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Diabetic foot ulcers represent one of the most serious long-term complications associated with type 2 diabetes mellitus, often contributing to increased rates of morbidity and mortality, while significantly impairing patients' quality of life. Among the various underlying causes, peripheral neuropathy and vascular disorders (vasculopathy) are frequently linked to dyslipidemia. This study aimed to examine the characteristics of total cholesterol and triglyceride levels, along with the prevalence of diabetic foot ulcers in patients with type 2 diabetes mellitus. A descriptive retrospective approach was used by analyzing medical record data collected from Dr. H. Chasan Boesoirie General Hospital in Ternate. The findings indicated that the majority of patients with type 2 diabetes were aged 45 years or older (80%) and were predominantly female (60%). In terms of lipid profiles, most patients exhibited normal total cholesterol levels (82.2%) and normal triglyceride levels (51.1%). Despite these normal lipid values, a significant portion of the patients (53.3%) were identified as being at risk of developing diabetic foot ulcers. These results suggest that while dyslipidemia is commonly implicated in the development of diabetic foot complications, normal lipid levels do not necessarily eliminate the risk. The study concludes that the typical profile of type 2 DM patients includes those aged ≥ 45 years, females, and individuals with normal cholesterol and triglyceride levels who are still susceptible to diabetic foot ulcers. This highlights the multifactorial nature of diabetic foot ulcer development and underscores the importance of comprehensive risk assessments beyond lipid profile evaluation alone in diabetic patient care.

Diabetes Mellitus merupakan salah satu penyakit kronis yang jumlah penderitanya terus bertambah setiap tahunnya, termasuk di wilayah Puskesmas Brebes. Banyaknya pasien dengan kondisi klinis yang beragam mendorong perlunya suatu metode untuk mengelompokkan pasien berdasarkan tingkat keparahannya. Penelitian ini bertujuan untuk menerapkan algoritma K-Means dalam proses pengelompokan pasien Diabetes Mellitus dengan menggunakan beberapa parameter klinis, yaitu Gula Darah Puasa (GDP), kadar HbA1c, Kolesterol Total (CHOL), serta tekanan darah sistolik dan diastolik. Pendekatan yang digunakan dalam penelitian ini adalah deskriptif kuantitatif dengan metode data mining berbasis algoritma K-Means. Data yang digunakan diperoleh dari rekam medis Puskesmas Brebes. Proses klasterisasi menghasilkan tiga kelompok, yaitu kategori risiko rendah, sedang, dan tinggi. Hasil penelitian menunjukkan bahwa algoritma K-Means mampu melakukan pengelompokan data pasien secara akurat sesuai tingkat keparahan. Hasil tersebut kemudian divisualisasikan melalui sistem berbasis web yang bertujuan untuk mempermudah pihak puskesmas dalam menganalisis kondisi pasien serta mendukung pengambilan keputusan medis yang lebih efektif.

Stem cells are unspecialized cells with the ability to self-renew over long periods of time without undergoing significant changes in their basic properties. The discovery of adult stem cells has revolutionized therapeutic and regenerative medicine and led to the development of new therapies for previously untreatable terminal conditions. Hematopoietic stem cell transplantation was the first example of successful stem cell therapy and has been widely used in the treatment of a variety of diseases, including leukemia, adult T-cell lymphoma, and multiple myeloma. Meanwhile, autologous mesenchymal stem cell transplantation is increasingly being used to repair mesenchymal tissues and other organs such as the lung and heart, and has shown promise in the treatment of stroke, multiple sclerosis, and diabetes. Interest in the therapeutic potential of other adult stem cells including neural, mammary, intestinal, inner ear, and testicular stem cells is also growing. The discovery of induced pluripotent stem cells has opened new insights into the epigenetic mechanisms underlying pluripotency and carcinogenesis. This study employed a qualitative approach with a literature review method, aiming to conduct an in-depth review of the scientific literature related to the development of stem cell therapy and its epigenetic implications. Through a systematic analysis of various academic sources, this study seeks to formulate a comprehensive conceptual understanding and identify future directions for safer and more targeted stem cell therapy development.

