Publication Search

Aceh Tamiang Regency is an area with a high risk of annual flooding. This emergency condition often triggers a surge in environment-related diseases such as skin diseases, respiratory infections, and diarrhea. The success of managing health crises heavily depends on pharmaceutical logistics management, especially the availability of essential medicines and ease of access for refugees at evacuation points. This study aims to analyze the extent of medicine availability at community health centers and health posts, as well as to evaluate the barriers to medicine accessibility for flood victims in Aceh Tamiang Regency. This study uses a qualitative/quantitative descriptive method (choose one) with a case study approach. Primary data were collected through in-depth interviews with pharmaceutical logistics officers and surveys of flood survivors. Secondary data were obtained from the drug stock reports of the Aceh Tamiang District Health Office. Analysis was conducted on variables such as drug types, stock amounts (Buffer Stock), and distribution channels during the emergency response period. The results of the study indicate that the availability of drugs in the initial disaster phase tends to be (state the prediction, e.g., sufficient/limited). However, accessibility is often hindered by damaged road infrastructure and uneven distribution to remote posts. There is an urgent need to strengthen the logistics early warning system so that the types of medicines available match the disease patterns that emerge after floods. Although medicine stocks are generally available in central pharmacy warehouses, geographical constraints and distribution coordination are the main factors hindering accessibility. It is recommended that local governments map out alternative distribution routes and provide disaster-specific buffer stock of medicines at the sub-district level.

Hypertension in the elderly requires long-term treatment to prevent cardiovascular consequences. Adherence to antihypertensive medication is crucial for blood pressure management. Adherence to antihypertensive medication is a crucial aspect in hypertension management. Poor adherence can lead to uncontrolled blood pressure, thereby increasing the risk of cardiovascular problems, including stroke, myocardial infarction, and heart failure. This study aims to determine the correlation between adherence to antihypertensive medication and blood pressure in the elderly at the Ronggo Husada Primary Inpatient Clinic in Malang. This study used a cross-sectional design. The cohort consisted of 52 geriatric patients with hypertension who consistently visited the Ronggo Husada Primary Inpatient Clinic in Malang. The sample consisted of 40 patients. The sampling method used was purposive sampling. Research factors included medication adherence and blood pressure. Data collection was conducted through a questionnaire. This study was conducted at the Ronggo Husada Primary Inpatient Clinic in Malang on November 6, 2025. Data processing used the Chi-square test. The analysis included univariate and bivariate analyses, using the Chi-square test. The results showed that more than 50% of elderly participants demonstrated moderate adherence to antihypertensive medication (18 individuals (45%). Nearly 50% of elderly participants suffered from stage I hypertension (14 individuals (35%), and stage II hypertension (11 individuals (27.5%). Statistical analysis using the Chi-square test showed a significant correlation between adherence to antihypertensive medication and blood pressure in the elderly, with a p-value of 0.000, which is below the alpha threshold of 0.05 (5%). Elderly individuals who demonstrated strong adherence had better blood pressure regulation compared to those with poor adherence. These results emphasize the importance of adherence to therapy in the management of hypertension in the elderly.    

Long-term treatment adherence is critical for schizophrenia patients, yet non-adherence remains a significant global challenge, contributing to relapse, re-hospitalization, and increased healthcare costs. Understanding the underlying multidimensional factors is crucial for developing effective interventions. This systematic literature review aims to identify and categorize the dominant factors contributing to medication non-adherence among schizophrenia patients, based on current quantitative evidence (2019-2024). A systematic search of Google Scholar and PubMed targeted quantitative cross-sectional studies using the PICOST framework. Article selection followed PRISMA guidelines, and quality was assessed using the JBI Critical Appraisal Checklist. Seven articles were included in the final narrative synthesis. The synthesis confirms that non-adherence is multifactorial. Identified factors were categorized into three groups: (1) Patient-related factors (e.g., poor illness insight, feeling cured, treatment fatigue); (2) Treatment-related factors (e.g., medication side effects, therapy duration); and (3) System and social factors (e.g., low family support, stigma, poor therapeutic alliance). Non-adherence is a complex issue arising from the interplay of patient, treatment, and social factors. Low family support and poor patient knowledge consistently emerge as key determinants. Interventions require a holistic approach extending beyond pharmacotherapy, focusing on comprehensive psychosocial education for patients and families, active side-effect management, and strengthening the family's role in care.

