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This study aimed to determine the effect of coffee husk waste application and shallot extract soaking on the growth of cat’s whiskers (Orthosiphon aristatus) cuttings. The research employed a factorial Randomized Block Design (RBD) consisting of two factors with 48 experimental plots. The first factor was the application of coffee husk waste, symbolized as “L,” with four treatment levels: L0 = 0 g/polybag (without coffee husk waste), L1 = 75 g/polybag, L2 = 150 g/polybag, and L3 = 225 g/polybag. The second factor was shallot extract soaking, symbolized as “B,” with four treatment levels: B0 = 0 ml/L of water, B1 = 5 ml/L of water, B2 = 10 ml/L of water, and B3 = 15 ml/L of water. Thus, there were 16 treatment combinations with three replications. The observed parameters included time to shoot emergence, number of shoots, plant height, number of leaves, leaf area, and survival percentage. The results showed that the application of coffee husk waste and shallot extract soaking had no significant effect on the growth of cat’s whiskers (Orthosiphon aristatus) cuttings across all observed parameters.

Granola bar is an instant snack product in the form of a bar that has high nutritional value and generally commercial products use imported ingredients such as oats and almonds, but can be developed using local food ingredients such as Job's Tears seeds and walnuts that have high nutritional content such as carbohydrates, protein, fiber, fat, and antioxidants. This study aims to obtain the ratio of Job's Tears seeds and walnuts to produce granola bars with the best physicochemical and organoleptic characteristics. The method used is a Randomized Block Design (RBD) with one treatment factor in the form of the ratio of Job's Tears seeds and walnuts (100:0, 80:20, 70:30, 60:40, and 50:50) with five replications to obtain 25 experimental units. Data were analyzed using Analysis of Variance (ANOVA) and Honestly Significant Difference (HSD) test. The results showed that the ratio of Job's Tears seeds and walnuts significantly affected the levels of fat, protein, carbohydrate, total calories, as well as organoleptic attributes including taste, aroma, texture, and overall preference. This research contributes to efforts Granola bar is an instant snack product in the form of a bar that has high nutritional value and generally commercial products use imported ingredients such as oats and almonds, but can be developed using local food ingredients such as Job's Tears seeds and walnuts that have high nutritional content such as carbohydrates, protein, fiber, fat, and antioxidants. This study aims to obtain the ratio of Job's Tears seeds and walnuts to produce granola bars with the best physicochemical and organoleptic characteristics. The method used is a Randomized Block Design (RBD) with one treatment factor in the form of the ratio of Job's Tears seeds and walnuts (100:0, 80:20, 70:30, 60:40, and 50:50) with five replications to obtain 25 experimental units. Data were analyzed using Analysis of Variance (ANOVA) and Honestly Significant Difference (HSD) test. The results showed that the ratio of Job's Tears seeds and walnuts significantly affected the levels of fat, protein, carbohydrate, total calories, as well as organoleptic attributes including taste, aroma, texture, and overall preference. This research contributes to efforts to diversify local Indonesian food as raw materials for highly nutritious functional food products diversify local Indonesian food as raw materials for highly nutritious functional food products.

Ballast water plays a crucial role in maintaining ship stability during shipping, but it also carries environmental and human health risks due to the heavy metals it carries. This study aims to examine the health risks posed by exposure to heavy metals in ballast water and to assess the effectiveness of management practices implemented in the maritime industry. Using a literature review method, this study examines various scientific sources related to the content of heavy metals such as lead (Pb), cadmium (Cd), copper (Cu), and zinc (Zn) in ballast water, as well as their impacts on human health and marine ecosystems. The results indicate that heavy metals in ballast water can cause long-term toxic effects such as neurological disorders, kidney damage, and respiratory and reproductive disorders. The greatest risk is experienced by maritime workers who are directly exposed through inhalation or skin contact during the ballast water sampling and processing process. To minimize these risks, strict work safety protocols, improved ballast water treatment technology, and regular monitoring of heavy metal levels are required. Thus, this study emphasizes the importance of strengthening ballast water management policies and practices that are oriented towards human health and environmental sustainability.  

