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Degenerative disease is a health condition of an organ or related tissue whose condition can deteriorate over time due to changes in body cells that affect organ function as a whole. The factor is due to unhealthy life changes such as lack of activity and frequent exposure to harmful substances into the body. Degenerative diseases include hypertension, diabetes, cholesterol, cancer, and death. Harmful substances or free radicals can be inhibited by antioxidants. One drug that has antioxidant activity is ascorbic acid (Vitamin C) which functions as an immune booster and is used by the public because it is effective as an antioxidant and health therapy but there are side effects in the form of gastrointestinal. The research aimed to find candidate drug ingredients from compounds contained in black pepper seeds (Piper nigrum L.) as in silico antioxidants. The methods used are molecular docking and molecular dynamics. The results showed BLH19 had better toxicity than the comparator drug and had hydrogen interactions that could be stabilized by the amino acid Gln139. The results of molecular dynamic calculations for BLH19 have an RMSD value of 1.5 Å with a ΔGTotal of -33.50 Kcal/mol. While the comparator drug has an RMSD value of 1.6 Å with ΔGTotal -3.39 Kcal/mol. The results showed that the affinity level of ascorbic acid compared to BLH19 for the 4RP9 receptor was predicted to be a candidate for a new antioxidant drug.

Background: Dysmenorrhea is pain experienced by adolescents during menstruation in the lower abdomen due to changes in the hormone prostaglandin. Based on the interviews conducted, 10 out of 67 young women experienced dysmenorrhea in Pilangrejo Village. Warm water compresses are a non-pharmacological treatment because they are effective in helping reduce dysmenorrhea pain. Objective: To find out the results of implementing warm water compress therapy for dysmenorrhea pain. Method: This application uses the case study method with 2 respondents in Cungkup, Pilangrejo, Juwangi, Boyolali who experienced primary dysmenorrhea with a moderate pain scale. Each respondent was given warm water compresses for 3 consecutive days with a duration of 20 minutes and a water temperature of 46°C. Result: The management of dysmenorrhea in adolescents with warm water compresses decreased in the first respondent from a pain scale of 6 to 2 with the moderate to mild pain category, and the second respondent experienced a decrease in the pain scale from 5 to 1 with the moderate to mild pain category. Conclusion: There is a difference in the pain scale of dysmenorrhea in the 2 respondents before and after being treated with warm water compresses with a moderate pain scale to mild pain.    

Magnetic resonance imaging (MRI) is a diagnostic examination modality in medicine using a magnetic field without using X-rays, MRI has the advantage of being able to create images and can show clearer and more sensitive anatomical differences in soft tissues in the body such as the brain,Bone marrow and musculoskeletal. An MRI machine can produce diagnostic images of the inside of the human body, both in sagittal, coronal and transverse sections, without using ionizing radiation (X-rays) and also without using radioactive substances, but based on the principle of magnetic resonance of the hydrogen atom to reveal anatomy and pathology. clinical diagnosis, one of which is Hernia Nucleus Pulposus in the Cervical vertebrae. Hernia  Nuecleus pulposus is a condition of biochemical ad physical changes in the spinal disc tissue caused by degeneration in old age,or acute external pressure that causes a bulge into the spinal canal,putting pressure on the durameter or nerve roots, thereby triggering symptoms of neurological pain. The use of the Dixon sequence was proposed for the assessment of metaphyseal bone marrow water water content,with a short scan time. Dixon sequence imaging can be used for fat suppression in the extremities and spine, but also quantification of fat in the bones.. The research method used is descriptive research with an observation approach. Data collection was carried out from 01 January 2022 to 28 February 2023 using a Mr. Philips aircraft with a power of 3 Tesla. The sample of patients used in this study were 5 patients with vertebral complaints. Data collection was carried  out  through observation,interviews and documentation. Cervical MRI examination with clinical Hernia Nucleus Pulposus using a Philips 3 Tesla MRI machine has an examination procedure with a Survey sequence design, Myelo, Sagittal TSE T2 dixon, Sagittal TSE T1, Coronal TSE STIR, Axial TSE TA, and axial mFFE

