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Breast cancer remains a major global health challenge, with treatment effectiveness often limited by drug resistance and the toxic side effects of chemotherapy on normal cells. The exploration of bioactive compounds from natural sources through a medicinal chemistry approach offers a promising alternative strategy. This study aims to examine the molecular mechanisms of action and Structure-Activity Relationships (SAR) of various natural compound scaffolds as potential breast anticancer agents. The method employed was a systematic narrative literature review of 15 recent scientific articles evaluating computational parameters, including molecular docking, as well as in vitro and in vivo activities. The results indicate that polyphenols, flavonoids such as quercetin and EGCG, and curcumin possess strong cytotoxic activity and high binding affinity toward cancer-related target macromolecules. SAR analysis demonstrates that key structural features, including the number and position of free phenolic hydroxyl groups, the presence of gallate ester groups, and conjugated diketone systems, play a crucial role in determining ligand receptor complex stability. These interactions are supported by hydrogen bonding, hydrophobic interactions, and favorable steric compatibility within receptor binding sites. Computational findings further suggest that structural optimization can enhance ligand selectivity and improve pharmacokinetic properties. This study concludes that natural phytochemical scaffolds have significant potential as lead compounds and provide a rational basis for Computer-Aided Drug Design in developing more potent, selective, multi-target, and safer breast anticancer therapies.

Background: Menstruation is a natural physiological process that indicates the functional maturity of the female reproductive system. Menstrual cycle disorders can be influenced by several factors, including stress and obesity. Stress may cause hormonal changes through the hypothalamic-pituitary axis, leading to decreased luteinizing hormone (LH) levels and menstrual irregularities. Obesity can also affect ovarian function and disrupt the menstrual cycle. Objective: To determine the relationship between stress and obesity with menstrual cycle disorders among female adolescents at SMAN 1 Majene in 2026. Methods: This study used an analytical observational design with a cross-sectional approach. Data on stress levels, obesity status, and menstrual cycle disorders were collected simultaneously from 84 female respondents. The chi-square test was used to analyze the relationships among variables. Results: The analysis showed a significant relationship between stress and menstrual cycle disorders (p = .006; α < .05). A significant relationship was also found between obesity and menstrual cycle disorders (p = .002; α < .05). Many obese respondents experienced irregular menstrual cycles. Conclusion: There is a significant relationship between stress and obesity with menstrual cycle disorders among female adolescents at SMAN 1 Majene.

Risk factors for melasma have been identified at several points such as the use of birth control pills, cosmetics, sun exposure, estrogen therapy, decreased thyroid and ovarian function, ovarian tumors, nutrition, drugs that are classified as phototoxic or photoallergic, and epilepsy drugs. This article aims to determine the incidence of melasma and its risk factors. This study uses articles collected from the Google Scholar database. The data collection step uses the keyword "Risk Factor Melasma" according to the title and keyword criteria. The articles used are publications in the 2018-2023 year range. The stages of analysis are carried out using VOSviewer software for visualization and trend analysis in the form of bibliometric maps. The bibliometric approach was applied to identify publication patterns, research developments, and relationships among topics related to melasma risk factors. Based on the visualization results, 100 selected documents were published within 5 years, from 2018 to 2023. The findings provide an overview of the main research trends and contribute to a better understanding of the incidence of melasma and the factors associated with its occurrence

This study aims to determine the leadership competency of Catholic religious education teachers in creating a conducive learning environment at SMP Negeri 4 Nubatukan. This research used a qualitative approach with a case study approach. Data collection was conducted through observation, interviews, and documentation involving Catholic religious education teachers, students, and school officials. The results indicate that Catholic religious education teachers have demonstrated leadership competency through their ability to manage the classroom, provide good role models, build positive relationships with students, and provide motivation during the learning process. Teachers also strive to create a safe, comfortable, and orderly learning environment to encourage students to be more active in learning. Furthermore, several supporting factors exist, such as collaboration between teachers and the school, parental support, and the application of religious values ​​in the school environment. However, this study also identified several obstacles, such as limited learning facilities, lack of student participation, and limited learning time. Based on the results, it can be concluded that the leadership competency of Catholic religious education teachers plays a crucial role in creating a conducive learning environment and supporting student development, both academically and spiritually.

