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Stem cells are unspecialized cells with the ability to self-renew over long periods of time without undergoing significant changes in their basic properties. The discovery of adult stem cells has revolutionized therapeutic and regenerative medicine and led to the development of new therapies for previously untreatable terminal conditions. Hematopoietic stem cell transplantation was the first example of successful stem cell therapy and has been widely used in the treatment of a variety of diseases, including leukemia, adult T-cell lymphoma, and multiple myeloma. Meanwhile, autologous mesenchymal stem cell transplantation is increasingly being used to repair mesenchymal tissues and other organs such as the lung and heart, and has shown promise in the treatment of stroke, multiple sclerosis, and diabetes. Interest in the therapeutic potential of other adult stem cells including neural, mammary, intestinal, inner ear, and testicular stem cells is also growing. The discovery of induced pluripotent stem cells has opened new insights into the epigenetic mechanisms underlying pluripotency and carcinogenesis. This study employed a qualitative approach with a literature review method, aiming to conduct an in-depth review of the scientific literature related to the development of stem cell therapy and its epigenetic implications. Through a systematic analysis of various academic sources, this study seeks to formulate a comprehensive conceptual understanding and identify future directions for safer and more targeted stem cell therapy development.

Weaving and fabric painting techniques were alternative in making textile motif designs for Ready to Wear. The exclusive value of fabric painting could be a proponent of more beautiful and unique clothing. The problem studied was how to apply weave and fabric painting to clothing and making Ready To Wear exotic dramatic style of Wayang Krisna. The aim of this report was to find out the application of weave and  fabric painting in the manufacture of Ready To Wear exotic dramatic style of wayang Krisna. The method used was R&D.The process of making Ready To Wear includes determining the fashion design, preparing tools and materials, applying measurements, making basic patterns, cutting materials, marking the stitches on the fabric, ironing upholstery, and sewing clothes. The materials for this dress were red and black drill fabric, red and black toyobo fabric and batik Sekar Jagat fabric. Using variations of woven and painted fabrics on Ready To Wear with an exotic dramatic style of Wayang Krisna. The use of brushes should be in a smooth way and not pressed firmly, in order to produce natural color strokes and form fine bristles. The process of pressing fabric painting should be at a temperature of 150 degrees and the material part was given a fabric base so that the fabric painting part was not wreck.

Physical mobility impairment refers to limited physical movements from one or more extremities independently, this condition can lead to significant difficulties in movement and the inability to perform daily activities. This study aims to apply acupressure therapy to address physical mobility impairment in Mrs. N, a patient diagnosed with ischemic stroke and left-sided hemiparesis at Mardi Rahayu Hospital, Kudus. The method used in this study is a case study involving nursing care and the implementation of interventions, including assessment, diagnosis, planning, implementation, and evaluation, as well as the application of acupressure therapy. The result of the case study acupressure therapy intervention for 7 days at a frequency of once daily for 15 minutes, it was effective in addressing the problem of physical mobility impairment in the patient with ischemic stroke and sinistra hemiparesis, as indicated by increased muscle strenght. The conclusion from this acupressure therapy is that before the intervention, it improved to    and after the intervention . It is expected that this acupressure therapy can be applied and integrated into the provision of medical-surgical nursing care for patients with ischemic stroke and sinistra hemiparesis.  

The prevalence of hypertension in the world is currently quite high, both in Africa and Southeast Asia. The only hospital that is a referral center for the Batanghari community is the Haji Abdoel Madjied Batoe Regional Hospital. cases of hypertension are also still quite common in this hospital. Hypertension that is not controlled properly will cause various impacts on sufferers such as stroke, heart disease and even death. This study aims to determine the relationship between self-efficacy and self-management in hypertension sufferers at the Polyclinic and Inpatient Unit of the Haji Abdoel Madjid Batoe Regional Hospital, Batanghari. This study is a quantitative study with a cross-sectional design. The time and place of the study were carried out on June 12, 2023-June 30, 2023 at the Haji Abdoel Madjid Batoe Regional Hospital, Batanghari. The population in this study were all hypertension patients in June 2023 at the Polyclinic and Inpatient Unit of the Haji Abdoel Madjid Batoe Regional Hospital with a total of 110 people. The sample consisted of 87 respondents. The sampling technique was accidental sampling. The results of the study showed that more than half had poor self-management (54.0%), more than half had poor self-efficacy (56.3%). There was a significant relationship between self-efficacy and self-management in hypertension patients at the Polyclinic and Inpatient of Haji Abdoel Madjid Batoe Batanghari Hospital. Nurses should provide leaflets about hypertension self-management when patients are going home so that the contents of the leaflet can be applied, become a concern and direction to control their blood pressure.  

