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The selection of appropriate solvents in sterile injection formulations plays a pivotal role in determining the stability, efficacy, and safety of pharmaceutical products. Among the commonly utilized solvents, Dimethyl Sulfoxide (DMSO), Polyethylene Glycol (PEG), and pyrogen-free water exhibit distinct physicochemical properties and functional roles. This study aims to analyze the characteristics, functions, and implications of these three solvents within the context of sterile injectable preparations. The research methodology involves a comprehensive review of six peer-reviewed scientific articles published within the last five years, focusing on solvent performance, compatibility, and safety profiles. Findings reveal that DMSO is highly effective in dissolving lipophilic compounds due to its strong solvating capacity. However, its use at elevated concentrations may lead to irritation and cytotoxicity, necessitating careful dosage regulation. PEG, particularly in its flexible molecular weight variants, serves as a co-solvent and viscosity modifier, enhancing solubility and stability of active pharmaceutical ingredients. Pyrogen-free water, characterized by its inertness and biocompatibility, remains the gold standard for injection solvents, offering minimal risk and broad applicability across drug classes. The study underscores the importance of aligning solvent selection with the physicochemical nature of the drug, intended route of administration, and patient safety considerations. Furthermore, the potential for combining solvents to achieve optimized formulations is highlighted as a promising avenue for future pharmaceutical development. Such combinations may offer enhanced solubility, reduced toxicity, and improved delivery mechanisms, particularly for complex or poorly soluble compounds. In conclusion, understanding the nuanced roles of DMSO, PEG, and pyrogen-free water is essential for formulating safe and effective sterile injections. This research contributes to the growing body of knowledge supporting rational solvent selection and encourages further exploration into innovative solvent systems for advanced drug delivery.

This study explores the integration of musical drama as a medium to strengthen computational thinking (CT) among high school students in Jakarta. Computational thinking, a critical 21st-century skill, involves problem-solving through decomposition, pattern recognition, abstraction, and algorithmic thinking. Despite its importance, CT remains underutilized in art education. This research employs a Research and Development (R&D) approach using the ADDIE model (Analysis, Design, Development, Implementation, Evaluation) to design and implement a project-based learning (PjBL) framework centered on musical drama. The study involved 35 grade XI students who participated in an 8-week musical drama project, divided into creative teams to handle various production aspects. Observations, interviews, and documentation revealed that students effectively applied CT components: decomposing tasks, recognizing patterns in performance elements, simplifying complex narratives (abstraction), and organizing systematic workflows (algorithmic thinking). Results indicated significant improvements in students' logical thinking, creativity, collaboration, and confidence. The study highlights the effectiveness of musical drama as an interdisciplinary tool to enhance CT skills while fostering emotional engagement and character development. It also underscores the teacher's role as a facilitator in promoting reflective and participatory learning. The findings align with prior research on PjBL and CT, suggesting broader applicability in art education. Future research could extend this model to basic education or incorporate digital technologies.

The rapid pace of urbanization has intensified competition among businesses, prompting the adoption of innovative strategies to enhance sales performance and customer engagement. PT Inspirasi Bisnis Nusantara, under the HAUS! brand, introduced “Huling,” a hyperlocal distribution service utilizing electric bikes (e-bikes) equipped with integrated storage boxes to improve delivery efficiency and environmental sustainability. This study aims to evaluate customer acceptance of the Huling service by applying the Technology Acceptance Model (TAM). The model incorporates five core variables: Perceived Ease of Use (PEOU), Perceived Usefulness (PU), Attitude Towards Usage (ATU), Behavioral Intention (BI), and Actual Usage (AU). A quantitative research approach was employed, collecting data from 258 respondents through structured questionnaires. The data were analyzed using the Partial Least Squares Structural Equation Modeling (PLS-SEM) method to assess the relationships among the TAM variables. The findings reveal that PEOU has a significant positive effect on both PU and ATU, indicating that ease of use not only improves perceptions of usefulness but also fosters favorable attitudes toward adoption. PU significantly influences ATU and BI, suggesting that perceived benefits drive both positive attitudes and intentions to use the service. Furthermore, BI has a direct and significant effect on AU, confirming that stronger behavioral intentions translate into actual utilization. The analysis highlights the strongest impact along the pathway PEOU → ATU → BI → AU, underscoring the critical role of user-friendly design and positive attitudes in driving customer adoption. This research contributes to the literature by demonstrating the applicability of TAM in the hyperlocal distribution sector, offering practical implications for service providers seeking to enhance user acceptance through improved usability and perceived value. The findings suggest that optimizing ease of use and communicating tangible benefits can significantly increase customer engagement and sustained usage of innovative delivery services.

