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Photosynthesis is a vital process for plants in converting light energy into chemical energy stored in organic compounds. Light intensity is one of the main factors influencing the efficiency of this process. This study aims to determine the effect of different light intensities on the photosynthesis rate and growth of spinach plants (Amaranthus sp.), which is a C4 plant species.The method used was a quantitative experiment with three light intensity treatments: low (0–10 lux), medium (10–20 lux), and high (>20 lux), each replicated three times over six weeks. Observed parameters included plant height, number and length of leaves, as well as the photosynthesis rate measured using the IRGA method.The results showed that light intensity significantly affected the growth and photosynthesis rate of spinach plants. The high light treatment produced the most optimal growth, with an average plant height of 4.92 ± 0.4 cm and the highest photosynthetic activity. Conversely, the low light treatment caused symptoms of etiolation, reduced vitality, and faster plant death, averaging by the third week.In conclusion, increasing light intensity significantly enhances photosynthesis efficiency and growth in spinach plants. These results can serve as a basis for regulating light intensity in cultivation systems, both conventional and hydroponic.  

Fertilization is one of the important activities in plant cultivation because it plays a role in increasing productivity by maintaining soil fertility. This experiment aimed to test the effectiveness of NPK fertilizer (20-51-13) on the growth and production of cabbage plants and its agronomic effectiveness. The experimental design used was a randomized block design. The treatments tested: without application of the tested fertilizer (P0), application of inorganic fertilizer comparison (2 kg/ha/application) (P1), and 5 levels of NPK fertilizer (20-51-13) tested, namely: 1.0, 1.5, 2.0, 2.5, and 3.0 kg/ha/application. The recommended doses of urea, SP-36, and KCl fertilizers were  200, 100, and 100 kg/ha, respectively. The results showed that the application of NPK fertilizer (20-51-13) can increase the growth of cabbage plants as indicated by the variables of plant height and number of cabbage leaves compared to the control treatment. In addition, the application of NPK fertilizer (20-51-13) increased the yield components of cabbage plants compared to the control treatment. The treatment of 0.75 doses of NPK fertilizer (20-51-13) was agronomically effective because it produced the highest relative agronomic effectiveness value of 145%, which means it can increase yields by 1.45 times. The recommended dose for cabbage plants is 1.5 kg/ha/application of NPK fertilizer (20-51-13) applied 5 times at 2, 3, 4, 5, and 6 WAP.

Putu ayu was traditional Indonesian caked with a soft texture that was a sweet and dominant colour of green. Wheat flour in Indonesian was grew used, so local materials need to be developed to reduce their dependence on wheat flour. This studied aimed to determined of soy flour and extract of katuk leaves which had high antioxidant and preferred consumer. This studied used was two factor Completetly Randomized Design (CRD) with ratio wheat flour and soybeans flour (90:10), (80:20) and (70:30) and extract concentration katuk leaves 10%, 15% and 20%. Putu ayu caked the best treatment was on ratio wheat flour and soy flour (70:30) with extract katuk leaves 15% because had high antioxidant activity 18,35%, aw moistured content 44,99%, ash content 8,35%, total fat 3,53%,8,59% protein, and 9,18% fiber. Soy flour substitutions and the addition of katuk leaves had the potential to increased the protein level of the putu ayu caked.

Responsibility is a key factor underlying children's attitudes, influencing their problem-solving abilities and self-confidence. This study explores the effectiveness of economic tokens in enhancing responsibility among preschool-aged children, particularly regarding the initiative to brush their teeth. Utilizing a single-case experimental design with one 4-year-old subject, data were collected through interviews, observations, and documentation, and analyzed descriptively. Results indicated a decline in responsible behavior from baseline 1 (A1) to baseline 2 (A2). However, from treatment 1 (B1) to treatment 2 (B2), there was an increase in responsible behavior. In conclusion, the economic token technique proved effective in improving the initiative to brush teeth in children.    

