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Tuberculosis (TB) is one of the top 10 causes of death worldwide. Anti-tuberculosis drugs (OAT) are the most important component of TB treatment. CRP can be used as a marker of tuberculosis activity and severity and can predict the course of the disease. This study aimed to determine CRP levels in TB patients at the Oebobo Community Health Centre in Kupang City as a monitor of response to TB treatment. The research design was observational analytic using a cross sectional approach by measuring CRP levels in the form of high sensitivity CRP in pulmonary TB patients with OAT therapy. The results showed that of the 27 respondents (20 men, 7 women), 18 people (66.66%) had CRP ≤ 10 mg/L and 9 people (33.33%) had CRP > 10 mg/L. Based on the length of treatment, CRP levels > 10.0 mg/L were most prevalent in respondents who were undergoing intensive treatment, namely 6 people (22.22%). Respondents with advanced treatment had more CRP levels ≤ 10.0 mg/L (26.63%) than > 10.0 mg/L (11.11%).

This study aims to explore the potential of plant species used in traditional medicine, the organ parts used and the processing of medicinal plants. This research was conducted for 2 weeks from March 14 to March 27, 2023 in Hepang Village. This study uses a type of science research with identification and exploration survey methods. The population of this study amounted to 15 people consisting of Battra (Traditional Medicine) 3 people, 6 patients and 6 people in general. Based on the results of the study found 22 types of medicinal plants namely Peperomia pellucida, Euphorbia thymifolia, Piper batle, Euphorbia hirta, Momodirca charantia, Curcuma domestica, Choromolaena odorata, Orthosiphon stamineus, Morinda citrifolia, Paederia foetida, Kaemferia galanga, Morus alba, Sonchus arvensis, Anomianthus dulcis, Gynura procumbens, Centella asiatica, Phyllanthus niruri, Androrapis paniculata Ness, Pluchea indica, Alstonia scholaris, Physalis angulata, Elephantopus scaber, which consists of 14 families, the most widely used Asteraceae. The most widely used organ parts are leaves 53%, roots 26%, rhizomes 7%, while the least used organs are stems, fruits and sap 3%. The processing is very traditional, namely by boiling, pounding, squeezing, squeezing, chewing, soaking, grinding and cutting.    

Abstrak. Hipertensi atau penyakit darah tinggi sebenarnya adalah suatu gangguan pada pembuluh darah yang mengakibatkan suplai oksigen dan nutrisi yang dibawah oleh darah terhambat sampai ke jaringan tubuh yang membutuhkan. Peran edukator berperan membantu pasien meningkatkan kesehatannya melalui pemberian pengetahuan tentang perawatan dan tindakan medis yang di terima sehingga pasien atau keluarga dapat mengetahui pengetahuan yang penting bagi pasien atau keluarga untuk meningkatakan kepatuhan obat terhadap hipertensi. Tujuan penelitian ini untuk mengetahui hubungan peran perawat sebagai edukator dengan kepatuhan minum obat pada pasien hipertensi di Puskesmas Bitung Barat.Metode penelitian ini adalah metode kuantitatif dengan pendekatan cross sectional. jumlah populasi 302 pasien hipertensi. Sampel yang diambil berdasarkan jumlah responden sebanyak 45 responden dengan menggunakan Teknik purposive sampling . Pengumpulan data dilakukan dengan menggunakan kuesioner dan lembar observasi. Untuk di analisa dengan uji statistic Uji Chi-Square dengan tingkat kemaknaan (α) 0,05.Hasil penelitian ini didapatkan Nilai ρ=0,019 artinya Ha diterima yaitu ada hubungan antara peran perawat sebagia edukator dengan kepatuhan minum obat.Kesimpulan semakin baik peran perawat sebagai edukator terhadap pasien hipertensi maka semakin patuh minum obat. Saran perawat harus selalu memberikan penjelasan tentang hipertensi dan kepatuhan minum obat kepada setiap pasien yang datang.      