Background: Adenoid hypertrophy is a condition characterized by enlargement of the adenoid tissue which can cause nasopharyngeal obstruction and potentially affect the function of the Eustachian tube. Dysfunction of the Eustachian tube may disrupt middle ear ventilation and increase the risk of otitis media. The degree of adenoid hypertrophy can be objectively assessed using a lateral nasopharyngeal radiograph by calculating the adenoid–nasopharyngeal ratio (A/N ratio). Objective: This study aimed to determine the relationship between adenoid hypertrophy based on the adenoid–nasopharyngeal ratio and the incidence of otitis media. Methods: This study was a quantitative research with an analytic observational design using a cross-sectional approach. Data were obtained from the medical records of patients with adenoid hypertrophy who underwent lateral nasopharyngeal radiographic examination at RSI Purwokerto from 2022 to 2025. The sample consisted of 31 patients who met the inclusion and exclusion criteria. Data analysis was performed using the Spearman correlation test because the data were not normally distributed based on the Shapiro–Wilk test. Results: The results showed that most of the subjects were male (17 subjects, 54.8%) and female (14 subjects, 45.2%). The median age of the subjects was 7 years with an age range of 4–9 years. The median adenoid–nasopharyngeal ratio was 0.90 with a range of 0.68–0.99. Otitis media was found in 11 subjects (35,5%), while 20 subjects (64,5%) did not experience otitis media. The Spearman correlation test showed a correlation coefficient of r = 0.015 with a p-value of 0.936 (p > 0.05), indicating that there was no significant relationship between the adenoid–nasopharyngeal ratio and the incidence of otitis media. Conclusion: There was no statistically significant relationship between adenoid hypertrophy based on the adenoid–nasopharyngeal ratio and the incidence of otitis media.

Diabetes Mellitus is a non-communicable disease with an increasing prevalence and has become a major public health concern globally and nationally. The incidence of diabetes mellitus is influenced by various individual and environmental factors. This study aimed to analyze the relationship between age, gender, and residential proximity to landfill areas and the incidence of diabetes mellitus in Bendosari District. A quantitative analytic observational design with a cross-sectional approach was employed. The study population consisted of 1,890 patient visit records recorded in the Management Information System of Bendosari Public Health Center in 2025. A total of 363 respondents were selected using proportionate stratified random sampling. Data were analyzed through univariate analysis, bivariate analysis using the Chi-Square test, and multivariate analysis using multiple logistic regression. The findings showed that age was significantly associated with diabetes mellitus incidence (p=0.000; OR=79.790; 95% CI=53.511–118.974). Gender was also significantly related to diabetes mellitus incidence (p=0.000; OR=0.298; 95% CI=0.203–0.435), indicating that females had a higher risk than males. In contrast, residential proximity to landfill areas was not significantly associated with diabetes mellitus incidence (p=0.308; OR=1.247; 95% CI=0.439–3.540). Multivariate analysis revealed that age and gender were the dominant factors influencing diabetes mellitus incidence, with the model explaining 56.1% of the variation. The study concludes that age and gender are significant determinants of diabetes mellitus incidence, whereas residential proximity to landfill areas has not been proven to significantly affect its occurrence.

This study was conducted to analyze the relationship between students’ critical thinking skills and mathematical problem-solving abilities through a literature review approach. The study is based on the importance of mastering higher-order thinking skills in the mathematics learning process, particularly when students are faced with complex problems related to real-life situations. The method used in this research was a literature review by examining various relevant scientific journals and academic books published between 2021 and 2026. The data analysis process was carried out through stages of identification, classification, evaluation, and synthesis of the collected sources. The findings revealed a significant and positive relationship between critical thinking skills and students’ mathematical problem-solving abilities. Critical thinking skills play an important role in helping students understand problems, process and analyze information, select appropriate solution strategies, and systematically review the results obtained. Students with strong critical thinking skills generally demonstrate more optimal mathematical problem-solving abilities. In addition, the implementation of learning models such as Problem-Based Learning and contextual approaches has been considered effective in improving both abilities. Therefore, critical thinking skills are regarded as an essential aspect that needs to be developed in mathematics learning in order to enhance students’ mathematical problem-solving abilities.

Medical students need to take the Competence test as Doctor Profession Program (UKMPPD) to be passed and earned their medical profession. Exams are one of the most common stressors experienced by medical students and the body will respond to these stressors in the form of feelings of depression or anxiety. Anxiety and depression itself can affect student performance during exam preparation. The purpose of this study was to determine the relationship between anxiety and depression on the preparation of the Professional Doctoral Program Competency Test (UKMPPD) for students of the Faculty of Medicine, University of Pattimura. The method used is quantitative analysis with cross sectional research design and total sampling technique. The sample is all the student population of the Faculty of Medicine, University of Pattimura who meet the inclusion and exclusion criteria, totaling 90 respondents. The results showed that the majority of respondents experienced mild anxiety symptoms, which is 37% during the CBT exam and 34% during the OSCE exam. The majority of respondents also did not experience depression, which is 68% during the CBT and 70% during the OSCE and the majority had an optimal level of preparation for UKMPPD, which is 63% during the CBT and 64% during the OSCE. Data analysis using the chi square test showed a significant relationship between anxiety symptom and the level of preparation for UKMPPD both CBT (p=0.030) and OSCE (p=0.012). There was no significant relationship between depression symptom and the level of preparation for UKMPPD for both CBT (p=0.123) and OSCE (p=0.07). It can be concluded that there is a significant relationship between anxiety and preparation for UKMPPD, but there is no significant relationship between depression and preparation for UKMPPD.

