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Abdul Hamid; Nurlaila Agustikawati; Lina Eta Safitri

Jurnal Pelayanan dan Pengabdian Masyarakat Indonesia (JPPMI) 2026 Sekolah Tinggi Ilmu Administrasi Yappi Makassar

Complications of Diabetes Mellitus often arise and without being realized have developed to cause acute and chronic complications that make it difficult for DM sufferers to maintain their condition and will affect the condition of DM sufferers that impact the quality of life of sufferers. Consuming too many carbohydrates causes insulin in the body to work extra, so that the insulin's ability to work in the body will be reduced, which can cause blood sugar to rise. Nutritional therapy can be done by replacing carbohydrate intake with tubers that are low in glucose levels, one of which is Ganyong and pharmacological therapy through herbal medicines, one of which is sentalo leaf tea which is easily obtained and inexpensive. The objectives of this community service activity are to improve the knowledge, skills and quality of service of partners in the implementation of family posyandu related to DM. The method used is empowering posyandu groups through educational activities and training. The results of this activity show an increase in knowledge and skills of partners before and after the community service activity was carried out. And an increase in visits to the posyandu after the implementation of PMT using ganyong flour as the raw material.

Eliyunus Gulo; Esra Siahaan; Dian Lumbantobing; Josep Harianja; Josua Simatupang +1 more

Coram Mundo : Jurnal Teologi dan Pendidikan Agama Kristen 2026 Sekolah Tinggi Teologi Injili Arastamar (SETIA) Ngabang

This study aims to overhaul the conventional understanding of tourism through a missiological lens, by positioning social interactions at the Parbubu Tarutung Soda Water Tourism Object as the locus of Missio Dei (God's Mission) manifestation. Amidst the tendency of modern humans to be trapped in egocentrism, alienation, and minimal openness due to secular routines, God is present with a mission to transform human relations. Using a qualitative descriptive-theological method, this study analyzes three axes of social interaction (inter-tourists, tourists-managers, and tourists-local communities). The results of field research indicate that although the pattern of interaction between visitors is still minimalist and egocentric-group due to a purely physical recreation orientation, there is a strong spiritual modality in the service aspect (hospitality) of the managers that reflects the restoration of the image of God (Imago Dei). The absence of social conflict and the presence of sincere hospitality are identified not merely as business strategies, but as real implications of the work of the Holy Spirit who precedes the church (prevenient grace) in destroying human egoism. This study concludes that tourism can be an eschatological means by which social interactions are transformed into encounters that bring about God's Shalom, meaning that tourism can be a way to bring about God's peace through authentic encounters between tourists, rather than simply ordinary tourist transactions. The author recommends the reconstruction of public spaces in this destination as inclusive communal spaces that facilitate reconciliation and social transformation.

Ma’rifat Istiqa Mukty; Nina Isywara Kusuma; Andi Ade Ulasaswini; Nurhidayah Tiasya Sanas

Jurnal Sains dan Kesehatan (JUSIKA) 2026 Universitas Muhamadiyah Manado

Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose levels due to impaired insulin secretion, insulin action, or both. Uncontrolled diabetes can lead to various complications and decreased quality of life. Moringa oleifera leaves contain bioactive compounds, including flavonoids, vitamins A, C, and E, as well as selenium, which possess antioxidant properties and are believed to help reduce blood glucose levels. This study aims to determine the effect of Moringa leaf decoction on reducing blood glucose levels in patients with diabetes mellitus in Padaleu Village, Kambu District, Kendari City. The study employs a quantitative pre-experimental design using a one-group pretest-posttest approach. The population consists of 35 diabetes mellitus patients, with 17 respondents selected through purposive sampling. Blood glucose levels are measured before and after the administration of Moringa leaf decoction using a glucometer and observation sheets. Respondents receive 200 ml of Moringa leaf decoction daily for five consecutive days. Data analysis is conducted using paired statistical tests to determine differences in blood glucose levels before and after the intervention. The findings of this study are expected to provide scientific evidence regarding the effectiveness of Moringa leaf decoction as a non-pharmacological therapy for controlling blood glucose levels among diabetes mellitus patients. Furthermore, the results may contribute to nursing science development and serve as a reference for healthcare providers and future researchers in implementing complementary therapies for diabetes management.

