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This literature review explores the effects of tomato juice on lowering systolic and diastolic blood pressure in elderly individuals with hypertension. Hypertension is a prevalent condition among the elderly and a major risk factor for cardiovascular diseases. The objective of this review is to evaluate the effectiveness of tomato juice as a non-pharmacological intervention to manage hypertension. The research methodology involved a comprehensive review of studies published between 2020 and 2024, sourced from reputable databases such as Google Scholar and ScienceDirect. The findings indicate that tomato juice, rich in potassium and lycopene, significantly reduces blood pressure in elderly patients. Potassium helps regulate sodium levels in the body, while lycopene provides antioxidant benefits and promotes vascular health. Although tomato juice demonstrates potential as an effective and natural remedy for hypertension, further research with larger sample sizes and longer durations is needed to confirm its long-term benefits. The implications of these findings suggest that tomato juice could be considered as a supportive therapy for hypertension management in the elderly, though it should not replace conventional antihypertensive medications.

Breast cancer is the most prevalent type of cancer in women worldwide, with approximately 2.3 million new cases or 11.7% of all cancer cases. Human Epidermal Growth Factor Receptor 2 (HER-2) is one of the important therapeutic targets in breast cancer that is overexpressed in 15-25% of cases. Conventional cancer treatments such as chemotherapy often cause adverse side effects, so safer alternative therapies are needed. This study aims to assess the potential of active compounds from medicinal plants as HER-2 inhibitors through a molecular docking approach. The literature review method was used by analysing related research articles in the last five years obtained from PubMed and Google Scholar databases. The results showed that several active compounds have high potential as HER-2 inhibitors, including beta cystosterol from guava leaves (Psidium guajava L.) with a binding energy value of -12.3 kcal/mol, vitexin from dandang gendis (Clinacanthus nutans L.) with a value of -9.3 kcal/mol, and isovitexin from basil mekah (Ocimum gratissimum) with a value of -9.11 kcal/mol. These findings provide a basis for further development of natural active compounds as potential breast anticancer drug candidates with minimal side effects.

The problem of accessibility and efficiency of book search is still a major challenge in school libraries, especially those that still rely on manual systems. This study aims to implement and test the effectiveness of an information retrieval system (IRS) based on the Dice Similarity method in the SMA Negeri 1 Siantan Library, West Kalimantan. The research method used is experimental descriptive quantitative, with data collection through observation, interviews, and documentation, as well as system testing on collection data and library user activities. The system was developed using the Laravel framework and MySQL database, and evaluated using precision and recall metrics. The results showed that the system has a Precision value of 100% and a variable Recall value, with the highest value of 66.66% and the lowest of 14.28%. The implementation of this system significantly speeds up the search process, minimizes recording errors, and increases user satisfaction. The findings recommend the adoption of Dice Similarity-based IRS as an applicable solution for school libraries in supporting literacy and easy access to information. The findings are expected to be a reference for the development of library information systems in educational environments with limited resources.

Vergence movement is an important mechanism in eye coordination to maintain visual focus. The neural pathways controlling vergence involve complex interactions between various brain structures, such as the mesencephalic nucleus of the oculomotor nerve (CN III), the abducens nucleus (CN VI), the reticular pontine formation (PRF), and the visual and motor cortices. Disorders in this system can lead to convergence insufficiency, esotropia, exotropia, as well as diplopia which impacts the quality of binocular vision. This study aims to conduct a systematic review of the neural pathways that play a role in the vergence system. This research design is a study that uses the Systematic Literature Review (SLR) method. 5 articles were obtained using a method of secondary analysis of literature review through scientific database portals such as SINTA, Scopus and Google Scholar published in 2015-2025 both national and international articles. The results of the analysis show that vergence disorders are common in children and the elderly, with various causes ranging from benign factors to more serious neurological conditions. Studies show that activities in the parietal eye field (PEF), frontal eye field (FEF), superior colliculus (SC), and PRF have important roles in vergence coordination. In addition, vergence deficits were also found in Parkinson's patients, who showed prolonged latency and reduced vergence gain. In the context of technology, research on virtual reality (VR) shows that vergence errors often occur when users interact with virtual environments, leading to visual fatigue and incorrect depth perception. This study also highlights that neurotransmitters such as GABA, glutamate, and dopamine have a role in the modulation of neural signals that control vergence. A deeper understanding of the neural pathways of vergence is crucial in ophthalmology and neurology, especially in the diagnosis and therapy of binocular vision disorders. In addition, research on vergence also contributes to the development of visual technologies, such as VR and eye tracking systems, that are more adaptive to human physiological characteristics.

