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COVID-19 is a viral respiratory disease that has caused a global health emergency and was declared a pandemic by the World Health Organization. The lack of certain drug molecules or treatment strategies for this disease is making it worse. Therefore, effective drug molecules are urgently needed to fight COVID-19. Specific therapies for the SARS-COV2 virus are still being developed in several countries around the world. One of the molecular targets that is thought to be specific to SARS-COV 2 is 3CLpro or the main protease of the COVID-19 virus which is an important enzyme to be able to replicate related viruses. The purpose of this study is to explore the role of medicinal chemistry in the development of anti-sars-cov 2 drugs through the exploration of bioactive compounds from natural sources, namely green tea. Green tea (Camellia sinensis) also contains eight native monomeric catechins or polyphenolic compounds. The method used was literature review with analysis of 3 selected articles from international databases such as PubMed, ScienceDirect, and Springer, as well as SINTA accredited national journals. The results showed that all test compounds except caffein had stronger binding energy than lopinavir. Epicatecin and catechin have the same binding energy value as lopinavir, which is -7.1 kcal/mol. Catechin gallate and epicatechin gallate have the strongest bond among all test compounds because they have the most negative AG, namely -9.0 and 8.2 kcal/mol.    

Morbus Hansen, or leprosy, is a chronic infectious disease caused by the bacterium Mycobacterium leprae. There are two types of leprosy, namely MB (Multi Bacillary) and PB (Pauci Bacillary). According to the WHO, the level of disability due to leprosy is divided into three levels: Level 0, Level 1, and Level 3. This study is an analytic observational study using a cross-sectional research design, involving 45 respondents selected through total sampling technique. Data collection was carried out by filling out a questionnaire consisting of questions regarding leprosy medication compliance. Data analysis used the chi-square test and prevalence rate. The results showed no association between medication compliance (p=0.092, PR=2.0) and the incidence of leprosy disability at the Batumarmar Health Center, Pamekasan Regency. The conclusion of this study indicates that although theoretically adherence to medication can lead to disability in leprosy patients, the results of this study show something different. The difference between the results of this study and the theory may be due to other factors affecting disability. The suggestion is that the health center is expected to improve the monitoring system to evaluate patient compliance with treatment. Support from medical personnel and families is also needed to encourage patients to be more consistent in undergoing therapy.

Hypertension is one of the chronic diseases suffered by many people in Indonesia, including in the Kebondalem Health Center area, Pemalang District. In its treatment, some patients choose to use herbal medicine as a complementary therapy in addition to medical treatment. However, patients' understanding of the benefits and risks of using herbal medicine is still not fully known. Objective: This study aims to examine the level of knowledge of hypertensive patients regarding the benefits and risks of using herbal medicine as a complementary therapy at the Kebondalem Health Center, Pemalang District. Method: This study uses a descriptive method with a quantitative approach. The research sample was hypertensive patients who visited the Kebondalem Health Center and met the inclusion criteria. Data were collected through a validated closed questionnaire, then analyzed descriptively. Results: The results showed that most patients had a moderate level of knowledge regarding the benefits of herbal medicine, but were still low in understanding the risks that might arise from using it simultaneously with medical drugs. Some patients also still believe in myths related to herbal medicine without a strong scientific basis.

Hypertension is a chronic disease that often attacks the elderly and can cause serious complications, including stroke and heart disease. This study aims to evaluate the use of antihypertensives and analyze drug interactions based on severity in hospitalized patients at RSU Royal Prima Marelan. The research method is descriptive retrospective of patient medical records in 2024. The results showed that the majority of patients were women (62.5%) aged 60–74 years (50%). The use of a combination of two antihypertensive drugs was most commonly found (40%), with the combination of amlodipine and candesartan being the most frequently used. The severity of the most drug interactions was in the moderate category (82.35%), followed by major (10.50%) and minor (7.14%). The most significant interactions occurred in the combination of candesartan and spironolactone (major), and amlodipine and bisoprolol (moderate).    