Sharon Sheilla Shane; Wilmaya Firmandatiyas; Gabriella Paulita Morong; Febrina Lusianna Manik; Afifah Trista Ayunda

ISAINTEK: Jurnal Informasi, Sains dan Teknologi 2026 Politeknik Negeri FakFak

Perkembangan teknologi informasi saat ini mendorong organisasi, termasuk Usaha Mikro, Kecil, dan Menengah (UMKM), untuk meningkatkan efisiensi operasional melalui penerapan sistem yang terintegrasi. Penelitian ini bertujuan untuk merancang Enterprise Architecture (EA) pada UMKM Golden Spice menggunakan pendekatan The Open Group Architecture Framework (TOGAF) melalui metode Architecture Development Method (ADM). Permasalahan utama yang dihadapi adalah sistem penjualan dan manajemen stok yang masih dilakukan secara manual dan tidak terintegrasi, sehingga menyebabkan inefisiensi operasional, ketidaksesuaian data, serta keterbatasan dalam pengambilan keputusan. Metode penelitian yang digunakan meliputi observasi, wawancara, dan studi literatur dengan referensi terbaru pada rentang tahun 2021-2026. Hasil penelitian menunjukkan bahwa perancangan Arsitektur Perusahaan yang diusulkan mampu mengintegrasikan sistem penjualan dan manajemen stok secara terstruktur, sehingga meningkatkan efisiensi operasional dan akurasi data. Selain itu, sistem yang diusulkan juga mampu menyediakan informasi secara real-time untuk mendukung pengambilan keputusan berbasis data. Penelitian ini diharapkan dapat menjadi solusi praktis bagi UMKM dalam mendukung transformasi digital serta menjadi referensi bagi penelitian selanjutnya.

Marini Marini; Hesti Setiorini; Lussyefrida Yanti; Andry Sartika

Jurnal Pengabdian Kepada Masyarakat 2026 Sekolah Tinggi Pastoral Kateketik Santo Fransiskus Assisi

Elderly people are a vulnerable group experiencing declining body functions and an increased risk of degenerative diseases, requiring promotive and preventive efforts to maintain their health. One alternative is the utilization of kitchen spices as herbal drinks because they contain various bioactive compounds that are beneficial for health. However, knowledge among the elderly regarding the benefits and processing methods of herbal ingredients is still limited. This community service activity aimed to improve the knowledge and skills of elderly participants in utilizing kitchen spices as herbal drinks at LKS Payung Besurek Bengkulu City. The method used a participatory approach through educational sessions, interactive discussions, and direct practice in preparing herbal drinks. The results showed high enthusiasm from participants during the activities. Around 85% of participants experienced increased understanding of the health benefits of kitchen spices. Participants were also able to independently prepare herbal drinks using easily available local ingredients. In addition, the activity generated positive social impacts, including improved interaction, increased awareness of healthy lifestyles, and greater independence in maintaining health through natural ingredients. Therefore, this education program is an effective community-based health empowerment strategy for the elderly.

Naila Nabila; Esti Nur Janah

Jurnal Praba : Jurnal Rumpun Kesehatan Umum 2026 STIKES Columbia Asia Medan

Thalassemia is an inherited hemolytic anemia caused by genetic abnormalities in chromosomes 11 and 16 that impair globin chain production, leading to insufficient hemoglobin and red blood cells. This study aims to describe nursing care for An. W with thalassemia at the Anggrek 2 Ward of RSUD dr. Soeselo, Tegal Regency. The method used was a descriptive approach through anamnesis, documentation, observation, and literature review. Nursing care was carried out over two days (January 13–14, 2026). Physical examination results on January 12, 2026 showed a pale face, anemic conjunctiva, weakness, CRT >3 seconds, decreased skin turgor, weak peripheral pulse, cold extremities, and laboratory hemoglobin of 5.9 g/dL, with vital signs of pulse 111x/minute, temperature 36.7°C, and respiration 22x/minute. Two nursing diagnoses were established: ineffective peripheral perfusion related to decreased hemoglobin concentration (D.0009), and activity intolerance related to weakness (D.0056). Nursing interventions included circulatory care (I.02079) and energy management (I.05178). Nursing implementation was carried out according to plan. Evaluation on January 14, 2026 showed that both nursing diagnoses were resolved; the patient's hemoglobin improved to 10.7 g/dL after two blood transfusions, and the patient was declared fit for discharge. It is recommended that hospitals establish support groups for thalassemia patients to provide adequate emotional and social support.