Hypertension is one of the most common non-communicable diseases in Indonesia. Hypertensive patients must have high self-efficacy to comply with antihypertensive medication so that blood pressure can be controlled and complications prevented. Therefore, intervention is needed to improve therapy compliance. One intervention that can be given is the provision of pill cards. This study was a quasi-experimental design with a pre-intervention post-intervention control group design. Sampling was conducted using non-probability purposive sampling from July to September 2025. A total of 106 respondents were divided into two groups, with 53 respondents in the control group and 53 respondents in the intervention group. The control group was only given the MMAS-8 questionnaire, while the intervention group was given pill cards and the MMAS-8 questionnaire. In the intervention group, prior to intervention, 25 patients (47.2%) had low compliance, 21 patients (39.6%) had moderate compliance, and 7 patients (13.2%) had high compliance. After the intervention, there was a significant increase, with 21 patients (39.6%) showing high compliance, 26 patients (49.1%) showing moderate compliance, and 6 patients (11.3%) showing low compliance. Providing pill cards to outpatients with hypertension can improve patient medication adherence. Based on the results of the Wilcoxon Signed Ranks Test, a value of (p<0.001) was obtained, indicating that H0 was rejected and there was a significant effect.

The community in Cibangkong Village, Pekuncen District, Banyumas Regency, still widely uses jamu (traditional herbal medicine) as part of their daily healthcare practices, often in combination with modern medical drugs. Limited understanding of the potential interactions between herbal and pharmaceutical medicines may pose health risks. This community service activity aimed to improve public knowledge and awareness regarding the dangers of drug–herb interactions through educational and interactive approaches. The implementation methods included health education sessions and group discussions. Participants of the activity were members of Muslimat NU 1 Pekuncen. The results showed a 60% improvement in community understanding, based on simple pre-test and post-test evaluations. The community also became more cautious and motivated to consult healthcare professionals before consuming jamu together with prescription medicines. This activity successfully increased public awareness about the safe and responsible use of both modern and traditional medicines.

Karangtalun Village, located in Kalidawir District, Tulungagung Regency, East Java, has significant potential for developing Family Medicinal Plants (TOGA) to support community-based health practices. However, the utilization of TOGA in daily health care remains limited due to a lack of knowledge and practical skills among residents. At the same time, the community faces a growing social challenge—digital exposure among young children, which negatively affects their physical, psychological, and social well-being. To address these issues, a capacity-building program was implemented for women involved in the Integrated Guidance Post (Posbindu) through training on TOGA cultivation and digital literacy education using the Community-Based Participatory Research (CBPR) approach. This participatory model actively engaged community members in the planning, implementation, and evaluation stages. The program results showed an increase in participants’ understanding of TOGA as an alternative for self-care and traditional medicine, greater awareness of the adverse effects of excessive gadget use among children, and positive behavioral changes in parenting, such as setting screen-time limits and replacing gadget use with creative family activities. These findings demonstrate that integrating local wisdom–based education with digital literacy can effectively strengthen family resilience and promote sustainable well-being in the digital era.

Karangtalun Village, located in Kalidawir District, Tulungagung Regency, East Java, has significant potential for developing Family Medicinal Plants (TOGA) to support community-based health practices. However, the utilization of TOGA in daily health care remains limited due to a lack of knowledge and practical skills among residents. At the same time, the community faces a growing social challenge—digital exposure among young children, which negatively affects their physical, psychological, and social well-being. To address these issues, a capacity-building program was implemented for women involved in the Integrated Guidance Post (Posbindu) through training on TOGA cultivation and digital literacy education using the Community-Based Participatory Research (CBPR) approach. This participatory model actively engaged community members in the planning, implementation, and evaluation stages. The program results showed an increase in participants’ understanding of TOGA as an alternative for self-care and traditional medicine, greater awareness of the adverse effects of excessive gadget use among children, and positive behavioral changes in parenting, such as setting screen-time limits and replacing gadget use with creative family activities. These findings demonstrate that integrating local wisdom–based education with digital literacy can effectively strengthen family resilience and promote sustainable well-being in the digital era.