  Abstract. This study aims to determine how effective the Inquiry Social Complexity (ISC) model is in increasing critical thinking in elementary schools. The Inquiry Social Complexity (ISC) learning model is a way of learning that focuses on the use of critical thinking and social complexity to identify and resolve dilemmas. Critical intelligence means cognitive skills that demonstrate a high level of thinking skills, involving analysis, drawing conclusions, and assessing the problem-solving process, which is one of the important competencies in the 21st century. This study uses a quantitative approach using the Pratung Pre-Experimental design. The design applied is the One Group Pretest-Posttest Design. After the treatment was given, the average homogeneous value obtained was 78.11, while the t-test results gave a sig value (2-tailed) of 0.00 with a significance level of 5%. These results indicate that sig (2-tailed) is less than 0.05, so the alternative hypothesis (Ha) is accepted and the null hypothesis (H0) is rejected. This means that there is a significant disparity between the pretest and posttest. The conclusion of this study is an example of Inquiry Social Complexity (ISC) learning that has effectiveness in improving critical thinking skills of students in PPKn subjects at Elementary School 1, class V, Natar District. In addition, the analysis with the n-gain test produced an n-gain of 0.511 which is classified as moderate, which strengthens the acceptance of the other method hypothesis (Hα). This confirms that there has been a significant disparity between the pretest and posttest, regarding the effectiveness of the Inquiry Social Complexity (ISC) learning model on students' thinking skills in PPKn subjects at SDN 1, class V, Natar District.

Anesthesia is an act of relieving pain when performing surgery and various other procedures that cause pain in the body. Anesthesia procedures include pre-anesthesia, intra-anesthesia and post-anesthesia. Nephrolithiasis is very common, causing immense pain and incurring huge economic costs. It is known that nephrolithiasis can cause post-renal acute kidney injury (AKI) through obstruction of urine flow, which is often associated with rapid decline in renal function. Nephrolithiasis can be treated by pharmacologic means, laser treatment as well as radiologic stone crushing with the help of electromagnetic waves, and surgery (4). In surgical procedures such as open kidney general anesthesia is more recommended than regional anesthesia because the position of the patient can cause the patient to feel uncomfortable and pain arises from diaphragmatic stimulation.

Minor wounds, such as abrasions, scratches, or small cuts, are commonly experienced by teenagers, especially in school environments. However, improper treatment of minor wounds can lead to infections and more severe complications. This study aims to raise awareness and educate students at SMP Negeri 1 Kairatu on the proper management of minor wounds. The research employs a descriptive approach with an interactive educational method involving presentations, discussions, and live demonstrations. Respondents in this study were students from grades 7 to 9. The results indicated that prior to the socialization, most students had inadequate knowledge regarding proper wound care, often resorting to inappropriate methods (e.g., using toothpaste or oil). After the educational intervention, there was an 85% increase in students’ understanding of proper wound management, such as cleaning wounds with clean water, applying antiseptics, and covering wounds with sterile bandages. The socialization program also successfully raised awareness among students about the importance of wound hygiene to prevent infections. Thus, this initiative proved effective in enhancing teenagers' knowledge of proper wound care practices.

The purpose of this study is to ascertain the development and productivity of Odot grass in the presence of fermented cow dung. This study used a completely randomized design (CRD) non-factorial research method consisting of 4 treatments and 5 replications. An experiment was conducted using the parameters of odot grass plant height, number of odot grass leaves, fresh forage production, and dry forage production to ascertain the impact of feeding fermented cow feces on the growth of odot grass (Pennisetrum purpureum Cv.Mott) in order to yield the best results. When odot plants are treated according to the level of need, the best treatment is the provision of fermented cow feces fertilizer. This has a significant impact on the growth and productivity of odot grass, allowing it to produce maximum results in terms of plant height, number of leaves, fresh forage, and dry weight. 200 grams, one odot grass cutting, 100 milliliters of water, and a polybag with a 1:10:50 fermentation ratio.

The revitalization of urban heritage areas in Indonesia, exemplified by Panggung Street in Surabaya, faces multifaceted challenges encompassing the preservation of historical character, socio-economic enhancement, and the creation of inclusive public spaces. Current revitalization efforts often misalign with the area’s authentic features such as inappropriate facade treatments while neglecting accessibility for vulnerable groups and failing to foster effective collaboration among stakeholders. This study employs a descriptive qualitative case study approach, synthesizing field observations, in-depth interviews with local actors, comprehensive literature reviews, and precedent analyses of Braga Street in Bandung and heritage zones in Malacca. Data were analyzed using SWOT and root cause analysis to identify systemic barriers and leverage opportunities, while comparative-historical interpretation contextualized Surabaya’s urban identity. Triangulation ensured methodological rigor and validity. The research culminates in a holistic revitalization framework emphasizing three key strategies: restoration of authentic architectural features, including original colors and ornamentation, enhancement of inclusive infrastructure, such as accessible pedestrian pathways and universal signage and active community participation through workshops and cultural initiatives like the Kya-Kya night market. This integrated approach not only preserves the area’s historical integrity but also fosters social cohesion, economic vitality, and collective pride. The study demonstrates that combining heritage conservation with inclusive design principles can transform urban spaces into dynamic, accessible, and sustainable environments. The findings offer valuable insights for other Southeast Asian cities facing similar heritage revitalization challenges.

