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Neonatal sepsis is a major factor contributing to morbidity and mortality in newborns. C-Reactive Protein (CRP) and leukocytes are laboratory tests used as indicators of inflammation. This study aims to determine the relationship between C-Reactive Protein levels and leukocyte profiles in neonatal sepsis patients. The research method used was an observational analytic with a cross-sectional approach. Neonatal sepsis at PKU Muhammadiyah Yogyakarta in the period 2021-2026 consisted of 30 samples using a total sampling technique. The distribution of respondents was dominated by male gender compared to female gender, who had a low birth weight <2,500 grams. Based on the study, normal CRP levels were found in 21 respondents, which was caused by a delay in increasing CRP levels. Leukocytes had high levels in 18 respondents. Leukocytes are an initial phase of examination in detecting inflammation that does not require a long time, have several different morphological types in detecting inflammation in the body. This study shows that the most dominant increase in leukocyte levels is found in eosinophils and neutrophils. Based on medical record data at PKU Muhammadiyah Hospital Yogyakarta, analysis using the Spearman correlation test yielded a correlation coefficient of 0.261 with a significance value of 0.164 (p > 0.05). The results showed no significant relationship between the studied variables, with a positive direction and weak correlation strength. The conclusion of this study is that there is no significant relationship between C-Reactive Protein levels and leukocyte profiles in neonatal sepsis patients.

This study is motivated by the importance of preserving local wisdom amid the flow of modernization that influences community life, particularly in the tradition of Ramadan Sahur Patrol in Kademangan Village, Pagelaran District, Malang Regency. This research aims to describe the implementation of the sahur patrol, identify the local wisdom values embedded within it, and analyze community responses to the tradition. The method used is qualitative with a cultural anthropology approach and a descriptive research design. Data were collected through interviews and documentation involving purposively selected informants, including community leaders, patrol participants, and local government officials. Data analysis was conducted using an interactive model consisting of data reduction, data display, and conclusion drawing. The results show that the sahur patrol is carried out in a structured manner by utilizing traditional musical instruments, involving cross-generational participation, and being integrated with the community’s religious activities. This tradition contains religious, social, educational, cultural, mutual cooperation, togetherness, and responsibility values. In addition, the community shows a highly positive response through active participation and support for the sustainability of the tradition. The implications of this study emphasize that the sahur patrol plays an important role as a medium for cultural preservation, strengthening social solidarity, and forming collective identity and character within the community.

Neonatal sepsis is a major factor contributing to morbidity and mortality in newborns. C-Reactive Protein (CRP) and leukocytes are laboratory tests used as indicators of inflammation. This study aims to determine the relationship between C-Reactive Protein levels and leukocyte profiles in neonatal sepsis patients. The research method used was an observational analytic with a cross-sectional approach. Neonatal sepsis at PKU Muhammadiyah Yogyakarta in the period 2021-2026 consisted of 30 samples using a total sampling technique. The distribution of respondents was dominated by male gender compared to female gender, who had a low birth weight <2,500 grams. Based on the study, normal CRP levels were found in 21 respondents, which was caused by a delay in increasing CRP levels. Leukocytes had high levels in 18 respondents. Leukocytes are an initial phase of examination in detecting inflammation that does not require a long time, have several different morphological types in detecting inflammation in the body. This study shows that the most dominant increase in leukocyte levels is found in eosinophils and neutrophils. Based on medical record data at PKU Muhammadiyah Hospital Yogyakarta, analysis using the Spearman correlation test yielded a correlation coefficient of 0.261 with a significance value of 0.164 (p > 0.05). The results showed no significant relationship between the studied variables, with a positive direction and weak correlation strength. The conclusion of this study is that there is no significant relationship between C-Reactive Protein levels and leukocyte profiles in neonatal sepsis patients.