This study aims to analyze the interaction of local culture and climate change from an environmental science perspective, with a focus on the socio-ecological adaptation strategies of coastal communities in the Indonesian archipelago. Climate change has had significant impacts on coastal areas, ranging from increased tidal flooding and coastal erosion to decreased fisheries productivity. In this context, coastal communities rely not only on technical approaches but also utilize local wisdom that has been passed down through generations. The research method used is a qualitative study with an environmental ethnography approach, which allows researchers to explore the relationship between culture, ecology, and environmental adaptation. Data were collected through participant observation, in-depth interviews with traditional leaders, fishermen, and local communities, and analysis of cultural documents covering rituals, customary rules, and traditional ecological practices. Data analysis was conducted thematically to identify adaptation patterns, then compared with technical approaches in environmental studies. The results show that coastal communities in the Indonesian archipelago have various forms of culturally based adaptation that are relevant to the challenges of climate change. For example, the practice of marine sasi in Maluku serves to preserve fishery resources, traditional rituals in Bali support collective ecological awareness, and mutual cooperation (gotong royong) on ​​the coast of Java helps mitigate tidal flooding. These practices demonstrate that local wisdom serves a dual purpose: strengthening social cohesion and sustainably protecting the environment. The study's conclusions confirm that adaptation strategies will be more effective if they integrate local wisdom with science-based technical approaches. This integration not only strengthens ecological resilience but also ensures the socio-cultural sustainability of coastal communities.

This research aims to determine the effect of fraud diamonds on the tendency for fraudulent financial reports in Manufacturing Companies in the Consumer Goods Industry Sub-Sector listed on the IDX in 2019-2021. This research was conducted using the associative causal method. The sample selection in this study used a purposive sampling method, with the sample criteria being the financial reports of 10 companies in the Consumer Goods Industry Sub-Sector Manufacturing Company registered on the IDX in 2019-2021. This research data was obtained from literature and documentation studies, data analysis techniques were obtained from IBM SPSS statistics version 26. Data analysis used in this research is, descriptive statistics, classical assumption tests using normality tests, autocorrelation tests, multicollinearity tests and heteroscedasticity tests, analysis multiple linear regression, hypothesis testing using partial test (t), simultaneous test (f) and coefficient of determination test (R2). The results of the research partially show that external pressure and ineffective supervision have proven to have a positive effect on financial report fraud. Meanwhile, the financial target variables, change of auditor, change of director were proven to have no positive effect on financial statement fraud. The variables pressure, opportunity, rationalization and ability simultaneously have a significant effect on financial statement fraud at a significant level of 5%. In this research, the fraud variable is explained by independent variables by 31.3%, the remaining 68.7% is explained by other external factors which are not in this study.

Background : The need for sleep can not only be seen from the aspect of sleep quality but can also be seen from the quantity or long duration of a baby's sleep. If the baby's sleep duration is met properly, the baby's growth and development can be achieved optimally. Nearly 44.2% of babies experience sleep disturbances or sleep problems, so far 72% of parents think it is not a problem, whereas if a baby has sleep problems it will have a negative effect on growth, including vulnerable immunity, as well as changes in the endocrine system. affect the growth of the baby. Currently, various ways of therapy have been carried out so that there is an increase in the baby's sleep duration. One of the safe and accessible therapeutic efforts to increase the baby's sleep duration is using murottal Al-Qur'an. Al-Qur'an murottal therapy can reduce stress hormones, activate natural endorphins, increase feelings of relaxation, and distract from anxiety, anxiety and tension. The surah used is surah Al-Mulk. Objective : To determine the effect of giving Al-Qur'an murottal therapy on the sleep duration of infants aged 3-6 months. Method : This type of research uses a pre-experimental method with a one group pretest-posttest design. The samples obtained from the federar formula were 20 infants aged 3-6 months using the accidental sampling technique. Results : the results of the study using the Wilcoxon test obtained a p value = 0.000 where the value (p <0.005) means that there is an effect of giving Al-Qur'an murottal therapy on the baby's sleep duration. Conclusion: There is an effect of giving Al-Qur'an murottal therapy on the sleep duration of infants aged 3-6 month.