Stroke is one of the leading causes of disability and mortality worldwide, with significant neurological and biochemical consequences. This study aimed to examine the effect of a neuroprotective nutritional intervention consisting of protein, phosphatidylcholine, phosphatidylserine, and inulin on glial fibrillary acidic protein (GFAP) levels and National Institutes of Health Stroke Scale (NIHSS) scores in acute ischemic stroke patients. The study employed a quasi-experimental design with a pretest-posttest control group, involving 18 patients divided equally into intervention and control groups. Data were collected at Dr. Kariadi General Hospital Semarang from January to February 2020, measuring serum GFAP levels using ELISA and assessing NIHSS scores before and after a seven-day intervention. The intervention group showed a significant decrease in GFAP levels and a more pronounced improvement in NIHSS scores compared to the control group. These findings suggest that the neuroprotective nutritional intervention may support both biochemical and clinical recovery in acute ischemic stroke patients. Implementing such nutritional strategies could complement standard care and enhance rehabilitation outcomes. Further research with larger sample sizes and longer follow-up is recommended to confirm these results and optimize the intervention protocol.  

Chronic diseases in Indonesia remain a serious challenge in improving the quality of life of the community, particularly in terms of prevention and early detection of chronic diseases. This community service activity aims to educate family members of students on preventing and detecting chronic diseases, particularly diabetes mellitus and stroke, by adopting a healthy lifestyle, maintaining a balanced diet, reducing excessive consumption of sugar, salt, and fat, and engaging in regular light physical activity daily. Additionally, participants are encouraged to regularly monitor blood pressure and blood sugar levels, manage stress, and ensure adequate rest. The activity was conducted over two weeks through three stages: preparation, implementation, and evaluation. The community service activity was carried out in three stages: preparation, implementation, and evaluation. The results of this activity found that there was a 62% increase in knowledge about the prevention and detection of Diabetes Mellitus, a 57% increase in knowledge about the prevention and detection of stroke, and a 54% increase in knowledge about the role of nutrition, healthy lifestyle, and physical activity. Additionally, there was a 54% change in behaviour for the prevention and early detection of Diabetes Mellitus, a 35% change for the prevention and early detection of stroke, 32% for the role of nutrition, activities, and healthy lifestyles among student families affected by Diabetes Mellitus and stroke. This was measured by assessing blood sugar levels and blood pressure before and after the activity, which showed a decrease of 16% in blood pressure and 11% in blood sugar levels. It is hoped that after this activity, participants can apply the knowledge gained in their daily lives and serve as role models for children in fostering a culture of healthy living. Translated with DeepL.com (free version).

Background: The increasing number of elderly people has an impact on increasing problems, especially those that occur in the elderly, one of which is physical problems, namely the limitations of the elderly in carrying out daily activities, strokes that attack the elderly cause elderly dependence to increase, one form of measuring the ability of the elderly with stroke to carry out daily activities is to assess the Activity of Daily Living (ADL) of the elderly. Determination of functional independence is carried out to identify the abilities and limitations of the elderly, as well as to create the selection of appropriate interventions, The impact of decreased independence can make vulnerability to disease in old age. Methods: The research design used is descriptive method. The research location was carried out at TK.II Udayana Army Hospital, with a total sample of 58 respondents selected by purposive sampling technique. The instrument of this study was the Barthel Index Questionnaire, data processing was carried out using computerization. Data is presented textually/narrative and accompanied by tables and figures. Results: The characteristics of respondents were mostly female with 51.7%, the age group was mostly in the elderly age range of 60-74 years with a percentage of 55.2%, hypertension became the highest disease history experienced by the elderly as much as 43.1% and 98.3% of the elderly lived with their families. The level of independence of stroke elderly in carrying out daily activities shows that most of the elderly experience mild dependence as much as 67.2% and moderate dependence of 24.2%. Conclusion: The results showed that the level of independence of the elderly with stroke in carrying out daily activities experienced mild dependence.