Penyakit tidak menular (PTM), termasuk diabetes mellitus, menjadi masalah kesehatan utama yang membutuhkan deteksi dini. Pemeriksaan kadar gula darah merupakan metode screening yang efektif untuk mendeteksi risiko diabetes. Kegiatan pengabdian masyarakat ini dilakukan di Lapangan Pemuda Kutacane, Kabupaten Aceh Tenggara, pada Mei 2025. Sebanyak 102 orang yang aktif berolahraga diperiksa kadar gula darahnya menggunakan glucometer standar. Hasilnya menunjukkan 17 orang (16,7%) memiliki kadar gula darah > 200 mg/dL, mengindikasikan risiko diabetes, sementara 85 orang (83,3%) dalam batas normal. Edukasi tentang gaya hidup sehat juga diberikan. Temuan ini menggarisbawahi pentingnya screening dan edukasi berkelanjutan untuk mencegah PTM.

Sugar level disease or commonly called diabetes mellitus is a degenerative disease that rarely heals, often affecting health so that the quality of life can decrease. The purpose of writing this study is to find out what demographic relationship factors have an impact on the Quality of Life of Patients with Sugar Mellitus Disease or also known as Diabetes Mellitus at Hospital X. This quantitative research uses a research design on the cross sectional method. The research sample totaling 47 respondents was selected through total sampling techniques. Data was collected through the WHOQol-Bref survey instrument. The data analysis in this study applied the kendal test and the Chi-Square  test to test the relationship between the variables studied. After the research was carried out, a result was obtained that showed demographic factors, namely the age factor to the quality of life had a relationship and as seen from the kendal test with a value of Sig. 0.003 which was below 0.05), other demographic factors there were gender factors that had a relationship with quality of life which was shown through the chi-square test where  the Continuity Correction value sig = 0.022 < 0.05), In addition to demographic factors of age and gender, there are also demographic factors that have a relationship with quality of life, namely the work factor shown in the Chi-square  Test with a value of Continuity Correction sig = 0.008 < 0.05), and there are demographic factors, namely education factors and marital status factors that are not related to the quality of life of people with sugar level disease or diabetes mellitus. For the education factor shown in the kendal test where the sig value = 0.871 > 0.05), and marital status is shown in the Chi-square test based on the Pearson Chi-Square Sig value = 0.594 > 0.05), there are also demographic factors that have a relationship with quality of life, namely the long-suffering factor shown by the Chisquare test with the Pearson Chi-Square Sig value = 0.014 < 0.05). To break the chain of diabetes mellitus, actions are carried out for health workers to be able to anticipate, including periodic socialization to the community about the dangers of diabetes mellitus so that it can help people improve their quality of life by maintaining a healthy diet.

Type 2 Diabetes Mellitus (DM) is a disease caused by impaired insulin function, impaired insulin secretion, or both, resulting in a hyperglycemic condition. Patients with type 2 DM generally exhibit characteristics such as a Random Blood Glucose level exceeding 200 mg/dL and an HbA1c  level exceeding 6.5%. The accuracy of medication administration to patients must also consider the rationality of antidiabetic therapy in order to influence the success rate of optimal therapy. This study aims to evaluate the rationality of patient appropriateness and indication appropriateness in outpatients with type 2 DM at Tabanan Regional Public Hospital (RSUD Tabanan). This study employed a semi-quantitative observational research design with a retrospective approach by reviewing patient medical records from the initiation of therapy. Sampling was conducted using purposive sampling, whereby samples had to meet predetermined inclusion criteria. The results indicated that the age group with the highest prevalence of DM patients at RSUD Tabanan was over 56 years old (74%), with a predominance of females (63%). The most common comorbidity among DM patients was hypertension alone (24.5%). Based on the findings, the percentage of patient appropriateness rationality among DM outpatients at RSUD Tabanan was 97.5%, while the percentage of indication appropriateness rationality in type 2 DM outpatients at RSUD Tabanan was 98.5%.