Background; Hypertension in the elderly increases every year, in Pacitan Regency there are 6,211 people, in Nawangan District there are 1,290 people with hypertension and in Sempu Village there are 87 elderly people with hypertension. The cause of high hypertension is influenced by lifestyle, scale factors and environmental factors, and if not immediately overcome it will cause premature death and disability rates for sufferers.Purpose; Knowing changes in blood pressure in elderly people with hypertension before and after the application of ergonomic gymnastics. Method; This application is with descriptive research methods and observing an event. Descriptive research is research conducted to describe or describe an event that occurs in society. Result; The results of blood pressure measurements before ergonomic exercise were carried out on the two respondents, namely Mrs.T with a blood pressure of 165/90 mmHg and Mrs. W with a blood pressure of 160/100 mmHg, both classified as having stage 2 hypertension or moderate hypertension.. The results of blood pressure measurements after ergonomic exercise on Mrs. T 150/80 mmHg and Mrs. W to 140/90 mmHg classified as stage 1 or mild hypertension.. Conclusion; This ergonomic exercise can lower blood pressure in elderly people with hypertension

This research aims to analyze consonant sequences in the phonology of the Indonesian language, focusing on patterns of distribution, combinations, and variations of consonants. The analytical method involves collecting data from representative Indonesian language texts, including books, articles, and everyday conversations. The analysis is conducted by examining the sequence of consonants, frequency of usage, and potential phonological changes. The results of this research can provide further insights into the phonological structure of the Indonesian language, the contribution of consonant patterns to language expression, and their potential implications for language learning and teaching. This study is expected to contribute to a deeper understanding of Indonesian phonology and to encourage further development in the field of linguistics.

Such quick change in information technology and computers have required changes in the educational paradigm, particularly in teaching and learning methods. Computer applications are software services that use computers as the medium. Programming language is the language used in computing to create programs. An algorithm, a systematic sequence of steps, is used to solve a problem, and an example of one of these is the Winnowing algorithm. The Winnowing algorithm is a document fingerprinting method that utilizes hashing to detect text similarities. In an essay exam, an instructor must carry out a manual assessment by checking and correcting each participant's answers. Currently, automatic assessment is still generally limited to multiple choice questions. The purpose of this study is to investigate the extent to which previous studies have examined the assessment of essay questions using the Winnowing algorithm. The results of the study indicate that the application of the Winnowing algorithm in automatic evaluation of essay responses on online learning platforms (e-learning) provides good and stable results, and has a high degree of accuracy.

The role of fractal geometry in analyzing growth patterns of tropical plants and its application in precision agriculture has become an emerging interdisciplinary topic in the modern era. Tropical plants often exhibit complex and irregular structures that cannot be fully described by conventional Euclidean geometry. This study aims to examine fractal-based mathematical models to identify self-similar patterns in tropical leaves and to explore their potential for optimizing precision farming practices. The methodology employs image-based mathematical analysis, using digital images of tropical plants to measure fractal dimensions and quantify growth complexity. The findings reveal that consistent fractal patterns can be observed across different species of tropical plants, particularly in leaf venation and branching structures, indicating a universal growth principle. Such patterns demonstrate high predictive potential for estimating biomass, monitoring plant health, and assessing responses to environmental changes. Furthermore, the study highlights how fractal-based approaches, when combined with precision agriculture technologies, can improve resource efficiency by supporting accurate irrigation scheduling, soil quality monitoring, and yield forecasting. The implications extend to sustainable agricultural development, as fractal analysis provides a scientific foundation for balancing productivity with environmental preservation. In conclusion, this research underscores the significance of fractals not only as mathematical concepts but also as powerful analytical tools with practical benefits, offering new pathways to advance digital farming, ecological monitoring, and sustainable food security in the modern era.