Rasidi Rasidi; Dandy Wirawan; Zainal Fatah

International Journal of Humanities and Social Sciences Reviews 2026 Asosiasi Penelitian dan Pengajar Ilmu Sosial Indonesia

Kampung Batik Okra, located in Kranggan Urban Village, Bubutan District, Surabaya City, represents a community-based creative economy initiative officially inaugurated on 28 December 2022 by the Surabaya City Government. This study aims to analyze the facilitating role of the urban village administration in strengthening the creative economic capacity of residents through the batik industry, as well as to identify supporting and inhibiting factors for community empowerment in Kampung Batik Okra. A descriptive qualitative approach was employed, with data collected through in-depth interviews, participatory observation, and document analysis. Informants were purposively selected, encompassing village government officials, batik group administrators, artisans, and academic facilitators. The findings reveal that the urban village administration performs three principal facilitative roles: (1) facilitation of training and skill enhancement; (2) facilitation of market access and promotion; and (3) facilitation of multi-stakeholder partnerships. These roles contribute significantly to the strengthening of residents’ creative economic capacity, as evidenced by an increase in active artisans, product diversification, and expanded marketing networks. Nevertheless, limited human resource capacity within the village administration, inconsistent community participation, and restricted access to capital remain structural barriers requiring more systemic policy interventions. This research offers a conceptual framework of empowerment-based facilitating roles for urban villages, which may serve as a reference for developing creative economy villages in Indonesian urban areas.

Ahmad Sodikin; Arga Satrio Prabowo; Meilla Dwi Nurmala; Angga Sugara Febriantiko

Jurnal Pengabdian Masyarakat Sains dan Teknologi 2026 Fakultas Teknik Universitas Cenderawasih

Correctional institutions impose sustained psychological burdens on inmates, including social isolation, fractured family bonds, and disrupted identity development, which collectively heighten the risk of mental health deterioration. Unlike preventive psychoeducational approaches, group counseling operates as a curative, therapeutically structured service that enables participants to process shared difficulties through interpersonal dynamics. This community service study implemented group counseling within a Participatory Action Research (PAR) framework involving 50 early adult inmates at Lapas Kelas III Rangkasbitung. PAR was operationalized as an implementation framework in which each counseling cluster cycle followed the Plan-Act-Observe-Reflect sequence, enabling iterative refinement of therapeutic content. Pre-service needs assessment using the Alat Ungkap Masalah (AUM) Umum Masyarakat instrument identified dominant problems in family relations (13.33%), personal self (12.97%), and social relations (10.76%). Group counseling was conducted across three thematic clusters. Program evaluation revealed improvements in social interaction, self-acceptance, and emotional regulation among participants, with the PAR reflective cycle enabling context responsive adaptation of each session. These findings affirm that PAR-grounded group counseling constitutes a contextually adaptive model for psychosocial rehabilitation in correctional settings.