This study evaluated the effects of compound and single-nutrient fertilizers on the growth and yield of cabbage (Brassica oleracea L.). The experiment was conducted using a randomized complete block design with seven fertilization treatments, including varying doses of compound fertilizer and a single-nutrient control. Results showed that the application of a 1.0× dose of compound fertilizer significantly improved plant height at 3 and 4 weeks after transplanting (WAT), and increased leaf number at 5 WAT. Yield components, including yield per plant, per plot, and hectare, were significantly higher in the 1.0× treatment, with an average yield of 1.92 kg per plant—an increase of 86.4% and 11.6% compared to the control and single-nutrient treatments, respectively. The relative agronomic effectiveness of the 1.0× dose reached 139%, indicating superior performance over the standard fertilizer. Economic analysis confirmed its viability, with the highest benefit-cost ratio (R/C) of 2.23 and a net profit of IDR 14,487,900. These findings suggest that compound fertilizer is both agronomically effective and economically profitable. The recommended application rate for cabbage is 211 kg/ha, applied one week after transplanting.

Sweet corn is a high-value horticultural crop with steadily increasing demand for both fresh consumption and use as a raw material in the food industry. This study aims to evaluate the effectiveness of NPK 16-16-16 fertilizer on the growth and yield of sweet corn. The research was conducted at Sindangbarang Experimental Field, Faculty of Agriculture, IPB University from July to October 2025. This experiment used a Randomized Complete Block Design (RCBD) with a single factor, namely the dose of fertilizer application. Treatments were using fertilizer dosages of 0, 50, 0,75, 1,00, and 1,50 NPK 16-16-16, with a control treatment for comparison. During the vegetative phase, sweet corn exhibited similar growth responses across all fertilization levels relative to the control. However, all fertilizer doses significantly improved stover weight, cob weight with and without husk, cob length, cob diameter, yield per plot, and overall productivity compared to the control. The application of NPK 16-16-16 fertilizer at the recommended (1.0) rate achieved the highest relative agronomic effectiveness (103.11%), corresponding to a 1.03-fold yield increase over the control and outperforming the comparison treatment. Application of NPK 16-16-16 at the 1.0 recommended dose is suggested as the most efficient fertilization strategy for sweet corn production, as it maximizes yield and productivity without unnecessary increases in fertilizer input.     

Introduction: The incidence of ARI in children is estimated at 0.29 cases per child/year in developing countries and 0.05 cases per child/year in developed countries. There are 156 million cases of ISPA and most of them occur in India (43 million), China (21 million) and Pakistan (10 million) as well as Bangladesh, Indonesia and Nigeria with 6 million cases each. Of all ISPA cases that occur in the community, 7-13% are serious cases and require serious cases and require hospital treatment. Method: This research is a pre-experimental research with one group pre-post test design.Results: The results of the study showed that there was an effect of giving water vapor therapy and eucalyptus oil on reducing the frequency of ineffective airway clearance in children at RSIA Sitti Khadijah, Gorontalo City because it was found that the average frequency of coughing was 10.33 times per day before and after giving honey. Of 2.5 cc every day for 3 days, it was found that the average cough frequency decreased to 5.73 times per day so it can be seen that the difference between the cough frequency before and after was 4.6 times per day. Therefore, giving water vapor therapy and eucalyptus oil to children who are experiencing airway clearance is not effective in reducing the frequency of coughing.Conclusion: The conclusion of this study is that there is an effect of giving water vapor therapy and eucalyptus oil on ineffective airway clearance in children at RSIA Sitti Khadijah, Gorontalo City with a significant value of 0.000.

Pregnancy is a period marked by significant emotional challenges for expectant mothers, with stress and anxiety being common issues that may adversely affect maternal well-being and fetal development. The limited availability of safe treatment options for pregnant women, particularly concerning pharmacological interventions, has prompted the exploration of more natural and non-invasive therapeutic alternatives. One increasingly popular method is aromatherapy, which utilizes essential oils to stimulate the limbic system in the brain, thereby promoting relaxation and reducing anxiety. This study aims to explore the effects of aromatherapy in lowering stress and anxiety among pregnant women through a literature review. The method employed involves collecting and analyzing findings from previous studies regarding the use of aromatherapy in pregnancy. Based on the available evidence, aromatherapy—particularly with lavender essential oil—has been proven effective in lowering levels of stress and anxiety in pregnant women. Several studies report a reduction in anxiety levels of up to 40% following the inhalation of lavender oil. However, factors such as the type of essential oil used, the method of application, and individual sensitivity may influence therapeutic outcomes. Despite its potential benefits, the safety of aromatherapy use remains a concern, particularly regarding essential oils that may be unsafe for use during pregnancy.

