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Skin that is prone to bacterial infections requires proper care using products containing antibacterial agents. One potential alternative is kaffir lime leaves (Citrus hystrix), which are known to contain antibacterial compounds. This study aimed to evaluate the formulation of liquid soap containing kaffir lime leaf extract and to determine the optimal concentration for inhibiting bacterial growth. An experimental laboratory design was applied, and the antibacterial effectiveness was tested using the disk diffusion method against two test bacteria, namely Staphylococcus aureus and Escherichia coli. Statistical analysis was performed using One-Way ANOVA, followed by Scheffe’s post-hoc test to identify significant differences among treatment groups. The results indicated that the liquid soap containing kaffir lime leaf extract exhibited good physical quality and met standard parameters, including organoleptic evaluation, pH, viscosity, and foam height tests. Antibacterial testing showed that the highest inhibition zone against Staphylococcus aureus was observed at a 15% concentration with a zone diameter of 18.28 mm (strong category), while the highest inhibition zone against Escherichia coli was also at a 15% concentration with a diameter of 19.03 mm (strong category). The One-Way ANOVA results showed a significance value (p < 0.05), indicating a statistically significant difference among treatments for both bacterial species. These findings suggest that liquid soap formulated with kaffir lime leaf extract, particularly at a 15% concentration, has strong antibacterial activity and potential as an effective skin care product. Further studies are recommended to evaluate safety, stability, and long-term effectiveness.

Anxiety is an emotional condition that causes feelings of discomfort, helplessness, and uncertainty, often without a clear reason. Among breast cancer (carcinoma mammae) patients, anxiety commonly arises due to treatment processes, physical changes, and uncertainty regarding recovery. Spirituality, which involves belief in God Almighty and connection with transcendental aspects, is believed to help individuals cope with uncertain and challenging situations, including serious illness. This study aimed to determine the relationship between spiritual level and anxiety level among breast cancer patients in Semarang. The research used a quantitative correlational design with a sample of 110 respondents selected through purposive sampling based on inclusion criteria. The instruments employed were the Depression Anxiety Stress Scale (DASS-42) to assess anxiety levels and the Daily Spiritual Experience Scale (DSES) to measure spirituality. Data were analyzed using the Chi-Square test to examine the relationship between variables. The results showed a p-value of 0.000 (p < 0.05), indicating a significant relationship between spirituality level and anxiety level in breast cancer patients. The findings suggest that higher levels of spirituality are associated with lower anxiety levels. Therefore, interventions that support and strengthen spiritual aspects may be effective in reducing anxiety among breast cancer patients. This study recommends that healthcare professionals incorporate spiritual approaches as part of holistic care to improve psychological well-being in patients undergoing cancer treatment.

The increase in traffic volume in urban areas often triggers various problems, especially at Road intersection points that have a high level of interaction between vehicles. One of the locations that experience these problems is the intersection with the island of traffic without signal on Jl. Tebu-Jl. Tabrani Ahmad, City Of Pontianak. This study aims to analyze the performance of the intersection in the existing condition and project its performance in the next five years (2030), as well as formulate alternative treatment that can improve the smoothness of traffic. The analysis method refers to Indonesian road capacity guidelines (PKJI) 2023 and modeling using software PTV VISSIM. The data collected include intersection geometry, traffic volume, and vehicle speed. Traffic volumes were obtained through CCTV recordings for three consecutive days, then processed and presented in the form of tables and graphs for easy interpretation. The results of the existing condition analysis showed that the degree of saturation (DS) reached 0.407 with an average delay of 9.539 seconds (Level of Service/LOS B) based on PKJI, while VISSIM simulation resulted in a delay of 12.54 seconds (LOS B). The five-year projection (2030) shows an increase in DS to 0.878 with a delay of 15.177 seconds (LOS C) from PKJI, and 23.35 seconds (LOS C) from VISSIM, which indicates a decrease in Junction performance as traffic grows. Two handling alternatives were analyzed, namely the construction of roundabouts and the implementation of traffic flow management. VISSIM simulation shows that the roundabout can reduce the delay to 14.31 seconds with a queue length of 20.34 m (LOS B), while the flow management produces a delay of 11.81 seconds with a queue of 13.14 m (LOS B). This result confirms that both alternatives are able to improve the performance of the intersection compared to the projected condition without handling, so that it can be a technical recommendation for urban traffic planning in Pontianak.