Hypertriglyceridemia is a metabolic condition that often occurs in the elderly and contributes greatly to an increased risk of cardiovascular diseases such as stroke, heart attack, and acute pancreatitis. This condition often does not show symptoms in the early stages, so regular triglyceride level checks are an important step for early detection. The Community Service Program (PKM) at Panti Werdha Hana aims to increase awareness of the elderly about the importance of early detection of dyslipidemia through blood triglyceride level screening activities. This activity uses the Plan-Do-Check-Act (PDCA) approach which includes lipid profile examination and educational counseling on risk factors and prevention of hypertriglyceridemia. Of the 76 elderly participants, it was found that 33 people (43.42%) had high triglyceride levels, while 43 people (56.58%) showed normal levels. These results emphasize the importance of routine checks and education to reduce the risk of cardiometabolic disease and support a healthier and more independent quality of life for the elderly.

This study aims to determine the effectiveness of breaststroke leg movement training modifications in improving swimming skills of extracurricular swimming participants at SMP Yos Sudarso. The background of this study is based on the low mastery of basic leg movement techniques in breaststroke which is one of the inhibiting factors in student achievement. The research method used is a quantitative approach with a quasi-experimental design. The subjects of the study were 20 students participating in extracurricular swimming who were selected purposively. The instrument used was an observation sheet for breaststroke leg movement technique skills. The results of the study showed that the application of training modifications, such as the use of a buoy board and variations in movements on land, significantly improved the quality and coordination of students' leg movements. Thus, training modifications have proven effective and can be used as an alternative learning approach that is fun and adaptive for beginner students in extracurricular swimming activities.

Dyslipidemia is one of the most common metabolic disorders among the productive-age population and plays a major role in increasing the risk of cardiovascular diseases, including coronary heart disease and stroke. This condition often remains asymptomatic in its early stages, making regular monitoring of cholesterol and HDL levels a critical step in the early detection of atherosclerosis risk. Community-based screening programs revealed that 42.25% of participants had elevated total cholesterol levels, while 26.76% had very low HDL levels and 43.66% had low HDL levels. These findings highlight the urgency of early detection of dyslipidemia to prevent long-term complications that may impair individual quality of life. Through timely interventions involving nutritional education, dietary modifications, and increased physical activity, blood lipid levels can be effectively managed to prevent the progression of cardiometabolic disease and support long-term heart health.

Stroke is a cerebrovascular disorder that disrupts blood flow and oxygen supply to the brain, leading to tissue damage and impaired function. This study examines the impact of physiotherapy interventions, including Neuromuscular Electrical Stimulation (NMES), stretching, strengthening, and ankle exercises, on a 60-year-old patient with hemiparesis sinistra post-stroke. The patient presented with abnormal gait, postural imbalance, and weakness in the left upper and lower limbs. After undergoing physiotherapy sessions twice a week for two weeks, the patient demonstrated increased muscle strength in the left lower extremity, reduced edema in the left leg, and improved range of motion, particularly in the hip and knee joints. These findings highlight the effectiveness of physiotherapy in enhancing functional recovery for post-stroke patients with hemiparesis sinistra.

High blood pressure is a problem that is widely suffered by the community, especially in Indonesia. Hypertension that is not detected early and treated properly can trigger coronary heart disease, heart failure, stroke, chronic kidney failure, blindness due to hypertensive retinopathy and peripheral arterial disease. The purpose of community service is to lower blood pressure in people with hypertension. It is hoped that through this activity it will be a source of information to increase the knowledge of people with hypertension about finger grip gymnastics techniques to lower blood pressure. The implementation method in this community service is to carry out finger grip gymnastics activities and before the activity, blood pressure measurements are carried out. This community service activity was carried out on people with hypertension aged >40 years as many as 36 elderly people at the Posyandu, Bogoarum Village, Plaosan District, Magetan Regency, East Java Province. The results of the blood pressure of people with hypertension who participated in finger grip gymnastics obtained pretest blood pressure with a mean blood pressure value of 157.78 / 92.22 mmhg. While the posttest blood pressure with a mean blood pressure value of 145 / 83.3 mmhg. It was concluded that there was a decrease between the pretest and posttest blood pressure values. This service is expected to be a preventive recommendation that can be given to hypertension sufferers, namely so that the community remains active in participating in finger grip gymnastics activities that can be done routinely at the integrated health post so that it can reduce the number of hypertension complications.