In 2020, non-communicable diseases (NCDs) accounted for 73% of global causes of death, claiming the lives of 36 million people annually. The rising rates of morbidity and mortality are influenced by hypertension. One of the most prevalent cardiovascular disorders in the world today is hypertension.The research objective was to determine the correlation between knowledge with compliance with taking medication for hypertension sufferers at the Wonogiri Public  Health Center in North Lampung Regency. This research type is quantitative using a cross-sectional design with a population of 471 people. The sampling technique used purposive sampling of 83 respondents. The statistical tests used are Gamma and Logistic Regression. The study findings demonstrated a significant correlation between knowledge and hypertension patients' compliance to taking their medications (p-value=0.000).

Parkinson adalah penyakit neurodegenerative jangka panjang yang ditandai dengan gangguan pergerakan, dan tremor saat istirahat. Penyakit parkinson belum bisa disembuhkan dan hanya bisa di lakukan penanganan menggunakan obat dan terapi. Pengobatan yang dilakukan jangka panjang akan mempengaruhi pasien secara ekonomi secara langsung. Selain biaya yang dikeluarkan untuk obat, pasien Parkinson juga dapat kehilangan produktivitas karena meninggalkan pekerjaan akibat gejala dari penyakitnya. Penelitian ini bertujuan untuk mengetahui analisis biaya berdasarkan persepsi pasien penderita parkinson yaitu biaya langsung dan biaya tidak langsung. Biaya langsung terdiri dari biaya pengobatan sedangkan biaya tidak langsung terdiri dari biaya hilangnya produktivitas. Penelitian ini menggunakan desain deskriptif observasional dengan pengambilan data dari rekam medik dan wawancara kepada pasien. Data dianalisis untuk melihat besar atau rata-rata biasa langsung yaitu biaya medis langsung maupun non medis langsung dan biaya tidak langsung yaitu hilangnya produktivitas. Hasil penelitian ini adalah terdapat 23 sampel yang terdiri dari laki-laki 70% atau sebanyak 16 orang dan Perempuan sebesar 30% atau sebanyak 7 orang.  Biaya medis langsung dengan komponen biaya tertinggi adalah biaya pemeriksaan dengan rata-rata Rp. 12.130, biaya obat rata-rata Rp. 64.503, biaya asuhan perawat rata-rata Rp. 64.500. Biaya non medis langsung dengan komponen biaya tertinggi yaitu biaya transportasi rata-rata Rp.  20.652, biaya konsumsi rata-rata Rp. 16.965. Biaya tidak langsung pada jenis hilangnya produktivitas dengan rata-rata Rp. 1.388.894. Hasil penelitian dapat disimpulkan bahwa biaya medis langsung merupakan biaya tertinggi dibandingkan biaya non medis langsung dan biaya tidak langsung.   Kata kunci: Analisis biaya, Parkinson, Persepsi pasien,

Non-compliance with taking medication in diabetes mellitus sufferers will cause blood sugar levels to decrease or increase beyond normal limits  and as a result will cause complications or death. There is a need for health education regarding knowledge of diabetes patient medication adherence to prevent this. This research was conducted using a quasi-experimental research method (one-group pre-post test design). The sample in this study was 29 respondents taken using purposive sampling instruments using SAP, lealeats and questionnaires. the collected data was processed using the SPSS 24 version of the computer program to be analyzed using the Mc.Nemar nonparametic test with a significance level (α) of 0.05. The results of the bivariate analysis show that there is an influence of health education on knowledge of the level of dringking compliance in patients with type diabetes mellitus. The value obtained is p = 0,000 which means that Ha is accepted and Ho is rejected. The conclusions in the research show that there is an influence of knowledge education on treatment compliance.