This study presents a modal analysis of Pertamina EP Cepu’s closed drain pump 510-P9002, which operates in the condensate–water treatment unit of the Jambaran Tiung Biru field. Field vibration measurements conducted in August 2024 indicated a fundamental frequency of 25 Hz, corresponding to 1×RPM of the driving motor, with maximum amplitudes reaching 13.46 mm/s. Such excessive vibration poses risks of mechanical damage, reduced equipment service life, and potential operational failure. To address this issue, finite element analysis (FEA) was employed to examine the dynamic response of the pump, determine its natural frequencies, and identify possible resonance conditions. A CAD model of the pump–vessel assembly was developed, meshed, and analyzed under actual boundary conditions. The results showed several natural frequencies ranging between 23.16 and 26.65 Hz, which are close to the excitation frequency, suggesting a very high likelihood of resonance. Various structural modifications were then evaluated, including a half casing and two types of full casings. Among these, the full casing B design provided additional stiffness in the motor support area; however, none of the modifications effectively reduced vibration within the internal components. Based on these findings, the study recommends the implementation of a dynamic vibration absorber (DVA) tuned to the excitation frequency, along with the redesign of structural components to shift natural frequencies away from operating excitation. These solutions are expected to improve operational stability, extend equipment lifespan, and enhance overall system reliability. The outcomes of this research provide important insights for managing vibration issues in pump systems operating under similar conditions, particularly in the oil and gas industry where continuous, stable operation is critical.

Purple sweet potato yogurt is a form of local food innovation made from milk fermented by lactic acid bacteria (LAB), with the addition of purple sweet potato paste to enhance flavor and color, thereby increasing consumer appeal. During fermentation, LAB require carbon derived from carbohydrates as an energy source for their metabolism and growth. Differences in carbon sources are expected to influence and produce distinct yogurt characteristics. Therefore, this study aimed to investigate the effect of various carbon sources on the characteristics of purple sweet potato yogurt. The experiment was conducted using a Randomized Block Design (RBD) with a single treatment factor: the type of carbon source. Six treatments were tested, namely: no sugar (control), granulated sugar, palm sugar, sugarcane juice, coconut sugar, and honey. The results indicated that different carbon sources caused variations in total dissolved solids, total lactic acid bacteria, total titratable acidity, and total reducing sugars. Carbon sources significantly affected titratable acidity, reducing sugar content, total dissolved solids, color, taste, and the overall sensory evaluation of purple sweet potato yogurt. The yogurt produced exhibited titratable acidity values ranging from 1.69% to 1.86%, reducing sugar content from 1.11% to 1.46%, total LAB counts from 0.28 to 89.50 × 10¹0 CFU/g, and total dissolved solids from 10.25 to 17.75 °Brix. Sensory evaluation scores ranged as follows: color preference 2.83–4.26 (dislike to like), texture 3.43–3.76 (like), aroma 3.53–3.70 (like), taste 2.67–3.70 (dislike to like), and overall acceptability 3.43–3.90 (like).

Indonesia has many types of junk food that have a strong taste, but are generally not nutritionally balanced, namely high in fat, salt, or sugar and low in fiber. One of the most popular is nuggets which are generally made from meat. As a healthier alternative, nuggets are made using oyster mushrooms which are low in fat and higher in fiber, and combined with gluten-free and high-fiber corn and tapioca flour to replace wheat flour which contains gluten. This study aims to determine the effect of the combination of corn and tapioca flour on the physicochemical characteristics of oyster mushroom nuggets. This study used a Completely Randomized Design (RAL) with 5 treatments in duplicate. The formulation was used with a combination of corn and tapioca flour, namely 60: 0 (P1), 45: 15 (P2), 30: 30 (P3), 15: 45 (P4), and 0: 60 (P5). The results of the analysis have an effect (P <0.05) on chemical characteristics with a range (db%) of ash content of 3.9% -4.71%; fat content 1.37% - 7.76%; protein content 6.79% - 18.79%; carbohydrate content 71.46% - 77.43%; crude fiber 3.9% - 8.27%, and on physical characteristics with a textured range of 1.1N-2.69 N; color L 50.55- 53.73; color a 2.78- 4.64; color b 10.89-13.71. The implications of this study indicate that online substitution into mushrooms with a combination of corn flour and tapioca can affect the nutritional value and quality of nuggets.

