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Breast cancer remains a major global health challenge, with treatment effectiveness often limited by drug resistance and the toxic side effects of chemotherapy on normal cells. The exploration of bioactive compounds from natural sources through a medicinal chemistry approach offers a promising alternative strategy. This study aims to examine the molecular mechanisms of action and Structure-Activity Relationships (SAR) of various natural compound scaffolds as potential breast anticancer agents. The method employed was a systematic narrative literature review of 15 recent scientific articles evaluating computational parameters, including molecular docking, as well as in vitro and in vivo activities. The results indicate that polyphenols, flavonoids such as quercetin and EGCG, and curcumin possess strong cytotoxic activity and high binding affinity toward cancer-related target macromolecules. SAR analysis demonstrates that key structural features, including the number and position of free phenolic hydroxyl groups, the presence of gallate ester groups, and conjugated diketone systems, play a crucial role in determining ligand receptor complex stability. These interactions are supported by hydrogen bonding, hydrophobic interactions, and favorable steric compatibility within receptor binding sites. Computational findings further suggest that structural optimization can enhance ligand selectivity and improve pharmacokinetic properties. This study concludes that natural phytochemical scaffolds have significant potential as lead compounds and provide a rational basis for Computer-Aided Drug Design in developing more potent, selective, multi-target, and safer breast anticancer therapies.

This study aims to analyze in-depth cognitive learning theory and its implications for improving the effectiveness of Islamic Religious Education (PAI) teaching at the elementary school level. The adopted methodological approach is qualitative through library research, with the application of content analysis and theoretical synthesis techniques. Primary data sources were obtained from academic literature including textbooks, scientific journals, and the latest empirical research relevant within the last decade. The results of the analysis indicate that cognitive learning theory positions cognitive processes as the core of learning activities, allowing students to function as active agents in constructing knowledge through understanding, analysis, memory representation, and integration with pre-existing cognitive schemas. In the context of PAI, this approach enables meaningful learning through interactive pedagogical strategies such as collaborative discussions, problem-solving, case studies, and metacognitive reflection, which are empirically adapted to the stages of students' cognitive development. The implementation of cognitive theory significantly contributes to strengthening conceptual understanding, increasing learning engagement, developing critical thinking skills, transferring knowledge, and internalizing Islamic values. Thus, cognitive learning theory makes a substantial contribution to optimizing the effectiveness of PAI teaching in elementary schools through an interactive, systematic, and understanding-oriented approach.

The practice of money politics remains a serious challenge in the implementation of the 2024 General Election and the 2024 Regional Elections in Indonesia, as it has the potential to undermine the principles of fairness, honesty, and democratic integrity. This study aims to analyze the role of the Election Organizer Ethics Council (DKPP) in adjudicating violations related to money politics, particularly from the ethical perspective of election organizers. The method used is a qualitative approach through literature study of laws, regulations, and DKPP decisions. The findings indicate that DKPP plays a strategic role in maintaining the neutrality and professionalism of election organizers by enforcing the code of ethics, imposing sanctions, and supervising behaviors that may involve or tolerate money politics practices. Although DKPP's authority is limited to the ethical domain and does not extend to criminal law enforcement, its existence remains crucial as a moral guardian within the electoral system. Therefore, synergy between DKPP, law enforcement institutions, and public participation is necessary to minimize money politics and to realize democratic and integrity-based elections.

This research examines the potential application of the Right to Be Forgotten (RTBF) in Indonesia's criminal justice system, focusing on individuals who have been acquitted or have completed their sentences. The study explores the legal, social, and ethical implications of RTBF in relation to criminal records, aiming to assess how it could support the rehabilitation and reintegration of acquitted individuals. In Indonesia, criminal records often remain publicly accessible long after a person has been legally exonerated, creating barriers to social reintegration due to the stigma associated with past accusations. The study investigates the gaps in the current legal framework, such as the lack of provisions for the removal or anonymization of criminal records for acquitted individuals, and explores how RTBF could promote justice and fairness. The research uses a literature review methodology, analyzing relevant legal texts including Law No. 11 of 2008 on Information and Electronic Transactions (ITE Law), Law No. 39 of 1999 on Human Rights, and the 1945 Indonesian Constitution. The review critically evaluates the challenges and opportunities of implementing RTBF, focusing on balancing privacy rights with public safety concerns. The findings suggest that RTBF could reduce the negative impact of criminal records on individuals who have been acquitted, facilitating their reintegration into society. However, the study also highlights the challenges in implementing RTBF due to societal and legal factors. Legal reforms recommendations allow individuals to request the removal of criminal records, aligning Indonesia's legal system with international human rights standards.