Hypertension is a primary risk factor for cardiovascular diseases, including stroke, coronary artery disease, atrial fibrillation, and peripheral vascular disease. Often referred to as "The Silent Killer," its onset is frequently asymptomatic, making early detection challenging. Effective interventions, both pharmacological and non-pharmacological, are necessary to manage hypertension and reduce complications. Long-term treatment requires adherence to prescribed medications, with self-care management playing a vital role in minimizing hypertension's adverse effects. Self-efficacy, or an individual's belief in their abilities, is crucial for improving medication adherence and self-care activities. This study aimed to examine the correlation between self-efficacy and self-care management in relation to medication adherence among hypertension patients at RSUD Mandau District. A non-experimental, quantitative, analytic correlation study with a cross-sectional design was conducted, involving 38 hypertension patients. Self-efficacy was measured using the MASES-R (Medication Adherence Self-Efficacy Scale-Revision), medication adherence was assessed with the MMAS-8 (8-item Morisky Medication Adherence Scale), and self-care management was evaluated using the HBP-SCP (Hypertension Self-Care Profile). The findings revealed a significant correlation between self-efficacy and medication adherence (p=0.000, r=0.594). Additionally, self-care management was significantly correlated with medication adherence (p=0.027, r=0.360). In conclusion, self-efficacy and self-care management both significantly correlate with medication adherence in hypertension patients at RSUD Mandau District.

Mistakes in obtaining, using, storing, and disposing of medication (DAGUSIBU) remain a major issue in Indonesia, including in Kedungpring Village, Kemranjen District, Banyumas Regency. This study aims to improve the knowledge of PKK mothers in Kedungpring Village regarding DAGUSIBU practices through interactive counseling. The method used is a community-based empowerment approach, involving active participation of PKK members in the planning, implementation, and evaluation of activities. The results showed a significant improvement in the participants' knowledge and behavior regarding proper medication management, including proper storage and disposal of expired medication. This activity also encouraged the formation of medication health cadre groups at the RT level to continue educating the community. This DAGUSIBU counseling was proven effective in improving medication literacy at the household level and reducing the risk of medication errors.

This research investigates the application of the Economic Order Quantity (EOQ) method to improve drug inventory management in a primary hospital pharmacy, with a particular focus on reducing storage costs. A descriptive quantitative approach was applied using secondary data from January to December 2024, covering annual demand, purchase price, ordering cost, and holding cost. The analysis concentrated on fast-moving vital essential and moderate vital drugs that are critical for sustaining patient treatment. The study revealed inefficiencies in the hospital's procurement practices, with some medicines simultaneously facing overstock and stockout risks, indicating weak planning. EOQ calculations provided alternative procurement quantities that were smaller but more frequent, resulting in lower storage costs and better stock control. Simulation outcomes demonstrated notable cost savings, particularly for Flamicort, Diazepam, and Ventolin. These findings emphasize the value of integrating EOQ into hospital pharmaceutical logistics to reduce financial losses, strengthen supply chain efficiency, and ensure the continuous availability of essential medicines in primary hospital settings.

Corticosteroids are hormones that play an important role in the human physiological system, affecting self-defense against environmental changes. However, the perception of their efficacy often drives irrational self-medication behavior in the community, which can lead to detrimental effects if used long-term without supervision. This community service activity was carried out in Kepolorejo Village, Magetan Regency, based on initial observations showing errors in corticosteroid use, such as doubling dosages. The method used was educational counseling with material presentation and Q&A discussions regarding irrational corticosteroid use. Knowledge measurement was conducted through pre-test and post-test questionnaires. The results showed an increase in public knowledge regarding the impact of irrational steroid use.

Hypertension is a common health problem in the elderly that can affect quality of life. Hypertension in Batam city is a non-communicable disease that ranks 2 and with a percentage of 30.9%. The World Health Organization (WHO) said that there are 50 70% of hypertensive patients who do not comply with prescribed medications. Compliance with taking antihypertensive drugs is important to maintain blood pressure stability. Non-compliance in using antihypertensive drugs is one of the risk factors for increasing morbidity and uncontrolled hypertension events that can worsen the quality of life of hypertensive patients. This study aims to find out "The Relationship between Compliance with Taking Hypertension Medication and the Quality of Life of the Elderly in the Working Area of the Sei Lengkai Health Center in 2024". The research design used in this study is cross sectional. Data collection uses secondary data with the population of hypertension patients in Batam city in 2023 and primary data, namely a questionnaire on adherence to taking hypertension medication and quality of life for the elderly. Sampling was done using a purposive sampling technique with a total of 93 elderly people. The measuring tools in this study are the Morisky Medication Adherence Scale (MMAS-8) and WHOQOL-BREF questionnaires. Based on the results of the analysis, it is known that the p value is 0.003, this states that there is a relationship between compliance with taking hypertension medication and the quality of life of the elderly in the Sei Langkai Health Center Work Area in 2024. The conclusion of this study is that adherence to taking antihypertensive medication is positively related to the quality of life of the elderly, so efforts are needed to increase medication adherence to support a better quality of life in the elderly. It is hoped that families and health workers will provide support and education to the elderly to maintain compliance in taking their medication to improve their quality of life