The increase in medical disputes in Indonesia occurs along with the development of health services and increasing public legal awareness. Dispute resolution through litigation is often considered ineffective because it takes a long time, is expensive, and creates a confrontational relationship between medical personnel and patients. Therefore, mediation is present as an alternative dispute resolution that prioritizes deliberation, communication, and mutual agreement. This study aims to analyze the regulation, implementation, and effectiveness of mediation as an alternative resolution of medical disputes based on Supreme Court Regulation Number 1 of 2016 concerning Mediation Procedures in Court. The research method used is normative legal research with a statutory, conceptual, and case approach. Data were obtained through literature and document studies, then analyzed descriptively qualitatively. The results of the study indicate that mediation has a strong legal basis and provides various advantages, such as a faster resolution process, lower costs, maintaining confidentiality, and being able to maintain good relationships between medical personnel and patients. However, the implementation of mediation still faces obstacles such as low public understanding, limited mediators who have competence in the health sector, and a legal culture that still tends to be litigative. Therefore, optimization is needed through improving mediator competence, strengthening public legal awareness, and maximizing mediation implementation to achieve fair, effective, and humane dispute resolution.

Amidst rising global pressure regarding sustainability and cross-border trade, customs agencies are no longer viewed merely as gatekeepers but as strategic actors in global environmental governance through the Green Customs Initiative (GCI). This research aims to uncover the evolutionary patterns of GCI research within the context of adaptive policy, map its intellectual structure, and identify future thematic directions. The methodology employs a bibliometric analysis of documents sourced from the Web of Science database, utilizing VOSviewer software to perform co-authorship, bibliographic coupling, and co-word analysis.The results demonstrate that the dominance of scientific actors in this field is determined more by the strength of collaboration networks than by the mere volume of publications. The findings identify that the primary intellectual foundations of GCI research rest upon the critical relationship between environmental regulation, international trade, market responses, and eco-innovation. Furthermore, country-level analysis highlights the central roles of China, the United States, and the United Kingdom in shaping the knowledge structure of this domain. Overall, these findings underscore that the GCI has evolved into a multidisciplinary field that requires an adaptive policy framework to respond to the dynamics of ecological risks and global trade demands through institutional flexibility and cross-actor collaboration. By integrating environmental protection into border management and risk assessment, this study provides a strategic reference for customs authorities to move toward a more responsive and knowledge-based green customs administration.

In Islam, prayer (salat) is a fundamental obligation that must be performed under all circumstances, including during illness. Muslim patients have high spiritual needs, in which religious practices serve as a source of strength in coping with disease. Although Islam provides concessions (rukhsah) in performing prayer for the sick, limitations in patients’ understanding of how to perform prayer according to their health conditions are still found. This lack of knowledge may affect the proper practice of prayer during hospitalization. Therefore, this study aims to identify patient characteristics related to the practice of prayer, to examine the level of knowledge of the five daily prayers in relation to their practice among patients, and to analyze patients’ overall level of knowledge regarding prayer. This study employed a quantitative method with a cross-sectional design. The results show that patient characteristics, particularly productive age and higher educational level, contribute to their ability to perform prayer during hospitalization. A significant relationship was found between the level of knowledge of prayer and its practice, where better understanding was associated with more optimal religious practice. Overall, most patients had a high level of knowledge of prayer, although a small proportion still had low knowledge, indicating the need for spiritual education. It can be concluded that the level of knowledge of prayer is associated with the quality of prayer practice among Muslim patients at RSUD Haji Makassar. Strengthening spiritual education is needed to support the fulfillment of patients’ religious needs during hospitalization.