Teachers, as professionals, play a crucial role in managing learning in the classroom. One essential skill that teachers must have is managerial skills, which involve organizing learning activities, setting up the learning environment, and applying suitable methods for learning tasks. In the context of differentiated learning focused on student needs, teacher managerial competence is vital for designing and managing instruction tailored to each student's requirements. Differentiated learning is an approach that emphasizes meeting the needs, interests, and learning styles of individual students. This study was conducted using a literature review method, drawing data from various sources including books, articles, and relevant previous research. The review shows that for successful differentiated learning, teachers need to implement managerial strategies for identifying students’ learning needs, managing content, processes, learning products, and conducting regular formative assessments. Furthermore, teachers must create an environment that supports the learning process through strong collaboration among students, between teachers and students, and with parents. Therefore, improving teacher managerial skills is one way to achieve inclusive learning and accommodate student diversity.

Environmental-based diseases remain a major public health issue associated with unsafe drinking water, inadequate sanitation, poor hygiene behavior, improper household waste management, and unsafe domestic wastewater disposal. Community-Based Total Sanitation, known in Indonesia as Sanitasi Total Berbasis Masyarakat or STBM, is a community empowerment approach designed to change hygiene and sanitation behavior through five pillars. This article aims to develop an STBM program planning design and an impact evaluation model for reducing environmental-based diseases, particularly diarrhoeal disease. This study used a narrative review method by analyzing national regulations, official guidelines, global WASH reports, and recent scientific literature. The proposed program design includes situation analysis, multisectoral advocacy, community triggering, household mentoring, strengthening sanitation facilities, monitoring, verification, and impact evaluation. The evaluation model uses process, output, outcome, and impact indicators, with diarrhoea incidence as the main measurable health indicator. The findings indicate that an integrated STBM program supported by community participation, valid baseline data, and periodic evaluation can strengthen the prevention of environmental-based diseases. This article recommends implementing STBM as a sustainable community-based public health intervention rather than a short-term sanitation activity. 

Clean water is a basic human necessity that plays a vital role in public health and well-being. However, access to clean water remains a challenge in many drought-prone areas. This condition requires effective planning and evaluation to ensure the sustainability of clean water supply programs. This article aims to examine the application of the Problem Solving Cycle (PSC) method in the planning and evaluation of clean water supply programs in drought-prone regions. The study employed a literature review method by analyzing various scientific articles and relevant documents. Data were analyzed descriptively through identification, classification, and information synthesis. The findings indicate that PSC supports program planning and evaluation through the stages of problem identification, cause analysis, action planning, implementation, monitoring, and evaluation. Clean water supply programs contribute to improving community access to safe water and adequate sanitation, although several challenges remain, including limited resources, infrastructure management issues, and program sustainability. Therefore, PSC can serve as an effective approach to support the success of clean water supply programs in drought-prone areas.

Vector-borne infectious diseases remain a public health concern, particularly in tropical regions such as Indonesia. Sanitation clinics at public health centers (Puskesmas) play a role in identifying environmental risk factors and planning interventions to support vector-borne disease control. This study aimed to evaluate the performance of sanitation clinics in environmental intervention planning. The method used was a literature review of scientific articles, journals, and related documents published between 2015-2025. Data were analyzed descriptively to identify forms of environmental interventions and their effectiveness. The results showed that sanitation clinics play an important role in environmental health counseling, sanitation inspections, health education, and environmental intervention planning. However, their implementation still faces challenges, including limited numbers of sanitarians, inadequate facilities and infrastructure, and suboptimal environmental interventions. Nevertheless, sanitation clinics continue to contribute to the prevention of environment-based diseases and vector control. Therefore, strengthening resources and improving the quality of intervention planning are necessary to enhance the effectiveness of sanitation clinic programs.