This community service program aims to transform the management of tempeh MSMEs in the Sanan area through the integration of management strengthening, business digitalization, and legality based on the Asset-Based Community Development (ABCD) approach. The activities were carried out by combining the ABCD and Participatory Action Research (PAR) approaches through the stages of discovery, dream, design, and destiny, involving the active participation of business actors in every process. This approach emphasizes the utilization of local potential and community assets, enabling MSME actors to develop their businesses independently and sustainably. The results of the program indicate that the implementation of standard operating procedures (SOPs) and cross-training programs improved the consistency of production processes, work efficiency, and workforce flexibility in responding to changing production demands. In addition, the use of social media and business location tagging on digital platforms contributed positively to expanding market access and increasing product visibility. Assistance in copyright registration also strengthened the legality and protection of MSME products. Overall, this activity significantly enhanced the adaptive capacity of MSMEs in facing market dynamics and encouraged more structured, competitive, innovative, and sustainable business management.

Student dropout in higher education remains a persistent socioeconomic challenge, yet many predictive models reported in the literature are methodologically compromised by randomized cross-validation schemes that introduce temporal data leakage and artificially inflate predictive performance. This study proposes a longitudinal prescriptive learning analytics framework integrating three complementary methodological components: a Leave-One-Cohort-Out (LOCO) temporal validation protocol, a hybrid SMOTE-ENN class balancing strategy, and temporal velocity feature engineering derived from Learning Management System (LMS) behavioral trajectories. The framework was evaluated on a longitudinal dataset comprising 464,739 enrollment records and 77 features. Five predictive algorithms—XGBoost, LightGBM, CatBoost, Random Forest, and Logistic Regression—were comparatively assessed on a strictly isolated blind holdout cohort (2022), with CatBoost emerging as the champion estimator, achieving a PR-AUC of 0.8859, a Macro F1-Score of 0.9143, and the lowest Brier Score (0.0221), thereby demonstrating superior calibration and discriminative capability under severe class imbalance (93:7 ratio). Comprehensive ablation analysis revealed that temporal velocity features function not merely as additive predictors, but as a structural prerequisite enabling Synthetic Minority Oversampling Technique with Edited Nearest Neighbors (SMOTE-ENN) to generate high-quality synthetic boundary instances; removing these features reduced minority-class precision from 0.8302 to 0.6721. To operationalize predictive outputs into actionable intervention pathways, Diverse Counterfactual Explanations (DiCE) were implemented under a three-tier causal constraint architecture on 96 borderline high-risk students, generating 384 feasible intervention scenarios exclusively targeting forward-looking behavioral velocity metrics without constraint violations. Collectively, these findings advance the paradigm of prescriptive learning analytics by providing educational institutions with interpretable risk diagnostics and operationally feasible intervention guidance grounded in empirically validated behavioral and temporal dynamics.

Helicobacter pylori infection is one of the main factors associated with the occurrence of active gastritis and duodenal ulcers. This bacterium can survive in the acidic environment of the stomach by producing the urease enzyme, allowing it to colonize the gastric mucosa and trigger an inflammatory response. This study aims to analyze the relationship between Helicobacter pylori infection and the incidence of active gastritis and duodenal ulcers. The method used was a literature review with a narrative approach of scientific articles published between 2021–2025 from the Google Scholar, OpenAlex, and Crossref databases. The results of the review indicate that Helicobacter pylori infection is significantly associated with increased gastric mucosal inflammation and a higher risk of duodenal ulcers. Early detection and eradication therapy using a combination of antibiotics and proton pump inhibitors (PPI) are effective in preventing disease progression and complications. Additional findings highlight the importance of hygiene, sanitation, and public awareness in reducing transmission rates and improving gastrointestinal health outcomes globally..

