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This research aims to develop liquid organic fertilizer (LOF) made from goat livestock waste and paitan (Tithonia diversifolia) conducted in Makale, Tana Toraja Regency, from March to June 2025. This study aims to determine the response of cucumber plants to the application of LOF derived from the combination of goat livestock waste and paitan plants. Goat livestock waste contains macro nutrients such as nitrogen (N), phosphorus (P), and potassium (K), while paitan plants are green organic materials rich in nutrients and easily decomposed. The combination of both is expected to naturally improve soil fertility and optimally support the growth and yield of cucumber plants. The research method uses a Completely Randomized Design (CRD) with four different LOF concentration treatments and five replications. Parameters observed include plant height, number of leaves, stem diameter, number of flowers, number of fruits, and fruit weight per plant. The LOF production process is carried out through fermentation for 21 days with a ratio of goat livestock waste and paitan of 3:1, and the addition of EM4 as a microorganism activator. This research also aims to evaluate the effectiveness of LOF application on growth parameters (plant height, number of leaves) and yield (number and weight of fruits) of cucumber plants, and compare it with treatments without LOF or with inorganic fertilizers. The results of this research are expected to serve as a reference for local farmers in developing organic fertilizers based on local resources that are environmentally friendly, efficient, and sustainable to increase agricultural productivity in the Tana Toraja region.

Blepharitis or inflammation of the eyelids is one of the common eye diseases, characterized by inflammation of the edges of the eyelids that can cause discomfort, irritation, and even visual disturbances. This disease can be chronic with recurrent symptoms such as red eyes, itching, watering, and the appearance of crust on the eyelashes. Proper and prompt diagnosis is necessary so that medical treatment can be carried out effectively and further complications can be prevented. This study aims to design and build an expert system based on the Fuzzy Logic method in helping diagnose blepharitis. The fuzzy method was chosen because it is able to handle the uncertainty of symptom data that often arises in the medical diagnosis process. This system is developed through the identification of the common symptoms of blepharitis, then processed using the fuzzy membership function to determine the type of disease based on the degree of symptom onset. The output of the system is in the form of the results of the diagnosis of blepharitis along with initial treatment recommendations that can be used as a reference for users. The results of the system test show that the application of fuzzy logic is able to provide diagnosis results that are quite accurate, fast, and easy to understand both medical personnel and the general public. This system is expected to help increase public awareness about the importance of early detection of blepharitis, as well as being a tool in the initial medical decision-making process. However, the limitations of this study lie in the limited amount of data and coverage of the type of blepharitis, so further development is needed, both in expanding the knowledge base, increasing the variety of symptoms, and improving system interaction with users.

Nephrolithiasis, commonly known as kidney stone disease, can be experimentally induced in animal models using ethylene glycol (EG) in combination with ammonium chloride, which closely mimics calcium oxalate stone formation in humans. This condition is associated with significant renal tissue injury, including glomerular atrophy, tubular necrosis, and hyaline droplet accumulation, ultimately impairing kidney function. The present study aimed to investigate the histopathological changes in the kidneys of EG-induced rats and evaluate the nephroprotective potential of combined avocado (Persea americana) and gooseberry (Physalis angulata) leaf extracts. A total of 30 male Sprague Dawley rats were randomly divided into five groups: a standard control (no induction), a negative control (EG-induced without treatment), a positive control (EG-induced and treated with a commercial nephroprotective agent), and two treatment groups receiving the combined extracts at different doses. Nephrolithiasis induction was performed over 28 days, followed by oral administration of the respective treatments. At the end of the experiment, kidney tissues were collected and processed for histological examination using hematoxylin-eosin staining to assess the extent of tissue damage. The negative control group exhibited the most severe histopathological alterations, with hyaline droplet formation reaching 15.0 ± 5.25%. In contrast, extract-treated groups demonstrated a marked reduction in tissue damage, with the most significant improvement observed in the group receiving 300 mg/kg avocado extract and 100 mg/kg gooseberry extract, which recorded hyaline droplet formation of only 5.27 ± 2.74%, a result comparable to that of the standard control group. These findings suggest that the combination of P. americana and P. angulata leaf extracts confers protective effects against EG-induced renal injury. Therefore, this herbal combination may represent a promising natural nephroprotective agent that warrants further investigation in preclinical and clinical settings.