This article examines the use of cooperative learning strategies in Christian Religious Education (CRE) as an instructional approach that emphasizes the strengthening of students’ faith and Christian character. The discussion covers the definition, objectives, conceptual foundations, principles, and operational procedures of cooperative learning, which are then connected to the theological goals of CRE. The study employs a qualitative approach using a library research method, analyzing pedagogical and theological literature to construct a conceptual framework for implementing cooperative learning within the context of CRE. The findings indicate that cooperative learning strategies are highly aligned with the essence of CRE, as they foster dialogical interaction, shared responsibility, empathy, and the internalization of Gospel values through collaborative learning processes. The effective implementation of this strategy can create a participatory, reflective, and formative learning community that enhances not only cognitive understanding but also students’ attitudes, spirituality, and Christian character. This research is significant in providing both theoretical and practical foundations for CRE educators in designing learning experiences that are relevant, relational, and transformative in accordance with the goals of faith formation.

This article examines the urgency of strengthening Islamic creed (aqidah) as a preventive instrument in addressing religious radicalism. The rise of extremism is not merely driven by sociological factors, but is also rooted in a theological crisis, namely textual interpretations that give rise to exclusivism and takfiri doctrines. Employing a conceptual literature review method, this study deconstructs the pathology of radicalism and reconstructs the preventive dimensions of aqidah. The findings reveal that ideological mitigation is grounded in three dimensions of aqidah: Tawhid as a means of liberating reason from group arrogance, wasathiyyah (moderation) in maintaining tolerance, and the absolute integration of faith with social morality. To be effective, these values must be institutionalized within Islamic education through the transformation of critical pedagogy, the strengthening of religious digital literacy, and the development of an inclusive school culture. Strengthening aqidah is therefore not merely a transfer of dogma, but the formation of a moderate worldview as a strong shield against the infiltration of radical ideologies.

Dengue fever remains a major global health challenge, particularly in tropical regions, due to the high transmission of Dengue virus by Aedes aegypti and the limited sustainability of current control strategies. Artocarpus odoratissimus, an endemic Bornean plant, contains diverse secondary metabolites with potential pharmacological activities; however, a systematic synthesis of its biomedical relevance to Dengue is still lacking. This study aimed to systematically evaluate the biomedical potential of A. odoratissimus in Dengue prevention and control through a systematic literature review. This study employed a systematic literature review method following the PRISMA 2020 guidelines. Literature searches were conducted in Scopus, ScienceDirect, SpringerLink, PubMed, Google Scholar, Garuda, SINTA, and other relevant scientific databases for publications from January 2016 to February 2026. A total of 303 records were identified, and after duplicate removal, title and abstract screening, and full-text eligibility assessment, 23 studies were included for narrative synthesis. The findings revealed that A. odoratissimus contains major bioactive compounds, including flavonoids, phenolics, arylbenzofurans, stilbenoids, and prenylated chalcones, which demonstrate antioxidant, anti-inflammatory, immunomodulatory, and potential antiviral activities based on in vitro and molecular docking studies. Fruit peel, seeds, and stem bark exhibited the strongest biological evidence, particularly in reducing oxidative stress, inhibiting inflammatory mediators, and potentially interacting with Dengue viral target proteins. Furthermore, several species within the Artocarpus genus showed larvicidal and ovicidal activities against Aedes aegypti, highlighting the potential development of A. odoratissimus as a plant-based biolarvicide candidate.

Dengue fever remains a major global health challenge, particularly in tropical regions, due to the high transmission of Dengue virus by Aedes aegypti and the limited sustainability of current control strategies. Artocarpus odoratissimus, an endemic Bornean plant, contains diverse secondary metabolites with potential pharmacological activities; however, a systematic synthesis of its biomedical relevance to Dengue is still lacking. This study aimed to systematically evaluate the biomedical potential of A. odoratissimus in Dengue prevention and control through a systematic literature review. This study employed a systematic literature review method following the PRISMA 2020 guidelines. Literature searches were conducted in Scopus, ScienceDirect, SpringerLink, PubMed, Google Scholar, Garuda, SINTA, and other relevant scientific databases for publications from January 2016 to February 2026. A total of 303 records were identified, and after duplicate removal, title and abstract screening, and full-text eligibility assessment, 23 studies were included for narrative synthesis. The findings revealed that A. odoratissimus contains major bioactive compounds, including flavonoids, phenolics, arylbenzofurans, stilbenoids, and prenylated chalcones, which demonstrate antioxidant, anti-inflammatory, immunomodulatory, and potential antiviral activities based on in vitro and molecular docking studies. Fruit peel, seeds, and stem bark exhibited the strongest biological evidence, particularly in reducing oxidative stress, inhibiting inflammatory mediators, and potentially interacting with Dengue viral target proteins. Furthermore, several species within the Artocarpus genus showed larvicidal and ovicidal activities against Aedes aegypti, highlighting the potential development of A. odoratissimus as a plant-based biolarvicide candidate.