Leprosy remains a significant public health problem in various developing countries, including Indonesia. This disease is caused by Mycobacterium leprae, which attacks the skin and peripheral nerves and can cause long-term physical, psychological, and social impacts if not treated early and adequately. Health-seeking behavior in leprosy patients is also influenced by structural factors such as the availability of health facilities, distance, transportation costs, and the quality of communication between health workers and patients. Research in various endemic countries confirms that friendly, accessible primary health care services that provide comprehensive education can improve early detection and therapy adherence. Patient SA, an 11-year-old child diagnosed with multibacillary (MB) leprosy and has been undergoing treatment for four months. The progression of the disease to MB indicates limitations in early symptom recognition and the family's health-seeking behavior, which may be influenced by low perceptions of disease susceptibility and severity, lack of knowledge, and barriers to accessing health services. However, after the diagnosis was confirmed and education provided by health workers, positive behavioral changes occurred, indicated by the patient's adherence to routine therapy as recommended.

Pulmonary Tuberculosis (TB) is a contagious infectious disease caused by the bacterium Mycobacterium tuberculosis through droplets from patients diagnosed with TB. Based on the Global TB Report 2024, WHO reported that Indonesia ranks second in the world, where 81% of cases were confirmed and 90% of them had received treatment, where there was an increase in the number of cases compared to 2023 with 77% of confirmed cases and 88% of them received treatment. The increase in the number of pulmonary TB cases is inseparable from factors that determine the transmission of M. tb such as the concentration of organisms in the air related to ventilation and the length of time a person inhales contaminated air. To determine the relationship between ventilation conditions and home lighting to the incidence of pulmonary TB in the working area of ​​the Glugur Darat Health Center in 2025 This study is an analytical study with a cross-sectional study design. Sample selection used the consecutive sampling method with 56 patients who met the inclusion criteria. Of the 56 people who met the criteria, 30 people (53.6%) were pulmonary TB sufferers and 26 people (46.4%) were not pulmonary TB sufferers. The majority of respondents were male (38 people) and the highest number was found in the 18-59 age range (48 people) (85.7%). Regarding ventilation conditions, 34 people (60.7%) did not meet adequate ventilation requirements, and 29 homes (51.8%) did not meet adequate lighting requirements. There was a relationship between ventilation conditions and the incidence of pulmonary tuberculosis in the Glugur Darat Community Health Center work area, but there was no relationship between home lighting and the incidence of pulmonary tuberculosis in the Glugur Darat Community Health Center work area.

Pneumonia caused by extensively drug-resistant (XDR) Pseudomonas aeruginosa is still  clinicaly chalenging, particularly among geriatric patients with neurological comorbidities such as stroke. This report presents a case of XDR P. aeruginosa pneumonia complicated by sepsis in a 73-year-old patient, characterized by persistent leukocytosis until the tenth day of hospitalization despite empirical meropenem therapy. This evidence-based case report aims to analyze clinical outcomes, specifically 28-day and 30-day mortality rates, and to identify mortality predictors in the adult population through a systematic literature search of the PubMed and Google Scholar databases for the 2019–2026 period. Synthesized evidence from six core studies indicates that XDR P. aeruginosa infections carry a profoundly high 28-day mortality rate, ranging from 41% to 51% in cohorts receiving antibiotic monotherapy. Key mortality predictors identified include the presence of sepsis or septic shock, a delay in initiating adequate therapy exceeding 52 hours, advanced age, and the requirement for Intensive Care Unit (ICU) admission. The phenomenon of persistent or worsening leukocytosis during treatment, as observed in this case, serves as a critical clinical indicator associated with antimicrobial response failure and a dismal prognosis. Ultimately, XDR P. aeruginosa pneumonia is associated with poor clinical outcomes, where therapeutic success is strictly contingent upon the timely administration of antibiotic regimens with proven activity against these highly resistant isolates.