Type 2 diabetes mellitus (T2DM), hypertension, anemia, nephrotic syndrome, and urinary tract infection (UTI) are interrelated clinical conditions frequently encountered in patients with chronic kidney disease (CKD). This case report presents a 33-year-old woman who was admitted with complaints of generalized weakness, accompanied by headache, generalized edema, and pruritus. Laboratory findings revealed hyperglycemia (>300 mg/dL), elevated blood pressure (210/120 mmHg), increased urea and creatinine levels, 2+ proteinuria, and microcytic hypochromic anemia (hemoglobin ranging from 7.9 to 9.9 g/dL). Urinalysis showed leukocyturia, hyaline casts, and bacteriuria. The patient was diagnosed with uncontrolled T2DM, hypertensive urgency, microcytic hypochromic anemia, nephrotic syndrome, and UTI. Management included basal-bolus insulin regimen, combined antihypertensive therapy, packed red cell transfusions, and supportive treatments. Throughout the hospitalization, improvements were observed in hemoglobin levels and blood pressure, although subjective symptoms such as fatigue and headache remained fluctuating. This case highlights the importance of comprehensive and multidisciplinary management in patients with complex multisystem chronic conditions to prevent complications and improve clinical outcomes.

Background: Type II Diabetes Mellitus is increasingly affecting young adults. Sleep quality is one of the factors influencing blood glucose levels. Poor sleep can impair glucose metabolism and worsen diabetic conditions. Objective: To determine the relationship between sleep quality and blood glucose levels among young adults with Type II Diabetes Mellitus at RSD Gunung Jati. Methods: This study used a quantitative approach with a cross-sectional correlational design. A total of 151 young adult respondents were selected using accidental sampling. Instruments included the Pittsburgh Sleep Quality Index (PSQI) questionnaire and a glucometer to assess sleep quality and blood glucose levels, respectively. Data were analyzed using the Spearman Rank test. Results: Statistical analysis showed a significant relationship between sleep quality and blood glucose levels, with a significance value of 0.001 (p < 0.05). Conclusion: There is a significant relationship between sleep quality and blood glucose levels among young adults with Type II Diabetes Mellitus. Good sleep quality plays a crucial role in diabetes management and glycemic control.

Background: In 2021, there were 19.5 million diagnosed cases of Type 2 Diabetes Mellitus (T2DM) in Indonesia. In Riau Province, T2DM ranked fifth among the most common conditions treated at community health centers in 2022. Obesity, a major risk factor for T2DM, had a national adult prevalence of 21.8% (Riskesdas 2018) and 24.1% in Riau. At Puskesmas Karya Wanita, 483 new T2DM cases were recorded in 2024, with 434 patients having a BMI ≥ 25 kg/m². The productive age group is particularly at risk for obesity and T2DM, yet screening remains suboptimal. Therefore, research on the relationship between obesity and T2DM at this primary healthcare facility is essential.Objective: To determine the association between obesity and the incidence of T2DM among individuals of productive age at Puskesmas Rawat Inap Karya Wanita, Pekanbaru.Methods: This was a quantitative analytic observational study with a cross-sectional design. The sample included productive age outpatients at the general clinic of Puskesmas Karya Wanita, selected using quota sampling. Data were analyzed using univariate, bivariate (Chi-square test), and Odds Ratio analyses.Results: A significant association was found between obesity and T2DM (p = 0.0029), with an Odds Ratio of 4.517.Conclusion: There is a significant relationship between obesity and T2DM in the productive age group. Individuals with obesity are 4.517 times more likely to develop T2DM compared to those without obesity.

Type 2 diabetes mellitus (T2DM), once primarily affecting adults, is now increasingly prevalent among adolescents due to lifestyle changes. Adolescents represent a critical age group for the development of healthy behaviors, making it essential to identify factors influencing T2DM preventive behavior. This study employed a quantitative approach with a cross-sectional design, conducted in Ciledug District, Tangerang City, from April to June 2025. A total of 224 adolescents aged 15–24 years were selected using stratified random sampling. Data were analyzed using the Chi-Square test. The results showed that 49.1% of adolescents exhibited poor preventive behavior against T2DM. Gender and perceived barriers were significantly associated with preventive behavior (p < 0.05), whereas other factors such as age, family history, and other Health Belief Model (HBM) constructs were not significantly related. In conclusion, adolescents’ preventive behavior toward T2DM remains relatively low and is influenced by perceived barriers. Therefore, interventions should focus on reducing perceived barriers while enhancing environmental support and self-motivation. Active involvement from schools, governments, families, and communities is crucial to foster positive behavioral change.

