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Hypercholesterolemia is one of the main factors that contribute to the development of life-threatening cardiovascular diseases. Bitter melon (Momordica charantia L.) is known to contain antioxidant compounds that have the potential to reduce cholesterol and triglyceride levels, making it an alternative natural treatment for hyperlipidemia.  This study aims to evaluate the effectiveness of bitter melon juice in reducing triglyceride levels in Wistar rats induced by high-fat feed. This study used a true experimental design with a pretest-posttest with control group design. A total of 24 Wistar rats were induced with high-fat feed and divided into four groups: negative control, positive control, treatment group 1 (given bitter melon juice 1.8 mL), and treatment group 2 (given bitter melon juice 2.7 mL). Data analysis was performed using paired t test... A significant decrease in triglyceride levels was found in the groups given bitter melon juice 1.8 mL (p < 0.003) and 2.7 mL (p < 0.001) compared to the control group. Higher doses showed greater effectiveness in reducing triglyceride levels... Bitter melon (Momordica charantia L.) juice was shown to be effective in reducing triglyceride levels in Wistar rats induced by high-fat diet. These findings support the potential of bitter melon as a natural intervention to manage hyperlipidemia..  

The risk of sarcopenia and metabolic complications in the elderly can be caused by the aging process and decreased muscle mass in the elderly group. Sarcopenia and obesity in the elderly also increase the risk of cardiovascular disease, diabetes, and physical disability, which have the potential to reduce quality of life and increase morbidity and mortality. The purpose of this community service activity is to screen protein levels and lipid profiles in the elderly group in order to detect the risk of sarcopenia and dyslipidemia early. This activity is carried out using the Plan-Do-Check-Action (PDCA) method which includes planning, implementation, supervision, and follow-up. The community service activity was carried out at Panti Bina Bhakti, South Tangerang, involving 93 elderly participants aged >65 years. The results of the activity showed that 35 people (37.63%), 9 people (9.68%), 35 people (37.63%), and 7 people (7.53%) each had abnormal lipid profiles for HDL, Cholesterol, LDL, and Triglycerides. While 24 people (25.81%) had abnormal albumin levels. Therefore, it is necessary to monitor protein levels and lipid profiles regularly as well as early intervention through a healthy diet, regular exercise, and education for the elderly to maintain muscle mass and muscle strength.

        Tribulus terrestris L.,Gokshur in Sanskt,  is an annual herbaceous, little prostrate, silky from the Zygophyllaceae family. It is found in extensive, arid, and scorching regions of India. is used in traditional folk medicines as an aphrodisiac, astringent, lithotriptic, diuretic, and urinary disinfectant.     however, uneven, pinnae, elliptical leaves. Sprinkled, round, compressed, five-cornered, transverse partitioned carpel fruits with many seeds ripen in July. Pieces of the cylindrical-fibrous root are 7-18 cm and 0.3-0.7 cm wide. According to reported studies, the investigations indicated the presence of the saponins ;gitogenin, tigogenin, neogitogenin, hecogenin, and flavonoid tribuloside was kaempferol-3-glucoside. Furthermore, Tribulus terrestris plays a vital role in hepatotoxicity and is greatly reduced by Tribulus extracts. Similarly, T.terrestris plays a remarkable role in reducing the elevated level of serum glucose, triglycerides, VLDL, and cholesterol. This study aims to conduct a preliminary analysis of the phytochemicals of Tribulus leaves cultivated in Iraq and to determine the active constituent of the ethanolic extract of the leaves using Gc-Mass. Qualitative detection of herbal leaves in Iraqi soil, investigated by GC-MASS revealed important constituents. The funding shows a new compound; dihydrocoumarin and other major constituents neophytadiene and alpha-tocopherol.

