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The development of the nervous system is a crucial process during early organogenesis that impacts overall body function. This research aims to understand the mechanisms involved in the formation of the nervous system, focusing on early embryonic development. Previous studies indicate that interactions between genetic and environmental factors significantly influence this development, yet many specific aspects remain to be explored. This study provides an in-depth analysis of the role of progenitor cells and molecular signals in neuron differentiation. By identifying the pathways involved, it aims to uncover new approaches to understanding developmental disorders of the nervous system. Utilizing experimental methods and systematic data analysis, this research not only enhances our understanding of the fundamental mechanisms of nervous system development but also opens possibilities for developing therapies for related disorders

A new snack innovation that is high in albumin and iron content in the form of dumplings uses snakehead fish substitution and the addition of Moringa leaves. The aim of this research was to determine the effect of snakehead fish substitution, the addition of Moringa leaves, the interaction of the two factors on the acceptability of dumplings (color, aroma, taste, texture), as well as the best albumin and iron content of dumplings. This research used an experimental method with a 3x2 factorial design which resulted in 6 treatments. The data collection technique uses a sensory test based on the liking level of 50 untrained panelists. The results of the sensory test data were analyzed using the Two Way Anova Test followed by the Duncan Test to determine significant differences in results, as well as to determine the best dumplings. Based on the results, the acceptability of dumplings only had an effect on texture, and had no effect on color, aroma, taste, either from the substitution of snakehead fish or the addition of Moringa leaves, while the interaction between snakehead fish substitution and the addition of Moringa leaves had no effect on color, aroma, taste and texture. The best dumplings are snakehead fish (100%) and Moringa leaves (20%) with a nutritional value of 4.10 mg albumin and 2.10 mg iron per 100 grams. The conclusion of this research is that substitute snakehead fish dumplings and the addition of Moringa leaves only affect the texture, however, the dumplings can still be consumed by the panelists and are useful for increasing albumin levels and body endurance as well as speeding up wound healing.

Background: The endocrine system is a network of glands that produces body hormones to regulate various body functions, such as growth, metabolism, regulation reproduction, and homeostasis. This research aims to provide a comprehensive overview of the role of the endocrine system, the function of the hormones produced, and the impact of their disorders on health. The research was carried out using a literature study method of six relevant national journals published in the last five years. The results of the analysis show that the endocrine system plays an important role in maintaining body balance through feedback mechanisms and interactions with the nervous system. Disorders of glands such as the pancreas, thyroid and adrenals can lead to serious illnesses, including diabetes mellitus, hypothyroidism and Cushing's syndrome. This study emphasizes the importance of understanding the endocrine system for the development of early detection and intervention strategies for hormonal disorders. It is hoped that the research results can become a reference for medical personnel and scientists in improving the quality of public health.

The learning process can proceed well if aided by the presence of teaching aids.Because the teaching aid for the electrical system of the motorcycle rear brake light was not available, this teaching aid was created.The purpose of this research is to determine: (1) the method of creating a teaching aid for the rear motorcycle brake light system, (2) the feasibility level of the teaching aid for the rear motorcycle brake light system, and (3) the students' response to the teaching aid for the rear motorcycle brake light system.This research uses a development research approach, also known as Research and Development (R&D). The Research and Development (R&D) method is a research method used to produce a specific product and test its effectiveness. This research will be conducted at SMK Negeri 1 Nisam. The implementation will be carried out in the even semester of the 2024/2025 academic year. This research and development uses 3 methods in data collection. The methods used are observation, questionnaires, and documentation. The data analysis technique used in this research is descriptive analysis, which presents the results of product development in the form of learning media, testing the validity and suitability of the product for implementation in the electrical system of motorcycle rear brake lights.The results of the research on the development of teaching media props, which have gone through several stages such as potential issues, data collection, product design, product validation, design revision, product testing, until it became a teaching media prop for the electrical system of the motorcycle brake light. The results obtained from the material expert validation were 91.31% by validator 1 and 95.13% by validator 2. The media expert validation results were 97.91% by validator 1 and 97.91% by validator 2. The results of the students' responses to the teaching aids, after calculations, showed a total response score of 506 out of 572 overall. With a final score percentage of 88.46% and the qualification of the developed teaching aids' response being in the "Very Good" category.