Mental health issues such as depression, anxiety, and stress continue to increase globally and are recognized as critical factors that influence social functioning, productivity, and overall quality of life. Conventional mental health services are often limited by barriers including high cost, geographical distance, and persistent stigma that discourage individuals from seeking timely help. The digital era provides an alternative through the integration of technology into mental health counseling, offering greater accessibility, flexibility, and anonymity. Nevertheless, a key limitation of many digital counseling platforms lies in their inability to fully capture and respond to the emotional nuances of users during interactions. This study aims to address that gap by developing a speech-based emotion detection framework designed to be integrated into digital counseling environments. The proposed methodology includes the collection and preprocessing of speech samples, feature extraction using acoustic parameters, and training machine learning models to classify emotions in real time. Experimental results demonstrate that this approach significantly improves the accuracy of emotion detection, enabling digital counseling systems to provide more adaptive and personalized support. Beyond counseling, the research highlights the broader applicability of speech emotion recognition in education, telemedicine, and interactive digital assistants, all of which benefit from improved sensitivity to human emotions. These findings underscore the potential of artificial intelligence to strengthen digital mental health interventions, ensuring services that are not only more efficient and inclusive but also capable of fostering long-term emotional well-being in diverse populations.

The heirs' clause in the credit agreement raises legal problems because it concerns the attachment of third parties. This study aims to analyze the inclusion of heirs' clauses based on privity of contract and its legal implications for legal protection for creditors and heirs. Normative juridical method has used with regulatory and conceptual approach. The results shown that the heir's attachment clause in a credit agreement does not necessarily bind the heirs automatically because the privity of contract limits the engagement only to the parties who made the agreement. This is based on the existence of the principle of saisine in Civil Law and the principle of ijbari in Islamic Law where the heir automatically becomes the owner of the heir's legacy. However, the attachment that arises is only limited to the management of heritage property before it is distributed as inheritance. The applicability of the clause must also take into account whether there is an inheritance by the heirs, because the liability for the heir's debts only arises if the inheritance is received. If the inheritance is rejected, the creditor cannot impose payment obligations on the heirs even though there is an attachment clause. On the other hand, Islamic Law has emphasized that inheritance received by heirs is only inheritance that has been reduced by burdens, including the heir's debt. Therefore, the inclusion of the heir's clause is only a notification that reminds the heirs that there are still unfulfilled heirs' obligations, namely debts.  

Digital image segmentation is essential in image processing, influencing the accuracy of higher-level tasks. Thresholding is widely used, yet identifying optimal threshold values remains challenging. The Firefly Algorithm with Neighbourhood Attraction (FaNA), a metaheuristic approach, is efficient for color image thresholding but underperforms on grayscale images due to suboptimal thresholds. To overcome this, an enhanced version (eFaNA) was developed by integrating a chaotic tent map for population initialization and a Lévy flight-based random walk for improved exploration. eFaNA was compared with FaNA, fuzzy firefly algorithm (FFA), and the standard Firefly Algorithm (FA) in multilevel thresholding of grayscale images. Results demonstrate that eFaNA achieves superior segmentation quality with minimal detail loss, outperforming the others. The average PSNR obtained by eFaNA, FFA, FaNA, and FA was 25.5320 dB, 25.4075 dB, 24.1522 dB, and 24.4506 dB, respectively; average SSIM was 0.8641, 0.8604, 0.8432, and 0.6703; and execution time was 50.5322, 38.7726, 38.7528, and 107.6340 seconds, respectively. This reflects a PSNR improvement of 5.71% over FaNA, 0.49% over FFA, and 4.42% over FA, and an SSIM gain of 2.48% over FaNA, 0.43% over FFA, and 28.92% over FA. While eFaNA lags behind FFA and FaNA in execution time by ~11.8 seconds, it significantly outperforms FA. The performance gain is attributed to the chaotic tent map’s diverse initialization and the Lévy flight’s enhanced search capability. These improvements enable eFaNA to deliver consistently better threshold values and segmentation results. However, its relatively higher computational cost may limit applicability in real-time image processing.