The use of drugs for hyperuricemia and gout arthritis is given for conditions that cause higher purine metabolism in the body. This study was conducted at RSU Royal Prima Marelan to determine the pattern of drug use for hyperuricemia and gout arthritis due to inflammation caused by uric acid deposits in the joints. Data collection in this study was carried out retrospectively by collecting medical records of patients with hyperuricemia and gout arthritis. The descriptive method used in this study was a cross-sectional plan. Qualitative descriptive analysis was applied to the data. Tables or narratives were used to present the data in this study. The results showed that 30 patients out of 50 were male and 20 were female. The results of the evaluation of the rationality of drug use for hyperuricemia and gout arthritis showed that patients who were given several versions of drugs with the xanthine oxidase inhibitor group 64% were allopurinol with patients with the most appropriate indications, the right patient, and the right dose of 96%.

Cancer is one of the leading causes of death in the world, with the incidence rate continuing to increase every year. Conventional treatments such as chemotherapy and radiotherapy often have limitations, especially related to selectivity towards cancer cells and toxic side effects caused to normal cells. Therefore, an alternative approach that is more effective and safe is needed. One promising approach is the utilization of bioactive compounds from natural materials that are optimized through a medicinal chemistry approach. This study aims to examine the potential of natural compounds such as epigallocatechin gallate (EGCG) from green tea, berberine from Berberis vulgaris, curcumin from turmeric (Curcuma longa), and cardiotonic steroids (CTS) from Digitalis purpurea and Nerium oleander as anticancer agents, as well as their optimization strategies through structural modification, increased stability, and modern delivery technology. The method used is a systematic literature review of scientific articles from 2020 to 2025 obtained through the PubMed, ScienceDirect, and Google Scholar databases. The results of the study indicate that these compounds have various anticancer mechanisms of action, such as apoptosis induction, cell cycle inhibition, and activation of specific signaling pathways such as PI3K/Akt, MAPK, and ferroptosis. However, challenges such as low bioavailability, poor stability, and toxicity are still obstacles in their application. Through a medicinal chemistry approach, these compounds can be structurally modified or reformulated to improve their clinical effectiveness. In conclusion, the combination of natural wealth with medicinal chemistry innovation opens up great opportunities in the development of more selective, effective, and safe anticancer therapies in the future.    

Diabetes mellitus is a chronic disease that requires proper management, including the use of conventional and alternative medicines such as herbal medicines. Patient knowledge about the benefits, risks, and potential interactions of herbal medicines with conventional medicines is very important to prevent complications. Objective This study aims to describe the level of knowledge of diabetes patients about the use of herbal medicines, including the benefits, risks, and interactions with conventional medicines at the Kebondalem Health Center, Pemalang Regency. This study uses descriptive observational analytic Data were collected through questionnaires distributed to diabetes patients who were treated at the Kebondalem Health Center. Data analysis was carried out quantitatively with percentages to measure the level of patient knowledge.

Hypercholesterolemia is a significant global health problem, with a high prevalence in Indonesia. Although conventional therapies such as statins have been the mainstay of treatment, limited efficacy and side effects necessitate the development of new, more effective and selective drugs. This article explores the role of medicinal chemistry in the discovery and development of cholesterol-lowering drugs, focusing on structure-activity analysis (SAR) and molecular targets. Through structure-based approaches, compounds such as statins and PCSK9 inhibitors have been optimized to increase affinity for biological targets. In addition, exploration of new targets and formulation innovations have shown great potential in improving therapeutic efficacy. Thus, medicinal chemistry contributes significantly to providing safer and more effective therapeutic solutions for the management of hypercholesterolemia.  

Knowledge is the result of the process of understanding and recognizing something obtained through sensing an object. Beta-lactam antibiotics are a type of broad-spectrum antibiotic commonly used to treat bacterial infections, but their use still has the potential to cause side effects in the form of Adverse Drug Reactions (ADRs). This study aims to assess the level of patient knowledge regarding ADRs due to the use of beta-lactam antibiotics at Bendan Pekalongan Regional Hospital in 2024. This study used a prospective correlation design with a non-experimental approach. A total of 29 outpatients taking beta-lactam antibiotics were sampled, selected using a purposive sampling technique. Data were collected through questionnaires, medical records, and analyzed descriptively using Microsoft Excel. The results showed that 41% of respondents had low knowledge regarding ADRs, 28% had sufficient knowledge, and 31% had good knowledge. These findings indicate the need for more intensive education regarding the risks of ADRs in order to improve the safety of antibiotic use.