Breast cancer is the most prevalent type of cancer in women worldwide, with approximately 2.3 million new cases or 11.7% of all cancer cases. Human Epidermal Growth Factor Receptor 2 (HER-2) is one of the important therapeutic targets in breast cancer that is overexpressed in 15-25% of cases. Conventional cancer treatments such as chemotherapy often cause adverse side effects, so safer alternative therapies are needed. This study aims to assess the potential of active compounds from medicinal plants as HER-2 inhibitors through a molecular docking approach. The literature review method was used by analysing related research articles in the last five years obtained from PubMed and Google Scholar databases. The results showed that several active compounds have high potential as HER-2 inhibitors, including beta cystosterol from guava leaves (Psidium guajava L.) with a binding energy value of -12.3 kcal/mol, vitexin from dandang gendis (Clinacanthus nutans L.) with a value of -9.3 kcal/mol, and isovitexin from basil mekah (Ocimum gratissimum) with a value of -9.11 kcal/mol. These findings provide a basis for further development of natural active compounds as potential breast anticancer drug candidates with minimal side effects.

This study aimed to evaluate the effect of compost fertilizer and potassium chloride (KCl) fertilizer, as well as their interaction, on the growth and yield of sweet corn (Zea mays saccharata Sturt). The experiment was conducted from May to August 2022 in Kuning Village, Bambel District, Southeast Aceh, using a factorial randomized block design with two factors: compost dosage (480 g/plot, 960 g/plot, 1,440 g/plot) and KCl dosage (20 g/plot, 40 g/plot, 60 g/plot), each replicated three times for a total of 27 plots. Observed parameters included plant height, stem diameter, leaf area, days to flowering, ear length, and ear weight per plot. Results indicated that compost and KCl fertilizers significantly affected plant height, leaf area, days to flowering, and ear length, but had no significant effect on stem diameter or ear weight per plot. The interaction between compost and KCl produced the highest plant height (165.89 cm) and ear length (21.69 cm) in treatment K3C1. The findings suggest that optimal fertilization using compost and KCl can enhance sweet corn productivity by improving vegetative growth and reproductive development. Nevertheless, the absence of significant effects on stem diameter and ear weight per plot indicates that nutrient balance, especially nitrogen (N) and phosphorus (P), remains crucial for maximizing yields. Therefore, integrating compost and KCl with complementary sources of macronutrients could promote more consistent outcomes. This research also highlights the role of organic matter in enriching soil fertility, maintaining soil structure, and supporting sustainable agriculture. The combination of organic and inorganic fertilizers demonstrates the potential for eco-friendly crop management practices that balance productivity with environmental responsibility. These results provide valuable insights for farmers, agronomists, and policymakers in developing efficient fertilization strategies for sweet corn cultivation within local conditions.

This research aims to explore the potential of secondary metabolites from babandotan plant (Ageratum conyzoides L.) as breast cancer drug candidates through a medicinal chemistry approach using in silico studies. Breast cancer has the highest prevalence among women in Indonesia, with conventional treatments often causing serious side effects, prompting the search for new anticancer agents from natural sources. Babandotan plant (Ageratum conyzoides L.) has been empirically proven to have cytotoxic effects against cancer cells and possesses various pharmacological activities with anticancer potential based on its bioactive compounds such as flavonoids, terpenoids, alkaloids, and sterols.

Oil palm plants (Elaeis guineensis Jacq.) are one of Indonesia's leading commodities which have quite high productivity as a producer of vegetable oil, as well as being a source of foreign exchange for the country and employment for the community. The aim of the study was to determine the effect of urea, KCl and chicken manure on the growth of oil palm seedlings. The research location was conducted on Jalan Tapak Lebar I Rt.04, Sidorejo Village, Lubuklinggau Barat II District, Lubuklinggau City, South Sumatra, from September to December 2024. Treatment P1 = No treatment, P2 = Urea fertilizer 5 g/plant, P3 = KCl fertilizer 5 g/plant, P4 = Chicken manure 250 g/plant, P5 = Urea fertilizer 5 g + KCl 5 g/plant, P6 = Urea fertilizer 5 g + chicken manure 250 g/plant, and P7 = KCl fertilizer 5 g + chicken manure 250 g/plant. Each sample treatment consisted of 3 seedlings and was repeated 3 times. Using a non-factorial Completely Randomized Design (CRD), Duncans Multiple Range Test (DMRT). The administration of urea fertilizer at a dose of 5 g/plant and chicken manure at a dose of 250 g/plant gave the best effect on all observation variables, namely: increase in height, increase in the number of leaf stalks, stem diameter, number of leaflets, length of leaflets.  

