their best to treat gout arthritis using traditional medicine. Health education for residents can increase knowledge and skills in using simple traditional medicines

Law Number 35 of 2009 concerning Narcotics in Indonesia provides a strong legal basis for regulating the use of narcotics in the medical field. This regulation aims to ensure that the use of narcotics is carried out safely, in a controlled manner and in accordance with the interests of health services. This research aims to analyze legal aspects related to the use of illegal drugs in the medical field, identify challenges in implementing regulations, and provide policy recommendations to overcome existing obstacles. The research method used is normative juridical, with a legal approach and literature studies from various legal and health journals. The research results show that although regulations have been prepared comprehensively, their implementation in the field faces obstacles, such as complicated bureaucracy, lack of education for medical personnel, and social stigma against narcotics use. This hampers patient access to treatment, especially for palliative therapy needs and chronic pain management. The conclusions of this research emphasize the need for strategic steps to increase understanding of medical personnel, simplify administrative procedures, and educate the public to reduce stigma. Thus, existing regulations can be implemented optimally to support public health goals without ignoring aspects of supervision. It is hoped that this recommendation can strengthen the legal system and health services in Indonesia, so that patients' rights to health can be fulfilled more effectively.

Hydroponic Cultivation and Family Medicinal Plants (TOGA) is an innovation that supports food security. The Community Service Program in Getas Village, Kendal Regency, Central Java, aims to improve agricultural land use through sustainable management and development of medicinal plants. The target of this program is for farmer groups and youth organizations. These activities include counseling, establishment of hydroponic houses, training, mentoring, monitoring, collaboration between the government and educational institutions, and evaluation and feedback. This program has succeeded in achieving several achievements, namely increasing knowledge, increasing skills, increasing production, and changing behavior.