Tinea incognito is a dermatophyte fungal infection when the clinical picture becomes unclear due to inappropriate treatment, which is usually caused by the use of topical steroids in cases of skin infections. A 46-year-old woman came with complaints of itchy reddish patches all over her body, experienced for 2 years. The itching worsened when consuming anchovies. The patient said she often took medication bought from a pharmacy without a doctor's prescription, the patient took methylprednisolone tablets and ointment. The itching complaint improved, but after stopping taking the medication, the itching complaint increased, and the patches widened. The patches first appeared on the right leg, initially resembling prickly heat spots then widened and spread to other parts of the body. Currently, the patches appear red in the shape of a ring with a clearer center. The patches were found on the face, neck, chest, abdomen, back, buttocks, left hand, and left foot. The patient noticed within a few months after taking the medication that her body was swollen, her weight increased, and her face looked rounder. A 20% KOH examination found hyphae and spores. Thus, the patient was diagnosed with Tinea Incognito caused by long-term topical steroid use. The patient was prescribed antifungal therapy with Ketoconazole 200 mg tablets once daily and Ketoconazole cream twice daily.

Litopenaeus vannamei is a brackish-water aquaculture commodity that is highly favored by the Indonesian community and represents one of the country’s leading aquaculture products, with production continuing to increase in response to rising domestic and export demand. One of the main factors triggering disease in L. vannamei is the presence of Vibrio sp. bacteria, which are recognized as serious pathogens in various aquaculture organisms and serve as causative agents of bacterial diseases. These bacteria naturally inhabit marine environments and are categorized as opportunistic, meaning they become pathogenic when environmental conditions decline and host health is compromised. Disinfectants are chemical substances used to inhibit or eliminate microorganisms such as bacteria, viruses, and fungi (excluding bacterial spores) on non-living surfaces. One disinfectant material is Smart Care (Intracare B.V., The Netherlands), which contains stabilized hydrogen peroxide with a prolonged-release mechanism. This study employed an experimental method using a Completely Randomized Design (CRD) with four treatments and five replications. The treatments included a control (without H₂O₂) and applications of H₂O₂ at concentrations of 1 ml/L, 2 ml/L, 3 ml/L, and 4 ml/L. The results indicated that the addition of hydrogen peroxide at different concentrations did not produce statistically significant differences in suppressing the growth rate of Vibrio sp. Nevertheless, treatment C (3 ml/L H₂O₂) showed the highest inhibitory effect, with no bacterial colony growth observed. Therefore, the application of H₂O₂ at 3 ml/L demonstrates potential in reducing Vibrio sp. growth and supporting sustainable shrimp aquaculture practices.

Stroke is a leading cause of disability that requires long-term rehabilitation. Herbal-based therapies, such as Shengmai San, may complement conventional medical treatments in aiding post-stroke recovery. This quasi-experimental study involved 10 post-stroke patients who received Shengmai San therapy for four weeks, with one session per week. Key parameters measured included blood pressure, muscle strength, motor function, sensory complaints (e.g., tingling, numbness), sleep quality, and Traditional Chinese Medicine diagnostic findings (pulse and tongue). The results showed clinical improvements across all patients, including stabilized blood pressure, enhanced muscle strength and mobility, reduced sensory complaints, better sleep quality, and increased physical stamina. Pulse and tongue diagnostics suggested improved Qi and Xue circulation. No significant side effects were reported. The study concludes that Shengmai San is a promising adjunct therapy for post-stroke rehabilitation, especially for patients with Qi deficiency and impaired blood circulation. However, the study suggests that Shengmai San should not replace conventional treatments but be used as a complementary therapy to support recovery.