Background: Schizophrenia is a type of mental disorder that affects how sufferers behave, think, and feel. This condition can trigger nursing problems such as low self-esteem (harga diri rendah). In 2023, approximately 970 million people worldwide experience mental disorders, with schizophrenia prevalence in Indonesia reaching 3 per 1,000 households and in Central Java approximately 5.1% of households. Methods: This study used a descriptive approach in the form of a case study through the nursing process, including observation, interview, documentation study, and literature review. The general objective of this writing was to implement psychiatric nursing care for Ny. W with the main problem of Self-Concept Disorder: Low Self-Esteem Due to Undifferentiated Schizophrenia. Results: Nursing diagnoses that emerged were low self-esteem, social isolation, and self-care deficit. Interventions carried out included SP 1 and SP 2 for low self-esteem (HDR) and SP 2 for self-care deficit (DPD). Conclusion: After 4 days of nursing care on Ny. W according to the nursing action plan, the patient was able to establish a trusting relationship, identify positive abilities she possessed, perform chosen activities, and interact with her environment.

The fiqh principle stating that a leader’s policies and actions toward the people must be based on public welfare is an Islamic legal principle emphasizing that every action and policy of a leader should be oriented toward the interests and well-being of society. This study aims to examine the meaning, normative foundations, concepts, and implementation of this principle in state governance. The research employs a library research method with a normative approach through the analysis of the Qur’an, Hadith, fiqh literature, scholarly journals, and relevant legislation. The findings indicate that this principle has a strong foundation in the Qur’an and Hadith, particularly regarding trustworthiness, justice, and the responsibility of leaders toward their people. Conceptually, this principle is closely related to the theories of maqashid al-shari’ah and siyasah shar’iyyah, which place public welfare as the primary objective of Islamic law. In practice, the principle is applied in various fields, including public administration, law and legislation, religious policies, as well as economic and fiscal policies. Its implementation can be seen in policies concerning the prohibition of interfaith marriage, marriage dispensation, marriage legalization hearings (isbat), the suspension of Hajj departures during the COVID-19 pandemic, and the management of state finances during the era of the Rightly Guided Caliphs. Therefore, this principle demonstrates that Islamic law possesses flexible and adaptive characteristics while maintaining a strong orientation toward public welfare, making it relevant to modern systems of governance.

. The effort to re-visualize regional architectural elements combined with modern touches is known as neo-vernakular architecture. In North Sumatra, there are various ethnic groups, including Batak, Mandailing, Malay, and others, each possessing rich traditional architectural values. This study aims to identify and analyze traditional architectural elements applied to the façade of the North Sumatra Regional House of Representatives (DPRD) building. The DPRD North Sumatra building is one of the government buildings that functions as a workplace for representatives of the people, council members, and the secretariat in carrying out governmental duties and public services. The building is located on Jalan Imam Bonjol with an area of approximately 8,000 square meters. This study uses a qualitative descriptive method with data collection techniques through direct field surveys and literature studies related to the façade design of the DPRD North Sumatra building. The results show that the neo-vernakular character on the building façade is represented through several architectural elements, such as exposed columns, sunshading, opening forms, and other supporting elements that reflect a combination of traditional and modern architectural features.  

This study designs and implements an up-down counter system based on an AT89C2051 microcontroller programmed in assembly using the MC-51 application. The system modifies an existing digital clock board by mapping the display selector pins, seven-segment segment pins, pushbuttons, and buzzer to the microcontroller ports. The research method consists of literature review, hardware identification, algorithm design, assembly programming, program downloading, and functional testing using a 5 V DC supply. The implementation uses a four-digit common-cathode seven-segment display and a multiplexing routine to show the counter value in real time. The functional test shows that the system can display the initial value, increase the value through the up button, and decrease the value through the down button. The display is readable during operation, and the program can run on the target circuit after being downloaded to the AT89C2051. This study confirms that assembly programming on MC-51 can be applied to implement a simple counter system on a reused digital clock circuit. The main limitations are the absence of explicit button debouncing, overflow and underflow protection, quantitative response-time measurement, and non-volatile data retention.