This study aims to analyze the causes of data duplication in companies, its impact on operational efficiency, and the solutions that can be implemented to prevent and address it. Using a qualitative method with a library research approach, this study examines various literature related to data management. The findings indicate that data duplication is caused by a lack of standardization, input errors, and weak integration systems. The recommended solutions include the implementation of database management technology, regular data audits, and strict data governance policies. With the right strategies, companies can enhance efficiency and ensure data accuracy in business decision-making.  

Diphtheria is a type of infectious disease that can be prevented by immunization. The cause of diphtheria is toxigenic Corynebacterium diphtheriae strains. Humans are the only reservoir for the spread of diphtheria which is transmitted either through droplets, through eating utensils, as well as through close direct contact with skin lesions. This disease is characterized by sore throat, fever, malaise, and on examination pseudomembranes are found in the tonsils, pharynx and/or nasal cavity. Objective: To find out the magnitude of the Diphtheria outbreak problem and the risk factors that influence it. Method: This research is a literature study. The search was carried out in the Google Scholar database published in the period 2013 to 2023. Results: Shows that in extraordinary cases of diphtheria there are some who have received the DPT vaccine and there are also those who have not received the DPT vaccine, as well as a lack of public knowledge regarding diphtheria which can lead to outbreaks diphtheria. Conclusion: Epidemiological investigations of diphtheria outbreaks at this stage are still influenced by several factors which often occur, namely incomplete coverage of DPT vaccine in the toddler group, diphtheria transmission is prone to occur in the age group ≤ 15 years and low level of knowledge of the population due to lack of providing education about diphtheria disease.

Diabetes mellitus is a condition of elevated blood glucose levels due to impaired insulin secretion, insulin resistance, or both. This disease can lead to various serious complications that impact quality of life if not properly managed. Current diabetes management generally involves dietary modification, physical activity, and antidiabetic drug therapy. However, recent research has revealed the potential of bioactive compounds from natural sources such as curcumin in minimizing the risk of diabetes-related complications. This literature review examines and analyzes research evidence on the effects of curcumin supplementation on health parameters in patients with diabetes mellitus. The review was conducted on English-language publications in the last 10 years (2014-2024) using electronic databases. The reviewed experimental and cohort studies demonstrate the influence and beneficial effects of curcumin on glycemic control, lipid profile, weight reduction, and kidney function protection in diabetic patients. Curcumin has the potential to contribute to reducing oxidative stress and inflammation as the main triggering factors for complications of diabetes mellitus.

COVID-19 is a viral respiratory disease that has caused a global health emergency and was declared a pandemic by the World Health Organization. The lack of certain drug molecules or treatment strategies for this disease is making it worse. Therefore, effective drug molecules are urgently needed to fight COVID-19. Specific therapies for the SARS-COV2 virus are still being developed in several countries around the world. One of the molecular targets that is thought to be specific to SARS-COV 2 is 3CLpro or the main protease of the COVID-19 virus which is an important enzyme to be able to replicate related viruses. The purpose of this study is to explore the role of medicinal chemistry in the development of anti-sars-cov 2 drugs through the exploration of bioactive compounds from natural sources, namely green tea. Green tea (Camellia sinensis) also contains eight native monomeric catechins or polyphenolic compounds. The method used was literature review with analysis of 3 selected articles from international databases such as PubMed, ScienceDirect, and Springer, as well as SINTA accredited national journals. The results showed that all test compounds except caffein had stronger binding energy than lopinavir. Epicatecin and catechin have the same binding energy value as lopinavir, which is -7.1 kcal/mol. Catechin gallate and epicatechin gallate have the strongest bond among all test compounds because they have the most negative AG, namely -9.0 and 8.2 kcal/mol.    