Students' motivation to learn can be seen if the student tries to make an effort diligently to achieve what he wants. A student who has good motivation will get good results too. Learning motivation is like a machine, if there is a driving force then the machine will operate according to what the operator wants. Likewise with motivation, if there is a driving force then there is an effort within a person to carry out certain activities to achieve a goal. However, motivation is not always shared by everyone. In his book, Soemanto defines motivation as a change in energy within a person which is characterized by effective encouragement and reactions in achieving a certain goal.   What is meant by learning motivation is an urge that arises within students to act or carry out an activity or business because of a goal, need or desire that must be satisfied. Looking at some of the explanations above, the author sees that the lack of student motivation in learning is a significant problem because remembering the objectives of learning and the efforts made by the teacher do not bring the results as expected. Thus learning is considered less successful. In this research, the type of research used is classroom action research (PTK). The research location is Elpida Noelbaki Elementary School, which is located at Jalan Sahabat no. 01, Oehau Hamlet, Noelbaki Village, Central Kupang District, Kupang Regency, East Nusa Tenggara Province. The subject of this research is a religious education subject teacher for grade 2 elementary school students. The methods used in the research are interviews and observation. The teacher's treatment at the initial stage of learning has an impact on the growth of students' learning motivation. This is characterized by enthusiasm in following lessons. As many as 88.8% of students showed an enthusiastic attitude in participating in lessons. The teacher's treatment at the initial and final stages of learning has an impact on increasing student learning motivation. This is characterized by enthusiasm in following lessons. As many as 100% of students showed an enthusiastic attitude in participating in the lesson. Based on the implementation of the first to third cycles, it is known that the application of teacher social competencies such as teacher interaction, social skills, sympathetic attitudes and the teacher's adaptability towards students in following lessons will increase student motivation in learning. Students look enthusiastic and enthusiastic in receiving lessons in class.  

This article examines the influence of agrarian law in the development of legal politics in Indonesia with a focus on issues of land ownership and human rights. This article explains that land ownership is often a source of conflict and disputes in Indonesian society, especially when land does not have clear certificates. The Basic Agrarian Law (UUPA) is the legal basis that provides guarantees for land rights for the people of Indonesia. The National Agrarian Operations Project Program (PRONA) is the government's effort to provide land certificates to people with economically weak groups. This article also reviews changes in legal political views in Indonesia following the transition from the New Order era to the reform era. During the New Order era, there were shackles in various sectors, including law and politics. However, during the reform period, efforts to restore Indonesia's image as a rule of law through changes in government policy were carried out concerning the 1945 Constitution and Pancasila. In the context of land ownership and human rights, this article underscores the need to protect the rights of rural communities and indigenous peoples whose ownership is inherited hereditary, regardless of the completeness of the ownership papers. This article examines the need for a balance between public interest and individual rights in the context of land ownership in Indonesia. In conclusion, this article presents a comprehensive analysis of the influence of agrarian law in the development of legal politics in Indonesia. By highlighting changes in legal politics, protection of human rights, and issues of land ownership,    

Currently Indonesia is in the industrial revolution 4.0 where technological changes affect living habits, ways of working and communicating with one another. In other words, this era is the main axis in life. The changes in this era also have an impact on the economic sector towards a digital economy. Visible changes are the convenience that people get in accessing online services such as ordering food through applications, shopping for necessities online, selling online to studying at home online. In Talang village, Nganjuk district, only 2 micro, small and medium enterprises that have been recorded have run their businesses using digital marketing. Therefore, KKNT 66 KKNT students have the goal of improving the micro, small and medium business sector by providing socialization as well as digital marketing assistance to micro, small and medium enterprises. So that it can make it easier for micro, small and medium enterprises in Talang village to expand the market and develop their business. After conducting outreach and assistance to micro, small and medium enterprises in Talang village, the result was an increase of 4 small and medium micro businesses that had registered their business in digital marketing. While the other 4 still haven't got it. There are several small and medium micro businesses that are not willing to register their business for digital marketing.