Obesity is a growing global health issue affecting both developed and developing countries. Despite various preventive efforts, the prevalence of obesity continues to rise. One of the emerging approaches in managing obesity and its complications is by modulating gut microbiota balance. Gut microbiota plays a significant role in energy metabolism, inflammation regulation, and insulin sensitivity. An imbalance in gut microbiota, known as dysbiosis, is frequently observed in obese individuals and has been associated with increased insulin resistance, a key feature of type 2 diabetes mellitus. This study aims to systematically review the relationship between gut microbiota imbalance and insulin resistance in obese patients, based on literature from 2016 to 2024. The literature search was conducted through accredited databases such as PubMed, Google Scholar, and others using the keywords “Gut Microbes,” “Insulin Resistance,” and “Obesity.” From 500 initial articles, 10 highly relevant journals were selected for further analysis. The review findings reveal a strong association between dysbiosis and increased insulin resistance through various mechanisms, including short-chain fatty acid (SCFA) production, activation of inflammatory pathways, and disruption of glucose metabolism. Several studies also suggest that interventions such as probiotics, prebiotics, and fecal microbiota transplantation may improve insulin sensitivity. However, more longitudinal and interventional studies are needed to establish a strong causal relationship. These findings highlight the importance of maintaining gut microbiota balance as a potential strategy in managing obesity and insulin resistance.

Preeclampsia is a complex illness that can cause health issues and even death for both the mother and the fetus. The three signs of preeclampsia include elevated blood pressure (up to 140/90 mmHg), proteinuria (high protein in the urine), and edema. Preeclampsia is linked to a number of characteristics, including as parity, age, education, occupation, history of hypertension, multiple pregnancies, history of diabetes mellitus, and kidney disease. The purpose of this study is to identify the variables linked to the prevalence of preeclampsia in Tidore Regional Hospital patients who are pregnant or giving birth. This study employs a case control methodology and a descriptive analytical approach. Up to 132 respondents, comprising 66 case groups and 66 control groups, were sampled by accidental sampling. Medical records of moms who had preeclampsia were used as secondary data. A p-value of 0.001 (Sig. <0.05) indicated a relationship between parity and the incidence of preeclampsia; a p-value of 0.001 (Sig. <0.05) indicated a relationship between employment and the incidence of preeclampsia; a p-value of 0.000 (Sig. <0.05) indicated a relationship between the incidence of preeclampsia and a history of diabetes mellitus and kidney disease. preeclampsia at Tidore Regional Hospital with a p-value of 0.042 (Sig. <0.05).

This research aims to examine how product quality and price influence the purchasing decisions of consumers buying Fukumi brand porang rice in Bandar Lampung City. As a healthier rice alternative, Fukumi porang rice has become popular among individuals who are health-conscious, particularly those on diets or managing diabetes. A quantitative method was applied, using surveys distributed to 150 buyers of Fukumi rice. The data were analyzed using multiple linear regression. The findings reveal that both product quality and price have a significant impact on purchasing decisions. The regression analysis shows that product quality accounts for 54.1%, while price accounts for 57% of the decision-making process. An Adjusted R² of 0.567 indicates that 56.7% of the variation in purchase decisions is explained by these two factors, with the remaining 43.3% influenced by other variables not included in this study. These results emphasize the need for businesses to consistently deliver high product quality and set prices that reflect customer value to stay competitive.

Diabetes mellitus, especially type 2, is a growing epidemic with almost 90% of cases reported worldwide. Antioxidants are compounds that are in lower concentrations compared to the concentration of oxidizable compounds, can significantly prevent or inhibit the oxidation of the substrate. The formation of more stable oxidant compounds through intramolecular hydrogen bonds in the further oxidation process. Data collection was carried out using Google Scholar, Science Direct and PubMed databases. The literature sources used were in the form of research results that had been published in 2011-2021 in national and international journals. Providing antioxidants is an effort to inhibit the production of intracellular free radicals or increase the ability of defense enzymes against free radicals in order to prevent the emergence of oxidative stress and diabetes-related blood vessel complications. Various supplements containing antioxidants and/or factors that can increase the production of nitric oxide (NO) have the potential to improve endothelial dysfunction and mitochondrial function in cells, as well as reduce the activity of the NAD(P)H oxidase enzyme. 

