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Thalassemia is a genetic disorder characterized by impaired hemoglobin synthesis. This disease is caused by mutations in the globin gene, leading to disrupted production of globin chains. As a result, the red blood cells produced are dysfunctional and have a shorter lifespan, causing anemia. This condition requires proper medical management, including blood transfusions and other treatments. One way to detect and monitor the progression of thalassemia is by using biochemical markers that can identify changes in the patient’s body. Therefore, the aim of this systematic literature review is to identify biochemical markers that can be used for the diagnosis and monitoring of thalassemia. The literature used in this study includes articles on human thalassemia research published in the last 10 years. Literature searches were conducted in several academic databases using relevant keywords such as “biochemical markers for thalassemia,” “diagnosis of thalassemia,” and “thalassemia monitoring.” Based on the search results, several biochemical markers related to thalassemia were identified, including hepcidin, ferritin, and lipid profile. Ferritin plays a role in monitoring iron levels, which are often elevated in thalassemia patients, while hepcidin regulates iron homeostasis in the body. Additionally, other components involved in thalassemia diagnosis and monitoring include Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), and hemoglobin levels. The findings of this systematic literature review are expected to provide a comprehensive overview of biochemical markers that can be used in the diagnosis and monitoring of thalassemia. By identifying relevant markers, it is hoped that more accurate and effective diagnostic methods will be developed in the future, leading to better monitoring of thalassemia patients.

Background: Anemia during pregnancy remains a major public health concern in Indonesia, contributing to increased maternal and fetal morbidity. Iron supplementation often faces challenges in compliance and side effects, prompting the need for natural alternatives. Natural honey has been shown to help increase hemoglobin levels due to its iron, folate, and antioxidant content. Objective: This community service aimed to educate pregnant women on the benefits and utilization of natural honey as a complementary strategy to prevent anemia. Method: The activity was conducted at PMB CH Mala in Palembang City using health education sessions, demonstrations, and distribution of printed educational materials. Participants' knowledge and hemoglobin levels were assessed pre- and post-intervention using a questionnaire and digital hemoglobinometer. The intervention lasted for 2 weeks, with honey consumption recommended at 2 tablespoons daily. Results: There was a notable improvement in participants' knowledge about anemia and the role of honey. Preliminary observations also showed a slight increase in hemoglobin levels among pregnant women who regularly consumed honey during the intervention period. Conclusion: Educational intervention on the use of natural honey proved effective in improving knowledge and potentially supporting anemia prevention among pregnant women. Further studies are recommended to evaluate long-term outcomes and larger-scale implementation.

Iron-deficiency anemia during pregnancy remains a major public health concern in developing countries. This study aims to evaluate the effectiveness of iron and folic acid supplementation, known as iron tablets, in reducing the risk of anemia among pregnant women. A descriptive qualitative literature review method was employed by analyzing nine eligible studies published between 2013 and 2023. Articles were selected from databases including Google Scholar, PubMed, and ScienceDirect using specific keywords. The findings suggest that regular consumption of iron tablets, particularly starting in the second trimester and meeting the minimum recommended dose of 90 tablets, is effective in improving hemoglobin levels and lowering anemia prevalence. However, compliance remains a significant challenge, influenced by side effects, maternal knowledge, and social support. The review highlights the need for behavior-based interventions and family involvement to enhance adherence. The implication of this review supports the integration of targeted health education and follow-up strategies within antenatal care services to reduce anemia-related risks in pregnancy.

Chronic Kidney Disease (CKD) is a major global health issue that can lead to serious complications and long-term medical care. This study aims to identify key clinical factors associated with CKD status using binary logistic regression analysis. The dataset, obtained from Kaggle, contains 400 patient records with various clinical and demographic attributes. The dependent variable is CKD status (positive or negative), while the independent variables include age, blood pressure, hemoglobin level, urine albumin level, and serum creatinine. Initial analysis involved descriptive statistics and multicollinearity checks, followed by model estimation and evaluation using likelihood ratio and Wald tests. The final model identified four significant predictors: blood pressure, hemoglobin, urine albumin, and serum creatinine. The model achieved a high classification accuracy of 95.50% and an Area Under the ROC Curve (AUC) of 98.78%, indicating excellent predictive performance. These results highlight the importance of these clinical indicators in early CKD detection and support their use in risk assessment models for kidney disease screening Keywords: Chronic Kidney Disease, Binary Logistic Regression, Likelihood Ratio Test, Wald Test, Classification Accuracy