Diabetes mellitus, as a persistent non-infectious metabolic pathology increasingly prominent in the global epidemiological spectrum, is fundamentally characterized by dysfunctional hyperglycemia rooted in primary disruptions of pancreatic insulin hormone synthesis or peripheral resistance to its biological action, thereby inducing dynamic imbalances in gluconeogenesis and glycolysis pathways; amid the hypothesis that body mass index (BMI) as a measure of central adiposity potentially mediates variability in serum glucose levels, this quantitative observational study with a cross-sectional design rigorously tests the causal relationship between BMI and fasting/random blood glucose concentrations in a cohort of 134 adult subjects with type 2 diabetes mellitus affiliated with primary care services at Puskesmas Bongo II, Boalemo Regency, through an inclusive total sampling recruitment strategy, precision anthropometric measurement instruments (height, weight, WHO BMI categorization), and laboratory-validated glucometric validation, with multivariate inferential processing based on the Chi-Square independence test at a Type I error rate of α=0.05 using the latest edition of the SPSS analytical suite; the demographic profile highlights female gender supremacy (90 individuals, 67.2%), the normoweight group (78 cases, 58.2%), concurrent with substantial glycemic elevation prevalence (78 subjects, 58.2%), but the crucial statistical output reveals a p-value of 0.831 (>0.05) that negates any probabilistically meaningful association, thus the substantive conclusion affirms the non-significance of the BMI-glucose relationship in this local context, while implying the dominance of alternative etiopathogenic factors such as hypercaloric macronutrient intake patterns, deficits in aerobic/anaerobic physical activity, non-adherence to multidisciplinary pharmacological protocols (e.g., metformin/oral hypoglycemics), and a comprehensive management paradigm integrating behavioral education, continuous monitoring, and personalized interventions to mitigate long-term cardiovascular risks across the diabetes mellitus spectrum.

Malnutrition among children under five remains a major public health concern, particularly in areas with limited access to nutritious food and health services. This study aimed to determine the prevalence of stunting, underweight, and wasting among children under five in Kuatnana District, South Central Timor Regency in 2025. This research used a descriptive cross-sectional design with secondary data obtained from nutrition program reports at Tetaf Public Health Center. The sample included all children aged 0–59 months, totaling 1,179 children. Data were analyzed using univariate analysis to calculate frequency distribution and percentages based on WHO anthropometric indicators (z-score). The results showed that the prevalence of stunting was 44.78%, underweight 40.46%, and wasting 14.76%. Most children had normal nutritional status based on weight-for-height index (88.38%), although a considerable proportion still experienced undernutrition. In conclusion, malnutrition among children under five in Kuatnana District remains high, particularly stunting and underweight. Integrated interventions are needed, including improving caregiving practices, increasing access to nutritious food, and strengthening health services to reduce malnutrition sustainably.

Diabetes mellitus, as a persistent non-infectious metabolic pathology increasingly prominent in the global epidemiological spectrum, is fundamentally characterized by dysfunctional hyperglycemia rooted in primary disruptions of pancreatic insulin hormone synthesis or peripheral resistance to its biological action, thereby inducing dynamic imbalances in gluconeogenesis and glycolysis pathways; amid the hypothesis that body mass index (BMI) as a measure of central adiposity potentially mediates variability in serum glucose levels, this quantitative observational study with a cross-sectional design rigorously tests the causal relationship between BMI and fasting/random blood glucose concentrations in a cohort of 134 adult subjects with type 2 diabetes mellitus affiliated with primary care services at Puskesmas Bongo II, Boalemo Regency, through an inclusive total sampling recruitment strategy, precision anthropometric measurement instruments (height, weight, WHO BMI categorization), and laboratory-validated glucometric validation, with multivariate inferential processing based on the Chi-Square independence test at a Type I error rate of α=0.05 using the latest edition of the SPSS analytical suite; the demographic profile highlights female gender supremacy (90 individuals, 67.2%), the normoweight group (78 cases, 58.2%), concurrent with substantial glycemic elevation prevalence (78 subjects, 58.2%), but the crucial statistical output reveals a p-value of 0.831 (>0.05) that negates any probabilistically meaningful association, thus the substantive conclusion affirms the non-significance of the BMI-glucose relationship in this local context, while implying the dominance of alternative etiopathogenic factors such as hypercaloric macronutrient intake patterns, deficits in aerobic/anaerobic physical activity, non-adherence to multidisciplinary pharmacological protocols (e.g., metformin/oral hypoglycemics), and a comprehensive management paradigm integrating behavioral education, continuous monitoring, and personalized interventions to mitigate long-term cardiovascular risks across the diabetes mellitus spectrum.