Hypertension is still a health problem in the world, including in Indonesia. The increasing prevalence of hypertension is because there are still many hypertension patients who have not received treatment or who have been treated. Hypertension is not controlled properly and correctly and will have an impact on complications, this can increase morbidity and mortality. Hypertension patients are expected to be able to control hypertension properly and correctly with a good lifestyle according to recommendations to prevent hypertension complications. The purpose of this study was to determine the characteristics of hypertension patients in efforts to control hypertension in the Internal Medicine Polyclinic of the Hospital. This type of research uses a descriptive survey and a cross-sectional research approach. The results of this study show that the characteristics of respondents are mostly male compared to women, most are 45-64 years old, have excess body weight, have high school and college education, have civil servant jobs and are retired civil servants, have a history of hypertension from their families, have a duration of hypertension 0-1 years and a duration of hypertension treatment 0-1 years. It is recommended for hypertension sufferers to control hypertension and other researchers to conduct research with wider variables.

Hypertension is a disorder characterized by elevated blood pressure originating from abnormalities in blood vessels, leading to impaired delivery of oxygen and nutrients to essential body tissues. Family involvement in assisting relatives afflicted with hypertension constitutes a supportive mechanism to facilitate effective self-care management of the condition.This study aimed to investigate the correlation between familial support and self-care management in hypertensive patients at Tuminting Health Center. Cross-sectional methods. The study sample comprised 49 individuals selected by purposive sampling. A questionnaire was employed as the study instrument. The gathered data was analyzed with the SPSS 16.0 software employing the Chi Square statistical test at a significance level (α) of <0.05. The results indicated that the predominant age group was 56-65 years, including 27 respondents, which represents 55.1%. The majority of respondents were female, totaling 39 individuals, accounting for 79.6%. The most common educational attainment was high school, with 22 respondents, corresponding to 44.9%. The statistical test yielded a P value of 0.0001, which is less than the alpha value (α) of ≤0.05. This study concludes that a correlation exists between family support and self-care management in hypertension patients at Tuminting Health Center. The findings of this study are anticipated to serve as a resource for individuals with hypertension, emphasizing the importance of self-care management to prevent problems and facilitate recovery.

Dead skin cells can occur due to many factors, such as increasing age, sun exposure, and an unhealthy lifestyle. Signs of skin problems due to the buildup of dead skin cells are dull skin, acne, and dry skin.  Body scrub is a type of skin care that can provide many benefits for skin health and beauty. Scrub is the process of exfoliating dead skin cells using a scrub or natural ingredients. Pedada fruit scrub is a natural beauty care innovation originating from the coast of Indonesia, especially from areas rich in pedada fruit plants (Sonneratia spp.). Pedada fruit is known to have high antioxidant content which can provide benefits for the skin, such as brightening it, reducing wrinkles, and fighting the effects of free radicals. This scrub uses pedada fruit extract which is rich in flavonoids, tannins and vitamin C to care for the skin naturally. This body scrub product not only offers beauty benefits but is also environmentally friendly because the raw materials are easy to find in coastal areas and do not require complicated chemical processes. This research aims to examine the benefits of pedada fruit scrub as a natural beauty solution that is rich in antioxidants.

The Halal Product Guarantee Administering Body (BPJPH) is an official institution that has been authorized based on the mandate of Law no. 30 of 2014 concerning Halal Product Guarantees. BPJPH has high authority in implementing halal certification. Halal certification is mandatory for halal business actors in Indonesia. This research aims to find out how the halal certification process is carried out by BPJPH and the reasons behind why BPJPH implements regulations like this. The research method used is qualitative with a juridical or normative legal approach. This research is included in library research or library research by reviewing literature that is appropriate to the research object. The data sources used are the Halal Product Guarantee Law (UU JPH) and its derivatives and the official BPJPH account which is normative and can be accessed by the public. The research results show that halal certification by BPJPH is carried out in two ways, namely independently/regularly and self-declare. Each has a different halal certification flow. The legal basis for implementing halal certification by BPJPH is Law no. 30 of 2014 concerning Halal Product Guarantees, Government Regulation Number 31 of 2019 concerning Implementation of Halal Product Guarantees, Minister of Religion Regulation Number 26 of 2019 concerning Procedures for Halal Certification, and BPJPH Regulation Number 61 of 2022 concerning SOPs for Halal Certificate Application Services at BPJPH.    

Midwives are one of the health workers in reducing maternal and infant mortality rates by providing continuous midwifery services, promotion through partnerships and empowering communities with other health workers. The sample in this study was 24 pregnant women in the second and third trimesters consisting of 12 respondents for the control group and 12 respondents for the intervention group. The time of the study was May to June at the Negri Lama Health Center in 2022. The time of the study was May to June at the Negri Lama Health Center in 2022. The results of the bivariate analysis test using Mann Whitney showed a P-Value of 0.022 (P <0.05) so Ho was rejected, which means that there is a significant effect of giving dates on increasing hemoglobin in pregnant women in the second trimester. Pregnant women, especially pregnant women who experience anemia, are expected to routinely consume iron tablets and dates because if consumed properly, dates have many benefits, especially for pregnant women and dates do not have side effects on the fetus or mother so that they can meet the nutritional needs required by the body and can maximize iron absorption.