Type 2 diabetes mellitus (T2DM), hypertension, anemia, nephrotic syndrome, and urinary tract infection (UTI) are interrelated clinical conditions frequently encountered in patients with chronic kidney disease (CKD). This case report presents a 33-year-old woman who was admitted with complaints of generalized weakness, accompanied by headache, generalized edema, and pruritus. Laboratory findings revealed hyperglycemia (>300 mg/dL), elevated blood pressure (210/120 mmHg), increased urea and creatinine levels, 2+ proteinuria, and microcytic hypochromic anemia (hemoglobin ranging from 7.9 to 9.9 g/dL). Urinalysis showed leukocyturia, hyaline casts, and bacteriuria. The patient was diagnosed with uncontrolled T2DM, hypertensive urgency, microcytic hypochromic anemia, nephrotic syndrome, and UTI. Management included basal-bolus insulin regimen, combined antihypertensive therapy, packed red cell transfusions, and supportive treatments. Throughout the hospitalization, improvements were observed in hemoglobin levels and blood pressure, although subjective symptoms such as fatigue and headache remained fluctuating. This case highlights the importance of comprehensive and multidisciplinary management in patients with complex multisystem chronic conditions to prevent complications and improve clinical outcomes.

Iron deficiency anemia (ADB) is anemia that arises due to reduced iron supply for erythropoiesis, due to empty iron stores (depleted iron stores) which ultimately results in reduced hemoglobin formation. This study aims to determine the effect of giving blood supplement tablets on HB levels in female students suffering from anemia at SMAN 1 Tambakboyo, Tuban Regency. The research design used a pre-experiment using a one group pre test post test approach, with a total sampling technique on a population of 34 female students suffering from anemia in class X and analyzed using the Wilcoxon test. The instruments in this research were Standard Operating Procedures (SOP), hemoglobin level observation sheets and Easy Touch GCU brand hemoglobin measuring equipment. The results of the study showed that the average HB level before 10.17 g/dl and after 15.46 g/dl given blood supplement tablets was normal. The results of the Wilcoxon test obtained a significant value of p=0.000 (p<0.05), which means that there was a significant difference in the HB levels of class X female students before and after being given blood supplement tablets. Health workers, especially in school health offices, should provide blood supplement tablets at the right time so that female students can take the blood supplement tablets regularly and finish them.

The third trimester of pregnancy is a critical period with increased risks of obstetric complications, necessitating adequate knowledge of pregnancy danger signs. The Pregnant Women's Class (Kelas Bumil) is a preventive and educational initiative in antenatal care designed to enhance knowledge and preparedness among pregnant women. This study aimed to assess the impact of the Pregnant Women's Class on the knowledge of pregnancy danger signs and changes in hemoglobin levels among third-trimester pregnant women. Using a quasi-experimental pretest-posttest design, the study involved 30 pregnant women selected through purposive sampling. Knowledge was assessed via structured questionnaires before and after attending the class, while hemoglobin levels were measured at both intervals. Univariate and bivariate analyses were conducted, with the Wilcoxon test used for comparing pre- and post-intervention data (p < 0.05). Results revealed a significant increase in knowledge levels, with most women showing good knowledge after the intervention. Hemoglobin levels also improved significantly (p = 0.001). These findings demonstrate that the Pregnant Women's Class effectively enhances both cognitive knowledge and health status in pregnant women. In conclusion, strengthening and sustaining the Pregnant Women's Class should be a continuous part of integrated antenatal care to improve maternal health outcomes.

Anemia is a common nutritional problem that occurs in vulnerable groups such as pregnant women and teenage girls. One of its main causes is iron deficiency, which can be exacerbated by low vitamin C intake. Red guava (Psidium guajava L.) is a local fruit that is rich in vitamin C and has the potential to improve iron absorption, thus supporting an increase in hemoglobin levels. This study aims to review the effectiveness of red guava in increasing hemoglobin as an effort to prevent anemia. This study uses a literature review design on five experimental research articles published in the last 10 years. The study results show that the consumption of red guava, whether consumed alone or in combination, can significantly increase hemoglobin levels in pregnant women and adolescent girls with anemia. The vitamin C content in red guava plays a role in enhancing the bioavailability of iron needed for hemoglobin formation. Thus, red guava has the potential to be used as part of a locally based food nutrition intervention that is effective, affordable, and applicable in the effort to prevent anemia.