Adolescence is a crucial developmental phase often marked by a lack of responsibility, which can lead to negative behaviors such as juvenile delinquency and promiscuity. Therefore, developing a responsible character in adolescents is essential to guide them toward positive behavior. One effective approach is through life skills education implemented in the local village (gampong) environment. This community service initiative aims to instill a sense of responsibility in adolescents by involving them in the planting and maintenance of family medicinal plants (TOGA). Through this activity, adolescents are expected to develop care, discipline, and responsibility, which are reflected in their commitment to nurturing the plants. The activity was implemented in Gampong Cot Alue, Ingin Jaya District, Aceh Besar, and carried out over two days, from February 14 to 15, 2025. The method used in the planning and execution of the TOGA planting involved five stages: (1) creating an activity plan, (2) preparing tools and materials, (3) preparing the planting area, (4) plant nurseries, and (5) creating plant identification markers. These stages were designed to introduce a structured approach to life skills and community engagement.The outcomes of the program demonstrated an increase in adolescents' awareness and understanding of the importance of TOGA. Additionally, there was a noticeable improvement in their sense of responsibility and participation in daily activities beyond school. The broader community, particularly the youth, gained valuable knowledge about the benefits of TOGA for disease prevention, treatment, and health maintenance, contributing to a healthier and more proactive lifestyle within the village environment.

Diabetes Mellitus (DM) is a chronic disease that requires long-term adherence to treatment. One of the main challenges in managing type 2 DM is the low level of patient adherence to medication. This literature review aims to analyze the effect of health education on improving patients’ knowledge and medication adherence. The review is based on selected scientific articles that discuss the relationship between education, knowledge, and adherence in patients with DM. Findings indicate that health education-delivered through counseling, printed media, self-instructional modules, or home visits—generally improves patients’ understanding of the disease and the importance of regular treatment. This increase in knowledge contributes to better health behavior, particularly in terms of medication compliance. Interactive educational methods that involve healthcare providers and patient families are more effective than one-way communication approaches. Structured and continuous education tailored to patient characteristics has the potential to significantly enhance disease management. Therefore, health education should be prioritized as a key strategy to improve treatment adherence and prevent long-term complications in patients with diabetes mellitus.

Indonesia is also known to have many cultural diversities, one of which is the culture of traditional medicine that has been passed down from generation to generation from ancestors. The use of animals as traditional medicine is still carried out by the people of Kangae Village. The purpose of this study is to find out how the knowledge of vertebrate animals, especially reptiles and mammals, is used as traditional medicine in Kangae Village and how the use of vertebrate animals, especially reptiles and mammals, as medicine in Kangae Village. This study uses a qualitative method. This study was conducted in Kangae Village, Mekeng Detung Village, Kangae District. Data collection techniques were carried out by observation, interviews, and documentation. The results of this study indicate that the people of Kangae Village use vertebrate animals as medicine, namely there are 5 types of animals that are used as medicine. Among the 5 types of animals, there are 3 types of reptiles and 2 types of mammals. These animals are Geckos (Teke), Monitor Lizards (Oti), Snakes (Ular), Dogs (Ahu), and Bats (Ni’i). The knowledge of the Kangae Village community regarding the use of animals as medicine is obtained in two ways, namely, traditions passed down from ancestors and finding out for themselves (through relatives, neighbors and friends) and the method of processing medicinal animals consists of roasting, chopping, and making it into a dish according to the taste of the person consuming it.

Pulmonary tuberculosis (TB) is a public health problem of concern because of its contagious nature. Success in treating pulmonary TB, which is very important to prevent drug resistance, is largely determined by patient compliance in taking medication regularly. However, the most important factor in the diagnosis of this disorder is the extent to which recommendations are followed. Therefore, the task of the family exercise monitor (PMO) is very important in helping the patient accept the forced teaching. The aim of this research is to analyze family members on the health status of pulmonary tuberculosis patients who come to take medication at the Tlogosari Kulon Health Center. The design in this research analysis is cross-sectional correlation, specifically to test the relationship between two variables at the same time. This sample consisted of 71 cases of pulmonary tuberculosis registered at Balai Tlogosari Kulon. At this institution, a cross-sectional correlation analysis design is used to analyze the relationship between two variables over a period of time. The sample in this study was 71 TB patients registered at the Tlogosari Kulon Health Center. Purposive sampling is a sample collection technique used, where respondents are carefully selected based on predetermined criteria to ensure they meet the research objectives. The tool used to accumulate data is a questionnaire, which is designed to collect information about the variables studied. The data obtained from the questionnaire was then analyzed using the Chi-square test to analyze whether there was a significant relationship between these variables. The results of the study explained that the majority of respondents, namely 40 people (56.3%), rated the family's role as Medication Monitoring Supervisor (PMO) in the good category, while 28 respondents (39.4%) showed good compliance in taking medication. The Chi-square test results show that the significance value is p = 0.003, (<0.05). This shows that the null hypothesis (H0) is rejected. This research can be concluded that there is a relationship between the role of the family and compliance with taking medication for pulmonary TB clients at the Tlogosari Kulon Community Health Center.

