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Dyslipidemia is one of the most common metabolic disorders among the productive-age population and plays a major role in increasing the risk of cardiovascular diseases, including coronary heart disease and stroke. This condition often remains asymptomatic in its early stages, making regular monitoring of cholesterol and HDL levels a critical step in the early detection of atherosclerosis risk. Community-based screening programs revealed that 42.25% of participants had elevated total cholesterol levels, while 26.76% had very low HDL levels and 43.66% had low HDL levels. These findings highlight the urgency of early detection of dyslipidemia to prevent long-term complications that may impair individual quality of life. Through timely interventions involving nutritional education, dietary modifications, and increased physical activity, blood lipid levels can be effectively managed to prevent the progression of cardiometabolic disease and support long-term heart health.

Nutritional problems such as obesity warrant serious attention, due to their potential to contribute to various other health complications. One modifiable factor associated with obesity that can be targeted through intervention is dietary pattern, including adoption of vegetarian diet. Several previous studies have suggested that vegetarian diets may be effective in promoting weight loss. This study aims to examine the potential role of vegetarian diets in the management of obesity. The method employed in a literature review of relevant studies published within the last ten years. The findings indicate that vegetarian diets are effective in reducing body weight, insulin resistance, blood glucose levels, trimethylamin N-oxide (TMAO), low-density lipoprotein (LDL), triglycerides (TG), and total cholesterol levels. Additionally, they are associated with increased high-density lipoprotein (HDL) levels and improvements in lipid profiles, as well as kidney and liver function. Nevertheless, the implementation of vegetarian diets among individuals with obesity should be carefully supervised and planned by qualified professionals to minimize the risk of nutritional deficiencies.

Total cholesterol and HDL assessments are fundamental initial steps in evaluating the risk of cardiovascular disease. The ratio between total cholesterol and HDL is considered a sensitive indicator in predicting atherosclerotic events. Screening activities were carried out using the Plan-Do-Check-Act (PDCA) approach in adult participants. The examination was carried out using the Point-of-Care Testing (POCT) tool to assess total cholesterol and HDL levels from blood samples. Education was provided through leaflets containing information about lipid profiles and the importance of dietary changes. A total of 62 participants took part in this activity, with an age range of 23 to 76 years and the majority were female. Most participants had total cholesterol levels in the normal category, but almost all participants had HDL levels that were classified as low or very low. This lipid profile imbalance indicates a significant potential cardiovascular risk. The screening results underscore the need for continuous education on healthy dietary habits as a primary prevention strategy. Nutritional interventions emphasizing reduced intake of saturated fats, increased fiber consumption, and controlled sugar intake can help restore lipid balance and reduce the risk of atherosclerosis and long-term cardiovascular complications.

Hypercholesterolemia is one of the health problems that is often experienced by the elderly and has a major impact on their quality of life, especially because it increases the risk of cardiovascular diseases such as coronary heart disease, stroke, and peripheral vascular disorders. This condition often does not show symptoms, but the process of atherosclerosis can develop slowly and cause serious complications if not treated early. The Community Service Program (PKM) implemented at Panti Werdha Hana aims to increase awareness among the elderly of the importance of early detection of Cholesterol and High Density Lipoprotein (HDL) levels as part of efforts to prevent heart disease. This activity applies the Plan-Do-Check-Act (PDCA) approach, including total cholesterol and HDL examinations using the Point-of-Care Testing (POCT) method, as well as interactive education about risk factors and healthy lifestyles. The results of the activity showed that out of 76 participants, 38 people (50%) had total cholesterol levels above normal, while 22 people (28.95%) had low or very low HDL levels. Early detection through screening has proven effective in identifying cardiovascular risks earlier and providing a basis for timely medical and educational interventions. Through this activity, it is hoped that the elderly can understand their health conditions better and take preventive steps to maintain lipid levels within normal limits, to improve the quality of life and reduce the risk of cardiovascular complications in the future.