This study aims to encourage the effect of adding pineapple (Ananas Comosus L. Mer) in the marinating process on the level of tenderness, organoleptic, physical quality and protein content of buffalo meat. The method used is an experiment with a completely randomized plan (CRD), consisting of four treatments, namely: PO (without pineapple), P1 (250 g pineapple), P2 (500 g pineapple) and P3 (750 g pineapple). The results showed that the addition of pineapple significantly affected the quality of buffalo meat. The color of the meat became brighter with increasing pineapple levels while the texture of buffalo meat became more tender due to the bromelain enzyme which breaks down collagen. Organoleptic parameters using the Kruskal Wallis Test showed a significant difference in the level of tenderness, color, texture, aroma and taste in each treatment, although excessive use of pineapple produced a dominant sour taste. The protein content of buffalo meat changed due to the proteolysis process influenced by the bromelain enzyme. This study indicates that marinating buffalo meat using pineapple can improve the quality of buffalo meat physically, organoleptically and nutritionally.

Propagation of rose plants through stem cuttings is a widely used method; however, its success is often influenced by the availability of adequate plant growth regulators and nutrients. The use of natural materials such as shallot extract as a source of plant growth regulators and cow manure as an organic fertilizer is expected to enhance the growth of cuttings in an environmentally friendly manner. This study aimed to determine the effect of soaking duration in shallot extract, the application of cow manure, and the interaction between both treatments on the growth of rose (Rosa hybrida L.) cuttings. The research was conducted in November 2025 in Sampe Cita Glugur Rimbun Village, Kutalimbaru District, Deli Serdang Regency, North Sumatra, at an altitude of approximately 500 meters above sea level. The study employed a factorial Randomized Block Design with two treatment factors and three replications, resulting in 48 experimental units. The first factor was the soaking duration in shallot extract (0, 4, 8, and 12 hours), while the second factor was the dosage of cow manure (0, 50, 100, and 150 g per polybag). Observed parameters included survival percentage, time of shoot emergence, number of shoots, shoot length, number of leaves, and leaf length. The results showed that all treatments, both individually and in interaction, had no significant effect on all growth parameters. Nevertheless, plant growth increased with plant age, with a relatively high and uniform survival rate of approximately ±90%. These findings indicate that, at the treatment levels applied, shallot extract and cow manure were not effective in significantly improving the growth of rose cuttings, suggesting that further research with different concentrations or treatment combinations is needed.

Menstrual pain or dysmenorrhea is a common complaint experienced by adolescent girls throughout the world has shown that the incidence of dysmenorrhea is quite high, namely 43-93% of women experience dysmenorrhea and 5-10% of them experience very severe dysmenorrhea and leave their activities 1-3 days a month, where 8% of them have to leave school or work during menstruation The purpose of this study is to examine the effect of giving turmeric and tamarind with pineapple juice on reducing primary dysmenorrhea pain in TPMB "M".This study uses a qualitative research strategy, with a case study, which is a series of scientific activities carried out intensively, in detail and in depth about a program, event, and activity, both at the individual level, a group of people, institutions, or organizations to obtain in-depth knowledge about the event, this case study was conducted directly to adolescents who were menstruating and experiencing primary dysmenorrhea. The results of the study were conducted in Case 1, an adolescent who was experiencing Primary Dysmenorrhea pain with a pain scale of 9 after being given Turmeric Acid, the NRS value at Visit 1 was 7, Visit 2 was 5, Visit 3 was 3. While in Case 2 after being given Pineapple juice, the NRS value at Visit 1 was 7, Visit 2 was 4, Visit 3 was 2. both were the same in reducing pain, but consuming Turmeric Acid was more effective in reducing pain by 1 on the 2nd visit and the difference in pain reduction was 1 on the 3rd visit. It is hoped that this study can be used to add new knowledge about the treatment of dysmenorrhea pain in adolescents in a non-pharmacological way, namely by using turmeric acid and pineapple juice. as an alternative.