Chronic kidney disease is a progressive disease requiring long-term hemodialysis therapy that may cause physical, psychological, social, and spiritual problems. Patients undergoing hemodialysis often experience spiritual distress due to changes in health conditions and dependence on therapy. This study aimed to determine the relationship between the duration of hemodialysis and the level of spiritual distress in chronic kidney disease patients at the Hemodialysis Unit of Baiturrahim Hospital Jambi. This study used a quantitative design with a cross sectional approach. The sample consisted of 57 respondents selected using a purposive sampling technique. The research instrument used a spiritual distress questionnaire that had been tested for validity and reliability with a Cronbach’s Alpha value of 0.955. Data were analyzed using the Chi-Square test with a significance level of 0.05. The results showed that most respondents underwent hemodialysis for ≥12 months, totaling 39 respondents (68.4%), and the majority experienced moderate spiritual distress, totaling 20 respondents (35.1%). Statistical analysis showed a p-value of 0.030 (p<0.05), indicating a significant relationship between the duration of hemodialysis and the level of spiritual distress in chronic kidney disease patients. The longer patients undergo hemodialysis, the lighter the spiritual distress tends to be because patients gradually adapt to their disease condition and therapy.

Helicobacter pylori infection is one of the main factors associated with the occurrence of active gastritis and duodenal ulcers. This bacterium can survive in the acidic environment of the stomach by producing the urease enzyme, allowing it to colonize the gastric mucosa and trigger an inflammatory response. This study aims to analyze the relationship between Helicobacter pylori infection and the incidence of active gastritis and duodenal ulcers. The method used was a literature review with a narrative approach of scientific articles published between 2021–2025 from the Google Scholar, OpenAlex, and Crossref databases. The results of the review indicate that Helicobacter pylori infection is significantly associated with increased gastric mucosal inflammation and a higher risk of duodenal ulcers. Early detection and eradication therapy using a combination of antibiotics and proton pump inhibitors (PPI) are effective in preventing disease progression and complications. Additional findings highlight the importance of hygiene, sanitation, and public awareness in reducing transmission rates and improving gastrointestinal health outcomes globally..

Homemade food is increasingly dominating the choices of consumers who are oriented towards a healthy lifestyle. However, the belief that self-cooking is synonymous with food safety is not always supported by scientific evidence. This Narrative Review aims to build an in-depth thematic synthesis of the various dimensions of food safety risks that arise in the process of preparing healthy homemade food, ranging from biological and chemical contamination, to human behavioral factors as the main agents of contamination. The study was conducted against seven reputable sources of scientific literature published between 2010–2025, including observational, experimental, cross-sectional, and review studies. Four main themes were identified: (1) risky behaviors in the household kitchen as the dominant factor; (2) unexpected cross-contamination pathways including table salt as a vector; (3) chemical and biological contaminants hidden in "healthy" materials; and (4) evidence-based interventions that have been proven to be effective. This review confirms that homemade food safety is a behavioral issue, not just a technical one, so the intervention approach must be multidimensional and sustainable.

Stunting is a major indicator of chronic nutritional problems that affect children’s growth and development. In Indonesia, stunting prevalence remains high and is a national public health concern. This study aimed to analyze the relationship between socio-demographic factors and stunting incidence among toddlers in the working area of the Tanoh Alas Health Center, Southeast Aceh Regency, in 2025. This study used an analytical quantitative design with a cross-sectional approach. The sample consisted of 93 mothers with children under five selected through simple random sampling. Data were collected using questionnaires and observation sheets from June 19 to July 3, 2025. Statistical analyses included Chi-Square and multiple logistic regression tests. The results showed that 33.3% of children were stunted, 34.4% had poor access to health services, and 68.8% lived in unhealthy housing conditions. Bivariate analysis indicated significant relationships between maternal age (p = 0.007), maternal education (p = 0.012), maternal occupation (p = 0.002), access to health services (p = 0.001), family income (p = 0.032), and healthy housing conditions (p = 0.007) with stunting incidence. Multivariate analysis revealed that access to health services was the strongest factor associated with stunting (p = 0.010; OR = 4.294; 95% CI: 1.411–13.06). Children with limited access to health services were 4.3 times more likely to experience stunting. The study recommends improving the accessibility and quality of maternal and child health services and strengthening multisectoral interventions and health education programs to prevent stunting.