Vannamei shrimp (Litopenaeus vannamei) is one of the most important aquaculture commodities with high economic value and strong market demand. The transportation of broodstock shrimp is a critical stage that may affect survival due to decreased oxygen levels and water quality deterioration. High stocking density during transportation can accelerate oxygen depletion and increase metabolic waste, leading to higher mortality. This study aimed to determine the effect of different packing densities on the survival rate of broodstock shrimp during 12 hours of transportation. The experiment used four treatments with densities of 6, 8, 10, and 12 shrimp per bag, each with six replications. Observed parameters included temperature, dissolved oxygen (DO), and survival rate. The results showed that lower stocking density produced higher survival rates, with the best result obtained at 6 shrimp per bag. Water quality remained within acceptable limits, although oxygen levels decreased with increasing density. Therefore, proper stocking density is essential to maintain shrimp survival during transportation.  

Consumption of ethylene glycol–containing drugs can cause liver damage. This study aimed to evaluate the hepatoprotective potential of Moringa leaf extract (Moringa oleifera L.) on AST and ALT levels, liver morphology, hepatosomatic index, and liver histology in ethylene glycol–induced white rats (Rattus norvegicus L.). A Completely Randomized Design (CRD) was used with 20 male rats divided into five groups: normal control, ethylene glycol control, and three treatment groups (150, 300, and 450 mg/kg BW). Ethylene glycol was administered for 30 days, while the extract was given for 20 days. Blood samples were collected on day 31. Data were analyzed using One Way ANOVA and Duncan’s test. The results showed significant hepatoprotective effects (P = 0.000). AST and ALT levels in the treatment groups differed significantly from the normal control. Liver morphological changes were observed in both control and treatment groups. The hepatosomatic index, number of normal hepatocytes, and central vein diameter also showed significant differences. In conclusion, Moringa leaf extract demonstrates hepatoprotective potential by reducing AST and ALT levels, improving liver morphology, increasing normal hepatocytes, and decreasing central vein diameter, with the optimal dose at 450 mg/kg BW

Background: Autoimmune Hemolytic Anemia (AIHA) is a rare immunological condition that causes the destruction of red blood cells through autoantibodies. Case Presentation: This report discusses the case of a 38-year-old woman who presented with complaints of weakness and acute dizziness at RedaBolo, with a history of recurrent anemia over the past six months. Physical examination revealed clear signs of hemolysis, including icteric sclera and splenomegaly. Laboratory findings confirmed severe anemia (Hb 5.0 g/dL) with varied peripheral blood cell morphology (spherocytes, schistocytes, and teardrop cells). The diagnosis was supported by a positive Coombs test and hyperbilirubinemia.  Management: The therapeutic strategy focused on hemodynamic stabilization through transfusion of 4 units of packed red blood cells (PRC), immunosuppression with methylprednisolone 125 mg/day, and gastric protection. Conclusion: These interventions yielded satisfactory results, with the patient achieving significant clinical improvement and a hemoglobin level of 9.5 g/dL by the fourth day of treatment.

Diabetic foot ulcer is a disease of the feet of DM sufferers with the characteristics of sensory, motor, autonomic neuropathy as well as macrovascular and microvascular disorders. Diabetic foot injuries are one of the complications that DM sufferers fear because they can result in amputation. Modern Dressing wound treatment with the Moist Wound Healing method is effective in healing ulcer wounds in DM patients. The wound healing method aims to maintain the moisture of the wound by using a moisture-retaining bandage so that wound healing and tissue growth can occur naturally. To determine nursing care in dm patients with leg injuries the application of Modern Dressing wound care using metcovazin and foam in diabetic ulcer patients. This study presents a descriptive study describing the treatment of ulcer wounds in DM patients with Modern Dressing wound treatment using a case study approach. Based on the results of the application of Evidence Based Practice (EBP) dapart, it is concluded that the application of Modern Dressing wound care is more effective than conventional wound treatment. as evidenced by the change in the decreased score in Mrs. N with 3 intervention processes, namely by decreasing the initial score of 30 down to 22 after Modern Dressing wound treatment. Modern dressing is more effective for diabetic foot ulcer care because it accelerates new tissue growth, reduces pain, and lowers the risk of infection.