Anemia is a medical condition characterized by a decrease in the number of red blood cells (erythrocytes) or hemoglobin (Hb) levels in the blood which results in impaired oxygen transport to body tissues. Mild anemia is more common and is asymptomatic and does not require treatment. Anemia can have a negative impact on endurance, productivity, and is high risk during pregnancy because it can affect fetal growth and development, increase the risk of pregnancy and childbirth complications, and even maternal and child death. The Community Service (PKM) activity carried out at the Asisi Church, Tebet District aims to increase public awareness of the importance of early detection of anemia through hemoglobin and hematocrit screening activities. This activity uses the Plan-Do-Check-Act (PDCA) approach which includes capillary blood tests with Point-of-Care Testing (POCT) tools and education about symptoms, risk factors, and prevention of anemia. Of the 68 participants involved, 40 people (58.82%) were identified as having anemia, while 28 people (41.18%) had normal hemoglobin levels. These results emphasize the importance of early anemia screening to prevent long-term complications and build public awareness of the importance of maintaining optimal hemoglobin levels to support ongoing health and quality of life.   Keywords: Anemia, Early Detection, Hemoglobin, Hematocrit, Screening

Anemia is a common complication in cancer patients, especially in advanced stages, which affects quality of life and response to therapy. This study aims to analyze the relationship between cancer stage and hemoglobin (Hb) levels in female patients undergoing chemotherapy. This quantitative study used a cross-sectional design and involved 54 female cancer patients at the H. Adam Malik General Hospital Polyclinic, Medan. The sampling technique used convenience sampling. Data were analyzed using the Spearman's rho test to determine the relationship between cancer stage and Hb levels. The majority of respondents were in stage 3 (48.1%) and stage 4 (37.0%), with 63% experiencing moderate anemia (Hb 8–10 g/dL). The results of the Spearman test showed a significant positive correlation between cancer stage and Hb levels (r = 0.683; p = 0.000), indicating that the more advanced the cancer stage, the lower the hemoglobin levels tend to be. It was concluded that there was a significant relationship between cancer stage and hemoglobin levels in female patients. These results emphasize the importance of monitoring Hb levels in clinical management and nursing care of cancer patients, especially in advanced stages.

Anemia in pregnancy is a condition where the hemoglobin (Hb) level in the blood is less than normal and the hemoglobin (Hb) level in the mother has decreased from the normal Hb level, namely 11 g/dI. One of the main and common causes of anemia in pregnant women is a lack of nutrients. Iron in the body is caused by a lack of food sources that contain sufficient iron, but food sources that have low iron content, so that less iron is absorbed. Apart from the lack of food containing iron, routine antenatal care also influences the occurrence of anemia in pregnant women. Effective antenatal care provides a solid foundation for midwives to first assess the needs of pregnant women and families. The aim of this study was to analyze the relationship between diet and regular antenatal care with the incidence of anemia in pregnant women in the working area of the Maron Community Health Center. The design of this study was cross sectional. The population in this study were all pregnant women who were in the working area of the Maron Community Health Center, totaling 79 respondents. The research sample included 44 respondents of pregnant women who were in the working area of the Maron Public Health Center. With random sampling technique. The instruments used were questionnaires and KIA books. The research results show that almost all anemic pregnant women have poor eating patterns and irregular antenatal care. Based on the chi square statistical test, it is known that the P value is 0.000 α 0.05, so HO is rejected and HI is accepted that there is a relationship between diet and antenatal care with anemia in pregnant women in the working area of the Maron Community Health Center. It is hoped that the results of this research can be used to increase insight into health science, especially midwifery, that a good diet and regular antenatal care are very necessary to prevent risks that will occur during childbirth.

Hemoglobin and hematocrit levels are fundamental hematological screening parameters that are relevant for identifying potential erythropoiesis disorders. An imbalance in these two parameters often reflects undiagnosed anemia, especially in adults and the elderly. The activity was carried out at the Cengkareng Baptist Foundation using the Plan–Do–Check–Act (PDCA) approach. The examination was carried out using the capillary method based on Point-of-Care Testing (POCT). Nutrition education was provided using leaflets containing information about the importance of micronutrients for blood formation. A total of 62 participants took part in this activity, with an age range of 23–76 years. Most participants were female (74.2%). Hemoglobin values ​​ranged from 7.4 to 17.3 g/dL, with a median of 11.9 g/dL. A total of 64.5% of participants had anemia. Hematocrit values ​​ranged from 22.0 to 51.0%, with a median of 35.0%. The high prevalence of anemia identified through this screening underscores the importance of preventive efforts through targeted nutritional education. Emphasis should be placed on the adequate intake of iron, vitamin B12, and folate to promote behavior change and reduce anemia risk in the community.