Post-stroke condition is a neurological dysfunction condition that has an impact on changes and decline in body condition for a fairly long period of time. The need for support during recovery and rehabilitation by the family is very much needed by post-stroke patients in managing themselves to optimize their well-being and quality of life. The purpose of this study was to determine the relationship between family support and self-care management in post-stroke patients. The design of this study was correlational using a cross-sectional approach. A population of 23 respondents with purposive sampling obtained 21 samples. The measuring instrument used was a questionnaire and data analysis using the Spearman rank test. The results of the study showed that almost half of the respondents (47.8%) had good family support, and almost half of the respondents (47.8%) had good self-care management. The results of the statistical test from the Spearman's rho test showed a P value of 0.0001 <α 0.05, so it can be concluded that there is a positive (unidirectional) and very strong relationship (r = 0.870) meaning that the better the family support provided by the family, the stronger the self-care management in post-stroke patients. Family support is a health component that influences a person to improve their health status and quality of life.

Hypercholesterolemia is one of the health problems that is often experienced by the elderly and has a major impact on their quality of life, especially because it increases the risk of cardiovascular diseases such as coronary heart disease, stroke, and peripheral vascular disorders. This condition often does not show symptoms, but the process of atherosclerosis can develop slowly and cause serious complications if not treated early. The Community Service Program (PKM) implemented at Panti Werdha Hana aims to increase awareness among the elderly of the importance of early detection of Cholesterol and High Density Lipoprotein (HDL) levels as part of efforts to prevent heart disease. This activity applies the Plan-Do-Check-Act (PDCA) approach, including total cholesterol and HDL examinations using the Point-of-Care Testing (POCT) method, as well as interactive education about risk factors and healthy lifestyles. The results of the activity showed that out of 76 participants, 38 people (50%) had total cholesterol levels above normal, while 22 people (28.95%) had low or very low HDL levels. Early detection through screening has proven effective in identifying cardiovascular risks earlier and providing a basis for timely medical and educational interventions. Through this activity, it is hoped that the elderly can understand their health conditions better and take preventive steps to maintain lipid levels within normal limits, to improve the quality of life and reduce the risk of cardiovascular complications in the future.

Hypertension is one of the health problems, especially for hajj pilgrims, because hypertension is one of the entry points or risk factors for diseases such as heart disease, kidney failure, diabetes mellitus, and stroke. In 2024, cases of hajj pilgrims suffering from hypertension were 1,822 people (38.66%). This study aims to analyze the factors related to the incidence of hypertension in hajj pilgrims at the Aceh Embarkation. Quantitative research with a Cross Sectional Study approach using secondary data. The population is all hajj pilgrims at the Aceh Embarkation in 2024 totaling 4,713 people. The research sample is the total population. Bivariate data analysis with the chi-square test and multivariate with logistic regression. The results of the study obtained variables that have a significant relationship with hypertension are age (OR = 3.5; 95% CI: 3.08–3.95; p-value = 0.0001), family history (OR = 2; 95% CI: 1.74-2.25; p-value = 0.0001). Obesity (OR = 1.3; 95% CI: 1.14–1.44; p-value = 0.0001), diabetes (OR = 1.5; 95% CI: 1.28–1.75; p-value = 0.0001) and poor physical fitness OR = 1.7; 95% CI: 1.48–1.89; p-value = 0.0001). The conclusion of this study is that the age variable is the most dominant variable with the incidence of hypertension in the Aceh Embarkation Hajj pilgrims.