Peresepan yang tidak tepat menyebabkan masalah seperti penurunan kemanjuran terapi, meningkatkan morbiditas dan mortalitas, pemborosan sumber daya, penurunan ketersediaan obat, risiko efek samping, resistensi bakteri, serta dampak psikososial, yang dapat menyebabkan ketergantungan pasien pada obat yang tidak berguna. Tujuan dari penelitian ini adalah untuk mengevaluasi ketepatan peresepan untuk pasien Diabetes melitus type-2 (DM-2) di Puskesmas Buleleng II. Survei potong lintang dilakukan dari Februari hingga April 2023. Wawancara secara langsung menggunakan kuesiner dilakukan pada pasien DM-2 yang direkrut secara purposive. Sejumlah 120 responden berpartisipasi dalam penelitian ini (tingkat respon 100%). Hasil menunjukkan pola peresepan pada pasien DM-2 yaitu tepat indikasi (97.5%); tepat pemilihan obat (97.5%); tepat dosis (97.5%); tepat cara pemberian obat (97.5%); tepat waktu interval (88.3%); dan waspada efek samping obat (48.3%). Ketepatan peresepan obat pada pasien DM-2 secara umum sudah baik. Apoteker diharapkan lebih aktif dalam memberikan pelayanan informasi obat dan konseling terkait pengobatan pasien, agar tercapai terapi pengobatan yang optimal.

Storage is an activity of storing and maintaining by placing the received pharmaceutical supplies in a place that is considered safe from theft and physical disturbance that can damage the quality of the drug. The purpose of this study was to determine the drug storage system at the Dearh Lanto Dg Pasewang General Hospital Pharmacy Warehouse which includes spatial arrangements, storage methods, stock card recording and drug quality observation. This is done by direct observation The research conducted is descriptive in nature, the data collection method in this study is by direct observation. The data management and analysis techniques that the authors used in this study included reducing the checklists that had been obtained. Based on the results of research conducted at the Pharmacy Warehouse of the Lanto Dg Pasewang Hospital, in general, the drug storage system was 93.22% in the good category. The assessment includes the physical condition of the warehouse with a value of 90.47% in the good category. How to store drugs with a value of 93.33%. Stock card recording with a percentage value of 100% is in the good category. Drug quality monitoring with a percentage value of 100% is in the good category, so that the medicines stored in the Warehouse of the Regional General Hospital Lanto Dg Pasewang Jeneponto are in good condition and the quality of the drugs is maintained.

Hypertension is a disorder in the blood vessels that causes blood pressure to increase, causing the heart to pump harder to circulate blood to organs and tissues throughout the body. The incidence of hypertension in Indonesia continues to increase because the majority of people do not take medication and do not regularly take medication because they feel healthy. Therefore, people with hypertension must receive treatment to reduce mortality and morbidity associated with hypertension. This requires knowledge regarding the use of hypertension medication by providing education using audio-visual media

Drug information services were activities that carried out by pharmacists to provide information about drugs that is impartial, critically evaluated, and with the best evidence in all aspects of drug use to other health professionals, patients, or the public. Providing drug information has an important role in improving the quality of life of patients and providing quality services for them. The purpose of this study was to determine drug information services for outpatients in the pharmaceutical installation of Imelda Pekerja Indonesia Public Hospital. This study used qualitative research methods with a sample of pharmaceutical officers who provided drug information services to outpatients, as many as 100 patients. Data collection was carried out by interview, direct observation, and using a check list sheet of drug information components. The results showed that the percentage of components conveyed when delivering drug information, including the name of the drug, drug dosage, type of preparation, rules of use, how to use, time of use, amount of drug, and efficacy or indications, had a percentage of 100%. While the drug information component that is rarely conveyed is how to store the drug with a percentage of 8%, the drug information component that is not conveyed is the side effects of the drug. The results of this study indicate that drug information services to outpatients carried out by pharmaceutical officers in the pharmaceutical installation of the Imelda Pekerja Indonesia Medan Public Hospital have been well implemented, with a percentage of 80.80%. The results also concluded that the drug information services carried out by the pharmacist of Imelda Pekerja Indonesia Public Hospital, Medan, were in accordance with hospital procedures and Regulation of the Minister of Health of the Republic of Indonesia Number 72 of 2016 concerning Pharmaceutical Service Standards in Hospitals.