Mild anemia in pregnant women remains a common health problem at the primary healthcare level and may negatively affect both maternal health and fetal development. One non-pharmacological approach to managing anemia is the utilization of local food sources rich in iron, such as spinach. This study aimed to determine the effectiveness of spinach extract in increasing hemoglobin levels among pregnant women with mild anemia at Poskesdes Wiritasi. This study employed a quasi-experimental design using a one-group pretest–posttest approach without a control group. The sample consisted of 30 pregnant women diagnosed with mild anemia who were selected through purposive sampling. The intervention involved the regular administration of spinach extract for 14 consecutive days. Hemoglobin levels were measured before and after the intervention using a standard hemoglobin testing device. Data were analyzed to assess differences in hemoglobin levels before and after the intervention. The results showed a significant increase in hemoglobin levels following the administration of spinach extract. These findings indicate that spinach extract has a positive effect on improving hemoglobin levels in pregnant women with mild anemia. Therefore, spinach extract may serve as an effective, safe, and easily applicable local food–based nutritional intervention for the prevention and management of mild anemia among pregnant women at the village healthcare level.

Anemia is one of the most common health problems among pregnant women and remains a major challenge in midwifery services. Anemia in pregnancy is primarily caused by iron deficiency, which leads to decreased hemoglobin levels and poses a risk of impaired fetal growth as well as an increased likelihood of delivery complications. Anemia in pregnant women is also one of the contributing factors to the high maternal and neonatal mortality rates (Ministry of Health of the Republic of Indonesia, 2022). This study aimed to determine the effect of iron (Fe) supplement consumption patterns on the risk of anemia among pregnant women at BPM Aida Nospita, Manunggal Village, Labuhan Deli Subdistrict, Deli Serdang Regency, North Sumatra Province, in 2025. This research employed a quantitative design with a descriptive correlational approach. The population of this study comprised all pregnant women attending BPM Aida Nospita in Manunggal Village, Labuhan Deli Subdistrict, Deli Serdang Regency, North Sumatra Province, totaling 45 participants. The results of the analysis indicated a significant relationship between the pattern of iron (Fe) supplement consumption and the risk of anemia in pregnant women (p = 0.000).

Anemia in the elderly often occured chronically. Attention to anemia in the elderly is very lacking compared to women of childbearing age. The condition of the elderly is usually degenerative and food intake decreases, causing the condition of their body protein to decrease. Albumin protein in the elderly is still very much needed to affect the brain, bone and muscle mass, immune system, metabolism, and health of hair, skin, and nails. The purpose of utilizing local wisdom materials in the form of a combination of moringa leaf powder and snakehead fish has social and economic impacts. The elderly who have received this nutrition will improve their health. The activity method is the lecture method, discussion and coercion, and is applied directly by giving drinks to the elderly. Results of community service activities. The elderly experienced an increase in Hemoglobin after being given a combination of moringa leaf powder and snakehead fish by an average of 2 gr% and blood protein of 1.1 g dl before and after being given a combination of moringa leaf powder and snakehead fish.

Anemia during pregnancy remains a widespread public health issue, especially due to iron deficiency. The purpose of this study was to explore the relationship between maternal age, number of antenatal care (ANC) visits, and compliance with iron supplement intake with the incidence of anemia among pregnant women at Turi Health Center in Lamongan Regency. This research employed a cross-sectional approach involving 55 pregnant women who were chosen using a multistage random sampling technique. Information was collected through interviews and hemoglobin level measurements conducted using a digital hemoglobin meterThe results indicated that 69.1% of the participants belonged to the non-risk age category, 34.5% exhibited moderate adherence to iron tablet intake, and 60% were found to be anemic. Statistical analysis revealed a significant correlation between maternal age (p = 0.004), number of ANC visits (p = 0.014), and compliance with iron supplement tablets (p = 0.000) with the level of anemia. This indicates the presence of a statistically significant association between maternal age, frequency of ANC visits, and level of compliance with iron supplement tablet consumption related to the incidence of anemia in pregnant women. Therefore, pregnant women are advised to have frequent ANC and consume iron supplement regularly to prevent anemia.