Ginseng strengthens the body's resistance to disease through its effects on components of the immune system. This study aims to examine the immunomodulatory effects of ginseng (Panax sp.) in relation to its active ingredients and constituents that are beneficial to the immune system. This research is a systematic review conducted based on PRISMA items. Literature was searched through the PubMed, ScienceDirect, and Google Scholar databases, covering publications from 2020 to 2025. A total of 523 articles were collected from the three databases. Based on screening and analysis using PRISMA items, 6 articles met the inclusion and exclusion criteria. Ginseng may act as an immunomodulatory agent in the immune system, with various benefits derived from its active compounds.    

Cancer is one of the leading causes of death in the world, with the incidence rate continuing to increase every year. Conventional treatments such as chemotherapy and radiotherapy often have limitations, especially related to selectivity towards cancer cells and toxic side effects caused to normal cells. Therefore, an alternative approach that is more effective and safe is needed. One promising approach is the utilization of bioactive compounds from natural materials that are optimized through a medicinal chemistry approach. This study aims to examine the potential of natural compounds such as epigallocatechin gallate (EGCG) from green tea, berberine from Berberis vulgaris, curcumin from turmeric (Curcuma longa), and cardiotonic steroids (CTS) from Digitalis purpurea and Nerium oleander as anticancer agents, as well as their optimization strategies through structural modification, increased stability, and modern delivery technology. The method used is a systematic literature review of scientific articles from 2020 to 2025 obtained through the PubMed, ScienceDirect, and Google Scholar databases. The results of the study indicate that these compounds have various anticancer mechanisms of action, such as apoptosis induction, cell cycle inhibition, and activation of specific signaling pathways such as PI3K/Akt, MAPK, and ferroptosis. However, challenges such as low bioavailability, poor stability, and toxicity are still obstacles in their application. Through a medicinal chemistry approach, these compounds can be structurally modified or reformulated to improve their clinical effectiveness. In conclusion, the combination of natural wealth with medicinal chemistry innovation opens up great opportunities in the development of more selective, effective, and safe anticancer therapies in the future.    

Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder affecting reproductive-age women and is closely associated with metabolic disturbances such as overweight and insulin resistance. More than 50% of women with PCOS are overweight, which exacerbates ovulatory dysfunction and increases androgen levels. Insulin resistance, found in approximately 50% of PCOS patients—even those with normal body weight—triggers hyperinsulinemia that stimulates androgen production and suppresses ovulation. This study aims to analyze the contribution of overweight and insulin resistance to the development of PCOS through a literature review approach. Scientific articles were retrieved from databases such as PubMed and Google Scholar, focusing on publications from the last five years. The findings indicate that overweight and insulin resistance mutually reinforce hormonal and ovulatory dysfunction typical in PCOS patients. Recent studies show that higher body mass index (BMI) and elevated HOMA-IR levels are strongly associated with menstrual irregularities, hyperandrogenism, and reduced quality of life. In conclusion, overweight and insulin resistance are two major contributing factors to PCOS pathogenesis and influence reproductive success. Clinical management should consider a comprehensive approach targeting both factors through lifestyle interventions and pharmacological therapy.