Human Immunodeficiency Virus (HIV) infection leading to Acquired Immune Deficiency Syndrome (AIDS) remains a global public health issue, with 39 million people living with HIV worldwide in 2022. Although X Hospital in Malang City provides a comprehensive care program, internal data shows a significant level of non-adherence to antiretroviral (ARV) therapy, often in the form of irregular consumption or discontinuation of medication without medical recommendation. This observational study with a cross-sectional approach aims to identify the determinants of ARV non-adherence, involving 81 non-adherent AIDS patients at Hospital X through total sampling techniques. The characteristics of the respondents were dominated by males, highly educated, and working in the non-government sector, with the majority using the ARV regimen TLD, COTRIMOXAZOLE. The results of statistical analysis indicate that all eight determining variables tested show a highly significant positive correlation (p < 0.001) with non-compliance, meaning that the more severe the problems with these factors, the lower the patient compliance. Furthermore, the top five factors showed a very strong positive correlation (r > 0.80) with non-adherence, namely motivation/depression, social support, communication with service providers, treatment costs, and age or routine. These findings underscore that these five key determinants must be a crucial focus in designing and implementing targeted intervention strategies to effectively improve patient adherence to ARV therapy.

This study evaluated drug inventory management in a primary hospital pharmacy using the Economic Order Quantity (EOQ) method. A descriptive quantitative design was applied with secondary data collected from January to December 2024, covering annual demand, purchase price, ordering cost, and holding cost. The analysis revealed inefficiencies, as several drugs simultaneously faced overstock and stock out risks, indicating weaknesses in procurement planning. EOQ calculations suggested lower and more frequent procurement, reducing storage costs and improving stock control. The findings demonstrated that applying EOQ could minimize financial risks, optimize resource allocation, and ensure continuous access to essential medicines. This research highlights the relevance of structured inventory models in supporting hospital efficiency and sustainable pharmaceutical logistics, particularly in resource-limited primary hospitals.

This paper presents a narrative review focusing on the significance of in silico methodologies in identifying and evaluating natural bioactive compounds as promising antidiabetic agents. By examining scientific publications from 2020 to 2025, the review highlights substantial evidence that various plant-derived metabolites such as flavonoids, phenolic acids, terpenoids, and glycosides from Orthosiphon stamineus, Moringa oleifera, Syzygium polyanthum, Tinospora crispa, and Albizia saman demonstrate notable affinity toward several crucial enzymes implicated in type 2 diabetes, including DPP-4, SGLT-2, α-glucosidase, and PTP1B. Findings from molecular docking analyses and ADMET simulations indicate that many of these compounds exhibit favorable pharmacokinetic behavior, strong receptor interactions, and minimal toxicity, suggesting their potential as multitarget natural therapeutics with synergistic modes of action. Utilizing in silico screening as an initial step effectively predicts biological activity and pharmacological profiles prior to experimental validation through in vitro and in vivo testing, thus reducing both time and research expenditure. The synergy between computational modeling, medicinal chemistry, and phytochemical exploration establishes a scientific framework that supports the advancement of rational, safe, and sustainable herbal-based antidiabetic drug development derived from Indonesia’s vast biodiversity and encourages self-reliance within the national pharmaceutical sector.

Cancer remains a major challenge in modern medicine due to drug resistance and the adverse effects of conventional therapies, making it one of the leading causes of death worldwide. Continuous scientific efforts aim to discover safer and more effective treatments. Owing to their structural diversity, strong bioactivity, and relatively low toxicity, natural compounds show great promise as sources of anticancer drug candidates. This article aims to explore the role of medicinal chemistry in investigating, modifying, and optimizing natural bioactive compounds to develop more effective, selective, and stable anticancer agents with improved bioavailability. A narrative review was conducted using scientific literature published between 2020 and 2025 from PubMed, ScienceDirect, Google Scholar, and ResearchGate. The findings indicate that eugenol, berberine, hesperidin, piperine, and quercetin exhibit anticancer activities through apoptosis induction, inhibition of proliferation, and antioxidant and anti-inflammatory mechanisms. Modern medicinal chemistry relies on understanding structure–activity relationships (SAR), chemical modification, and nanoparticle formulation to enhance biological performance. In addition, in silico techniques such as molecular docking and QSAR analysis are applied to study ligands and receptors and predict bioavailability improvements. The development of natural products as rational, effective, and safe anticancer drug candidates is strengthened by integrating experimental, computational, and pharmaceutical approaches.