This study explores the relationship between service quality dimensions and customer loyalty in high-contact service industries, including healthcare, hospitality, and financial services, particularly in emerging markets. Using the SERVQUAL model, which identifies five key dimensions tangibles, reliability, responsiveness, assurance, and empathy the research examines how these dimensions influence customer loyalty. A quantitative research design is employed, with data collected through a cross-sectional survey of 400 respondents using a structured questionnaire. The study analyzes service quality, customer satisfaction, and loyalty using Structural Equation Modeling (SEM), regression analysis, and Exploratory Factor Analysis (EFA). Findings reveal that reliability and empathy are the most influential factors in fostering loyalty, with customer satisfaction acting as a mediator. Additionally, the research highlights the role of perceived value and customer experience in moderating these effects, particularly in sectors like healthcare and hospitality. The study extends the SERVQUAL model by integrating new dimensions such as customer experience and perceived value, offering a more comprehensive framework for understanding service quality in high-contact industries. These insights provide actionable recommendations for service managers to enhance customer loyalty by addressing both functional and emotional aspects of service quality

Stunting is a major indicator of chronic nutritional problems that affect children’s growth and development. In Indonesia, stunting prevalence remains high and is a national public health concern. This study aimed to analyze the relationship between socio-demographic factors and stunting incidence among toddlers in the working area of the Tanoh Alas Health Center, Southeast Aceh Regency, in 2025. This study used an analytical quantitative design with a cross-sectional approach. The sample consisted of 93 mothers with children under five selected through simple random sampling. Data were collected using questionnaires and observation sheets from June 19 to July 3, 2025. Statistical analyses included Chi-Square and multiple logistic regression tests. The results showed that 33.3% of children were stunted, 34.4% had poor access to health services, and 68.8% lived in unhealthy housing conditions. Bivariate analysis indicated significant relationships between maternal age (p = 0.007), maternal education (p = 0.012), maternal occupation (p = 0.002), access to health services (p = 0.001), family income (p = 0.032), and healthy housing conditions (p = 0.007) with stunting incidence. Multivariate analysis revealed that access to health services was the strongest factor associated with stunting (p = 0.010; OR = 4.294; 95% CI: 1.411–13.06). Children with limited access to health services were 4.3 times more likely to experience stunting. The study recommends improving the accessibility and quality of maternal and child health services and strengthening multisectoral interventions and health education programs to prevent stunting.

The Village Fund Direct Cash Assistance Program (BLT-DD) is a social protection instrument designed to help low-income families meet their basic needs. However, its implementation often faces challenges such as targeting inaccuracies, limited data, and varying administrative capacity at the village level. This study aims to evaluate the implementation of BLT-DD using William N. Dunn’s six policy evaluation criteria through a Systematic Literature Review (SLR) approach, covering effectiveness, efficiency, equity, responsiveness, conceptual alignment, and implementation. The findings indicate that BLT-DD is fairly effective in helping households maintain consumption, yet its effectiveness and adequacy remain constrained by the amount of assistance and the quality of data collection. Program efficiency and responsiveness are relatively good in villages with sufficient governance capacity, while equity emerges as the weakest aspect due to inaccurate data verification. Conceptually, BLT-DD aligns with the needs of low-income communities, but implementation accuracy still requires reinforcement. Furthermore, the study highlights the need for more systematic monitoring mechanisms, cross-sectoral data integration, and administrative training for village officials to enhance service quality. Overall, BLT-DD provides valuable support but requires improvements in governance and data systems to optimize outcomes, including regular evaluation strategies and refinement of supporting regulations.