Diabetes Mellitus is a metabolic disorder marked by hyperglycemia resulting from the body's failure to synthesize insulin. Nutritional therapy is effective in controlling glucose levels by providing low glycemic index and high in antioxidant foods, including sweet potatoes and red beans. The primary objective of this study was to elucidate the influence of wheat flour replacement with composite flour consisting of sweet potato and red bean flour on anthocyanin content and the sensory preferences of muffins. A single-factor completely randomized approach was used in this experimental investigation. The treatment involved substituting wheat flour with a composite flour consisting of sweet potato and red bean flours, in the following ratios: 30:20:50 (F1), 30:35:35 (F2), 30:50:20 (F3), and 100:0:0 (F0, control). Anthocyanin content was analyzed using the differential pH method, while sensory preferences were evaluated by 30 semi-trained panelists using a hedonic scale test. The results showed that substituting wheat flour with composite flour high in sweet potato content increased anthocyanin levels. However, the substitution of wheat flour generally reduced the overall sensory preference for muffins. Despite this, formulations with a higher proportion of sweet potato flour improved the preference scores. In conclusion, the substitution of wheat flour with composite flour rich in sweet potato increased anthocyanin content and improved sensory preferences for color, aroma, and taste in muffins

Type 2 Diabetes Mellitus (T2DM) is a chronic condition that requires optimal adherence to pharmacological treatment to prevent disease progression and complications. This study aims to analyze the level of adherence to anti-diabetic medication among T2DM patients and to explore the association between the experience of medication side effects and adherence levels. A descriptive-analytic cross-sectional design was employed, involving 97 T2DM patients in Bandung Regency and Bandung City, Indonesia. Data were collected through structured questionnaires and analyzed using descriptive statistics and the Chi-Square test. The results revealed that 53.6% of respondents exhibited low medication adherence. The majority reported having diabetes-related complications (88.7%) and experiencing medication side effects (57.7%). A significant positive association was found between medication side effects and adherence level (p = 0.039), indicating that patients who experienced side effects tended to be more adherent. Demographic factors such as place of residence, gender, and age showed no significant association with adherence. The findings suggest that side effects may hinder adherence; however, awareness of the body’s response to medication, including side effects, may also serve as a motivator for adherence.

This research examines the legal safeguards for children born outside of marriage in Indonesia after the release of Constitutional Court Decision (MK) No. 46/PUU-VIII/2010, which represented a pivotal shift in national family legislation. Up until now, children born outside of marriage have frequently encountered bias and unfair treatment, both socially and legally. The Constitutional Court (MK) Decision No. 46/PUU-VIII/2010 marks an important advancement in enhancing the civil status of children born outside of marriage, establishing connections not just with their mother and her relatives, but also with their biological father if scientifically validated, for instance, via DNA testing. In this research, the author will examine how judges define legal protection for children born outside of marriage in light of Constitutional Court Decision No. 46/PUU-VIII/2010 and how this decision is executed in legal practices and everyday life, especially concerning the acknowledgment of rights for children born outside of marriage and the obligations of their biological fathers.This study uses a normative research method with a legislative approach and a case approach.  Data was collected through library research covering primary, secondary, and tertiary legal materials, namely by collecting legal materials through studies of books, journals, legal research results,  as well as various official institutional documents such as regulations and other literature relevant to the issues being studied.  The research findings indicate that legal protection for children born out of wedlock needs to be further strengthened through legal reform, public education,  and legal recognition and validation mechanisms, so that the basic rights of children can be optimally fulfilled in accordance with human rights principles and applicable laws and regulations.