The high number of hypertension cases is due to the still low level of hypertension control, specifically medication adherence. Treatment adherence is crucial for maintaining health and well-being in patients with hypertension. In contrast, non-adherence to medication leads to treatment failure. This study aims to determine the relationship between self-management and adherence to hypertension medication in the elderly. This research employed an analytical design with a cross-sectional approach. The study consisted of 49 elderly people with hypertension in Cot Cut Village, Kuta Baro, Aceh Besar. The sample was chosen using a total sampling technique. The MMAS-8 questionnaire was used to assess adherence to hypertension medication with a Cronbach's alpha of 0.860. The self-management questionnaire showed a Cronbach's alpha of 0.766. The research was conducted from April 8th to 14th, 2025. The data analysis used univariate and bivariate methods, using the chi-square test. The results showed that out of 49 respondents, 21 (42.9%) were less adherent to hypertension medication, and 29 (59.2%) had less adherence to self-management. The chi-square test indicated a p-value of 0.001, showing a relationship between self-management and adherence to hypertension medication among the elderly. This research suggests that hypertensive patients should be supervised to improve medication adherence and self-care management to maintain stable blood pressure.

The implementation of the Frequent Pattern Growth (FPG) algorithm in a web-based drug purchasing application at Sumber Sehat Pharmacy aims to improve efficiency and accuracy in analyzing customer drug purchasing patterns. The FPG algorithm is a method used to identify frequent purchase patterns or frequent itemsets in purchase transactions, which can then be used to make relevant drug recommendations for customers. This study uses a case study at Sumber Sehat Pharmacy to explore drug purchasing patterns and provide a data-driven solution that can help pharmacies improve service and adjust drug stocks according to customer needs. The results show that the application of the FPG algorithm can identify significant purchasing patterns and assist pharmacies in determining more appropriate promotional strategies and inventory management. By using a web-based application that implements this algorithm, Sumber Sehat Pharmacy can provide drug recommendations that are more in line with customer preferences, thereby increasing customer satisfaction and pharmacy operational efficiency.

This community service program aimed to enhance students’ pharmaceutical literacy through the introduction of drug classification logos at SMP Muhammadiyah 04 Pangkatrejo. The background of this activity was the low level of drug-use literacy among adolescents, often leading to irrational self-medication. The activity employed a quantitative descriptive design with a one-group pretest–posttest approach. Educational interventions included interactive counseling, PowerPoint presentations, visual media using logo sticks, and pretest–posttest evaluation. Data were analyzed using the Wilcoxon Signed Rank Test. The results showed a significant improvement in students’ knowledge (p = 0.000), with mean scores increasing from 58% to 81% after the intervention. The highest gain was observed in the recognition of logo colors and drug classifications. Satisfaction analysis revealed that 96% of participants expressed satisfaction with the learning process, especially regarding material clarity and the presenters’ readiness to answer questions. The study concludes that participatory educational methods and visual media effectively improve rational drug-use awareness among junior high school students. Future programs are recommended to expand similar activities to other schools and integrate digital media for sustained impact on public health literacy.

Drug stock-outs are an indicator of pharmaceutical management failure that directly affects patient safety and the quality of hospital services. Gatoel Hospital Mojokerto experienced an increase in the percentage of drug debt from 3.14% in January to 6.20% in July 2025, with 1,607 patients affected. This study aims to identify the factors causing drug stock-outs and formulate preventive strategies through the optimization of the Minimum-Maximum Stock Level (MMSL) system based on the Hospital Information System. A mixed-method approach was used, combining secondary data analysis (January–July 2025) and in-depth interviews. Fishbone analysis was applied to identify root causes, USG analysis to determine priorities, and SWOT analysis to formulate intervention strategies. Priority drug classification was carried out using the ABC-VEN method. The intervention involved implementing an MMSL pilot project for 150 drug items under Pareto category A. The analysis identified six dimensions of stock-out causes: man, materials, methods, machines, measurement, and environment. The highest priority issue was drug demand forecasting based on historical data (USG score: 125). SWOT analysis placed the organization in quadrant II, recommending a Weakness-Opportunities (WO) strategy. MMSL implementation was initiated through the development of SOPs and the entry of 150 priority drug items into the system. Drug stock-outs are caused by multifactorial issues that require systemic intervention. MMSL optimization has the potential to serve as a long-term solution, provided there is expanded coverage, strengthened human resource capacity, and comprehensive system integration.