Background : Adolescence is a period of transition from children to adults which is accompanied by growth and physical changes, including the growth of the reproductive organs. The maturity of the female reproductive organs is marked by the arrival of menstruation, one of the problems during menstruation experienced by young women is dysmenorrhea. Dysmenorrhea is usually concentrated in the lower abdomen that occurs before and during menstruation caused by uterine contractions. The management of dysmenorrhea can use non-pharmacological therapy, one of which is by giving tamarind turmeric drink. Tamarind contains curcumin and anthocyanins which inhibit cyclooxygenase, thereby reducing inflammation and inhibiting uterine contractions. The content of curcumenol in turmeric acts as an analgesic agent that can reduce the production of prostaglandins. Research Methods: This study used quantitative research with the pre-experimental one group pretest posttest method. The population in this study were 35 teenagers. The sampling technique used was simple random sampling, with a sample of 21 adolescents who experienced dysmenorrhea in May-July in Pelem Hamlet. Data collection used a pain scale observation sheet, namely the NRS (Numeric Rating Scale) before and after administration of tamarind turmeric. Data were analyzed using the Wilcoxon Signed Rank Test. Results: Based on the analysis test using the Wilcoxon Signed Rank Test, a significance value of 0.00 (p <0.05) was obtained, which means that Ha was accepted. Conclusion: There are differences in the degree of pain in dysmenorrhea before and after administration of tamarind turmeric, so it can be concluded that there is an effect of tamarind administration on dysmenorrhea in young women.   Keywords: Dysmenorrhea, Tamarind Turmeric, Adolescents Background : Adolescence is a period of transition from children to adults which is accompanied by growth and physical changes, including the growth of the reproductive organs. The maturity of the female reproductive organs is marked by the arrival of menstruation, one of the problems during menstruation experienced by young women is dysmenorrhea. Dysmenorrhea is usually concentrated in the lower abdomen that occurs before and during menstruation caused by uterine contractions. The management of dysmenorrhea can use non-pharmacological therapy, one of which is by giving tamarind turmeric drink. Tamarind contains curcumin and anthocyanins which inhibit cyclooxygenase, thereby reducing inflammation and inhibiting uterine contractions. The content of curcumenol in turmeric acts as an analgesic agent that can reduce the production of prostaglandins. Research Methods: This study used quantitative research with the pre-experimental one group pretest posttest method. The population in this study were 35 teenagers. The sampling technique used was simple random sampling, with a sample of 21 adolescents who experienced dysmenorrhea in May-July in Pelem Hamlet. Data collection used a pain scale observation sheet, namely the NRS (Numeric Rating Scale) before and after administration of tamarind turmeric. Data were analyzed using the Wilcoxon Signed Rank Test. Results: Based on the analysis test using the Wilcoxon Signed Rank Test, a significance value of 0.00 (p <0.05) was obtained, which means that Ha was accepted. Conclusion: There are differences in the degree of pain in dysmenorrhea before and after administration of tamarind turmeric, so it can be concluded that there is an effect of tamarind administration on dysmenorrhea in young women. Keywords: Dysmenorrhea, Tamarind Turmeric, Adolescents  

Adolescence is a period marked by significant physical and psychosocial changes. These changes have potential risks that can affect an individual's future. One of the factors that increase the risk is the lack of knowledge and communication by parents to their children regarding reproductive health behavior. This study aims to determine the relationship between parental communication patterns and adolescent reproductive health behavior at SMK Negeri 15 Kota Bekasi. The type of quantitative research with a cross-sectional approach. The sample used was 34 respondents. The analysis used was univariate and bivariate. The results of the study showed that the communication patterns of parents with adolescents were mostly in the good category (91.2%). Adolescent reproductive health behavior was mostly in the less good category (70.6%). The results of the chi-square statistical test obtained a p value = 0.539, meaning there was no relationship between parental communication patterns and adolescent reproductive health behavior. There was no significant relationship between parental communication patterns and adolescent reproductive health behavior. Although effective communication between parents and adolescents is important, it is not enough to guarantee good reproductive health behavior among adolescents.

The aim of this paper is to highlight the role of Lextutor an online software for achieving educational objectives. Lextutor is an online resource which presents a new teaching-learning environment and also offers a variety of activities for educators and learners to use it in English vocabulary classroom and to nurture independent learning. Since vocabulary becomes very fundamental in language learning, both speaking and writing and independent learning is currently popular and needs to be developed, educators and learners can use wordlists, online concordance and dictionary, and texts, which can be accessed in the available programs. In addition, Lextutor also serves database to store the work and view the others’ work. Most importantly, this online software comes up with the transformation to change the traditional setting of learning by giving inputs on DDL learning. It is expected that learners can be more independent and active in learning, enabling greater motivation and deeper learning. This paper reviews literature and gives scholarly background by reviewing some contributions and concepts made by experts in the related field. Furthermore, some benefits of using Lextutor are found in this research.