Hypertension is a chronic disease whose management is substantially determined by an individual's capacity to access and utilize health-related information. Inadequate health literacy may lead to poor medication adherence and diminished quality of life. This study aimed to examine the association between health literacy, medication adherence, and quality of life among hypertensive patients at Polresta Sleman. An observational analytic quantitative design with a cross-sectional approach was employed, involving 80 respondents selected through purposive sampling. Data were collected using the HLS-ID-SF12, MARS-5, and WHOQOL-BREF instruments. Bivariate analysis was conducted using Pearson correlation, while multivariate analysis applied multiple linear regression. Results revealed that health literacy significantly correlated with medication adherence (r = 0.469; p < 0.05) and quality of life (r = 0.447; p < 0.05). Medication adherence also demonstrated a significant correlation with quality of life (r = 0.615; p < 0.05). Simultaneously, both variables accounted for 41.1% of the variance in quality of life (R² = 0.411; p < 0.05). These findings underscore the importance of jointly improving health literacy and medication adherence as an evidence-based strategy to optimize quality of life in hypertensive patients.

The ICU is one of the largest clinical cost centers in hospitals due to its high demand for human resources, medical equipment, and operational costs. This situation emphasizes that intensive care unit efficiency is a multidimensional issue that cannot be assessed solely from a single aspect. This study aims to analyze the efficiency of the intensive care unit at Ciremai Hospital, Cirebon City, using the Data Envelopment Analysis (DEA) model to determine resource optimization. Analytical quantitative study with a cross-sectional design. The population in this study consisted of personnel in the ICU of Ciremai Hospital from 2023 to 2025, with total sampling applied. The input variables included the number of physicians, nurses, beds, monitors, and ventilators, while the output variables consisted of BOR, LOS, and recovered patients. The ICU input variables remained stable during the study period, while output variables fluctuated with a declining trend in BOR and LOS. The results of the Data Envelopment Analysis (DEA) indicated that all study periods achieved an efficiency score of 1.00 (efficient), with a slack value of 0.00 across all input variables.

. Malnutrition rates among children remain quite high, according to 2024 national statistics, which indicate that good eating habits in accordance with balanced nutritional needs are not yet ideal. Children's eating habits, dietary diversity, and parental understanding all impact their nutritional status. To promote optimal growth and development in children, it is crucial to monitor and establish appropriate eating habits from an early age. The aim of this study was to determine the relationship between eating habits and nutritional status of preschool-aged children. This study used a cross-sectional analytical design and quantitative methodology. Purposeful sampling was used to select a sample of 33 children from the 50 children in the study population. The study was conducted between September 22 and October 1, 2025. A Food Frequency Questionnaire (FFQ) was used to examine dietary patterns, while nutritional status was measured through weighing using a digital scale. Based on the findings, 22 children (66.7%) had a healthy diet, while 11 children (33.3%) had a poor diet. The Chi-Square statistical test showed a p value of 0.008 (p < 0.05), indicating a relationship between eating habits and nutritional status in preschool children at Taman Annisa Miruek Kindergarten, Aceh Besar Regency. According to balanced nutrition guidelines, parents should regularly assess their children's growth and focus more on the diversity and balance of their food intake. To improve children's nutritional status as much as possible, schools are required to collaborate with health workers to educate parents and children about nutrition.

Patient satisfaction is one of the key indicators in assessing the quality of nursing care in hospitals. High-quality nursing care can enhance patient trust, comfort, and satisfaction during their treatment. This study aims to determine the relationship between the quality of nursing care and the satisfaction of inpatients at Bahteramas General Hospital in Kendari City. This is an analytical quantitative study using a cross-sectional approach. The sample consisted of 39 inpatients. Data were collected using a questionnaire and analyzed using univariate and bivariate analyses with the chi-square test. The results indicate a significant relationship between all dimensions of nursing service quality and inpatient satisfaction. The tangible dimension was associated with patient satisfaction (p = 0.003), reliability (p = 0.000), responsiveness (p = 0.000), assurance (p = 0.012), and empathy (p = 0.000). In general, patients who rated the quality of nursing care as “poor” tended to be more likely to fall into the “dissatisfied” category, while patients who rated the quality of care as “adequate” tended to be more likely to fall into the “satisfied” category. This study concludes that the quality of nursing care is significantly associated with inpatient satisfaction at Bahteramas General Hospital in Kendari City. . Therefore, hospitals need to improve the quality of nursing care, particularly in terms of physical evidence, reliability, responsiveness, assurance, and empathy, in order to enhance patient satisfaction.