Instagram social media addiction has become an increasingly common phenomenon among university students. Excessive use of Instagram can negatively affect mental, social, and academic well-being, and may increase the risk of social anxiety. Students who experience Instagram addiction tend to have reduced direct social interaction, and fear of negative evaluation from others, which are key factors contributing to social anxiety. This study aims to determine the relationship between Instagram social media addiction and social anxiety among students. This study used a quantitative approach with a cross-sectional design. The sample consisted of 105 respondents selected using purposive sampling. The instruments used were the Instagram Addiction Scale (TIAS) and the Social Anxiety Scale for Social Media Users (SAS-SMU). Data analysis was conducted using the Chi-Square test. The results showed that most respondents had a moderate level of Instagram addiction (56.2%) and a moderate level of social anxiety (68.6%). The Chi-Square test indicated a significant relationship between Instagram addiction and social anxiety, with a p-value < 0.001 (p < 0.05). There is a significant relationship between Instagram addiction and social anxiety among students. However, the relationship is not always linear, as higher levels of addiction do not necessarily correspond to higher levels of social anxiety.

This study aims to analyze the participation of the faithful in the Sacrament of Penance and to identify the pastoral challenges influencing its practice in the Vicariate of West Sulawesi, Archdiocese of Makassar. Theologically, the Sacrament of Penance serves as a means of reconciliation that restores the relationship between humanity, God, and the Church. However, in contemporary contexts, its practice encounters various social, psychological, and pastoral dynamics. This research employed a descriptive quantitative approach involving 267 respondents from four parishes through questionnaire distribution. The data were analyzed using percentage-based statistics to map participation frequency, spiritual motivation, level of understanding, post-sacramental experiences, and perceived obstacles. The findings indicate that although most respondents demonstrate strong theological understanding, sincere spiritual motivation, and positive spiritual experiences after receiving absolution, participation remains largely seasonal and periodic. The principal challenges include psychological factors such as shame and anxiety, structural limitations related to schedule and accessibility, and formative deficiencies such as insufficient ongoing catechesis. The study concludes that the primary issue is not a crisis of faith in the sacrament itself, but a gap between theological awareness and concrete practice, thus calling for more dialogical, communicative, and contextual pastoral renewal.

This research the development of a content-based website to overcome learning distractions from TikTok social media in Cuping Hamlet, Lamongan Regency. The purpose of this study was to determine the effect of TikTok social media on children's learning interest and to develop a content-based website to address learning distractions from TikTok social media in Cuping Hamlet, Lamongan Regency. The method used was a quantitative method with a questionnaire technique distributed to 30 parents of children aged 6-12 years. The results showed a significance level of <0.05, indicating a significant negative effect between TikTok social media use and children's learning interest. Furthermore, the relationship between TikTok social media and learning interest was strong and in the opposite direction, with a correlation coefficient of -0.60.. This can be interpreted that the higher the level of TikTok social media use, the lower the child's interest in learning and vice versa. Furthermore, a content-based website has been successfully developed to address learning distractions from TikTok social media. The website development used Wix which contains the home page, about, research, publications, posts (interesting learning materials and videos), and contact.

Instagram social media addiction has become an increasingly common phenomenon among university students. Excessive use of Instagram can negatively affect mental, social, and academic well-being, and may increase the risk of social anxiety. Students who experience Instagram addiction tend to have reduced direct social interaction, and fear of negative evaluation from others, which are key factors contributing to social anxiety. This study aims to determine the relationship between Instagram social media addiction and social anxiety among students. This study used a quantitative approach with a cross-sectional design. The sample consisted of 105 respondents selected using purposive sampling. The instruments used were the Instagram Addiction Scale (TIAS) and the Social Anxiety Scale for Social Media Users (SAS-SMU). Data analysis was conducted using the Chi-Square test. The results showed that most respondents had a moderate level of Instagram addiction (56.2%) and a moderate level of social anxiety (68.6%). The Chi-Square test indicated a significant relationship between Instagram addiction and social anxiety, with a p-value < 0.001 (p < 0.05). There is a significant relationship between Instagram addiction and social anxiety among students. However, the relationship is not always linear, as higher levels of addiction do not necessarily correspond to higher levels of social anxiety.

Increased caffeine intake is commonly used by students to cope with academic demands, especially during examinations and the completion of final projects. Excessive caffeine consumption may affected sleep quality and potentially influence nutritional status. This study aimed to determine the correlation between caffeine intake, sleep disturbances, and nutritional status among final – year unsergarduated students at Dr. Soekardjo University. This study used quantitative approach with an observational analytic and cross-sectinal design. A total of 108 students participated in the study. Data were collected using questionnaires and analyzed using the Spearman Rank correlations test. The findings indicated that the most of respondents with low caffeine intake experienced mild sleep disturbances, totaling 56 respondents (80%). Meanwhile, respondents with moderate and high caffeine intake mostly experienced moderated sleep disturbances, with 13 respondents (61.9%) and 9 respondents (52.9%), respectively. The results showed a significant correlation between caffeine intake and sleep disturbances (p-value=0.000). In all categories of caffeine intake, most respondents had normal nutritional status. However, no significant relationship was found between caffeine intake and nutritional status (p-value=0.351). In conclusion, caffeine intake was associated with sleep disturbances but not with nutritional status among final-year undergraduate students.