Shrimp shell waste is a potential marine biomass resource rich in bioactive compounds such as astaxanthin and chitin, yet remains underutilized in the livestock sector. This study aimed to evaluate the effect of incorporating shrimp shell meal into duck (Anas sp.) feed rations on the yolk color intensity of duck eggs. The experimental design applied a completely randomized design (CRD) with a single factor and four treatments: D0 (100% rice bran, control), A1 (rice bran + 2% shrimp shell meal), A2 (rice bran + 6%), and A3 (rice bran + 10%), with a 21-day observation period. The primary parameter measured was yolk color intensity, assessed visually using a standardized color scale. The results indicated that the addition of shrimp shell meal significantly enhanced yolk color intensity, with the highest pigmentation observed in the A3 treatment. Astaxanthin, functioning as a natural carotenoid pigment, was biologically absorbed and distributed into the yolk via lipophilic pathways, while chitin supported gut health and nutrient absorption efficiency. This study aligns with the principles of the circular economy by valorizing marine processing waste as a functional feed ingredient. A 10% inclusion rate was found to be visually optimal; however, further studies are required to assess its physiological impacts and economic feasibility in broader production contexts.

The handling of terrorism crimes in Indonesia requires a balance between safeguarding the rights of perpetrators as individuals entitled to human rights and fulfilling the rights of victims affected by such acts of violence. This study aims to evaluate how human rights protections for terrorism suspects are upheld during legal proceedings, as well as how the state strives to protect and rehabilitate victims of terrorism under Law No. 5 of 2018 on the Eradication of Criminal Acts of Terrorism. Using a normative juridical approach, this research analyzes a case study based on the North Jakarta District Court’s Decision No. 1580/Pid.Sus.Terrorism/2020/PN.Jkt.Utr. The findings indicate that terrorism suspects are granted fair legal treatment, including the right to defense, a fair trial, and protection from torture, in accordance with the principle of non-derogable rights under international human rights law. On the other hand, Law No. 5 of 2018 establishes a clearer and more comprehensive legal framework to ensure victims' rights, including rehabilitation, compensation, and restitution. However, the implementation of victim protections still faces various technical and administrative challenges. This study recommends strengthening mechanisms for victim protection and enhancing legal enforcers' awareness of human rights principles in handling terrorism cases.  

Disposal area is an area at an open pit mine that is used as a place to store or dispose of worthless materials. Disposal must also follow the specified safety factor standards, if the disposal design is not safe after being analyzed by a geotechnical engineer, the design must be redesigned to achieve the desired safety factor value. One way to increase the fk value is to make a Counterweight plan in making disposal. Where Counterweight is a fill material that is made with special treatment so that the soil bearing capacity increases which functions to withstand the load on it. Landslides on disposal slopes are one of the serious problems faced in mining activities, especially in areas with vulnerable geological and topographic conditions. PT Jembayan Muarabara, which operates in Marangkayu District, Kutai Kartanegara Regency, East Kalimantan Province, is no exception to this challenge. The A–A’ cross section shows a safety factor value of 1.118 in saturated conditions, which indicates that the slope is at a stable limit and needs to be improved through engineering such as adding counterweights. The B–B’ cross-section has a safety factor value of 2.332, which is included in the safe category and has met the provisions of the ESDM Ministerial Decree No. 1827 K/30/MEM/2018. The C-C’ cross-section has a safety factor value of 1.511, which is included in the safe category and has met the provisions of the ESDM Ministerial Decree No. 1827 K/30/MEM/2018.

This study examines the causes and impacts of hazardous and toxic waste (B3) spills in Bekasi Regency, West Java. B3 waste such as used oil, batteries, and heavy metals can pollute the environment and harm public health. Key causes include lack of treatment facilities, violations of disposal procedures, and weather factors like flooding. The research uses normative legal approaches. The findings of this study underscore the necessity of managing hazardous waste in compliance with established regulations, enforcing environmental laws rigorously, and ensuring active involvement from both government institutions and the public in monitoring efforts. The application of the strict liability principle is considered highly important in providing a deterrent effect against polluters through legal accountability.

Acute Otitis Media (AOM) is a common middle ear infection in children, particularly in rural areas. This study aims to explore the clinical characteristics of AOM in children treated at rural health centers (puskesmas) and to examine the barriers to effective management. A descriptive qualitative method was employed through a literature review analyzing symptoms, stages, risk factors, and treatment approaches. The findings reveal that AOM in children often begins with an upper respiratory tract infection and presents with sudden ear pain, high fever, sleep disturbances, and ear discharge. Risk factors include young age, poor environmental conditions, and limited access to healthcare services. Management of AOM depends on its clinical stage and requires accurate diagnosis. However, in rural puskesmas, a lack of diagnostic tools and limited public awareness often leads to delayed treatment. Therefore, it is essential to provide health workers with basic ENT training, ensure the availability of diagnostic equipment, and educate parents to enable early detection and prevent complications that could affect a child’s development.