Background The World Health Organization (WHO) estimates that the number of fever cases in children reaches 62%. Management of fever can be in the form of non-pharmacological therapy. One non-pharmacological therapy for fever is to apply a compress using aloe vera. Aloe vera contains lignin and saponin which can vasodilate the skin and reduce body temperature. The aim of this research is to determine the effect of information and actions on giving aloe vera compresses on reducing body temperature in children with fever at the Nassau Kec.Nassau Kab.Toba Tahun 2024. This research is a type of quantitative research with a quasi-experimental research design with a pre-test and post-test design without control with subjects of 30 children aged 3 – 6 years who had a fever at the nassau public health center,nasaau district,toba regency in 2024. Community Health Center. The sampling technique in this research is total sampling, namely a sampling technique when all members of the population are used as samples. The intervention carried out was applying compressaloe vera to the forehead for 15 minutes. Temperature measurement using a digital thermometer. The data analysis used is univariate and bivariate analysis. The test used is the non-parametric Wilcoxon test. The results of this research, namely the results of statistical tests using the Wilcoxon test stated that giving aloe vera compresses had an effect on changes in body temperature in fever sufferers with a p value = 0.002 (α < 0.005) with a temperature decrease of 0.486 ºC. The conclusion of this study is that there is a significant influence on the results of measuring body temperature before and after giving aloe vera compresses to children who have fever at  the nassau public health center,nasaau district,toba regency in 2024.

Providing education to the public by using bay leaves as a preparation will increase public awareness of the plants that grow in Indonesia, which are rich in health benefits, thereby increasing public enthusiasm. Bay leaves combined with white rice powder are often used as a moisturizer so they are made into a body scrub preparation that can increase moisture into the skin for better. The aim of this service is that the community is expected to provide education about bay leaves and white rice powder in Klambir V Village, Medan, Indonesia. This community service method was carried out using leaflets, modules, power points and presentations to the community. The result of this service was an increase in public knowledge of tamarind fruit as an antioxidant by 85%..

The settlement of carok as part of Madurese society is very important to analyze. This study aims to determine the social impact on the families of carok perpetrators in the perspective of criminology. The second objective is to determine the role of community leaders and the police in minimizing threats and taking preventive action against the families of carok perpetrators in Madura. The research method used in this research is the type of empirical legal research. The results showed that: First, from a criminological perspective, carok can be categorized as a crime. Carok in this case can be subject to articles of the Criminal Code related to crimes against the body and crimes against life. According to labeling theory, families of carok perpetrators are usually labeled by the community as families of criminals who are usually dubbed as “Kaloarga Tokang Carok”. Second, Kiai in carok cases plays a role in reconciliation and mediation efforts between the families of carok perpetrators and the families of carok victims to minimize threats to the families of carok perpetrators. The Sampang Police, among others, conducted counseling with the perpetrator's family and collaborated with community leaders.

Cashew leaves or also called monkey guava are known by many people, especially in Southeast Sulawesi and are believed to have a number of health benefits but are still rarely known by some people. This study aims to determine the profile of secondary metabolite content and determine the antioxidant activity of ethanol extract of cashew leaves (Anacardium occidentale Linn) using the extraction method by maceration. The extraction process of old cashew leaves is carried out by the maceration method using 96% ethanol solvent for 3 days of soaking and stirring every 24 hours, then concentration is carried out through the evaporation process. Phytochemical testing includes identification of alkaloids, flavonoids, polyphenols, tannins, steroids/triterpenoids and saponins, as well as testing antioxidant activity using the DPPH method (1,1-diphenyl-2-picrylhydrazyl). The results showed that the extract of cashew leaves (Anacardium occidentale Linn) strongly positive contains phenolic compounds, flavonoids, steroids and saponins. Based on the results of the IC50 calculation, 96% ethanol extract has the highest antioxidant activity at a concentration of 14.35 ppm (µg/mL) with a very high category. The content of secondary metabolites and very high antioxidant activity from the results obtained, explain that cashew nuts have the potential to increase body immunity and can be used in various antioxidant food products so that cashew leaves are more economically valuable for the community.