Rendi Maulana Akbar; Sopi Afrilia; Tika Wulandari; Tika Wulandari; Sri Mulyeni

Jurnal Bintang Manajemen (JUBIMA) 2026 Pusat Riset dan Inovasi Nasional

The development of technology in the digital era has significantly altered consumer behavior, particularly for Generation Z, who are known as digital natives. This group possesses unique characteristics, highly relying on social media to seek product information before making purchasing decisions. This study aims to analyze digital marketing management strategies through social media in enhancing brand engagement and loyalty among Generation Z consumers, as well as to identify the key determinants of its success. The research method employed is descriptive qualitative, utilizing literature review as the data collection technique across prior scientific sources. The analysis reveals that the implementation of digital marketing strategies based on visual content and short-form videos on platforms such as TikTok and Instagram is proven to be highly effective in capturing the audience's attention rapidly. In addition to content format, collaboration with highly credible influencers and the application of authentic, responsive two-way communication serve as the main pillars in building emotional proximity and trust among young consumers. Operationally, this strategy offers cost efficiency and a broader market reach. The conclusion of this study emphasizes that the optimal integration between management information systems and interactive, adaptive communication approaches toward digital trends is the main key to winning the market and sustaining the long-term loyalty of Generation Z.

Aliyaturofi’ah; Tati Karyawati

Jurnal Praba : Jurnal Rumpun Kesehatan Umum 2026 STIKES Columbia Asia Medan

Gout arthritis is joint inflammation that occurs suddenly due to the accumulation of excess uric acid levels in the body (hyperuricemia). In Indonesia, based on the 2018 Basic Health Research, the prevalence of gout diagnosed by health workers ranges from 11.9% to 24.7%, with the highest rates in the elderly age group. This scientific paper aims to provide family nursing care for Mr. T and family with musculoskeletal system disorder: gout arthritis in Tonjong Village, Karanganyar Hamlet, RT 03 RW 04, Tonjong District, Brebes Regency. The method used is narrative descriptive, focusing on nursing care given to patients according to the stages of the nursing process. The method of data collection includes observation, interview, and documentation. The nursing diagnoses that emerged were impaired physical mobility and knowledge deficit. Nursing interventions included ambulation support, oral medication administration, massage therapy, and health education. After 2 days of nursing implementation, the evaluation results showed that both nursing diagnoses of impaired physical mobility and knowledge deficit were resolved.

oktaviani, fifin; Oktaviani, Fifin; Muliana, Helda; Candra, Heldi

Perigel: Jurnal Penyuluhan Masyarakat Indonesia 2026 Universitas 17 Agustus 1945 Semarang

Substance and prescription drug misuse among adolescents continues to escalate and demands targeted preventive strategies within the school setting. This community service activity aimed to enhance students’ knowledge about the hazards of drug abuse through an interactive, school-based educational intervention. The program was conducted on 11 November 2026 at SMA Negeri 7 Kota Batam, involving fifty grade-X students as participants. A pre-experimental one-group pretest–posttest design was employed. The intervention combined interactive lectures, real-case illustrations, and two-way discussion, with knowledge measured using a content-validated questionnaire covering ten indicators. The mean score improved from 55.2 (pretest) to 86.3 (posttest), a gain of 31.1 points, while the proportion of correct answers across indicators rose from 48.6-62.9% to 80.0-91.4%. The largest gains appeared on items concerning rational drug use and the importance of professional health guidance, whereas the legal-consequence indicator improved more modestly. Interactive, contextually relevant education proves effective in elevating adolescent knowledge of drug abuse hazards, with stronger gains on experience-near content than on abstract regulatory aspects.

Ferry Yeferson Tulle; Fendy Ongko; Juanda Julianus

Coram Mundo : Jurnal Teologi dan Pendidikan Agama Kristen 2026 Sekolah Tinggi Teologi Injili Arastamar (SETIA) Ngabang

The wave of digitalization triggers a severe morality crisis among the younger generation through constant exposure to negative content, cyberbullying, and global communication ethics degradation. This descriptive qualitative study aims to analyze the specific internalization of Christian values at GPIB Harapan Kasih Congregation Bekasi to shield youth morality amidst ongoing technological disruption. Employing intensive in-depth interviews and participatory observations, data were analyzed interactively through systemic reduction, structured display, and final verification. The results indicate that the digital morality crisis explicitly manifests as pornography normalization, virtual toxicity, and the severe erosion of academic honesty. In response, pastoral strategies utilizing highly contextualized digital ethics sermons and youth cell groups prove thoroughly effective. The deep internalization of self-control and integrity successfully stimulates a holistic self-censorship mechanism across the youth's cognitive, affective, and behavioral domains. This study concludes that consistent accountability-based mentorship effectively transforms Christian youth from passive digital victims into active agents of change within global cyberspace.