Anemia juga diartikan sebagai suatu kondisi ketika tubuh kekurangan sel darah merah, dan dapat terjadi pada semua kelompok usia. Prevalensi anemia di kalangan remaja usia 15–24 tahun tercatat sebesar 15,5%. Jika dirinci berdasarkan jenis kelamin, prevalensi anemia pada remaja putri (rematri) mencapai 18%. survei yang dilakukan oleh Dinas Kesehatan DIY pada tahun 2018 terhadap 1.500 remaja putri di lima kabupaten dan kota menunjukkan bahwa 19,3% dari mereka mengalami anemia, yang ditandai dengan kadar hemoglobin di bawah 12 g/dl. Remaja atau santriwati di Pondok Pesantren Harun Asy-Syafi’i diperoleh informasi dan data sebanyak 92% remaja putri pernah mengalami gejala-gejala anemia. Bahkan pernah ada remaja putri di pondok pesantren ini yang dirujuk ke fasilitas kesehatan karena mengalami anemia. Tujuan pengabdian adalah remaja putri di Pondok Pesantren harun Asy-Syafi’i mengetahui tentang pecegahan anemia. Metode yang digunakan adalah memberikan sosialisasi atau edukasi tentang pencegahan anemia. Jumlah subyek kegiatan adalah 87 orang. Evaluasi dilakukan dengan memberikan pertanyaan tentang materi yang telah disampaikan. Hasil yang diperoleh adalah pengetahuan tentang pencegahan anemia pada remaja putri di Pondok Pesantren Harun Asy-Syafi’i semakin meningkat setelah diadakannya kegiatan pengabdian kepada masyarakat berupa sosialisasi tentang pencegahan anemia

Overview: Normal Hemoglobin levels during pregnancy are very important in preventing anemia and complications that can occur during pregnancy. Moringa capsules contain iron, vitamin C, and antioxidants that can support the absorption of iron in the body, Fe tablets that support oxygen transport and the formation of red blood cells. Objective: Analyzing the effect of giving moringa leaf capsules and iron tablets on hemoglobin levels in pregnant women. Research Method: This study used a Quasi-experimental design method. This study was conducted in the Ambal II Kebumen Health Center Working Area with a sample of 30 respondents. In this study, 2 groups were used, namely those who received intervention (moringa leaf capsules and Fe tablets) and the control group (Fe only). Data analysis using the Wilcoxon test. Research Results: Showed that there was a difference in Hemoglobin levels in the Moringa leaf and Fe groups with a p value = 0.008 and as many as 14 pregnant women experienced an increase in Hb. While in the control group the analysis results showed a difference with a p value = 0.007. However, as many as 13 mothers experienced a decrease in Hb levels. Conclusion: giving moringa capsules and Fe tablets has better effectiveness in increasing Hb levels compared to just Fe tablets alone.

Chronic disease caused by increased blood sugar levels and potentially causing many complications especially when uncontrolled conditions are known as diabetes mellitus. Glycosylated hemoglobin examination is a reliable method in evaluating long-term glycemic control because it is not affected by daily fluctuations and reflects glucose levels for 120 days. The province with the 10th highest number of diabetes mellitus cases in 2018 was Aceh. One of the districts in Aceh, namely North Aceh, is the area with the highest incidence of cases. This study aims to describe HbA1c levels and characteristics of type 2 diabetes mellitus patients at Cut Meutia Regional Hospital, North Aceh in 2023. Using a descriptive cross-sectional design, 77 patients were selected through purposive sampling. Data were collected from laboratory results and MMAS-8 and MIAS-8 questionnaires. The results showed that most patients had uncontrolled HbA1c levels (90.9%), uncontrolled HbA1c men (91.7%), 56–65 years old (40.3%), had pre-hypertension blood pressure (83.1%), and medication compliance in the moderate category (54.5%). This can be concluded that cases of diabetes with uncontrolled glycosylated hemoglobin levels are men.

Anemia is a hematological disorder that is often not recognized in the adult age group. One lifestyle factor that can affect hemoglobin and hematocrit levels is the consumption of tea or coffee with meals, because the tannin and polyphenol content inhibits the absorption of non-heme iron. Early detection of hemoglobin and hematocrit levels accompanied by education about eating and drinking habits is an important strategy in preventing anemia. This screening activity is carried out using the Plan-Do-Check-Act (PDCA) approach. Examination of hemoglobin and hematocrit levels is carried out using Point-of-Care Testing (POCT) from capillary blood. Education is provided to all participants through leaflets and group counseling regarding the effect of tea and coffee consumption on iron absorption. A total of 91 participants took part in this activity, consisting of 39.6% men and 60.4% women, with an average age of 47.4 years. The average hemoglobin was recorded at 11.2 ± 1.6 g/dL and hematocrit at 33.0 ± 4.7%. As many as 42.9% of participants experienced anemia based on hemoglobin levels below normal values ​​according to gender. Hemoglobin and hematocrit examinations successfully identified a significant proportion of individuals at risk of anemia. Education on the right time to consume tea or coffee and increasing consumption of foods rich in iron and vitamin C are preventive interventions that can be applied to maintain optimal hematological status.   Keywords: Hemoglobin, Hematocrit, Anemia, Iron, Tea, Coffee, Diet