Cervical cancer is a significant public health problem globally, including in Indonesia. This disease ranks fourth as the most common cancer in women in the world, with an estimated 604,000 new cases and 342,000 deaths in 2020. Analyzing the current condition of cervical cancer in Indonesia including prevalence, risk factors, impacts, prevention efforts, and treatment based on data to provide a comprehensive picture of the situation of cervical cancer in Indonesia. Cervical cancer is defined as a malignant tumor in the cervix that attacks the epithelial layer and has the potential to spread. Human Papilloma Virus (HPV) infection is the main cause of cervical cancer. In addition, several supporting risk factors include risky sexual behavior, long-term use of oral contraceptives, smoking habits, nutritional deficiencies (especially vitamins C, E, and folic acid), and poor personal hygiene. The Indonesian government has attempted to identify the disease early through the Visual Inspection of Acetic Acid (IVA) method used for early detection of cervical cancer in women aged 30 to 50 years. However, community participation in this program still needs to be improved sustainably. Treatment for cervical cancer can include surgery (eg cryosurgery, LEEP, hysterectomy), radiation, and chemotherapy. Cervical cancer remains a major health challenge in Indonesia. Improved education programs, participation in early detection of IVA, and strengthening of the health system as a whole are needed to effectively reduce morbidity and mortality caused by this disease.

Increasing the growth of tilapia can be done by improving the quality of feed by adding multivitamins in the right amount. The purpose of this study was to determine the right dose of multivitamins for the growth and feed conversion ratio of nirvana tilapia (O. niloticus) in the biofloc system. This study was conducted from February to April 2024. This study used nirvana tilapia seeds measuring 4-5 g, with 5 treatments and 4 replications, namely 0 ml / kg of feed (control), 10 ml / kg of feed, 20 ml / kg of feed, 30 ml / kg of feed, 40 ml / kg of feed. The data was analyzed first using normality and homogeneity tests, then the data was analyzed using the analysis of variance test and the Least Significant Difference (LSD) further test. The results of the study showed a significant effect of multivitamin doses on the growth and feed conversion ratio of nirvana tilapia in the biofloc system, the optimal dose of multivitamins on the growth and feed conversion ratio of nirvana tilapia in the biofloc system was 40 ml/kg of feed with an absolute weight of 6.38 g, a specific growth rate reaching 1.53% and a feed conversion ratio of 1.08.

Agricultural waste such as pineapple crown leaves (Ananas comosus) has not been optimally utilized, despite its high cellulose fiber content, making it a potential alternative raw material for paper production. One of the main challenges in this process is controlling the paper's moisture content, as excessive water content can reduce product quality. This study aims to investigate the effect of sodium hydroxide (NaOH) concentration on the moisture content of paper made from pineapple crown leaf fibers. Three NaOH concentrations (2%, 8%, and 14%) were applied during the pulping process to remove lignin and hemicellulose, followed by gravimetric analysis of the resulting paper’s moisture content. The results showed that the 8% NaOH treatment produced the lowest moisture content of 8.35%, while the 2% NaOH treatment resulted in the highest moisture content of 10.34%. One-way ANOVA indicated that variations in NaOH concentration had a statistically significant effect on moisture content (p < 0.001). The findings revealed a non-linear relationship between NaOH concentration and moisture content, with 8% being the optimal point. A lower concentration resulted in dense fiber structures that retained water, while a higher concentration led to the formation of cellulose II, which is more hygroscopic. This study highlights the importance of optimizing NaOH concentration in paper production from agricultural waste to achieve the best quality.

A common mental health problem affecting millions of women all around is anxiety before pregnancy and after delivery. Untreated, it might cause early deliveries, reduced birth weights, bad infant bonding, and children's long-term developmental difficulties. Many mothers choose natural cures than from drugs for safety worries relating to their children. Recent research on non-drug approaches to lessen anxiety in pregnant women and new mothers is examined in this review. Focusing on multiple non-drug treatments, a comprehensive search was conducted in PubMed and Google Scholar. The results indicate that yoga and mindfulness-based stress reduction measures practically reduce anxiety. For treating anxiety, non-drug treatments are safe choices that healthcare professionals should integrate into maternal care. More research is needed for consistent methods and long-term studies to support clinical practices.