Junita Junita

Coram Mundo : Jurnal Teologi dan Pendidikan Agama Kristen 2026 Sekolah Tinggi Teologi Injili Arastamar (SETIA) Ngabang

Urban poverty remains a complex social problem that affects various community groups, including scavengers who work within the informal sector. This study aims to analyze the survival strategies of scavengers in Tangerang City and reflect on their experiences from a Christian theological perspective. The research uses a qualitative approach through literature study and descriptive analysis of relevant social phenomena. The findings show that scavengers develop several survival strategies, including utilizing family and community networks, working persistently, selecting strategic collection areas, managing limited income, and adapting to uncertain environmental and economic conditions. Nevertheless, scavengers continue to face social marginalization, economic vulnerability, occupational risks, limited access to health services, and inadequate social protection. From a Christian theological perspective, this reality calls for a response grounded in love, justice, human dignity, and concern for marginalized communities. Therefore, churches, local communities, and wider society are expected to participate actively in empowering scavengers through holistic, inclusive, and contextual approaches that strengthen welfare, social recognition, and sustainable livelihoods.

Johan Juliawan Adhi; Matheus Mangentang; Stenly Reina Paparang

Coram Mundo : Jurnal Teologi dan Pendidikan Agama Kristen 2026 Sekolah Tinggi Teologi Injili Arastamar (SETIA) Ngabang

This article examines the influence of cell group (komsel) leadership, Christian lifestyle, and discipleship on the growth of the congregation at Christian Ministry Church (CMC) Jakarta. Employing a quantitative correlational design with 140 respondents, the study operationalizes three independent variables (X₁ = cell leadership; X₂ = lifestyle; X₃ = discipleship) against the dependent variable (Y = congregational growth). Pearson correlation analysis reveals significant correlations between cell leadership and lifestyle (r = .800, p < .01) and between cell leadership and discipleship (r = .591, p < .01), whereas direct correlations with Y were non-significant individually. Multiple regression yielded R = .752 and R² = .566, indicating that collectively the three predictors account for 56.6% of variance in congregational growth. These findings reinforce the argument that organic church growth is multidimensional and that the synergistic interaction of cell leadership, moral integrity, and discipleship constitutes a coherent growth ecosystem. Theological and pastoral implications are discussed within frameworks of contemporary missiology and cell ecclesiology.

Aurelius Gelu; Ines Genoveva Hane; Maria Regina Moi Pea; Natalia Imelda Seran; Marylin S. Junias +1 more

Jurnal Sains dan Kesehatan (JUSIKA) 2026 Universitas Muhamadiyah Manado

Keamanan dan kesehatan di tempat kerja adalah salah satu hal penting dalam membentuk suasana kerja yang aman, terutama bagi pekerja bongkar muat (TKBM) yang menghadapi risiko kecelakaan kerja yang cukup besar. Pemakaian Alat Pelindung Diri (APD) yang memenuhi standar merupakan salah satu langkah untuk mencegah terjadinya kecelakaan kerja di area pelabuhan. Namun, hasil pengamatan di Pelabuhan Tenau menunjukkan masih ada pekerja yang mengenakan APD tidak sesuai standar SNI dan tidak menggunakan APD secara lengkap saat bertugas. Studi ini bertujuan untuk mengevaluasi dampak pendidikan penggunaan APD terhadap pengetahuan keselamatan kerja pada pekerja bongkar muat (TKBM) di Pelabuhan Tenau. Penelitian ini mengaplikasikan metode kuantitatif dengan desain pre-eksperimental yang menggunakan pendekatan one group pre-test dan post-test. Sampel penelitian terdiri dari 28 responden dengan alat penelitian berupa kuesioner yang berisi 10 pertanyaan. Hasil penelitian menunjukkan bahwa sebelum mendapatkan edukasi, rata-rata responden berhasil menjawab dengan benar 6 pertanyaan (60%) dan memberikan jawaban salah pada 4 pertanyaan (40%). Setelah mendapatkan edukasi, hasil post-test menunjukkan peningkatan pengetahuan di mana sebagian besar responden dapat menjawab dengan benar sebanyak 9 pertanyaan (90%) dan jawaban salah berkurang menjadi 1 pertanyaan (10%). Berdasarkan hasil studi, dapat disimpulkan bahwa pelatihan penggunaan APD berdampak pada peningkatan pengetahuan keselamatan kerja bagi tenaga kerja bongkar muat (TKBM). Sehingga, diperlukan pengawasan dan pendidikan secara berkala mengenai pemakaian APD yang memenuhi standar SNI untuk meningkatkan keselamatan kerja di area pelabuhan.  