This study aims to analyze the relationship between self-compassion and self-objectification among female TikTok users in Jambi City. The study used a quantitative correlational approach with a cross-sectional design. A total of 218 female students in Jambi City aged 18–25 years who actively use TikTok were selected using a purposive sampling technique. The instruments used were the Self-Compassion Scale (SCS) adapted into Indonesian (Skala Welas Diri) and the Objectified Body Consciousness Scale (OBCS). Data analysis used the Pearson Product Moment correlation test. The results showed a significant negative relationship between self-compassion and self-objectification (r = -0.216; p = 0.001). The higher the self-compassion, the lower the tendency for self-objectification. The majority of respondents had moderate to high levels of self-compassion, while self-objectification was in the moderate category. The duration of TikTok use of more than 2 hours per day was associated with a higher tendency for self-objectification. These findings confirm the role of self-compassion as a protective factor against self-objectification in the context of visual-based social media use.

The rapid development of digital technology has significantly transformed the ways in which faith is experienced, particularly in the lives of adolescents. From the perspectives of digital religion and mediatization of religion, digital space is no longer merely a medium, but has become a cultural arena that actively shapes religious practices and meanings. The study aims to analyze these dynamics, especially within the context of Generation Alpha, by examining the opportunities and challenges that emerge in the lived experience of faith in the digital age. The findings indicate that digital environments offer creative, participatory, and contextual opportunities for evangelization, enabling young people to engage actively in constructing their religious experiences. However, this dynamic is inherently ambivalent, as it also risks reducing the meaning of faith to symbolic, instant, and less sacramentally grounded experiences, detached from the communal life of the Church. Furthermore, the formation of religious identity in digital spaces tends to be fluid and performative, potentially leading to superficial relationships and fragmented identities. Therefore, technologically mediated religious experience should be understood as a bridge, rather than a substitute, for authentic faith encounters. The Church is thus called to adopt adaptive and reflective pastoral approaches, positioning media as a means of fostering communio without obscuring the essence of faith. An integrative approach through the synergy of Church, family, and educational institutions is essential to balance digital literacy and spiritual depth, ensuring that adolescent faith continues to grow reflectively and remains rooted in real-life experience.

The development of social media, particularly TikTok, has played a significant role in shaping beauty trends and constructing ideal facial standards among young generations. The TikTok Beauty phenomenon not only provides diverse makeup references but also reinforces specific visual representations that influence perceptions of beauty. This study aims to examine the relationship between the TikTok Beauty phenomenon, the process of facial standardization, and its implications for the development of makeup techniques. A qualitative approach was employed through content analysis and literature review. Primary data were obtained from observations of popular TikTok videos under the hashtags #beautytrend, #makeup, and #tiktokbeauty, while secondary data were drawn from scholarly literature on beauty standards, social construction, and social media algorithms. The findings indicate that TikTok strengthens certain beauty standards such as fair skin, slim facial contours, and a flawless appearance which in turn influence techniques like complexion layering and visual manipulation. However, the platform also provides space for more inclusive and diverse beauty narratives. This study recommends enhancing aesthetic literacy to ensure that makeup practices prioritize diversity and the unique characteristics of each individual.

The study aims to analyze the role of digital media as a distracting factor affecting the faith loyalty of Catholic adolescents in their relationship with God amid religious pluralism in Indonesia. The development of digital media has transformed how adolescents understand, express, and live out their faith, while simultaneously presenting both opportunities and ambivalent challenges. This research employs a qualitative approach using a library research method, analyzing various theological, sociological sources, and Church documents. The findings indicate that digital media can serve as a broad and participatory space for expressing faith, but it also has the potential to create distractions in three main dimensions: cognitive, affective, and practical. Cognitively, adolescents experience confusion in understanding faith teachings due to the diversity of information available. Affectively, there is a shift in orientation from a relationship with God toward the pursuit of emotional gratification in digital spaces. Practically, there is a decline in engagement in concrete religious practices. Within the context of religious pluralism, this complexity intensifies and influences the formation of adolescents’ faith identity. This study also finds that digital media does not only have negative impacts but also holds positive potential as a means of deepening faith when used critically and reflectively. Therefore, the role of the Church is essential through contextual, dialogical, and integrative pastoral accompaniment combined with critical digital literacy. Through this approach, adolescents are expected to integrate their digital experiences into a more mature, authentic faith life rooted in a deeper relationship with God.