This study aimed to evaluate the effectiveness of liquid organic fertilizer (POC) derived from kirinyuh (Chromolaena odorata) leaves on the growth and yield of potted corn plants. The research was carried out at the Agricultural Development Center (BPP) of Malimbong Balepe’, Tana Toraja District, South Sulawesi Province, located at an altitude of 815 meters above sea level. The experiment was designed using a simple randomized block design (RBD) consisting of four treatments: K0 = control (without treatment), K1 = 20% concentration of kirinyuh leaf POC (200 ml POC + 800 ml water), K2 = 40% concentration of kirinyuh leaf POC (400 ml POC + 600 ml water), and K3 = 60% concentration of kirinyuh leaf POC (600 ml POC + 400 ml water). Parameters observed included plant height at 5 and 7 weeks after planting (WAP), number of leaves at 7 WAP, ear length, ear diameter, and ear weight per plant. The results showed that kirinyuh leaf POC significantly affected the growth and productivity of potted corn plants. Application of POC at 60% concentration (K3) produced the best results, indicated by increased plant height, greater number of leaves, longer ear length, larger ear diameter, and higher ear weight compared to other treatments and control. This finding suggests that kirinyuh leaves, which are often considered as agricultural weeds, have potential as an alternative source of organic fertilizer that is environmentally friendly, low-cost, and effective in improving crop growth and yield. In conclusion, kirinyuh leaf-based liquid organic fertilizer, particularly at a concentration of 60%, demonstrated the highest effectiveness in supporting corn growth and productivity. These results provide practical insights for farmers to utilize locally available organic materials as an alternative to chemical fertilizers in sustainable agricultural practices.

Molluscum contagiosum (MC) is a skin infection caused by the Molluscipox virus and is common in children and adults with active sexual activity. The disease is characterized by the appearance of small, smooth, papule-shaped lesions that have a hollow in the center (umbiliation). MC transmission takes place through direct contact with contaminated lesions or objects, such as towels and clothing, so the spread is quite wide globally. The diagnosis is established through an anamnesis, clinical examination, and physical evaluation. MC therapy is generally supportive, but in certain cases medical measures such as excision and curettage are required to remove the lesion effectively. The use of topical creams containing Fusidic acid, such as Fucilex cream, is often recommended to prevent secondary infections and speed up the postoperative healing process. Proper and prompt treatment is essential to prevent further complications and speed up the patient's recovery. MC has a psychosocial impact, especially on children, so education to parents and health workers is an important part of the treatment strategy. Prevention can be done through increased personal hygiene and avoidance of contact with contaminated objects. The study emphasizes the importance of a holistic approach in diagnosis, therapy, and education to reduce the prevalence of MC and its impact on public health.

This study aimed to identify the relationship between family support and body image disturbance among breast cancer patients undergoing chemotherapy at Sultan Agung Islamic Hospital, Semarang. Breast cancer and its treatment, particularly chemotherapy, often cause physical changes such as hair loss, weight fluctuations, and mastectomy, which can significantly affect patients’ body image perception. Family support is assumed to play a crucial role in helping patients adapt to these changes. This research employed a quantitative approach with a cross-sectional design. A total of 110 breast cancer patients were recruited using consecutive sampling. The research instruments consisted of a family support questionnaire comprising 20 items and a body image questionnaire with 10 items. Data were analyzed using Spearman’s Rank correlation test with a significance level of 0.05. The results showed that most respondents (60%) received good family support, while 55% experienced negative body image. Statistical analysis revealed a significant relationship between family support and body image disturbance (p = 0.004) with a correlation coefficient of r = 0.275, indicating a weak but significant correlation. These findings suggest that family support plays an important role in maintaining a positive body image among breast cancer patients undergoing chemotherapy. Therefore, nursing interventions should actively involve family members to provide both emotional and practical support, which may help patients cope with the psychological impact of treatment and improve their overall well-being.

Breast cancer, which typically develops from epithelial cells in the breast ducts or lobes, is a highly prevalent cancer among women worldwide. This disease requires intensive treatment, including chemotherapy, which plays a crucial role in stopping or slowing the growth of cancer cells. Although chemotherapy is effective, it often causes significant side effects, such as nausea, vomiting, fatigue, hair loss, and a weakened immune system. These side effects have the potential to reduce a patient's overall quality of life, both physically, psychologically, and socially. Therefore, this study aims to establish a link between the occurrence of chemotherapy-related side effects and the quality of life of breast cancer patients undergoing treatment at Cut Meutia General Hospital in North Aceh. This study used an observational cross-sectional approach, involving 50 patients undergoing chemotherapy between October and January. Participants were selected purposively to ensure compliance with the study criteria. Data collection was conducted using the Indonesian version of the WHOQOL-BREF, a valid and reliable instrument for measuring quality of life in various domains, including physical, psychological, social, and environmental. Data analysis using the chi-square test revealed a significant relationship between chemotherapy side effects and decreased quality of life in patients with a p-value of 0.002. The results of this study emphasize the need for an adaptive and comprehensive side effect management strategy so that patients can undergo therapy more comfortably and maintain an optimal quality of life during the treatment process. A multidisciplinary approach involving medical personnel, psychologists, and families is highly recommended to support the physical and mental condition of patients during chemotherapy.