This research examines North Korea's violation of the principle of good faith under the Nuclear Non-Proliferation Treaty (NPT) and its legal consequences. The main issue addressed in this study is North Korea’s breach of the good faith principle within the framework of the NPT, which raises legal implications regarding its status and obligations as a party to the treaty. Although North Korea was formally bound by the NPT, it secretly developed a nuclear weapons program, demonstrating non-compliance with the fundamental principle of international treaty implementation. This issue was further exacerbated by its refusal to allow inspections by the International Atomic Energy Agency (IAEA) and its unilateral withdrawal from the NPT, which has sparked debate over the legitimacy and legality of such action.Using a normative juridical approach, this study analyzes North Korea’s clandestine development of nuclear weapons while still a member of the NPT, as well as the validity of its withdrawal from the treaty. The findings show that North Korea violated the principle of good faith through its secret nuclear program, refusal of IAEA inspections, and withdrawal that did not meet the requirements of Article X of the NPT. The withdrawal may be deemed invalid as it was conducted in bad faith and without fulfilling the treaty's formal provisions. The legal consequences include the continued applicability of obligations under the NPT and state responsibility for breaches of international law. Ideal forms of accountability include the cessation of the nuclear program, payment of reparations, guarantees of non-repetition, and renewed compliance with NPT provisions through verifiable denuclearization.

Fire incidents in Indonesia remain relatively high, with a total of 2,286 cases recorded. In 2022, the frequency of fires in Jakarta reached 1,691 cases, marking a 10% increase compared to the previous year, which had successfully reduced fire frequency by 23%. The high fire risk in high-rise buildings can lead to both material losses and casualties. This study aims to design the layout and determine the requirements for portable fire extinguishers  in a hospital project in Jakarta. The design of the fire extinguisher layout and requirements is intended for the operational phase of the building, ensuring optimal applicability. The location, area, and/or environment with various work activities and risk levels ranging from low to high indicate that safety is of paramount importance and must be prioritized, and that any form of accident should be addressed as early as possible. This research employed a qualitative descriptive method to describe and illustrate existing phenomena, both natural and human-engineered, through observation, interviews, and documentation. The findings show that the design of the fire extinguisher layout and requirements amounted to 61 units across the 4th to 7th floors, with the fire extinguisher layout plan attached. The type of fire extinguisher used on each floor is a 6-kg dry powder extinguisher. The conducted fire risk assessment indicates that each floor presents a moderate hazard, while some rooms exhibit a high hazard level. This study provides recommendations for the placement and requirements of fire extinguisher in accordance with standards and is expected to contribute to fire prevention efforts in the hospital project in Jakarta once it becomes operational.

The common cold in infants is a frequent health problem that requires proper management to prevent potential complications such as pneumonia, bronchitis, sinusitis, laryngitis, and febrile seizures. Management strategies for the common cold can be carried out through pharmacological approaches, such as the administration of syrups and powders, and non-pharmacological approaches, including traditional methods like common cold massage. This study aims to analyze the effect of providing education about common cold massage on mothers’ knowledge in managing the common cold in infants. The research employed a quantitative method with a quasi-experimental design using a one-group pretest-posttest approach. The study population consisted of 40 mothers who had infants aged 4–12 months registered at the Gunungpati Health Center. A total sample of 36 respondents was obtained through simple random sampling. The research instrument was a structured knowledge questionnaire specifically developed to assess understanding of common cold massage techniques and their role in managing symptoms. Data analysis was conducted using the Wilcoxon signed-rank test to evaluate differences in knowledge levels before and after the educational intervention. The results showed a significant increase in mothers’ knowledge after receiving education, with a p-value of 0.000 (<0.05), indicating that the intervention was statistically significant. These findings highlight the importance of non-pharmacological educational programs, particularly common cold massage, as a complementary approach to infant health care. Implementing such education can empower mothers with practical skills to manage early symptoms and potentially reduce complications. It is recommended that further studies be conducted in different settings with more varied sociodemographic backgrounds to ensure broader applicability and to explore the integration of traditional massage education into community health programs.