Consumption of sweetened beverages contributes to increased blood glucose levels that lead to the risk of pre-diabetes and type II diabetes mellitus. Fasting blood sugar examination is an early screening tool to detect hidden metabolic disorders and educate the public about the importance of controlling sugar consumption. The examination was conducted through capillary blood sampling and point-of-care testing (POCT) analysis of 91 adult participants. Education was delivered in the form of a leaflet emphasizing the impact of sweetened beverage consumption on glucose regulation and the risk of insulin resistance. The results were classified into three categories: normal, pre-diabetes, and diabetes. The majority of participants (86.8%) were in the normoglycemic category. As many as 9.9% were classified as pre-diabetes and 3.3% were in the diabetes category. The average fasting blood sugar of the participants was 89.5 ± 20.1 mg/dL. These results emphasize the need for counseling regarding limiting the consumption of sweetened beverages to maintain stable blood glucose. Fasting blood sugar examination accompanied by education about sweetened beverages contributes to early detection of the risk of glucose disorders. Interventions based on examination results have the potential to increase awareness of fluid consumption patterns and encourage healthier lifestyle changes.   Keywords: Fasting Blood Sugar, Sugary Drinks, Pre-Diabetes, Type II Diabetes Mellitus, Nutrition Education

Background: Research of glucose detection is important in diabetes management and biosensor development. Taking into account the large amount of water retention, the biocompatibility of hydrogels makes them ideal candidates for glucose detection. The PBA groups, when grafted to hydrogel matrices, improve the glucose-related response of the hydrogels significantly. Objective: To create a novel PBA (phenylboronic acid) holographic glucose sensor, MAAm-co-4VPBA, for uninterrupted monitoring of blood glucose levels, which demonstrates the first successful glucose measurement in whole blood using PBA sensors. Methods: Methylacrylamide (MAAm) was copolymerized with 4-vinyl phenyl boronic acid (4-VPBA) by means of free radical polymerization employing 1,6-hexanedioldiacrylate (HDODA) as a crosslinker and the photoinitiator 1-hydroxycyclohexyl phenyl ketone. The responsive glucose behavior of the resulting polymer was characterized in terms of swelling dynamics, ex vivo flow tests, and error grid analysis mechanisms. Results: The MAAm-co-4VPBA polymer exhibits reversible glucose binding via PBA-diol interactions that allow complexation at different pH and concentration levels. Modulation of the responsive elements of the microcapsules by hydrophobic PBA and hydrophilic MAAm units yields maximum swelling and shrinking dynamics at 37 trail degrees. The sensor successfully detected glucose in opaque biological fluids, blood plasma, without any interference from antibiotics or other therapeutics or endogenous compounds. Ex vivo tests showed real-time glucose monitoring without hysteresis. Most importantly, this work is the first to report the use of PBA-based sensors in whole blood for measuring glucose. Conclusion: The MAAm-co-4VPBA holographic sensor possesses outstanding features such as accurate records and strong resistance to chemicals and slow response to detection, confirming its effectiveness in continuous glucose monitoring. Moreover, the ability to operate in the real world enables the aid in clinical diagnosis of diabetes.

Prolactin, a hormone primarily known for its important role in lactation and reproductive function have recently been implicated in metabolic-processes including glucose regulation. This study aims to investigation the relationship between serum prolactin levels and markers of glucose metabolism—specifically HbA1c and fasting blood glucose (FBG)—in women with T2DM. A cross sectional study was conducted on 100 adult female patients with T2DM, aged 35–50 years. Participants were classified based on HbA1c into three groups: good (≤7.0%), moderate (7.1–8.5%), and poor (≥8.6%) glycemic control. They were also stratified into low, normal, and high prolactin level groups. Serum prolactin was measured by ELISA, HbA1c by HPLC, and FBG using an automated analyzer. Statistical analysis was performed with significance at p ≤ 0.05. Although prolactin levels tended to increase with worsening HbA1c, the difference among HbA1c groups was not statistically significant. However, when stratified by prolactin levels, women in the high prolactin group had significantly higher HbA1c (7.38 ± 1.07%) and FBG (163.21 ± 25.23 mg/dL) compared to those in the low prolactin group (HbA1c: 6.82 ± 0.91%, FBG: 149.22 ± 22.24 mg/dL; p = 0.041 and p = 0.040, respectively). Elevated serum prolactin levels may be associated with poorer glycemic control in women with T2DM. These results showing the potential-role of prolactin hormone as a supplementary test in measuring glucose metabolism.