Background: Spinal anesthesia is anesthesia performed on patients who are still conscious with the aim of eliminating the conductivity process at the sensory nerve endings or fibers in certain parts of the body. Research Objectives: This study aims to determine changes in blood pressure before induction of spinal anesthesia and after induction of spinalanesthesia.        Research Methodology: Thisresearchisa descriptive observational study with a quantitative research design that focuses on variable analysis, especially intra-anesthesia blood pressure after application of spinal anesthesia. This research uses an analytical design with a cross-sectional approach. Results: It is known that the systolic blood pressure 5 minutes after spinal anesthesia was found to be mean (114.89 mmHg), median (118 times/minute) and mode (132 times/minute), diastole 5 minutes after spinal anesthesia was obtained as mean (70.09 mmHg), Median (70 times/minute), and Mode (70 times/minute). It is known that systolic blood pressure 10 minutes after spinalanes the siaobtained Mean (102.96mmHg), Median (102 times/minute) and Mode (80 times/minute), Diastole 10 minutes after spinal anesthesia obtained Mean (67.32mmHg), Median (70 times/minute), and Mode (60 times/minute). It is known that systolic blood pressure 15 minutes after spinal anesthesia obtained Mean (119.47 mmHg), Median (118 times/minute) and     Mode (100 times/minute), Diastole 15 minutes after spinal anesthesia obtained mean (71.11 mmHg), Median (70 times/minute), and Mode (80 times/minute). Conclusion: This study can conclude that patients undergoing spinal anesthesia may experience a decline due to the effects of spinal anesthesia.

Elderly people have a high risk of suffering from degenerative diseases, one of which is metabolic disorders. This is more widely recognized by the elderly when they are already in severe condition and with complications so that it has an impact on various aspects including increasing morbidity and mortality rates, as well as decreasing quality of life of the elderly and decreasing ability of the elderly to carry out daily activities. Metabolic disorders are caused by increased blood glucose levels in the body known as Diabetes Mellitus (DM) which is one of the health problems of the ten diseases that cause death and disability globally. The implementation of community service activities for Preventive Efforts for the Elderly in Diabetes Mellitus through several stages, namely the survey and field observation stages and counseling for Preventive Efforts for the Elderly in Diabetes Mellitus counseling is carried out for approximately 90 minutes, as well as evaluations in the form of pre-tests and post-tests. The provision of education was carried out on Wednesday, November 14, 2024 at the Antara Health Center, the number of participants was 32 people. Based on the results of the knowledge of the elderly before and after the counseling for Preventive Efforts for the Elderly in Diabetes Mellitus, it was found that 15 elderly people had sufficient knowledge and 17 elderly people had insufficient knowledge. After conducting counseling on Preventive Efforts for the Elderly in Diabetes Mellitus, the results obtained were a sufficient increase of 30 and less than 2 elderly. This means that community service on Preventive Efforts for the Elderly in Diabetes Mellitus is very effective in the elderly in order to prevent an increase in glucose levels. Counseling on preventive efforts for the elderly in diabetes regarding these degenerative diseases is very necessary so that the elderly maintain their health better. The elderly are expected to be able to understand about efforts to prevent and treat degenerative diseases in the elderly with diabetes. Hopefully this community service can be a reference for researchers and further community service, as well as the community.

Tuberculosis is a chronic infectious disease induced by the bacterium Mycobacterium tuberculosis and can attack human organs, especially the lungs. The entry of this antigen causes the release of various pro-inflammatory cytokines which cause liver cells to synthesize acute phase proteins such as C-Reactive Protein (CRP). C-Reactive Protein is a type of alpha globulin protein that appears in the blood in response to inflammation in the body. The aim of this study was to determine the description of CRP in pulmonary tuberculosis patients at the Naibonat Community Health Center. The method used is descriptive with a cross sectional study design method. This research was carried out at the Naibonat Health Center Laboratory, Kupang Regency from February to April 2024. The examination method used was the qualitative latex agglutination method. The results of CRP examination on pulmonary TB patients from a total of 23 respondents obtained reactive results for 8 samples (35%) and non-reactive results for 15 samples (65%). Based on the results of reactive CRP, the highest number was found in males, 6 people (26%), while the highest number was found in the age range 12-25 years, 4 patients (Teenagers) (17%), with the highest length of treatment at 0 -2 months (intensive stage) as many as 6 patients (35%), with the highest patient status being new TB as many as 8 patients (35%), with the highest treatment status being non-resistant as many as 6 patients (26%).