The elderly group (elderly), aged 60-69 years, is part of the community that is vulnerable to various health problems, both physically, mentally, and socially. Untreated health problems can reduce the quality of life and become a burden for individuals and society. In Borisallo Village, Parangloe District, Gowa Regency, there are around 320 elderly residents. Through the Community Service (PKM) program of the Fostered Village in collaboration with the Borisallo Village Government and funded by the UMI Endowment Foundation, a series of activities were carried out to improve the quality of personal health of the elderly. The activity was carried out in November 2024 at the Borisallo Village Hall and included two main forms, namely: (1) elderly health checks covering blood glucose, cholesterol, uric acid, blood pressure, body temperature, and weight; and (2) counseling on the importance of maintaining overall health quality. Although only 15 participants registered for the counseling, the number of participants who attended exceeded expectations, indicating high enthusiasm from the community. The results of the examination showed that some elderly people required medical follow-up for further treatment. The program also emphasizes the importance of regular and continuous monitoring of the health of the elderly so that their condition can be monitored objectively and early intervention can be carried out. The activity took place in an atmosphere full of empathy, care, and a spirit of service that respects and loves the elderly. 

Hypercholesterolemia is a common metabolic condition found in the adult population and significantly contributes to the increased risk of cardiovascular diseases, such as coronary heart disease and stroke. This condition is often asymptomatic, making early detection of total cholesterol and HDL levels a crucial step in identifying the risk of atherosclerosis at an earlier stage. A screening program conducted at the Asisi Church revealed that out of 68 participants, 34 individuals (50%) had abnormal total cholesterol levels, while 10 individuals (14.71%) had very low HDL levels, and 33 individuals (48.53%) had low HDL levels. These findings emphasize the importance of routine lipid profile assessments to prevent more severe cardiometabolic complications. Through education on healthy eating patterns, increased physical activity, and better control of risk factors, the community is expected to maintain optimal lipid profiles and improve overall quality of life.

. The Framingham Risk Score (FRS) assesses coronary heart disease (CHD) risk and predicts acute coronary events. Metabolic markers like LDL cholesterol, fasting blood glucose, uric acid, triglycerides, and TG/HDL ratio play critical roles in atherosclerosis and cardiovascular risk. Elevated LDL cholesterol, fasting blood glucose, and uric acid contribute to plaque formation, inflammation, and vascular damage, while high triglycerides and low HDL cholesterol exacerbate atherogenesis. This study explores the relationship between these markers and FRS to enhance CHD risk prediction and support targeted cardiovascular interventions. This study analyzed LDL cholesterol, fasting blood glucose, uric acid, triglycerides, and TG/HDL ratio with Framingham Risk Score in 85 participants, excluding those with incomplete data or chronic illnesses. The analysis found significant correlations between metabolic parameters and the 10-year myocardial infarction risk. LDL cholesterol, triglycerides, and uric acid showed moderate positive associations with cardiovascular outcomes, while the triglyceride-to-HDL ratio and fasting blood glucose had weaker but significant correlations. These findings highlight lipid profiles and metabolic markers as key contributors to cardiovascular risk. This study highlights significant correlations between LDL cholesterol, fasting blood glucose, uric acid, triglycerides, and the triglyceride/HDL ratio with 10-year cardiovascular risk. These findings emphasize the importance of lipid profiles, glycemic control, and metabolic markers in predicting coronary outcomes and guiding targeted preventive interventions for improved cardiovascular risk management.

Coronary heart disease (CHD) remains a leading cause of mortality worldwide. Early detection is essential to reduce complications and improve patient outcomes. This study aims to develop a classification model using machine learning algorithms to predict CHD risk based on clinical symptoms. The dataset used is the Cleveland Heart Disease dataset from the UCI Machine Learning Repository, consisting of 303 patient records with 14 clinical features. The preprocessing stage involved handling missing values, normalizing features, and transforming categorical variables. Four classification algorithms were applied: K-Nearest Neighbors (K-NN), Decision Tree, Random Forest, and Support Vector Machine (SVM). Each model was trained using stratified 10-fold cross-validation to ensure generalizability. Evaluation using accuracy, precision, recall, F1-score, and ROC-AUC metrics showed that the Random Forest algorithm achieved the highest performance with 87.2% accuracy. Feature importance analysis indicated that chest pain type, resting blood pressure, cholesterol, and ST depression were the most influential indicators. These results demonstrate that machine learning, particularly Random Forest, can effectively support early diagnosis of CHD in clinical settings and has the potential to be integrated into clinical decision support systems (CDSS).