Plant Growth Promoting Rhizobacteria (PGPR) is a group of microorganisms that colonize plant roots and play an important role as a biostimulant, biofertilizer, and bioprotectant that can increase plant growth and productivity. This study aims to determine the effectiveness of Tallang bamboo root PGPR on the growth and production of peanut plants (Arachis hypogaea L.) elephant variety. The study was conducted from March 2025 to July 2025 in Lion Tondok Iring Village, North Makale District, Tana Toraja Regency, at an altitude of 828 meters above sea level. The research method used a Randomized Block Design (RBD) with one treatment factor, namely the concentration of Tallang bamboo root PGPR, which consisted of four treatment levels: P0 = without Tallang bamboo root PGPR (control), P1 = 15 ml/L water, P2 = 30 ml/L water, and P3 = 45 ml/L water. The variables observed included the number of pods per plant, fresh weight of pods per plant, dry weight of pods per plant, seed weight per plant, seed weight per plot, seed yield per hectare, and harvest index. The results showed that the application of Tallang bamboo root PGPR at a concentration of 30 ml/L water (P2) had the best effect on all growth and yield parameters, namely the number of pods per plant, fresh weight of pods per plant, dry weight of pods per plant, seed weight per plant, seed weight per plot, seed yield per hectare, and harvest index, compared to the control or other concentration treatments. Thus, it can be concluded that the application of Tallang bamboo root PGPR at a concentration of 30 ml/L water is the most effective dose to increase the growth and production of Gajah variety peanut plants.

Fermentation of seluang fish (Rasbora spp.) pekasam is a traditional method for extending shelf life and enhancing flavor, typically produced through spontaneous fermentation dominated by lactic acid bacteria (LAB). However, uncontrolled production processes lead to significant variability in product quality. This research aims to optimize the fermentation process of seluang fish pekasam through a series of controlled microbiology-based experimental practicums. The experiments were designed to investigate the impact of two main parameters: (1) the use of a LAB starter culture isolated from high-quality pekasam, and (2) the control of incubation temperature (e.g., at 25°C and 30°C). During the fermentation period, samples were periodically analyzed to measure changes in physicochemical parameters, including pH, moisture content, and salt concentration. Microbiological analysis was performed to count the populations of LAB and other spoilage microbes. The results showed that the use of a LAB starter culture significantly accelerated the pH drop within the first 24 hours, reaching a critical pH below 4.5, which effectively inhibited the growth of pathogenic microbes. Furthermore, the optimal raw material ratio and controlled incubation temperature resulted in pekasam with a firmer texture and a more balanced sour-savory taste, differing significantly from spontaneously fermented products. Organoleptic tests confirmed panelists' preference for the product made with the optimal treatment. The conclusion of this study is that optimization through microbiology-based experimental practicums is key to the standardization and improvement of the quality and food safety of pekasam products.

Acid mine drainage (AMD) is one of the major environmental problems arising from coal mining activities. AMD is formed through the oxidation of sulfide minerals, resulting in acidic water with high concentrations of dissolved heavy metals. This condition is characterized by elevated levels of Fe, Mn, and total suspended solids (TSS), which, if left untreated, can pollute nearby water bodies, damage aquatic ecosystems, and pose risks to human health. Therefore, effective, eco-friendly, and low-cost treatment methods are needed to minimize the negative impacts of AMD. This study aims to investigate the effect of activated carbon derived from sugarcane bagasse as an adsorbent for reducing Fe, Mn, and TSS levels in AMD at the sump of PT Alreksa Bara Mitra. The selection of sugarcane bagasse is based on its abundance as an agro-industrial waste and its high lignocellulosic content, making it a potential raw material for activated carbon. The research involved the preparation of activated carbon through carbonization and activation processes, followed by its application to AMD samples with variations in adsorbent dosage and contact time. Laboratory analyses were conducted to measure the concentrations of Fe, Mn, and TSS before and after treatment. The results showed that sugarcane bagasse-based activated carbon significantly reduced Fe, Mn, and TSS concentrations. The highest removal efficiencies were achieved under optimum conditions, reaching 93.14% for Fe, 95.05% for Mn, and 85.04% for TSS. These findings demonstrate that activated carbon from sugarcane bagasse has a strong adsorption capacity for dissolved metals and suspended solids in AMD. In conclusion, sugarcane bagasse-derived activated carbon has potential as an environmentally friendly and cost-effective alternative for AMD treatment, while simultaneously providing added value to agro-industrial waste. This research is expected to serve as a reference for the development of more sustainable mine wastewater treatment methods.