Gangguan Psikotik Akut merupakan timbulnya gangguan psikotik secara tiba-tiba yang berlangsung kurang dari satu bulan yang ditandai dengan munculnya satu atau lebih dari gejala psikotik yaitu delusi,halusinasi,berbicara tidak teratur serta prilaku yang sangat tidak tertatur atau prilaku katatonik. Tujuan dari penelitian ini untuk mengetahui faktor-faktor apa saja yang berhubungan dengan kejadian Gangguan Psikotik Akut di Rumah Sakit Jiwa dr. Samsi Jacobalis Provinsi Kepulauan Bangka Belitung Tahun 2024. Penelitian ini adalah penelitian kuantitatif dengan pendekatan cross-sectional. Sampel dalam penelitian ini adalah keluarga dengan orang gangguan psikotik akut dan orang dengan ganggua psikotik yang terdaftar berkunjung di Poliklinik Rumah Sakit Jiwa Daerah dr. Samsi Jacobalis Provinsi Kepulauan Bangka Belitung sebanyak 78 orang. Analisa data menggunakan uji chisquare dengan derajat kepercayaan 95%. Hasil penelitian ini menyimpulkan faktor-faktor yang berhubungan dengan ganguan psiktoik akut adalah dukungan keluarga (p=0,000), pengalaman traumatis (p=0,001), penyalahgunaan napza (p=0,000 dan POR=323.000). Kesimpulan dalam penelitian ini adalah bahwa dukungan keluarga, pengalaman traumatis dan penyalahgunaan napza memiliki hubungan kejadian Gangguan Psikotik Akut di Rumah Sakit Jiwa Daerah dr. Samsi Jacobalis Provinsi Kepulauan Bangka Belitung Tahun 2024. Saran dari penelitian ini diharapkan dapat meningkatkan edukasi kepada keluarga untuk orang dengan gangguan jiwa agar dapat mengelola stress dengan baik serta menjauhkan obat-obatan terlarang. Meningkatkan literasi serta referensi pembelajaran dengan media edukasi lainnya mengenai gangguan jiwa terutama terkait pada gangguan psikotik akut.

Self-medication is a common practice among the public in managing health complaints, including coughs. This study aims to assess the level of knowledge regarding self-medication for cough medicine among patients at Sehati Bina Cakrawala Pharmacy in Karawang during the June–July 2024 period. A descriptive research method was employed, with a sample of 132 respondents selected using purposive sampling. Data were collected through questionnaires and analyzed using univariate analysis with IBM SPSS 26 and Microsoft Excel. The findings indicate that out of 132 respondents, 93% had a good level of knowledge, 6% had a moderate level of knowledge, and 1% had a low level of knowledge regarding self-medication for cough medicine.

Masalah kesehatan internasional adalah hipertensi, penyebab utama gagal ginjal, stroke, dan penyakit jantung. Diperkirakan 34,1% orang di Indonesia menderita hipertensi, dan sebagian besar dari mereka tidak mendapatkan pengobatan. Meskipun Puskesmas Welahan 1 menangani hipertensi, pasien sering mengalami kesulitan mengontrol tekanan darah mereka karena berbagai macam obat yang tersedia. Tujuan dari penelitian ini adalah untuk mengetahui seberapa efektif terapi monoterapi dan kombinasi untuk mencapai target tekanan darah pasien hipertensi di Puskesmas Welahan 1 dan bagaimana berbagai obat mempengaruhi kontrol tekanan darah. Data dari 60 pasien hipertensi yang memenuhi kriteria inklusi dianalisis selama tiga bulan menggunakan pendekatan cross-sectional. Digunakan statistik inferensial dan deskriptif, seperti uji chi-square. Tidak ada korelasi signifikan antara kontrol tekanan darah sistolik dan diastolik dan jenis terapi obat (p > 0,05). Namun, pasien yang menerima amlodipine atau amlodipine + captopril lebih mampu mengontrol tekanan darah mereka, dengan rasio kemungkinan 0,857 untuk tekanan sistolik dan 6,429 untuk tekanan diastolik, masing-masing.  Hasilnya menunjukkan bahwa terapi kombinasi mungkin membantu mengontrol tekanan darah diastolik, meskipun jenis obat tidak mempengaruhi tekanan darah secara langsung