This study aimed to improve the learning outcomes of second-grade students at SD Negeri Latsari Tuban in Indonesian language lessons, specifically focusing on the theme "My Unique Family." The classroom activities were designed to encourage active student participation through group discussions on related topics. The research was conducted over two cycles, applying a scientific approach to the learning process.The findings showed a 20% improvement in student learning outcomes, with the average score increasing to 8.68. Mastery levels also improved significantly, from 69% in the first cycle to 89% in the second cycle. These results demonstrate that the scientific approach effectively enhanced student understanding and engagement during the lessons.Overall, the study concludes that the scientific approach is a beneficial method for improving learning outcomes in Indonesian language subjects. It also suggests the broader applicability of this method for enhancing student achievement across other themes and subject areas.

A database is a fundamental element in an information system that is used to manage and store data. Two commonly used database types are NoSQL (Not Only SQL) and SQL (Structured Query Language). SQL uses a structured relational model with a fixed schema, while NoSQL is more flexible with various storage models such as document, key-value, column-width, and graph. This research aims to conduct a literature study on the comparison of these two types of databases, including their advantages, disadvantages, and applicability in various information system scenarios. The study results show that the choice between SQL and NoSQL is highly dependent on the specific needs of the application, in terms of performance, scalability, and data complexity.

This study examines Legal certainty is a crucial element in effective governance, especially in the context of laws and regulations. This research examines the enforceability of the Minister of Home Affairs Regulation No. 86/2017, which regulates the preparation of the Local Government Work Plan (RKPD). This research finds that legal certainty in the RKPD is strongly influenced by the implementation and supervision of the regulation. In addition, challenges in harmonization between central and local regulations are an important factor in ensuring effective enforcement. The results show that the ambiguity in Article 78 results in uncertainty in the integration of pokir into the RKPD, thus reducing the effectiveness of DPRD participation and potentially creating conflict between the executive and legislature. To improve legal certainty, it is suggested that further revision and explanation of the provision is needed, as well as training for local officials on more effective implementation of the regulation. The findings are expected to serve as recommendations for policymakers in drafting clearer and firmer regulations.This research recommends clarification and revision of Article 78 to create a clearer framework and support synergy between local governments and DPRDs. The findings are expected to contribute to the improvement of more inclusive and responsive regional planning policies.

The research aims to demonstrate the extent to which international accounting standards can be applied in the public sector. IPSAS And its impact on the quality of financial reporting in Iraq and providing a theoretical framework on the concept of international accounting standards in the public sector IPSAS The quality of financial reporting in Iraq and identifying the economic and social benefits of implementing it IPSAS In Iraqi government institutions and evaluating the positive impact of the application IPSAS on the local economy and society and studying the most important challenges that may hinder the implementation IPSAS and to provide recommendations to overcome them, the deductive approach was relied upon in building the proposed framework for the research by moving from the general to the specific and relying on the inductive approach by moving from the specific to the general by generalizing the conclusions and recommendations to the research community. The research community is represented by all government departments and institutions in Iraq. As for the research sample, the Financial Supervision Bureau was chosen because of the effective role of this body in imposing accounting and control systems on government departments and institutions, preserving public money, supporting public accountability and strengthening the economy. The most significant of the researcher's findings, however, was that the Iraqi Accounting Standards Board had failed to implement international accounting standards. the public sector and issue local standards that are consistent and compatible with the above standards to bridge the large gap between international and Iraqi standards because the current local rules are insufficient to address accounting practices.