The impact of drug use is extremely harmful in the long run. In this regard, this article aims to reflect more deeply on the real impacts of drug use in our society. Through a better understanding of this issue, it is hoped that a stronger collective consciousness can be formed to face this challenge in a more effective and holistic way. The method used in this research is qualitative. The result is that drug use is not only an individual problem, but also a complex social problem that requires a holistic approach from various parties, including the government, health institutions, education, and society as a whole. Prevention, education, and access to adequate rehabilitation and health care services are key to addressing the negative impacts of drug use.

Introduction Hard drugs are drugs that have hard properties and if used carelessly or not according to the rules, can cause dangerous side effects and even poison the body, aggravate the disease, trigger the emergence of other diseases, to cause damage to body organs and death. Hard drugs are drugs that can only be obtained by prescription. Its characteristics are marked with a red round circle with a black border with the letter K in the middle that touches the border. This drug should only be sold in pharmacies and must be prescribed by a doctor at the time of buying it. While Mandatory Pharmacy Drugs (OWA) are some hard drugs that can be submitted without a doctor's prescription, but must be submitted by a Pharmacist at the pharmacy. This research method uses qualitative descriptive research design. What was used was total sampling with the measuring instrument used, namely a questionnaire with the number of samples being 15 respondents who became pharmaceutical personnel at the pharmacy. The results of the study showed that for the variable level of knowledge of pharmaceutical personnel with good categories amounted to 12 respondents with a percentage (80.0%) and enough 3 respondents with a percentage (20.0%), Kesimplant from the results of the level of knowledge of pharmaceutical personnel at pharmacies Waimital Village, Kairatu District, West Seram was good because pharmaceutical personnel knew information about hard drugs without a prescription and it was known that the pharmacist profession and the pharmacist assistant have the same level of understanding.   

Diarrhea is a condition in which a person has bowel movements with a soft or liquid consistency, it can even be just water and the frequency is more frequent in one day. Diarrheal disease in toddlers is ranked 2 out of the top 10 childhood diseases at the Sadewa Mother and Children Hospital (RSKIA) in May 2022. Knowing the pattern of prescribing diarrhea drugs in toddlers in outpatient care at the Sadewa Mother and Children Hospital for the period January - June 2022. The research conducted was a non-experimental descriptive research with a retrospective method. The study was conducted by taking prescription data from electronic medical records at the Sadewa RSKIA pharmacy and then recording them on a data collection sheet. Data were analyzed using tabulations in the form of percentages (%). The results showed that out of 130 samples, the profile of diarrhea patients under five was dominated by males, 77 children (59%), aged 2-3 years 65 children (50%), and the degree of dehydration of patients without dehydration, 120 children (92%). ). The most widely used drug class was zinc with 120 prescriptions (34.3%), zinc has a protective effect against diarrhea and can reduce recurrence and probiotics with 119 prescriptions (33.8%), probiotic bacteria will help the process of nutrient absorption and prevent disturbances in water absorption. The dominating combination was a combination of 3 drugs namely electrolytes, zinc and probiotics 69 prescriptions (57%), oralit functioned to replace fluids and electrolytes in the body that are wasted during diarrhea, zinc supplementation and probiotics in diarrhea effectively reduced stool output. The rule for using the treatment of diarrhea in toddlers is mostly 1 time a day with a total of 132 drugs (37.7%). The dominating drug was zinc with 117 prescriptions (88.6%) The pattern of prescribing diarrhea drugs in toddlers in this study was dominated by male patients, aged 2-3 years with a degree of dehydration, patients without dehydration. The most widely used drug classes are zinc and probiotic groups. The most common drug combination found is a combination of 3 drugs, namely electrolyte, zinc and probiotic group drugs. The rule for using the treatment of diarrhea in most toddlers is 1 time a day.    