Marketing activities have experienced a fairly rapid development along with development of information technology. In today's all-digital era, digital marketing formed a new strategy that is very important in the marketing of a company, especially for businesses such as online stores that allow buying and selling at once. Current company competing in developing their marketing strategies in achieving and retain customers. The virtual world is getting closer to everyday life we, making the era of digitalization we cannot avoid. The customer is currently in commit Interaction with the company is carried out by utilizing social media and applications growing rapidly. This can be caused by various factors that go wrong only environmental factor. So the author makes an activity that can help these problems by holding socialization of the Role of Digital Marketing for MSMEs in this era digitization. The method of implementing community service activities is by doing an approach in the form of socialization and useful training to add insight/education to the community so that the knowledge gained can be applied in activities MSMEs. There are three stages of implementation, namely the planning stage in the stage planning, students collect data first through surveys and interviews regarding MSMEs in Segaran Village along with the behavior of MSMEs in the Village the. Every student who takes part in the community service activity program show the attitude of responsibility as an executor, it is shown by every student on time while carrying out each task. Good communication has been shown every students during discussions and evaluations after community activities. Student always conduct an evaluation to improve an activity that has been carried out to achieve more optimal activities. In the era of digital technology has changed the human way of life communicate, act, and make decisions. Marketing activities were not separated from influence of digital technology. The term digital-based marketing has evolved from Initially marketing activities for goods and services using digital channels to broader understanding, namely the process of acquiring consumers, building preferences consumers, promote brands, maintain consumers, and increase sales.

Background: Poor sleep quality is a disorder that often occurs in the elderly. The impact of sleep disturbances in the elderly can result in the body's inability to restore its original state, causing weakness, headaches, drowsiness, and fatigue. Treatment of sleep quality disorders is carried out with non-pharmacological treatment, one of the non-pharmacological therapies that can be done is Al-Qur'an Murottal Therapy. Purpose: To find out changes in the level of sleep quality in the elderly before and after carrying out murottal Al-Qur'an therapy. Method: This application uses a descriptive method on 2 respondents, done 1 time in 7 consecutive days. The instrument used is the Pittsburgh Sleep Quality Index (PSQI) to measure sleep quality. Results: Treatment of sleep quality disorders with Al-Qur'an murottal therapy which is given 1 time for 7 days in 15 minutes can affect the level of sleep quality of respondents, so that there is a change in the sleep quality score of the elderly. Conclusion: The application shows that after the Al-Qur'an murottal therapy there was an increase in the quality of sleep in both respondents from poor sleep quality to light sleep quality.      

Technological developments, especially in agriculture, must develop because of the increase in population and climate change requires us to look for innovative sustainable solutions in agriculture because agriculture is a very basic field in human life. Therefore, our group which is a group of students who carry out service in Penjaringansari village made an agricultural innovation with an appropriate technology aquaponics system in catfish cultivation as one of its work programs.This service is carried out by the method of active participation approach of partner groups that is tailored to the needs of the community by our group. The initial stage carried out is catfish cultivation then combines with a hydroponic system in plants to form an aquaponics system. The treatment process is carried out by checking thoroughly regularly.This service program is expected to provide benefits for the people of Penjaringansari Village and can be implemented properly after the completion of KKN. This program aims to improve food security and community independence through limited land use in the yard.  

Dengue hemorrhagic fever is an infection caused by the Dengue virus which is transmitted by the aedes aegypti mosquito which has most frekuently occurred in humans in recent years, so it is still a world health problem. The aim of this research is to gain knowledge about what Dengue fever is and its cause, gained truly real experience in implementing nursing care for the clien Mrs “S” with Dengue hemorrhagic fever in the baji life room at Labuang Baji Hospital, Makassar for 3 days starting from 18-20 April 2023. Collected techniquest  Data was collected using interview techniquest, Observation and physical examination. The result of this examination were an assessment of heartburn, the patien stated that the paint felt like a stabbing sensation,the pain was felt  when the patient moved, and the pain was reduced when the patient changed a half-sitting position or performed deep breathing relaxation techniques and grimaced facial expression. The patient said the pain he felt usually lasted 1-3 minutes, the patient said the pain scale was 3. In nursing diagnoses there are 3 diagnoses found in real cases, namely acute pain related to biological agents,nutritional imbalance less than the body’s needs related to lack of appetite,self-care devicits are related to weakness and fatigue. In implementing the action plan for Mrs “S” patients with cases of Dengue fever refers to nursing problems in patients by paying attention to the patient’s condition. Nursing implementation for Mrs”S” is adjusted to am action plan that has been determined so that the nursing problems faced by the patient are quickly resolved or prevented.After carrying out nursing care for the three diagnoses, all diagnoses are resolved.