Marriage is a sacred vocation that signifies a profound commitment between husband and wife, rooted in love and faith. Many couples, however, lack the emotional and mental readiness to navigate marital challenges. This study examines the impact of Pre-Marriage Catechesis (KPP) on the emotional and mental readiness of Catholic couples in the Holy Spirit Cathedral Parish, Denpasar. Using a pretest- posttest experimental design, data were collected from 89 participants (44 males, 45 females) in November 2024, utilizing the Sukoon Marriage Readiness Scale. Before KPP, participants were categorized as "Highly Ready for Marriage" (20%, 18 individuals), "Moderately Ready" (50%, 45 individuals), and "Not Ready" (30%, 26 individuals). After completing KPP, the "Highly Ready" group increased to 65% (58 individuals), "Moderately Ready" remained at 30% (27 individuals), and "Not Ready" decreased to 5% (4 individuals). Pearson correlation analysis showed a strong relationship between KPP and readiness (r = 0.842, p = 0.000). Gender had no significant effect (p > 0.05), indicating KPP's universal applicability. The study concludes that KPP significantly enhances couples' readiness for marriage, contributing 98.7% to their emotional and mental preparedness. Recommendations include adapting KPP modules to address modern couples’ needs and increase program efficacy.

Globalisation introduces substantial changes to human existence, combined with in social, economic and cultural elements. However, these adjustments furthermore offer critical obstacles, specifically for Muslims, United Nations agency generally need to confront beliefs and practices that contrast with monotheism teachings. With an emphasis on social, economic, and cultural facets, this analysis seeks to examine the applicability of Qur'anic interpretation in addressing the issues of globalization. It is intended that a wide range of flexible and conversational approaches to interpretation will provide fresh perspectives on how the holy text's lessons remain pertinent and relevant in today's modern world. Using literature reviews and material gathered from a variety of contemporary commentary, books, scientific papers, and journals, a qualitative analysis technique is employed. The findings of the analysis demonstrate that a discourse interpretation of the Qur'an will address the problems of economic injustice, social inequality, and the cultural psychological state brought on by globalization. Finally, in order to respond to the problems of globalization and ensure that the teachings of the Qur'an remain relevant in the current era, a dynamic interpretation method is absolutely essential.

Objective: This study investigates the critical role of risk management practices in enhancing corporate performance, with a specific focus on financial institutions and manufacturing sectors. The research aims to uncover how effective risk management contributes to organizational resilience, operational efficiency, and long-term sustainability.Methodology: A Systematic Literature Review (SLR) methodology was employed to analyze 11 peer-reviewed academic articles published between 2015 and 2023. The selected studies were drawn from reputable databases such as Scopus and Web of Science, using predefined inclusion criteria. The analysis focused on identifying patterns, gaps, and emerging trends in risk management practices.Findings: The study reveals that robust risk management significantly enhances organizational resilience, mitigates exposure to financial and operational risks, and fosters improved corporate governance. Frameworks such as ISO 31000 and Enterprise Risk Management (ERM) are identified as pivotal in aligning risk management with strategic objectives, thereby driving sustainable growth.Contribution: This research underscores the need for a unified and standardized risk management framework that addresses sector-specific challenges while promoting cross-industry applicability. Policymakers and industry leaders are urged to prioritize risk management as a strategic imperative, especially in times of crisis.

The role of education in shaping character has been a subject of discourse throughout history, with its significance amplified in the face of contemporary challenges. This study examines the relevance of Ibn Khaldun's educational philosophy in the context of modern character formation. The reseaarch aims to analyze Ibn Khaldun's perspective on education and its potential application in contemporary character-building efforts. A qualitative approach is employed, focusing on a comprehensive review of secondary sources and scholarly interpretations of Ibn Khaldun's educational theories. The study synthesizes various perspectives on Ibn Khaldun's educational philosophy and examines their applicability to current educational practices and challenges. This approach allows for a broader understanding of Ibn Khaldun's ideas within the context of modern educational needs. The study reveals that Ibn Khaldun's educational theory emphasizes the integration of religious, moral, and practical knowledge in character development. His holistic approach to education, which includes the cultivation of critical thinking, social skills, and ethical values, aligns closely with current educational needs. The findings suggest that Ibn Khaldun's educational principles can significantly contribute to addressing modern character-building challenges, particularly in fostering resilience, cultural understanding, and ethical decision-making among students. This research provides valuable insights for educators and policymakers in developing comprehensive character education programs that balance traditional wisdom with contemporary demands. Moreover, it highlights the importance of revisiting historical educational philosophies to inform and enrich modern a pedagogical practices, especially in the realm of character education.