Mrs. Km visited the Integrated Health Post (Posbindu) in Alue Keureunyai Village with complaints of throbbing neck pain that had occurred intermittently over the past two weeks and worsened in the last day. The pain intensified after consuming fatty or coconut milk-based foods and improved with rest or cholesterol-lowering medication. She also experienced a persistent, heavy, throbbing headache for two weeks and ongoing fatigue for the past three weeks, despite minimal physical activity. These symptoms led to reduced motivation in daily activities. Physical examination showed: BP 160/100 mmHg, HR 88 bpm, RR 20 breaths/min, T 36.8°C. Laboratory results revealed a total cholesterol level of 250 mg/dL. Data were gathered through auto-anamnesis, physical and laboratory examinations, home visits, completion of the family folder, and patient documentation. Assessment was based on holistic diagnosis at the initial, ongoing, and final stages of the visit, using both qualitative and quantitative approaches. Interventions included education on the causes of hypercholesterolemia, the importance of taking medication regularly, and awareness of complications due to high cholesterol levels.

Diabetes mellitus is gathering disease metabolic with hyperglycemia caused by abnormalities in insulin secretion , insulin action , or both of them . Loss central type 2 diabetes is caused by insulin resistance in muscles and liver as well failure pancreatic beta cells . Purpose This research is to find out How extract ethanol leaf stalk palm affect the lipid values of diabetic rats. Type This research is a experimental . This research is divided into 6 groups with different treatment​ namely normal, control negative CMC-Na (0.5%), control positive glibenclamide (0.45mL), 125mg/kgBW extract , 250mg/kgBW extract and 500mg/kgBW extract . The results of the lipid parameter data were analyzed with SPSS 22 with level 95% confidence level Results study show extract ethanol dose 250 mg/kgBW and 500 mg/kgBW or more Lots lower level total cholesterol , triglycerides , and LDL as well increase HDL levels

Background: Atherosclerosis is a chronic inflammatory cardiovascular disorder strongly associated with elevated low-density lipoprotein cholesterol (LDL-C) levels and serves as a major predictor of adverse cardiovascular events. This study aimed to investigate the relationship between inflammatory markers (adiponectin and TNF-α) and key biochemical parameters in atherosclerosis patients. Methods:  A case-control study was conducted on 60 participants (aged 40–65 years) recruited from private cardiac clinics in Fallujah, Iraq, between October and December 2024. Subjects were stratified into two groups: 30 atherosclerosis patients (diagnosed by specialists) and 30 age-matched healthy controls. Blood samples were collected, centrifuged, and analyzed for CRP, TNF-α, adiponectin, PAI-1, MDA, GSH, sodium (Na), and magnesium (Mg) levels using standardized biochemical assays. Statistical analysis was performed using SPSS, with significance set at *p* ≤ 0.001. Results: Atherosclerosis patients exhibited significantly elevated serum levels of CRP (2.21 ± 14.46 vs. 1.07 ± 7.76 mg/dL), TNF-α (15.14 ± 120.86 vs. 4.27 ± 65.16 pg/mL), PAI-1 (6.52 ± 0.82 vs. 2.02 ± 0.42 ng/dL), MDA (590.26 ± 29.64 vs. 155.52 ± 25.19 ng/mL), and Na (140.16 ± 1.18 vs. 125.46 ± 6.17 nmol/L) compared to controls (*p* ≤ 0.001). Conversely, adiponectin (0.18 ± 1.81 vs. 0.67 ± 4.18 mg/dL), GSH (22.79 ± 1.37 vs. 40.81 ± 3.05 μg/mL), and Mg (1.46 ± 0.175 vs. 1.84 ± 0.67 nmol/L) were markedly reduced in patients. ROC curve analysis demonstrated perfect diagnostic accuracy (AUC = 1.0) for CRP, TNF-α, and adiponectin in distinguishing patients from controls. Conclusion: The study highlights pronounced dysregulation of inflammatory, oxidative, and metabolic pathways in atherosclerosis, with CRP, TNF-α, and adiponectin serving as robust discriminative biomarkers. These findings underscore the potential of targeting these pathways for therapeutic intervention and early diagnosis.