Cipacing Village, Jatinangor District, Sumedang Regency is an area that has extensive plantation land and rice fields. This village is still beautiful with lush green trees and vast fields which are its own attraction. Many people in Cipacing Village still use plant species to treat diseases. The aim of this research is to identify the use and utilization of medicinal plants in Cipacing Village. This type of research is descriptive with qualitative research methods. Sampling was carried out using purposive sampling technique. Data collection was obtained from the results of semi-structured interviews. There were 30 respondents in this study who were described by characteristics such as gender, age and level of education. Based on research conducted, the plants used as medicine by the community are 23 families, 28 genera and 29 species with the dominant family being Zingiberaceae (26%) and the co-dominant family being Piperaceae (8.7%). The highest habitus was found in herbaceous plants (40%) while the part of the plant that was widely used was the leaves (57%). The most dominant plant processing used is by boiling the leaves and then filtering the boiled water for drinking.

Commercial activities contribute to increasing sales of agricultural products. One of the agricultural products is Tanaman Obat Keluarga (TOGa). TOGa plants are an additional source of income. However, the difficulty of selling is that often the price is not as good as the market. Through assistance in the use of social media and digital financial records, it is expected to contribute to increasing the income of residents of Purwoseco Hamlet and Karangrejo Hamlet. The results of service activities show that > 50% of residents experience an increase in understanding and knowledge of the knowledge provided. The satisfaction level of service participants showed an average score of 65%, which is very good. This shows that the service participants are satisfied with the course of service activities.

Drug-resistant tuberculosis (TB) is an escalating global health issue, particularly with the rise of multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB), which complicate treatment and control efforts. Resistance to both first-line and second-line drugs weakens the effectiveness of standard WHO-recommended therapies, while alternative drugs can cause severe side effects and reduce patient adherence. This study aims to explore the integration of bioinformatics and pharmacogenomics in supporting personalized TB treatment to improve therapeutic success and reduce the risk of further resistance. The research employed a laboratory-based experimental design with a bioinformatics approach, involving TB patients with clinical evidence of drug resistance. Clinical samples were analyzed through whole genome sequencing to identify gene mutations associated with resistance, followed by pharmacogenomic mapping to predict pharmacological responses based on patients’ genetic variations. The results revealed several specific gene mutations consistently linked to resistance and produced individualized therapeutic recommendations that were more targeted than standard protocols. Effectiveness evaluation demonstrated that genome-based personalized therapy yielded higher treatment success rates, faster recovery times, and lower rates of subsequent resistance. These findings highlight the significant potential of precision medicine in TB management, particularly for resistant cases that are difficult to treat with conventional approaches. In conclusion, the integration of bioinformatics and pharmacogenomics plays an essential role in strengthening TB treatment strategies through a personalized, adaptive, effective, and sustainable approach. Nevertheless, its implementation still faces challenges such as high costs, limited infrastructure, and the need for clear regulations regarding the use of patients’ genomic data.

Medicinal plants are plants with positive pharmacological effects on the human body and are usually grown on a home or communal scale. These medicinal plants can then be used as traditional medicine which can be made easily. The plants chosen are usually plants that can be used to treat simple health problems such as flu and coughs. Medicinal plants can increase the body's immunity because they can prevent disease through the secondary metabolites they contain. In this service activity, two activities were carried out separately, namely socialization and planting medicinal plants with residents. The outreach was carried out to provide information to the residents of Medan Helvetia District regarding medicinal plants so that these medicinal plants can be useful after being planted. Planting is also carried out to increase awareness regarding land use, as well as being a starting point for residents in cultivating medicinal plants. This socialization on the use of family medicinal plants aims to provide information to the people of Kexamatan Medan Helvetia in using medicinal plants. It is hoped that this community service activity will help increase public knowledge about the importance of planting and utilizing medicinal plants to create a healthy society.