Knee osteoarthritis is a global health issue with increasing prevalence, particularly among the elderly population. This condition is characterized by primary symptoms such as joint pain, stiffness, and reduced physical function, which significantly limit the patient's daily activities. One promising non-pharmacological approach to managing knee osteoarthritis is Home-Based Resistance Training (HBRT). HBRT combines the effectiveness of resistance training with the convenience of being performed at home and is increasingly supported by advancements in telerehabilitation technology. This study is a systematic review conducted based on the PRISMA-P guidelines, with literature searches from PubMed, Scopus, Semantic Scholar, Google Scholar, and Cochrane databases. The included articles were English-language publications from 2019 to 2024 that evaluated the effectiveness of HBRT in patients with knee osteoarthritis. The findings indicate that HBRT is significantly effective in reducing joint pain, with a decrease in WOMAC scores ranging from 24.78% to 29.64% (p < 0.001), and improving physical function by 21.54% to 30.2%. These improvements meet the Minimum Clinically Important Difference (MCID) criteria, indicating clinically significant benefits. Furthermore, the effectiveness of HBRT is comparable to machine-based training, particularly in patients with high baseline severity. With standardized exercise protocols and adequate technological support, HBRT can be considered a feasible and effective intervention strategy in the rehabilitation of knee osteoarthritis patients, especially in the digital era and in contexts where access to conventional healthcare facilities is limited.

A database is a fundamental element in an information system that is used to manage and store data. Two commonly used database types are NoSQL (Not Only SQL) and SQL (Structured Query Language). SQL uses a structured relational model with a fixed schema, while NoSQL is more flexible with various storage models such as document, key-value, column-width, and graph. This research aims to conduct a literature study on the comparison of these two types of databases, including their advantages, disadvantages, and applicability in various information system scenarios. The study results show that the choice between SQL and NoSQL is highly dependent on the specific needs of the application, in terms of performance, scalability, and data complexity.

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia due to insulin deficiency or insulin resistance. Currently available pharmacological treatments often cause unwanted side effects, so alternative therapies that are safer and more effective are needed. This study aims to analyze the effectiveness of telang flower extract in reducing blood glucose levels and preventing complications. The potential of Clitoria ternatea as an antidiabetic agent was explored through a systematic literature review, using scientific databases such as Google Scholar, ScienceDirect, and Mendeley with the keywords “Clitoria ternatea AND diabetes AND blood glucose.” Inclusion criteria applied included experimental studies conducted on diabetes-induced mice samples, interventions with telang flower extract administration, and publications within the last 5 years (2021-2025). From a total of 1,858 articles identified, by applying the PRISMA-ScR method, 8 articles were obtained that met the inclusion criteria. The analysis showed that telang flower extract was effective in reducing blood glucose levels. This antidiabetic effect is thought to be due to the presence of flavonoids and other bioactive compounds in telang flowers that act as α-amylase enzyme inhibitors, antioxidants, and anti-inflammatories. These findings indicate the potential of Clitoria ternatea as a promising therapeutic alternative in the management of diabetes mellitus.

Background: Hypertension is one of the most common cardiovascular diseases in society. One of the risk factors for hypertension is coffee consumption which is characterized by the emergence of many outlets or coffee shops and is influenced by massive cultural shifts. Objectives: Writing this literature review aims to determine the effect of coffee consumption on increasing blood pressure based on the results of previous studies. Methods: In the preparation of this article using the literature review method from searching articles through electronic databases published in the last 10 years. Results: From the results of the literature review conducted, it shows that there are two conditions where coffee consumption can have an effect on increasing blood pressure and coffee consumption has no effect on increasing blood pressure. Conclusion: Coffee consumption can have an effect on increasing blood pressure due to the presence of caffeine which has antagonistic properties against endogenous adenosine and can stimulate sympathetic nerves. However, coffee also contains micronutrient compounds to provide protective effects against hypertension, such as polyphenols, magnesium, potassium, niacin, and vitamin E. Further research using experimental methods so that clear evidence is obtained from previous studies.

Delays in filling in the School and Student Data Base (PDSS) by teachers at several schools in Indonesia, such as SMAN 1 Mempawah and SMK 2 Surakarta, have caused hundreds of students to risk losing the opportunity to take part in the National Achievement Based Selection (SNBP) in 2025. PDSS is an important database containing student and school information, including academic grades and other information required for SNBP. Filling in the PDSS is the responsibility of teachers, especially Dapodik operators and BK counselors, as well as school principals. This delay was caused by negligence in entering data before the specified time limit. As a result, students feel stressed and frustrated because they are threatened with not being able to continue their education to college. The delay in filling out the PDSS reflects a larger problem in the Indonesian education system, where adaptation to technology and development of the skills of teaching staff are urgently needed.