Ismatul Haerunnisa; Yunita Styaningrum; Arlina Nurhapsari

Jurnal Ilmu Kesehatan 2026 Lembaga Pengembangan Kinerja Dosen

Dental caries is an oral health problem associated with the activity of Streptococcus mutans. Water hyacinth (Eichhornia crassipes) contains bioactive compounds such as flavonoids, tannins, and alkaloids with antibacterial potential. This study aimed to evaluate the effectiveness of water hyacinth extract against the growth of Streptococcus mutans. The research method used was an in vitro experimental study with a post test only group design. A total of 24 samples were divided into four treatment groups with extract concentrations of 6.25%, 12.5%, 25%, and 50%. Antibacterial activity was tested using the disc diffusion method on Mueller Hinton Agar media. Data were analyzed using the Kruskal-Wallis and Mann-Whitney tests. The results showed that water hyacinth extract inhibited the growth of Streptococcus mutans. The largest inhibition zone was observed at 50% concentration, while the smallest was found at 6.25% concentration. Kruskal-Wallis analysis showed significant differences among groups (p<0.05). In conclusion, water hyacinth (Eichhornia crassipes) extract has antibacterial activity against Streptococcus mutans.

Ayu Febriasari; Jodion Siburian; Ali Sadikin

Bhinneka: Jurnal Bintang Pendidikan dan Bahasa 2026 Universitas Palan

This study aims to analyze the effect of the implementation of the Flipped Classroom model with a Deep Learning approach on the critical thinking and collaboration skills of Phase F XI students on the digestive system material. The study used a mixed methods with an embedded experimental design type. The research sample consisted of one experimental class that received Flipped Classroom learning with a Deep Learning approach and one control class that received Problem Based Learning (PBL) learning. Data on critical thinking skills were collected through essay tests, while collaboration skills were obtained through observation sheets. Quantitative data analysis used One-Way MANCOVA and qualitative analysis was carried out through data reduction, data presentation, and drawing conclusions assisted by NVivo. The results showed a simultaneous significant effect between the learning model on students' critical thinking and collaboration skills after controlling for initial abilities with a significance value of 0.002 (p<0.05). The average posttest critical thinking of the experimental group was 71.69 higher than the control group at 62.53. Meanwhile, the collaboration skills of both groups showed a relatively balanced increase. The ANCOVA results showed that the Flipped Classroom model with a Deep Learning approach significantly impacted critical thinking skills, but did not show a significant difference in collaboration skills. The research findings indicate that the integration of Flipped Classroom and Deep Learning is effective in improving students' critical thinking skills and supporting 21st-century learning.

Rizky Septika Utami; Rini Suryani; Meko Gustian; Venti Novitas Sari; Darwan Effendi

Jurnal Pengabdian Masyarakat Sains dan Teknologi 2026 Fakultas Teknik Universitas Cenderawasih