This study investigates the feasibility of applying zero-based budgeting in themunicipalities of Anbar Governorate in Iraq, verifies the existence of a writtenstrategy for its adoption, analyzes available resources and capabilities, andproposes a practical model for its implementation.This study uses a descriptive and analytical approach through data collection andanalysis. A survey research tool "questionnaire" was used, designed to achieve thestudy objectives, and distributed to 280 municipal employees, including managers,accountants, and local council members, to assess their perceptions of applyingzero-based budgeting. In addition, interviews were conducted with senior officialsto obtain their vision towards implementing zero-based budgeting in theirdepartments and whether it is in their minds and strategies. The results of our studyindicate major gaps in current practices, including the absence of a clear strategyfor adopting zero-based budgeting, insufficient financial resources, lack of skilledemployees, insufficient technological infrastructure, weak administrative support,and the absence of legislative frameworks supporting the implementation of thistype of budgeting. The study also identified critical areas for improvement,including developing a clear strategy, enhancing staff capacity through training,enhancing administrative support, upgrading technological resources, andreviewing legal frameworks to support the foundations of zero-based budgeting.The findings underscore the need for a comprehensive and well-supportedtransition plan to successfully implement zero-based budgeting in Anbarmunicipalities. By addressing these challenges, municipalities can improve resource allocation, prioritize projects more effectively, and ultimately enhancefinancial management practices. The paper concludes with a proposed model thatrepresents the basic steps that should be adopted initially when embarking on thezero-based budgeting process, to ensure the successful implementation of zero-based budgeting.

This study presents the development and evaluation of an automatic passenger counting system for public buses using the YOLOv8 algorithm based on Convolutional Neural Networks (CNN). Accurate passenger counting plays a crucial role in optimizing public transportation operations, as it enables effective capacity management, reduces operational costs, and improves overall passenger comfort. Conventional manual counting methods are often inefficient, time-consuming, and prone to human error, particularly in high-density urban transportation environments. Therefore, an automated and intelligent solution is required to support real-time monitoring and operational decision-making. The proposed system employs deep learning-based object detection to identify and count passengers from video streams captured by cameras installed inside buses. Two camera positions, namely front and rear views, were evaluated to assess system performance under different visual conditions. The experimental results show that the system achieves high detection accuracy in the front camera view, with a confidence score of 0.82, indicating reliable performance in scenarios with minimal object occlusion. In contrast, the rear camera view demonstrates slightly lower accuracy, with a confidence score of 0.76, mainly due to increased object overlap and variations in lighting conditions. These findings emphasize the importance of appropriate camera placement and environmental consideration in improving detection reliability. In addition, the implementation of the proposed system enables real-time monitoring of passenger flow, which supports dynamic scheduling, demand-based route planning, and efficient fleet management. Accurate passenger data allows transportation operators to optimize service allocation, reduce congestion, and enhance overall service quality. Overall, this study contributes to the development of intelligent transportation systems by demonstrating the practical applicability of deep learning-based passenger counting solutions. The proposed approach offers strong potential for real-world deployment in smart city environments, supporting the creation of more sustainable, efficient, and passenger-oriented public transportation services.

Basically, the only person who can pawn an object is the owner of the object, but now incidents have become widespread where other people pawn objects that do not belong to them without the consent of the owner of the object. In this case, the owner of the object can file a lawsuit for revindication when the object is taken by someone else. However, Article 1977 paragraph (1) BW states that whoever controls a movable object is considered the owner. Given these legal problems, this research wants to examine the legal protection of owners of pawned objects whose objects are used as pawn objects by other people without their consent. This research aims to analyze the applicability of the Nemo Plus Juris Transferre Potest Quam Ipse Habet principle as a basis for encumbrances on pledged objects without the consent of the owner of the object as well as legal protection for the owner of the object and the recipient of the pledge when the object is used as an object of pawn by another person without the knowledge of the owner of the object. The research method used in this research is normative legal research using a statutory approach and a conceptual approach. This research uses primary and secondary legal sources by collecting through literature studies which are then analyzed using descriptive analytical methods. The results of the research are that the agreement made by the pawnbroker and the debtor who is not the owner of the object is valid because the validity of the pledge is determined by handing over the pawned object to the creditor and the creditor cannot be blamed if he receives an unregistered movable object in good faith.