Abstract. Amino acids are indispensable components of human metabolism, playing essential roles in proteinsynthesis, energy production, and cellular regulation. Branched-chain amino acids (BCAAs)-leucine, isoleucine,and valine—are particularly significant due to their involvement in muscle repair, metabolic signaling, andinsulin sensitivity. While BCAAs are vital under normal physiological conditions, multiple studies have shownthat elevated plasma BCAA levels are linked to insulin resistance, obesity, and type 2 diabetes. This associationhas led researchers to investigate whether these elevations are a cause or consequence of metabolicdysfunction. Recent findings have revealed that impaired BCAA catabolism in tissues such as adipose and livercontributes to their accumulation in circulation. If skeletal muscle becomes insulin resistant, it may shift BCAAmetabolism further, exacerbating the imbalance. Moreover, the modulation of specific enzymes and transportershas been proposed as a therapeutic avenue to mimic the beneficial effects of dietary protein restriction.Although several mechanisms have been proposed, including mTOR activation, fatty acid oxidationinterference, and altered neurotransmitter synthesis, no single pathway fully explains BCAA-induced metabolicdisturbances. Therefore, a comprehensive understanding of amino acid metabolism is crucial, particularly ifdietary and pharmacological interventions are to be optimized for preventing or treating age-related andmetabolic diseases.

Prolanis merupakan program pengelolaan penyakit kronis seperti hipertensi dan DM tipe 2 untuk mencapai kualitas hidup yang optimal dengan biaya kesehatan yang efektif dan efisien. Penelitian ini bertujuan untuk menganalisis pengaruh kualitas pelayanan kesehatan terhadap kepuasan pasien peserta program prolanis di Rumah Sakit Umum Daerah Haji Kota Makassar. Metode yang digunakan yaitu penelitian kuantitatif deskriptif dengan pendekatan kajian potong lintang (cross sectional study). Populasi dalam penelitian ini adalah seluruh jumlah peserta Hipertensi dan Diabetes Mellitus yang mengikuti kegiatan Prolanis di wilayah kerja RSUD Haji Kota Makassar dengan sampel sebanyak 106 peserta. Teknik penentuan sampelnya adalah dengan menggunakan metode accidental sampling. Analisis data yang digunakan adalah chi square dan regresi logistik berganda. Hasil penelitian menunjukkan bahwa variabel keterjangkauan (p=0,000), keamanan (p=0,008), informasi (p=0,018), ketepatan waktu (p=0,002) berpengaruh terhadap kepuasan pasien. Sedangkan kenyamanan (p=0,089) tidak berpengaruh terhadap kepuasan pasien. Hasil uji regresi logistik berganda secara bersamaan diperoleh bahwa keterjangkauan merupakan variabel yang paling berpengaruh terhadap kepuasan pasien peserta prolanis di RSUD haji Kota Makassar. Kepada pihak Rumah Sakit Umum Daerah Haji Kota Makassar agar membenahi dan mengevaluasi hal apa saja yang menjadi keluhan pasien terutama dalam kenyaman pasien yang menggunakan fasilitas kesehatan di RSUD Haji Kota Makassar.

Diabetic retinopathy is a microvascular complication that often occurs in people with type 2 diabetes mellitus and is a major cause of blindness in older adults and the elderly. This study aims to describe the characteristics of diabetic retinopathy in people with type 2 diabetes mellitus through a literature review of 10 journals published between 2022 and 2025. The results of the analysis show that the prevalence of diabetic retinopathy globally reaches 35%, with the main risk factors including long duration of diabetes (>5 years), high HbA1c levels (>7%), and poor glycemic control. The majority of cases of diabetic retinopathy are found in the non-proliferative stage (65%), which is characterized by microaneurysms and retinal hemorrhages, while the proliferative stage is less common but has a high risk of causing blindness. The study also revealed that patients with comorbidities such as hypertension and dyslipidemia tend to experience more severe diabetic retinopathy. Further stages of diabetic retinopathy if not managed properly can cause vision-threatening conditions. However, low patient compliance in metabolic control and eye examination is a major challenge. Management of diabetic retinopathy requires a holistic approach that includes patient education, regular screening, and comprehensive risk factor control to prevent progression of diabetic retinopathy and maintain the quality of life of patients with type 2 diabetes mellitus.