A thalassemia is a group of inherited blood disorders characterized by decreased or absent production of hemoglobin. Symptoms of thalassemia vary greatly from patient to patient but may include anemia, fatigue, and susceptibility to infections that can plague their quality of life. Therefore, a detailed evaluation of the serum biomarker profile in thalassemia patients is necessary to elucidate its effects on the body. This study was performed to define the serum biomarker profile. This study aimed to evaluate the serum marker levels among 100 thalassemic patients and compare them with their physiological ranges. Blood urea (B.UREA), serum creatinine (S.CREAT), aspartate aminotransferase (AST), alanine aminotransferase (Alt), alkaline phosphatase (ALP), total serum bilirubin (TSB), serum uric acid (S.U.A), triglycerides (TG), cholesterol (CHOL), albumin (Alb), serum calcium (S.CA) and Carbohydrate Antigen 15-3 (CA15.3) were analyzed comprehensively as key indicators in this study. The test showed that B. UREA's mean number was 24.33±0.8805, which was safe within normal limits. So, no abnormal results were found for this indicator in our tests despite the fact that others showed irregularity. The means of the values measured by S.CREAT, AST, AlT, AlP, TSB, S.U.A, TG, CHOL, AlB, S.CA, and CA15.3 were respectively, 0.8109±0.2007, 28.93±3.325, 26.1±2.698, 101±13.64, 3.261±1.978, 12.78±8.951, 146.8±87.2, 147.5±22.89, 67.94±44.7. This study makes valuable contributions to the field by elucidating the serum biomarkers of individuals with thalassemia and presenting changes in some markers compared to normal levels. However, further research is required in order to investigate the clinical significance of such alterations.2, 9.392±0.4079, and 42.08±7.275.

Hyperlipidemia, characterized by elevated levels of lipids such as cholesterol and triglycerides in the blood, significantly increases the risk of atherosclerosis, which causes cardiovascular disease, ischemic stroke, and peripheral arterial disease. Genetic tendencies and unhealthy lifestyles such as diet, smoking, and physical activity can cause this. This condition often does not cause symptoms, so it is necessary to carry out regular health checks. This activity uses the PDCA (Plan-Do-Check-Act) methodology to screen for hyperlipidemia in the elderly at the Hana Nursing Home, South Tangerang. This activity included 61 respondents, and 28 people (45.9%) experienced hypercholesterolemia. These results highlight the importance of routine lipid screening in identifying individuals at risk early, enabling timely intervention. This examination can significantly reduce morbidity and mortality, thereby improving overall quality of life.

Triglycerides are fats carried by the lipoprotein system located in the blood, are the main cause of arterial diseases and are usually compared with cholesterol using lipoprotein electrophoresis. Triglycerides consist of glycerol linked to fatty acid groups. The High Intensity Interval Training method is a sport designed to increase metabolism and burn body fat so as to balance triglyceride levels in the body. This exercise is often included in training programs for long-distance runners. This study aims to obtain information about the effect of the High Intensity Interval Training (HIIT) exercise on the interval running model on triglyceride levels in PASI Athletes in Malang City. The research method and design used was an experiment in the form of the one group pretest-posttest design, namely recording the results of triglyceride levels before HIIT training and after HIIT training. This study involved 8 long-distance runners whose blood was taken from the cubital vein before the HIIT treatment. The design of this study was initiated by screening all research subjects according to predetermined inclusion criteria. And all subjects were instructed to fill out a willingness form (informed consent) then proceed with taking a blood sample before the HIIT exercise treatment of ± 10 µL. After taking blood, the HIIT training program is continued with an interval running model, namely by running fast for 2 minutes, then walking for 2 minutes, doing 10 repetitions. After completing the HIIT training treatment, all subjects took blood again as much as ± 10 µL. When all subjects' blood samples have been taken, it is followed by laboratory tests in the clinical pathology laboratory, Faculty of Medicine, Brawijaya University. The results of the study by conducting a paired sample T-test were used to analyze the data obtained with a significant (2-tailed) value of 0.938 greater than the p value of 0.05 (0.938> 0.05) indicating H0 was accepted and Ha was rejected which means that HIIT training has no significant effect on the leukocyte levels of PASI Athletes in Malang City. So it can be concluded that HIIT training has no effect on increasing leukocyte levels in PASI Athletes running long distances in Malang City. The conclusion in this study was that the HIIT training provided had no significant effect on the amount of triglycerides after and after exercise. Triglyceride levels in long-distance runners are at normal levels. This is because there has been regular practice given by the coach as preparation for the match.

The elderly are a group of people who are vulnerable to degenerative diseases such as hypertension, diabetes mellitus, and others. The causes include a lack of knowledge about healthy diet and the lack of health checks. The purpose of this community service activity is to improve the quality of life of the elderly in Kelurahan Utama of South Cimahi by socializing healthy diets and conducting health checks. Media used for healthy diet counseling are power points, videos, and posters. Health examinations conducted include measurements of body mass index, blood pressure, blood glucose levels, triglycerides, total cholesterol, and uric acid. The results of the health examination showed quite a lot of elderly people who suffer from degenerative diseases. Through this activity, the elderly in Kelurahan Utama of South Cimahi gained knowledge about healthy diet in order to avoid various diseases and know the disease that is being experienced so that they can immediately undergo proper treatment.