Malaria remains a significant public health issue in Indonesia, particularly in endemic areas such as Keerom Regency, Papua. Efforts to control this disease face challenges due to Plasmodium resistance to synthetic drugs, highlighting the need for safer and more effective alternative treatments. This study aims to identify the secondary metabolite content of several local plants traditionally used as antimalarial remedies. An experimental laboratory study was conducted using phytochemical screening methods. The plants examined included turmeric rhizome (Curcuma longa), meniran leaves (Phyllanthus niruri), papaya leaves (Carica papaya), sambiloto (Andrographis paniculata), and brotowali (Tinospora crispa). Extraction was carried out using the maceration method with 96% ethanol as the solvent. The results showed that all samples contained secondary metabolites such as flavonoids, alkaloids, tannins, and saponins, which are known for their antiplasmodial activity. Extract yields ranged from 18% to 24%, with turmeric rhizome showing the highest yield. These findings suggest that local plants from Keerom Regency hold potential as raw materials for the development of herbal antimalarial drugs. This study serves as a preliminary step for further in vitro and in vivo bioactivity testing.

Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis. Indonesia is one of the countries with the highest number of TB cases in the world. The key to successful TB treatment is treatment adherence. One factor that influences treatment adherence is stigma, which can result in incomplete treatment. This study aimed to determine the relationship between stigma and adherence to pulmonary TB treatment in the city of Lhokseumawe. The research method used was descriptive correlational with a cross-sectional approach. The sampling method was quota sampling with a sample size of 83 pulmonary TB patients. Data were filled in by filling out the Internalized Stigma of Mental Illness (ISMI) scale and Morisky Medication Adherence Scale (MMAS-8) questionnaires, and the data were analyzed using the Spearman correlation test (p = 0.05). The results of the bivariate test of age, gender, last education, occupation, and PMO did not have a relationship with adherence to pulmonary TB treatment, with a p value> 0.05. However, the duration of treatment had a relationship with the level of adherence to pulmonary TB treatment, with a p-value = 0.008. The study's results also showed that stigma and treatment compliance did not have a significant relationship, with p-value = 0.197. It was concluded that there was no relationship between stigma and compliance with pulmonary TB treatment. Health services in Lhokseumawe City are expected to continue to provide education and motivation to pulmonary TB patients to comply with their treatment.

Venous Thromboembolism (VTE) is a common complication in cancer patients. The treatment of VTE in cancer patients involves anticoagulant therapy using Vitamin K Antagonists (VKAs), including warfarin. VTE can be managed with warfarin administration, typically preceded by bridging therapy with heparin. The objective of this literature review is to examine and analyze studies related to the impact of warfarin use on cancer risk. The review was conducted on articles published in English over the past 10 years (2013–2024) using electronic databases such as Google Scholar and PubMed. The findings suggest that warfarin may be associated with improved overall survival in cancer patients and may have protective effects against certain types of cancer. Warfarin may exhibit antineoplastic properties through mechanisms both dependent on and independent of coagulation pathways, the latter mediated by the inhibition of the GAS6-AXL signaling pathway.  

The legal mechanism of bankruptcy relies on the concept of debt, because the absence of debt undermines the fundamental purpose of bankruptcy as a legal institution to liquidate the debtor's assets to satisfy creditors' claims. Debt is the main criterion that must be met in order to be able to apply for bankruptcy, along with additional provisions such as having two or more creditors, as stipulated in Article 2, paragraph (1) of Law Number 37 of 2004 concerning Bankruptcy and Suspension of Debt Payment Obligations (Bankruptcy Law). Notaries who have completed the bankruptcy process and are undergoing rehabilitation to improve their good name cannot re-apply to become Notaries. Here, the Notary will lose his/her right to work to carry out his/her position simply because the Notary has or has been sentenced to bankruptcy by the court. This bankruptcy is simply the notary's inability to pay the debt owed to the creditor, not a criminal act. If associated with the provisions contained in the 1945 Constitution of the Republic of Indonesia, namely Article 28 letter d concerning Human Rights which explains that everyone has the right to work and receive fair and proper compensation and treatment in employment relations, the efforts made in this problem are handled in accordance with the law and will be a substantial obligation for the curator. Based on Article 1 number 5 (Law Number 37 of 2004 concerning Bankruptcy and Suspension of Debt Payment Obligations), it states that a curator is an individual or an estate office appointed by the court to resolve and manage all problems of the bankrupt debtor's assets under the supervision of a supervising judge based on applicable laws. The citation of the law shows the clear jurisdiction of the curator over the debtor's property and assets.