Universities are educational institutions that have an important role in addressing various problems in rural areas by motivating, empowering, and broadening the perspectives of local communities. Through community service activities, universities can contribute to improving community skills and encouraging economic independence. This community service program aims to foster an entrepreneurial spirit among female farmers in APK Bandung Village, Selupu Rejang District, through training and assistance in producing pineapple-flavored papaya jam as a value-added agricultural product. The program was conducted in November 2025 and involved one partner, namely the Srikandi Women's Farmers Group (Kelompok Wanita Tani/KWT) 02 of APK Bandung Village. The implementation stages included socialization, product-making demonstrations, mentoring, monitoring, and evaluation activities. These stages were designed to enhance participants’ knowledge and practical skills in processing local agricultural commodities into marketable products. Out of 20 registered members of KWT Srikandi, 17 members attended and actively participated in the program. The results of the evaluation, based on questionnaires distributed to participants, showed that approximately 64.70% of the members demonstrated an entrepreneurial spirit. These findings indicate that the program contributed positively to increasing entrepreneurial awareness and encouraging the development of small-scale rural business opportunities among female farmers.

Anita; Wahyudi Hidayah

Penelitian ini bertujuan untuk menganalisis penerapan model Problem Based Learning (PBL) dalam pembelajaran Pendidikan Agama Islam di SMK N 1 Abung Selatan, Lampung Utara, serta pengaruhnya terhadap keaktifan dan hasil belajar siswa. Latar belakang penelitian ini didasarkan pada masih rendahnya partisipasi siswa dalam proses pembelajaran PAI yang cenderung berpusat pada guru. Oleh karena itu, diperlukan model pembelajaran yang mampu mendorong siswa berpikir kritis, aktif, dan mampu memecahkan masalah yang berkaitan dengan kehidupan sehari-hari. Penelitian ini menggunakan pendekatan kuantitatif dengan metode eksperimen semu (quasi experiment) melalui desain pretest-posttest control group. Subjek penelitian adalah siswa kelas XI yang dibagi menjadi kelas eksperimen dan kelas kontrol. Teknik pengumpulan data meliputi tes hasil belajar, observasi keaktifan siswa, dan dokumentasi. Data dianalisis menggunakan uji statistik untuk mengetahui perbedaan hasil belajar antara kedua kelompok. Hasil penelitian menunjukkan bahwa penerapan model PBL dalam pembelajaran Pendidikan Agama Islam memberikan pengaruh yang signifikan terhadap peningkatan hasil belajar dan keaktifan siswa. Siswa pada kelas eksperimen menunjukkan kemampuan berpikir kritis yang lebih baik serta keterlibatan yang lebih tinggi dalam proses pembelajaran dibandingkan dengan kelas kontrol. Dengan demikian, model Problem Based Learning dapat menjadi alternatif yang efektif dalam meningkatkan kualitas pembelajaran Pendidikan Agama Islam di SMK.

Saeful Amin; Icha Aisah Azzahra; Natasya Zakiatul Awalia Irhan; Syifa Alifia Azzahra

Jurnal Riset Rumpun Ilmu Kesehatan 2026 Pusat riset dan Inovasi Nasional

Breast cancer remains a major global health challenge, with treatment effectiveness often limited by drug resistance and the toxic side effects of chemotherapy on normal cells. The exploration of bioactive compounds from natural sources through a medicinal chemistry approach offers a promising alternative strategy. This study aims to examine the molecular mechanisms of action and Structure-Activity Relationships (SAR) of various natural compound scaffolds as potential breast anticancer agents. The method employed was a systematic narrative literature review of 15 recent scientific articles evaluating computational parameters, including molecular docking, as well as in vitro and in vivo activities. The results indicate that polyphenols, flavonoids such as quercetin and EGCG, and curcumin possess strong cytotoxic activity and high binding affinity toward cancer-related target macromolecules. SAR analysis demonstrates that key structural features, including the number and position of free phenolic hydroxyl groups, the presence of gallate ester groups, and conjugated diketone systems, play a crucial role in determining ligand receptor complex stability. These interactions are supported by hydrogen bonding, hydrophobic interactions, and favorable steric compatibility within receptor binding sites. Computational findings further suggest that structural optimization can enhance ligand selectivity and improve pharmacokinetic properties. This study concludes that natural phytochemical scaffolds have significant potential as lead compounds and provide a rational basis for Computer-Aided Drug Design in developing more potent, selective, multi-target, and safer breast anticancer therapies.