Background: Hypertension has a high prevalence of 43.11%, which is even higher among the elderly in Indonesia. The treatment of hypertension requires long-term therapy, making medication adherence crucial for controlling blood pressure and preventing complications. Sample: The sample in this study consisted of 76 pregnant women in Tangkil Tengah and Rengas villages. After screening according to inclusion and exclusion criteria, 62 pregnant women were selected as respondents. Method: This study employed a correlational analytical method using a quantitative approach. The sampling technique used was non-probability sampling. The research instrument was a questionnaire that included the variables to be studied. The analysis used was univariate analysis with frequency distribution and percentages, and bivariate analysis using the Statistical Program for Social Science (SPSS). Results: The knowledge of elderly individuals with hypertension about hypertension was categorized as high (9%), moderate (35%), and low (57%), while adherence to antihypertensive medication was categorized as high (24%), moderate (7%), and low (70%). The correlation analysis in this study, using the Chi-square test, showed a significant relationship between the level of knowledge and the level of adherence to antihypertensive medication among the elderly, with a p-value of 0.00. Conclusion: There is a significant relationship between the level of knowledge and the level of adherence to antihypertensive medication among the elderly at RSU Bhakti Asih Ciledug.

Hypertension is one of the non-communicable diseases that can cause death. This disease is called the silent disease because sufferers do not know they have hypertension. One of the absolute requirements for achieving effective therapy and improving the quality of life of patients is compliance, while patient non-compliance in taking medication is one of the main factors causing therapy failure. The role of nurses as educators helps patients increase their knowledge about medical care and actions so that patients get information to improve drug compliance for hypertension. This study was conducted to determine the relationship between the role of nurses as educators and medication adherence in patients with hypertension at the Larangan Utara Health Center. The study design was a correlational design with a cross-sectional approach. The study population was all patients with hypertension who came for treatment at the Larangan Utara Health Center in Tangerang City. The sampling technique was Non Probability Sampling using the Purposive Sampling approach, namely 96 respondents. Data analysis of univariate and bivariate analysis using the chi-Square test. The results showed that out of 96 respondents, 44 people chose the role of nurses with a moderate level of compliance (45.8%) and 28 respondents had high compliance (38.9%). The conclusion is that there is an influence between the role of nurses as educators and medication adherence. So the better the role of nurses as educators, the more patient compliance in taking medication

Human Immunodeficiency Virus (HIV) is a disease that attacks the body's immune system so that it is unable to fight various diseases. Communities with low levels of health literacy will face more problems. According to the Central Java Provincial Health Service, the number of HIV sufferers has also increased rapidly to Central Java, Semarang City with 331 cases, and the majority of those infected are men. The general aim of this research is to determine the relationship between health literacy and adherence to taking antiretroviral drugs (ARV) in people living with HIV (PLHIV). This research is a type of non-experimental descriptive analytical research with a cross-sectional approach. The samples taken were all patients with HIV (PLHIV) who took ARV drugs in the work area of ​​the Poncol Health Center, Semarang City. The technique used was consecutive sampling of 83 people. The correlation test used in this research is the chi-square test. From the results of the analysis, it was found that of the 83 research respondents, there was a relationship between the health literacy of people living with HIV (PLHIV) and the use of antiretroviral drugs (p value 0.003). The research results showed that the majority of respondents had high health literacy and were compliant with medication consumption with a total of 55 respondents (96.5%).

This article discusses the maintenance of Family Medicinal Plants (TOGA) in Mata Wawatu Village as an effort to improve public health. The aim of this program is to provide information to the public regarding the benefits and cultivation techniques of medicinal plants. The methods employed include qualitative research with a descriptive approach, encompassing observations, interviews, and documentation collection. The findings of this study indicate that this initiative has successfully enhanced the community's understanding of TOGA and encouraged them to utilize medicinal plants in their daily lives. This program is expected to improve the health and well-being of the community and reduce dependence on chemical medications