This study aims to determine the effect of palm oil fiber (PFFE) (Borassus flabellifer Linn.) levels in egg yolk citrate diluent (C-EY) on the quality of frozen semen from landrace crossbred boar. The material used was fresh semen from 3 landrace crossbred pigs aged 2-3 years. The experimental method was a Completely Randomized Design consisting of five treatments and five replications. T0 = S-KT, T1= C-EY + PFFE 0.75%, T2 = C-EY + PFFE 1.5%, T3 = C-EY + 2.25% PFFE, and T4 = C-EY + PFFE 3%, and the addition of 6% glycerol in each treatment. The parameters observed included motility, viability, abnormalities, and recovery rate of spermatozoa. The data obtained were analyzed using analysis of variance (ANOVA) and analysis using SPSS version 27. The results revealed that the addition of PFFE had a significant effect (P <0.05) on post-thawing semen motility. With a value of T2: 24.00±2.23%, followed by T3: 15.00±5.00%, T1: 14.00±6.51%, T4: 13.00±4.47% and T0: 12.00±7.58%. Post-thawing viability also revealed that the addition of palmyra fruit fiber extract had a significant effect (P<0.05) with a T2 value of 46.65±3.65% followed by treatment T3: 25.70±6.75, T1: 24.69±8.70, T4:24.24±7.81 and T0: 22.36±8.67. While semen abnormalities did not have a significant difference between treatments. It can be concluded that the use of 1.5% SSBL and S-KT resulted in the highest post-thaw semen motility in treatment P2, with a value of 24.00 ± 2.23% in crossbred Landrace boar semen.

Based on data from FAO (Food and Agriculture Organization of The United Nations), it has been predicted that the aquaculture subsector will become one of the most relied-upon resources in the future, especially in meeting food needs, fish-based nutritional needs, and empowering the global community's economy (FAO, 2016). Catfish is a type of freshwater fish that can grow and develop well because it can be cultivated in limited land areas (Marsela, 2018). The frequency of feeding is one of the important factors that need to be considered in catfish farming. To determine the effect of different feeding frequencies on the absolute weight of dumbo catfish, a study was conducted using an experimental design called the Completely Randomized Design (CRD), with 3 treatments and a total of 8 replications. The test treatments were as follows: Treatment 1 (feeding twice a day), Treatment 2 (feeding three times a day), and Treatment 3 (feeding four times a day). The results of the ANOVA test showed a significant value of 0.000 (P < 0.05), indicating a significant difference in each of the different feeding frequencies. The analysis of the Least Significant Difference (LSD) test at a 5% significance level also showed that the relationship between each treatment had a significant value of 0.000 (P < 0.05). The average absolute weight of the fish for Treatment 1 was 12.99 grams, for Treatment 2 was 15.03 grams, and for Treatment 3 was 17.03 grams. The highest growth in the absolute weight of dumbo catfish fry occurred in Treatment 3 (feeding four times a day).

Vaname shrimp is one of the export commodities with high economic value. Therefore, to meet increasing market demand, it is necessary to improve aquaculture productivity. However, the development of vaname shrimp farming in Indonesia faces several challenges, including the emergence of viral, fungal, and bacterial diseases (Astria et al., 2022). Vibrio sp. bacteria can cause bacterial infections and are opportunistic in nature. Vibrio sp. can attack shrimp at all stages and may lead to decreased production yields (Astria et al., 2022). Generally, farmers control bacterial diseases by adding antimicrobial compounds. However, bacterial disease control in vaname shrimp culture can also be carried out using hydrogen peroxide (Astria et al., 2022). This study examined the effect of different doses of hydrogen peroxide in suppressing Vibrio sp. bacteria using a Completely Randomized Design (CRD). The doses used were 7 ppm, 9 ppm, 11 ppm, 13 ppm, and 15 ppm, with five treatments and five replications. The results showed that the application of different doses of hydrogen peroxide had a significant effect based on the One Way ANOVA test (0.00 < 0.05). The lowest effectiveness was observed in treatment 1 (7 ppm), while the highest effectiveness was found in treatment 5 (15 ppm). Although hydrogen peroxide was able to reduce the number of Vibrio sp. bacterial colonies, the doses used in this study were not able to completely eliminate the colonies (0 cfu/ml).