Hypertension is one of the health problems that are often experienced by the elderly. This is caused by various factors such as an unhealthy lifestyle, an unbalanced diet, and a lack of physical activity. Hypertension can result in stroke, heart disease, kidney disorders, and can even result in death. The elderly need to know how to prevent hypertension. The number of elderly people in Borisallo Village, Parangloe District, Gowa Regency is around 310 people (10.75%). The partner in the PKM of the Assisted Village is Borisallo Village which fosters the elderly in its area. Based on the problems faced by partners, the PKM service program of the Assisted Villages that is expected to be a solution is (1) Education on the prevention of hypertension in the elderly (Elderly), (2) Blood pressure checks in the elderly in Borisallo Village. This activity is financed by the UMI Waqf Foundation.  The results of the implementation of PKM in the Assisted Villages (1) Counseling on the prevention of hypertension in the elderly community has been carried out at the Borisallo Village Hall which was attended by 15 elderly people, (2) Then continued with a hypertension examination showing that in general, the blood pressure of the elderly community in Borisallo Village, Parangloe District, Gowa Regency, is still normal unless there are as many as 2 (20%). It is recommended to have comprehensive and periodic health checks on the elderly, not only hypertension, but more comprehensive, including mental health, so that the health status of the elderly can be known

Hypercholesterolemia is a common metabolic condition found in the adult population and significantly contributes to the increased risk of cardiovascular diseases, such as coronary heart disease and stroke. This condition is often asymptomatic, making early detection of total cholesterol and HDL levels a crucial step in identifying the risk of atherosclerosis at an earlier stage. A screening program conducted at the Asisi Church revealed that out of 68 participants, 34 individuals (50%) had abnormal total cholesterol levels, while 10 individuals (14.71%) had very low HDL levels, and 33 individuals (48.53%) had low HDL levels. These findings emphasize the importance of routine lipid profile assessments to prevent more severe cardiometabolic complications. Through education on healthy eating patterns, increased physical activity, and better control of risk factors, the community is expected to maintain optimal lipid profiles and improve overall quality of life.

This study aims to determine the relationship between arm muscle strength and long service ability in badminton among students of SMP Negeri 2 Tondano. Long service is one of the essential basic techniques to master in badminton, particularly in singles play. Arm muscle strength is suspected to be one of the determining factors for the success of the long service technique. This study uses a quantitative approach with a correlational method. The sample consisted of 20 students selected through a selection technique based on specific criteria such as body height and basic long service skills. The instruments used were a 30-second push-up test to measure arm muscle strength and a badminton long service accuracy test to assess long service ability. The correlation analysis showed a correlation coefficient value of r = 0.22, which falls into the low category, with a contribution of 4.84% to long service ability. The t-test result showed a t-count of 0.95, which is smaller than the t-table value of 2.101, indicating no significant relationship between arm muscle strength and long service ability. Therefore, other components such as wrist flexibility, stroke technique, and accuracy are considered dominant factors in achieving an effective long service.

The scarcity of fuel that has an impact on the high selling price of fuel, then there needs to be an effort to save fuel in motor vehicles. The solution to this problem is to use renewable fuel, one of the renewable fuels is hydrogen gas. With the addition of renewable energy in the form of HHO gas (Hydrogen Hydrogen Oxygen) from water electrolysis. The purpose of this study was to determine the effect of the application of an electrolyzer on saving fuel consumption in motor vehicles. By using a quantitative method with an experimental research design to test the effect of two variables whether there is a change in the form of fuel savings before and after the installation of the electrolyzer tube. Based on the trials that the researcher has conducted, the results of the study were obtained, namely that the addition of an electrolyzer has an effect on the fuel consumption of 4-stroke motorcycles, both in static and dynamic tests. So with the addition of an electrolyzer, it will be able to save fuel consumption in motorcycles when compared to without using an electrolyzer    

This study aims to analyze the effectiveness of the Write it! Japanese application in improving the ability to write Hiragana and Katakana characters among beginners. The research involved 20 participants with no prior experience in learning Japanese. A pre-test and post-test design was employed, in which participants were asked to write 20 Hiragana and 20 Katakana characters before and after using the application independently for seven consecutive days, for 15 minutes per day. The results showed a significant increase in the average score from 45.05% (pre-test) to 79.05% (post-test), with an average improvement of 34%. The findings indicate that the Write it! Japanese application is effective in facilitating the learning process through stroke order animations, interactive writing practice, and gamified features that enhance motivation. Additionally, the application supports self-directed learning and serves as an efficient and engaging alternative medium for language acquisition. These findings reinforce the importance of integrating technology into foreign language education, particularly in the early stages of learning Japanese kana.