This study aims to: 1) to determine the description of the science abilities of children in group B before treatment with the guided inquiry method at Pembina Bungi State Kindergarten, 2) To determine the description of the development of science abilities of children in group B using the guided inquiry method at Pembina Bungi State Kindergarten. The research technique is an experiment with the design of this study One Groups Pretest-Posttest Design. Data collection techniques used in the study are observation, testing and documentation. The subjects of this study were 10 children divided by the study conducted pretest and posttest. The results of this study indicate that 1) the science abilities of children in group B1 with the guided inquiry method have the highest achievement of developing very well at 79% and the lowest value of 58%, and the average value is 71.3%. 2) the results of the posttest of the science abilities of children in group B1, the highest achievement developed very well at 92%, the lowest achievement developed according to expectations at 71%, and the average was 84.6%. This shows the influence of students' science abilities when given the guided inquiry method in group B at Pembina Bungi State Kindergarten, Baubau City. Overall, the study concludes that the guided inquiry method is effective in improving early childhood science learning outcomes, particularly in enhancing curiosity, critical thinking, and problem-solving skills in the classroom context.

Sunday school is an activity that is carried out every Sunday, Sunday school is carried out in order to foster, educate and become a bridge for children to be able to meet God or be able to know God through the truth conveyed. Sunday school children are children who must be instilled with the truth through Sunday school teachers, therefore the school teacher must be a role model or be an example and live God in himself, so that when teaching, children will receive the spirit that the teacher has. The method used in this research is qualitative through literature review collected through books, journals and articles to get very accurate data. With the aim of being able to help find solutions in dealing with ADHD children in Sunday school. Children who experience ADHD are not a disease, so as parents must know what the child is experiencing, and as parents must provide early treatment such as taking the child to a psychologist / therapist so that the child gets treatment before it is too late.

Burns can cause infection, hinder healing, and increase the risk of long-term complications. Staphylococcus aureus and Pseudomonas aeruginosa often infect burn wounds in general, infections are treated with antibiotics, but continued use of antibiotics can cause bacterial resistance. Binahong leaves (Anredera cordifolia) have potential as a substitute for antibiotics because of their antibacterial properties from active compounds such as alkaloids, polyphenols, tannins, saponins and ascorbic acid. This research aims to activate the antibacterial ability of binahong leaf ethanol extract against S. aureus and P. aeruginosa. This research uses an experimental method with a control group design using diffusion and dilution methods at varying concentrations. Statistical analysis of the inhibition zone showed that there was a significance difference of <0.05 between treatment groups. In the solid diluted method, S. aureus obtained an MIC value of 10.5% and a MBC of 11.5%, whereas P. aeruginosa had an MIC of 14.5% and a MBC of 15%. The results showed that the ethanol extract of binahong leaves was more sensitive to S. aureus than P. aeruginosa.  

Tuberculosis is one of world health problem, especially in developing countries. Treatment regimen with multiple first-line anti-tuberculosis drugs (ATD) such as Isoniazid, Rifampicin, Pyrazinamide, Ethambutol, And Streptomycin remains the most effective for treatment of tuberculosis. Adverse drug reactions (ADRs) to antituberculosis drugs may range from mild gastrointestinal disturbances to serious hepatotoxicity, peripheral neuropathy, and cutaneous adverse effects. We report a 65 year old male patient with a  complaint of yellowish discoloration of sclera, nausea and vomitting after three days of initiation of ATD theraphy. The patient has been diagnosed with Tuberculosis relaps and has been taking ATD since June 2024. Patient noted epigastric pain. Laboratory examination found an increase in bilirubin level and imbalance electrolyte. The treatment is in the form of discontinuation of ATD, supportive therapy and followed by hepatoprotective supplements. ATD should be discontinued in patients with hepatotoxicity and fixed drug eruption until liver function and clinical symptoms improve. Initiation of ATD administration is carried out by administering one by one regimen. The patient is currently experiencing antituberculosis drug-induced hepatotoxicity, which is managed by providing supportive care and  different AT regimen was prescribed.