The COVID-19 pandemic marked a significant turning point in the global church's approachto mission and ministry, particularly through the adoption of digital spaces. The rapid shift to digitalplatforms was not merely a practical adaptation but reflected a deeper transformation in how thechurch understands presence, community, and engagement in the world. This article aims to examinehow evangelism and discipleship practices have evolved in digital forms in the post-pandemic context,and to explore the theological and ethical implications of "digital presence" within contemporarymissiology. Using a practical theology approach, this study employs literature analysis, theologicalreflection, and case studies from digital church practices as its primary methods. The main findingsreveal that evangelism has shifted towards creative digital content targeting digital-native generations,while discipleship is increasingly practiced through online communities and digital spirituality. At thesame time, the study identifies key issues such as the validity of digital sacraments, the risk of faithcommodification, and the challenge of fostering authentic relationships in virtual spaces. This articlesynthesizes the idea that digital mission represents a new form of incarnational ministry in the digitalage, calling for a hybrid ecclesiology that integrates both physical and digital presence. In conclusion,digital mission is not simply a crisis response to the pandemic but a long-term theological and strategictransformation in how the church participates as the Body of Christ in a digitally connected world.

In the cracker production process at UMKM Kerupuk Subur, the process of drying crackers involves human labor so there is a risk of injury because when drying crackers, workers have to bend and squat. This study aims to determine the occupational dangers of workers during the drying process of crackers in UMKM Kerupuk Subur and provide recommendations for improvement. The method used to analyze body posture is Rapid Entire Body Assessment (REBA) then for improvement recommendations using an anthropometric approach with percentile calculations to determine dimensions as parameters for designing the work aids needed in the form of an ergonomic drying table. The results of REBA's analysis show a score of 9 with a high or high level, meaning there is a high risk of injury so immediate improvement is needed. The results of the design of an ergonomic drying table were then simulated through Inventor software which described the position of the worker's posture when carrying out cracker drying activities with a perpendicular working position. The results of the assessment of the working posture of the worker after the improvement showed a decrease in the risk level from medium to low and negligible.

School-aged children need adequate nutrients that support children's growth and development. Children can learn, play and develop optimally which is supported by nutritious and balanced food intake (Marfuah et al., 2022). School-aged or elementary school (SD) children are easily affected by malnutrition. Several factors that cause nutritional problems in school-aged children include parents' economic difficulties and low intake of nutritious food. Apart from that, parents' lack of awareness of the importance of nutrition, irregular eating patterns, and wrong eating habits also have negative effects related to nutrition (Rahmi, 2020). Apart from that, eating disorders such as anorexia or bulimia are related to social pressure, unhealthy body image and other emotional problems. Therefore, there is a need to increase awareness about the importance of healthy eating patterns, provide access to nutritious food, strengthen nutrition education in schools, and involve parents in supporting good eating habits at home, collaboration between parents, schools and communities as well. plays a role in supporting healthy eating patterns for children (Susanti et al., 2024).  The aim of this service activity is to increase students' knowledge about the importance of optimal nutritional intake in accordance with children's nutritional needs so that it can support optimal growth and development, producing an intelligent and accomplished generation, therefore it is necessary to carry out health promotion efforts in the form of providing education and evaluation to increasing knowledge about nutrition in school-aged children so as to create a healthy, superior and achieving generation.

One of the indicators based on the Sustainable Development Goals (SDGs 2030) is to support welfare and ensure a healthy life for all at all ages with the most important point being to reduce maternal mortality to less than 70 per 100,000 live births and prevent neonatal and toddler mortality rates of at least 12 per 1000 live births and 25 per 1000 live births in toddlers. A study was conducted to determine the effect of giving red guava juice on changes in hemoglobin levels in pregnant women in the third trimester at PMB Debby Deliserdang in 2022. In this study, the sample used was all pregnant women in the third trimester in March to May 2022, totaling 12 people. The study showed that in the intervention group before giving red guava juice, the majority had moderate anemia with a frequency of 8 respondents (66.7%) and a minority were normal with a frequency of 1 respondent (8.3%). Meanwhile, after giving red guava juice, the majority were normal with a frequency of 7 respondents (53.8%) and a minority of moderate anemia as much as 1 respondent (8.3%). The results of the analysis test in this study using Mann Whithney showed a P-Value of 0.022 (P <0.05), namely that there is an effect of giving red guava juice on increasing hemoglobin in pregnant women in the second trimester. Pregnant women, especially pregnant women who experience anemia, are expected to routinely consume red guava juice because if consumed properly, red guava juice has many benefits, especially for pregnant women so that it can meet the nutritional needs required by the body and can maximize iron absorption.