Pain is one of the main problems often experienced by patients during treatment in hospitals, including in the Zam-Zam 1 Ward of Sultan Hadlirin Hospital, Jepara. High levels of pain can affect comfort, quality of rest, and slow the patient's healing process. Various non-pharmacological interventions have been developed to help reduce pain, one of which is music therapy, which works through distraction and relaxation mechanisms. This study aims to analyze the effectiveness of music therapy in reducing pain levels in patients in the Zam-Zam 1 Ward of Sultan Hadlirin Hospital, Jepara. The research method used a quasi-experimental design with a pretest-posttest approach without a control group. The study sample consisted of 47 patients who met the inclusion criteria and were selected using a purposive sampling technique. The research instrument used a Numerical Rating Scale (NRS) to measure the patient's pain levels before and after the intervention. The music therapy process was carried out by playing relaxation music for a certain period according to the research procedure. Data analysis was carried out using a paired t-test to determine the difference in pain levels before and after music therapy. The results showed an average decrease in pain levels of 1.79 with a standard deviation of 1.05. The t-test results yielded a t-value of 9.017 with a p-value of 0.000 (p < 0.05), indicating a significant difference between pain levels before and after the intervention. These findings demonstrate that music therapy is effective in reducing pain perception in hospitalized patients. In conclusion, music therapy can be used as an alternative non-pharmacological intervention that is easily implemented by healthcare professionals to improve patient comfort and quality of care in hospitals.  

Leprosy is a chronic infectious disease caused by the bacterium Mycobacterium leprae. It is a neglected tropical disease, still found in more than 120 countries, with more than 200,000 new cases reported each year.. The purpose of this research is to characterize leprosy patients in Lhokseumawe City and to describe the Multi Drug Therapy therapy. Information about the therapy, including the kind of leprosy, age, gender, employment, and the precise period of treatment, is evaluated in this research. Instruments for measurement were derived using data collected from medical records in this cross-sectional observational investigation. A whole sampling population was used in the sampling procedure, with 42 respondents making up the sample. Based on these findings, MB leprosy is the most frequent form of the disease (90.5% of cases), men make up the majority (64.3%) of leprosy patients, and the majority of leprosy patients are adults (88.1%). Results from the MDT treatment protocol indicated that 76.2% of patients were considered to have finished therapy (RFT), with the biggest occupational category being patients who did not work, accounting for 50% of the total. It is imperative that leprosy officers work to promote health promotion in order to raise awareness, decrease negative stigma, and speed up the discovery of leprosy cases

Diarrhea is still the leading cause of infant morbidity and mortality in Indonesia, especially in areas with limited access to clean water and adequate sanitation. This community service activity is carried out with the aim of increasing maternal knowledge about the signs and symptoms of diarrhea in children, increasing maternal awareness in maintaining children's hygiene and health to prevent diarrhea, and providing practical training on early treatment of diarrhea. This activity involved 30 mothers who have early childhood in Bangun Rejo Village, Tanjung Morawa District. The methods used include interactive lectures, group discussions, demonstrations of making oralite solution (ORS), correct handwashing practices, and distribution of educational leaflets. Evaluation was carried out through pre-test and post-test to measure the increase in participants' knowledge before and after the activity. The results of the activity showed a significant increase in maternal understanding of the prevention and treatment of diarrhea. Participants were able to identify early symptoms of diarrhea, practice how to make ORS correctly, and show readiness to take the child to a health facility if signs of dehydration appear. This activity proves that community-based health education is effective in increasing maternal knowledge and preparedness in preventing and treating diarrhea in children. Strengthening similar educational programs is essential to be implemented sustainably, especially in areas with a high risk of diarrheal diseases. These efforts can make a real contribution to reducing the incidence of diarrhea and improving the health status of children in vulnerable communities.

Tuberculosis (TB) is one of the oldest infectious diseases that has existed throughout the history of human civilization and remains a major public health problem in the world today. Tuberculosis is caused by Mycobacterium Tuberculosis which can result in TB Pleuritis, which is inflammation of the pleura, both the parietal pleura and the visceral pleura, manifested by accumulation of fluid in the pleural cavity. A 20-year-old man came with complaints of coughing for the past 1 month, white phlegm, shortness of breath felt worse for the past 2 days, fever not too high for the past 1 week accompanied by cold sweats at night. The patient feels that it is difficult to gain weight and tends to lose weight this month. Chest X-ray show left massive pleural effusion. Acid fast baccili sputum was negative. USG Thorax show pleural fluids approximately 1600 cc.  Tuberculosis (TB) can cause TB pleutiritis with symptoms of shortness of breath and sometimes chest pain on the side of the pleural cavity where there is fluid.3 Treatment of TB Pleuritis is the same as the treatment of pulmonary TB in general with the 2RHZE/4RH combination. Optimal fluid evacuation is carried out according to the patient's condition.