Eating problems in children refer to various behaviors or conditions that interfere with a child's ability to consume food properly. This can include refusal of certain foods, difficulty chewing or swallowing, and unhealthy eating habits. Eating problems in children are not a focus in everyday life, so they become an ignored problem. The presence of eating problems in children has an impact on nutritional status and health in the future. Even eating behaviors that have been patterned since childhood can continue into adolescence and even adulthood. Parental eating habits and strategies used in feeding are dominant determinants of children's eating behavior and food choices. Therefore, examining eating problems in children is important to do because this problem can affect the growth and development of children if not handled properly so that fast and appropriate treatment is needed.

prevalent Intrapersonal intelligence is a person's ability to understand himself. Intrapersonal intelligence can be developed through puzzle play. Puzzle is a game consisting of pieces of one 2 particular image. intrapersonal intelligence that is developed through playing puzzles, namely the ability to be responsible and the ability to obey the rules. The formulation of the problem in this study is whether children's intrapersonal intelligence can develop through puzzle-playing activities at the RA Annajamissa’adah. The purpose of this study was to determine the development of intrapersonal intelligence of children through playing puzzles in the RA Annajamissa’adah. The research approach used is a qualitative approach using the experimental method. The subjects of this study were 5 children aged 4-5 years, all of whom were male. Data collection techniques used were the initial observation (pretest) and final observation (posttest). The initial observation is carried out before the treatment is given using a media puzzle and the final observation is carried out after the treatment is given. The results of the study showed that 4 out of 5 people were capable of being responsible, and the ability to obey the rules reached a value of 3 out of 4 values, namely with the statement of DAE (Developing According to Expectations). Thus the intrapersonal intelligence of children. aged 4-5 years in the RA Annajamissa’adah Regency can develop through puzzle play.

Dessert as a dessert, which is part of culinary in various cultures. Dessert is not only a dessert, but also reflects creativity and innovation in the culinary field. This study aims to analyze the comparative level of adding vannamei shrimp (Litopeaneus Vanname) to the cold dessert formulation on sensory properties (color, aroma, texture, and taste) and chemical composition (protein content and fat content). The study was conducted experimentally using a Completely Randomized Design (CRD) with three treatments of adding vannamei shrimp, namely 10% (A1), 20% (A2), and 30% (A3). The results of the organoleptic test showed that treatment A1 (10% shrimp addition) gave the best value on all sensory parameters, with an aroma value of 4.3 (like), taste 4.7 (like), texture 4.2 (like), and color 4.2 (like). Chemical analysis showed that treatment A1 produced a protein content of 4.21% and a fat content of 8.46%. The addition of vannamei shrimp to the cold dessert formulation is an attractive taste innovation for consumers. This study concludes that the addition of vannamei shrimp to cold dessert formulations can be an attractive alternative to improve the quality and nutritional value of products, as well as meet the growing needs of consumers.

This study investigates doctor–patient communication strategies in overcoming verbal and non-verbal language barriers within the Pain Clinic of RSUD Genteng Banyuwangi, a public hospital in East Java, Indonesia. Pain clinics pose unique communicative challenges, as patients often struggle to express their discomfort clearly due to limited health literacy, cultural norms, or emotional inhibitions. This research aims to identify and analyze the communicative methods employed by doctors to facilitate accurate information exchange and build therapeutic rapport with patients experiencing chronic pain. Utilizing a qualitative approach, this study applies Conversation Analysis (CA) to naturally occurring doctor–patient consultations recorded through non-intrusive video methods. Verbal and non-verbal interactions were transcribed and analyzed to uncover recurring communicative patterns. The data were interpreted through sociolinguistic and pragmatic lenses to account for the local language diversity and cultural context of Banyuwangi. Findings reveal that doctors employ multiple strategies to clarify meaning and adapt communication: repetition, strategic questioning, utterance correction, and linguistic adaptation. Additionally, doctors interpret and respond to patients' non-verbal cues, including vocal tone, facial expressions, and body gestures, to supplement incomplete verbal communication. These strategies not only enhance diagnostic accuracy but also promote empathy, trust, and patient-centered care. The study concludes that effective communication in pain clinics must account for linguistic diversity, cultural sensitivities, and emotional dynamics. Adaptive and empathetic communication fosters better understanding, reduces the risk of diagnostic error, and improves treatment outcomes. The findings offer practical implications for clinical training and healthcare policy, particularly in multicultural and linguistically diverse settings.