Liver disease is a health problem that often goes undetected in its early stages due to the absence of specific symptoms, despite the liver's vital role in metabolism, detoxification, and maintaining homeostasis. Early detection is crucial to prevent the progression of liver dysfunction. This community service activity aimed to raise public awareness of the importance of early liver disease screening through the examination of lipid ratios (total cholesterol/HDL and triglycerides/HDL) and physical evaluation for clinical signs of liver dysfunction. The program was conducted at the Cengkareng Baptist Foundation and involved 59 adult participants. The screening included basic laboratory tests and direct physical examinations, followed by health education tailored to each participant based on their screening results. Findings revealed that 83.1% of participants had elevated triglyceride/HDL ratios and 28.8% had total cholesterol/HDL ratios above the normal range, although 100% showed no physical signs suggestive of liver disease. These results indicate the presence of underlying metabolic risks that may affect liver function. This program had a positive impact by enhancing public understanding of the importance of a healthy lifestyle and regular check-ups as part of health promotion and disease prevention efforts related to liver health. Keywords: Early Detection, Liver Function, Lipid Ratio, Health Education, Community Service

Hypercholesterolemia is a significant global health problem, with a high prevalence in Indonesia. Although conventional therapies such as statins have been the mainstay of treatment, limited efficacy and side effects necessitate the development of new, more effective and selective drugs. This article explores the role of medicinal chemistry in the discovery and development of cholesterol-lowering drugs, focusing on structure-activity analysis (SAR) and molecular targets. Through structure-based approaches, compounds such as statins and PCSK9 inhibitors have been optimized to increase affinity for biological targets. In addition, exploration of new targets and formulation innovations have shown great potential in improving therapeutic efficacy. Thus, medicinal chemistry contributes significantly to providing safer and more effective therapeutic solutions for the management of hypercholesterolemia.  

Social changes and lifestyles of the elderly and children at the Al-Hikmah orphanage are very different from before living in the orphanage and after living in the orphanage. The purpose of this study was to see the extent of social changes and lifestyles of the elderly and children at the Al-Hikmah orphanage. The method used in this study is capacity building which aims to increase individual or group understanding of the problems they face while equipping them with ways to overcome them independently. The results of the analysis showed that there was a significant increase in the knowledge of the elderly about cholesterol and hypertension. Before the intervention, 40% of the elderly still did not understand the mpact of cholesterol and hypertension. The results of the analysis showed that there was a significant increase in children's knowledge about healthy lifestyles. As many as 30% of children at the Al-Hikmah orphanage still did not understand what a healthy lifestyle was

Green tea (Camellia sinensis) belongs to the genus Camellia from the Theaceae family. This plant has been used as traditional medicine for generations and is known to have various pharmacological activities. The purpose of this review is to discuss the benefits of green tea in reducing the risk of obesity by reviewing its botanical characteristics, phytochemical content, use and bioactivity to treat obesity obtained and compiled from literature searches through search engines such as Google Scholar, Science Direct, and PubMed. then discussed narratively. The results obtained indicate that green tea extracts and drinks can reportedly help increase the body's metabolism, which contributes to the reduction of body fat. Many studies report that this plant contains phytochemical compounds such as flavonoids, alkaloids, steroids, triterpenoids and carbohydrates. Epigallocationchin-3-gallate, L-theanine, and caffeine, which are respectively classified as flavonoids, amino acids, and alkaloids, are considered responsible for their pharmacological activity in treating obesity. EGCG has a hypocholesterolemic effect and suppresses cholesterol absorption in the intestine, L-theanine itself has physiological effects such as relaxation activities, and caffeine is useful in reducing food intake and has a thermogenic effect which can encourage weight loss.

Cardiovascular disease especially coronary heart disease (CHD) and stroke, is the main cause of global death, with increased blood lipid levels as one of the risk factors. This research offers the potential of anthocyanin-rich berry supplements in reducing low-density lipoprotein cholesterol (LDL-C) levels and improving blood lipid profiles through a meta-analysis of randomized controlled trial studies (RCTs). Data was collected from various databases and filtered based on inclusion and exclusion criteria. Analysis shows that consumption of berry supplements containing anthocyanins can reduce LDL-C levels by 0.29 mmol/L compared to the control group, with a p value <0.05 and I2 = 79%, indicating that the variation between these studies is heterogeneous. These findings are in line with previous research which showed a 13.6% reduction in serum LDL-C levels in the group consuming anthocyanins. In the whortleberry exposure group, the results showed that of the two journal articles analyzed, the data points fell outside the confidence interval (CI), indicating there was no significant difference in the results of the studies. The use of anthocyanins on berries other than whortleberries showed a significant effect, while on whortleberries, the difference with or without anthocyanins was not significant. The results of this study emphasize the importance of consuming anthocyanin-rich berry supplements in improving blood lipid profiles and reducing the risk of cardiovascular disease, and support the development of anthocyanin-based nutritional supplements as an effective public health strategy.