DHF cases in Indonesia in 2014 showed that there were 10 provinces in Indonesia that had the highest dengue cases and one of them was South Sulawesi Province (7). Based on data from the South Sulawesi Provincial Health Service, there were 2,166 people suffering from dengue fever from January to May 2020. 19 of them died. And the most in Gowa Regency were 6 people. Borisallo Village, Parangloe District, is one of the villages supported by the Indonesian Muslim University. We chose this location as a service partner area because dengue cases in Gowa Regency, based on the 2019 South Sulawesi Provincial Health Service Profile, were the 2nd highest area with dengue cases after Pangkep Regency, namely 474 sufferers. Then in 2020 Gowa Regency was the area with the most dengue cases, namely 457 people. The aim of this service is to improve cadres' skills in making their own mosquito repellent from natural ingredients that are safe and environmentally friendly, increase cadres' knowledge about the dangers of chemical mosquito repellent, increase cadres' knowledge in making preventive efforts against diseases transmitted by mosquito vectors. The solutions offered include training in making electric liquid mosquito repellent from sweet orange peel, providing education regarding the dangers of chemical mosquito repellent for health, providing education on preventive efforts to prevent diseases transmitted by mosquito vectors.  

The majority of people in Dadapan village earn their livelihood as farmers, so we can find many plants which have medicinal properties in their yards. However, the knowledge of the Dadapan Village community regarding the use of medicinal plants tends to be lacking. So, a new breakthrough alternative is needed to introduce TOGA to the people in Dadapan Village. Turmeric and secang wood are two of the many TOGA plants that can be used as family medicine. Most of PKK and ASMAN TOGA members are housewives so making ready-to-drink herbal medicine from TOGA plants grown by themselves can be a beneficial activity for the family, and improve the family economy. The results of the questionnaire that has been carried out show that this training is able to increase knowledge about the benefits and methods of making turmeric and secang herbal medicine ready to drink. The percentage before the training was carried out was 73.19%, while after the training it was 97.24, meaning there was an increase in participants' understanding about TOGA by 24.05%.

Indonesia's Health Profile in 2022, there were 845,000 cases of pulmonary TB and in 2021 there were 420,994 cases. There were 563,879 new confirmed cases of pulmonary TB and relapses. If this is not adhered to, it will cause drug resistance. The aim of the research was to determine the factors that influence the compliance of pulmonary TB sufferers in taking medication at the Batang Beruh Health Center UPT, Sidikalang District, Dairi Regency. The research design uses an analytical survey research method with a cross sectional research design. The population in this study was all 126 pulmonary TB patients. The sample was 56 people with a purposive sampling method. Data analysis uses univariate, bivariate and multivariate analysis. The results of the study showed that there was an influence of knowledge p = 0.010, attitude p = 0.006, family support p = 0.000 and drug side effects p = 0.000, while the variable that had no influence was gender, p = 0.057, on the compliance of pulmonary TB sufferers in taking medication. at UPT Batang Beruh Community Health Center, Sidikalang District, Dairi Regency, while the dominant factor was family support, p = 0.006 < 0.025, 95% CI = 2.715-519.110 and OR = 37.543. The conclusion is that there is an influence of knowledge, attitude, family support and side effects of drugs, while the variable that has no influence is gender on the compliance of pulmonary TB sufferers in taking drugs at UPT Puskesmas Batang Beruh, Sidikalang District, Dairi Regency. Recommended to UPT. Batang Beruh Community Health Center, Sidikalang District, increases public knowledge about pulmonary TB among sufferers and visiting residents by providing outreach and providing information on the SITB application. Targets at risk of contracting pulmonary TB are the sufferer's family and health workers. And as a Medicine Taking Supervisor are the families of pulmonary TB sufferers.