This research aims to analyze and compare traditional Islamic education systems in Indonesia, Malaysia, and Thailand, focusing on institutional aspects, education systems, learning methods, and curricula. Using a literature study method with a descriptive qualitative approach, this research examines various relevant literature regarding the dynamics of Islamic education in Southeast Asia. The results show that the three countries share fundamental similarities in educational forms, such as pesantren or pondok, which focus on Islamic sciences and moral cultivation. However, significant differences exist in management patterns and the level of integration with government policies. Indonesia maintains a variety of salaf and modern pesantren, Malaysia exhibits a more structured system integrated with the state, while Thailand specifically in the Patani region tends to be adaptive in response to its Muslim minority status. This comparison concludes that the development of traditional Islamic education systems in each country is heavily influenced by the respective social and political contexts.

Batik motif classification has attracted growing attention in visual computing due to its role in cultural heritage preservation, textile informatics, museum documentation, and automated cataloging. Although many studies report high classification accuracy, robustness under real-world acquisition conditions remains insufficiently understood. Batik images are frequently affected by illumination variation, blur, folds, watermark overlays, wearable deformation, scale inconsistency, and background clutter, creating challenges that extend beyond conventional image-noise assumptions. Existing studies largely focus on improving classification performance, while the interactions among acquisition variability, feature representation, evaluation practice, and deployment constraints remain fragmented. This systematic literature review addresses this gap by synthesizing batik classification research through a robustness-aware perspective. Using query expansion, backward and forward citation chaining, relevance screening, and thematic coding, 116 candidate records were identified, resulting in 50 highly relevant studies for detailed analysis. The review reveals that robustness is shaped less by denoising alone than by the combined effects of acquisition conditions, representation design, evaluation realism, and deployment context. Handcrafted descriptors remain competitive for small datasets and structured motifs due to their data efficiency and interpretability, whereas deep learning models achieve the highest reported accuracy when supported by sufficient data diversity and realistic augmentation. Hybrid representations emerge as the most consistently balanced approach, combining local texture stability with higher-level abstraction across heterogeneous acquisition settings. The review further identifies recurring robustness failure patterns, including background dependency, illumination instability, motif-scale inconsistency, wearable deformation, and source-shift vulnerability. Based on these findings, a robustness-oriented research agenda is proposed, emphasizing cross-acquisition evaluation, representation-stability analysis, batik-specific robustness benchmarks, acquisition-aware augmentation, and deployable lightweight or hybrid architectures. The study contributes a domain-specific synthesis that reframes batik motif classification from an accuracy-centric task toward a robustness-aware visual recognition problem.

This study was conducted to analyze the relationship between students’ critical thinking skills and mathematical problem-solving abilities through a literature review approach. The study is based on the importance of mastering higher-order thinking skills in the mathematics learning process, particularly when students are faced with complex problems related to real-life situations. The method used in this research was a literature review by examining various relevant scientific journals and academic books published between 2021 and 2026. The data analysis process was carried out through stages of identification, classification, evaluation, and synthesis of the collected sources. The findings revealed a significant and positive relationship between critical thinking skills and students’ mathematical problem-solving abilities. Critical thinking skills play an important role in helping students understand problems, process and analyze information, select appropriate solution strategies, and systematically review the results obtained. Students with strong critical thinking skills generally demonstrate more optimal mathematical problem-solving abilities. In addition, the implementation of learning models such as Problem-Based Learning and contextual approaches has been considered effective in improving both abilities. Therefore, critical thinking skills are regarded as an essential aspect that needs to be developed in mathematics learning in order to enhance students’ mathematical problem-solving abilities.

This study examines the concept of compassion-based education (rahmatan lil ‘alamin) from the perspective of Islamic educational philosophy and its relevance to bullying prevention in Islamic educational institutions. The study is motivated by the tendency of modern education to emphasize cognitive achievement while giving less attention to moral and affective development, resulting in the persistence of bullying behavior in educational settings. This study employs a qualitative approach using library research. Data were collected from the works of Muslim scholars, scientific journals, and relevant literature on Islamic education and analyzed through content analysis. The findings reveal that compassion-based education is built upon the integration of moral development, purification of the heart, and the cultivation of adab (proper conduct). These elements contribute to the development of empathy, social concern, and moral awareness among students. Therefore, compassion-based education (rahmatan lil ‘alamin) has strong relevance as a preventive approach to reducing bullying behavior and fostering a more humane and supportive educational environment in Islamic educational institutions.