Social changes and lifestyles of the elderly and children at the Al-Hikmah orphanage are very different from before living in the orphanage and after living in the orphanage. The purpose of this study was to see the extent of social changes and lifestyles of the elderly and children at the Al-Hikmah orphanage. The method used in this study is capacity building which aims to increase individual or group understanding of the problems they face while equipping them with ways to overcome them independently. The results of the analysis showed that there was a significant increase in the knowledge of the elderly about cholesterol and hypertension. Before the intervention, 40% of the elderly still did not understand the impact of cholesterol and hypertension. The results of the analysis showed that there was a significant increase in children's knowledge about healthy lifestyles. As many as 30% of children at the Al-Hikmah orphanage still did not understand what a healthy lifestyle was.

Heart disease is one of the biggest causes of death in the world. This research examines the use of the Artificial Neural Network (ANN) algorithm to classify heart disease based on 303 medical data of heart disease patients obtained from the Kaggle dataset center. The data used includes medical parameters such as age, gender, blood pressure, cholesterol levels and other examination results. Various ANN architectures were tested to find the optimal configuration in terms of the number of hidden layers and neurons in each layer. Model performance is evaluated using metrics such as accuracy, precision, recall, and F1-score. From the results of the performance measurement research, an accuracy rate of 97.06%, precision of 92.30%, recall of 92.30%, and F1-Score of 92.30% were obtained.

Decoction water betel leaf is a traditional Balinese medicine containing the active compound hydroxychavikol, has antioxidant and antidyslipemic activity. From the results of the study it was reported that decoction water of betel leaf contains the active compound hydroxycavicol (HC). The active compound hiroksikavikol has activity as an antioxidant and antidyslipidemia. As an anti-oxidant, it can scavenge ROS and inhibit the activity of free radicals. As an antidyslipidemia, it can normalize lipid metabolism by lowering total cholesterol, triglyceride, LDL and VLDL levels and increasing blood serum HDL levels. Oxidative stress and dyslipidemia are major risk factors for heart disease caused by atherosclerosis. Atherosclerosis is the occurrence of plaque formation in the lumen of blood vessels triggered by oxidative stress through endothelial cell dysfunction, inflammation and lipid peroxidation. Oxidative stress causes endothelial cell dysfunction, increased contractility, VSMC growth, monocyte invasion and lipid peroxidation, inflammation and increased deposition of extracellular protein matrix. Based on these things, it was concluded that HC loloh boiled water of betel leaf has antioxidant and antidyslipidemic activity to prevent heart disease.

Non-communicable diseases (NCDs) are currently still the leading cause of death at the global level resulting in around 41 million deaths each year or almost equal to 7 out of 10 deaths that occur worldwide. PROLANIS (Chronic Disease Management Program) is a health service system and proactive approach implemented in an integrated manner involving Participants, Health Facilities and BPJS Health insurance in the context of health maintenance for BPJS Health participants suffering from chronic diseases to achieve optimal quality of life with effective and efficient health service costs. The high incidence of hypertension and cholesterol and the lack of knowledge of the use of BPJS health and the prolanis program in Melebung Village, so that this is the main problem that occurs in Melebung Village. The purpose of the activity is to increase community insight and knowledge about the Chronic Disease Management Program (PROLANIS). In this case the service team will provide education and assistance to the community regarding the BPJS Program (PROLANIS) and Herbal Medicine as an effort to prevent disease. The location of this activity will be carried out in one of the neighborhoods in Pekanbaru City, namely the Melebung Village neighborhood. The goal is that after this community service is carried out, it can improve the degree of public health through the BPJS Program (PROLANIS) and also increase community knowledge in the neighborhood regarding the use of family medicinal plants (herbal medicine).