Isoflavones are compounds found in certain foods such as soy and may be used to reduce triglyceride levels in postmenopausal women. This meta-analysis aims to combine findings from multiple studies, with varying sample sizes, to gain a deeper understanding of the effects of isoflavones on changes in triglyceride levels in postmenopausal women. A literature search was conducted through electronic databases such as Google Scholar, PubMed, and Science Direct. The results of a meta-analysis of 10 research literatures showed that isoflavone administration had an impact on significantly reducing blood triglyceride levels in postmenopausal women under 65 years of age.

The current research aims to identify the role of digital transformation across its dimensions (technology, digitization of operations, databases, human resources) in promoting digital entrepreneurship in its dimensions (digital information base, digital business environment, digital skills and e-leadership, financing) among a sample of employees in private banks in the Middle Euphrates region. The research problem emerged regarding the ability of the private banks under study to use digital transformation and digital entrepreneurship. This problem lies in the lack of environmental stability, limited financial infrastructure, and weak human expertise. Therefore, the research problem was formulated in an important question: What is the impact of digital transformation on promoting digital entrepreneurship in Iraqi private banks? In order to determine the level of research variables, a questionnaire was adopted by distributing (136) questionnaires to employees in private banks in the Middle Euphrates region to measure the nature of the level of the research variables. To analyze the results, the statistical packages (SPSS & AMOS.V.29) were used. As a result, the research produced various results, most notably the existence of a significant correlation between digital transformation and entrepreneurship. Digital businesses contribute to encouraging innovation in developing new financial products and services that meet changing market needs. The results also showed that digital transformation helps private banks improve the efficiency of internal operations, leading to a reduction in transaction time. Furthermore, digital transformation processes can provide smoother and faster financial services, which supports customer satisfaction and loyalty.

Databases play an essential role in modern information systems because they enable the efficient storage, management, and retrieval of structured data. This study focuses on the implementation of a simple database using two relational database management systems (RDBMS), namely MySQL and PostgreSQL. The research stages are carried out through requirements analysis, designing entity-relationship diagrams, implementing tables and their relationships, and testing the system to assess functionality. The case study used is student data recording, where both RDBMSs are tested through a series of basic CRUD (Create, Read, Update, Delete) operations. The results show that both MySQL and PostgreSQL are capable of carrying out these operations effectively while maintaining data integrity and consistency. However, PostgreSQL offers additional advantages due to its support for more complex data types, a better level of compliance with SQL standards, and advanced features that support the needs of large-scale application development. Conversely, MySQL remains superior in terms of ease of use and application to simpler needs, making it more practical for small projects or applications with standard workloads. Based on these findings, it can be concluded that both RDBMSs are equally suitable for use, but the ideal choice depends heavily on the context of the needs; PostgreSQL is more suitable for applications that demand high scalability and size, while MySQL remains relevant for lightweight and efficient implementations.

Geopolitical tensions have evolved from peripheral risks to central drivers of global capital flows, disproportionately affecting Emerging Markets (EMs). This study provides a comprehensive bibliometric mapping of the academic landscape linking geopolitical dynamics, international finance, and investment in EMs. This study uses a dataset of 1,039 documents extracted from high-impact databases to analyze performance and conduct science mapping with R-Bibliometrix. The analysis covers publication trends, citation structures, and conceptual evolution over the last century, with a focus on the surge in literature post-2018. Results indicate an exponential growth in scientific production, peaking in 2024. The thematic structure reveals a shift from traditional debt crisis narratives (1990s) to contemporary concerns regarding sanctions, protectionism, and trade policy (2020s). Network analysis identifies three distinct clusters: (1) International finance and market mechanisms, (2) Political economy and development in the Global South, and (3) Institutional governance (IMF/World Bank). This paper bridges the gap between political science and financial economics by visualizing how international finance serves as the dominant anchor connecting developed economies (the USA and the UK) with key emerging markets (China and Indonesia) amid rising global fragmentation.