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This study investigates the levels of asprosin and irisin in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN), and evaluates their relationships with insulin resistance, glycemic control, and renal function. Additionally, it explores their diagnostic performance as potential non-invasive biomarkers for the early detection of DN using ROC curve analysis. A controlled prospective study was conducted involving 130 participants, categorized into healthy controls, T2DM patients, and T2DM with DN. Serum asprosin, irisin, and insulin levels were measured using ELISA, while biochemical and renal parameters such as fasting blood glucose, HbA1c, creatinine, urea, and eGFR were assessed using standard spectrophotometric techniques. ROC analysis was employed to assess the diagnostic accuracy of asprosin and irisin. Asprosin levels were significantly elevated, while irisin levels were markedly reduced in DN patients compared to T2DM and control groups (p < 0.001). Moreover, DN patients exhibited higher levels of fasting glucose, HbA1c, HOMA-IR, creatinine, and urea, with lower eGFR, indicating substantial renal dysfunction. ROC analysis revealed that asprosin had an AUC of 0.910 (95% CI: 0.839–0.981), with 90.0% sensitivity and 88.9% specificity at a cutoff value of 11.27 ng/mL. Irisin showed an AUC of 0.886 (95% CI: 0.812–0.960), with 95.0% sensitivity and 71.1% specificity at a 158.25 ng/mL cutoff. Asprosin and irisin are strongly associated with insulin resistance and renal impairment in patients with T2DM and DN. Their high diagnostic performance supports their utility as promising non-invasive biomarkers for the early detection and monitoring of diabetic nephropathy progression.

Down Syndrome (DS) is a genetic disorder characterized by trisomy of chromosome 21 and is inherently associated with clinical manifestations such as hypotonia, joint laxity, and neuromuscular deficits, all of which collectively contribute to impaired postural control and balance. These balance impairments significantly affect the attainment of motor milestones, performance of daily activities, and increase the risk of falls. This study aims to analyze the effectiveness of core stability training in improving balance among children with DS. A narrative review approach was employed by conducting a literature search across electronic databases including PubMed, Scopus, Google Scholar, and ResearchGate. Inclusion criteria consisted of primary studies (RCTs, quasi-experimental designs) published within the last ten years (2015–2025) that examined core stability interventions targeting balance or postural control in children with DS. A review of 10 relevant studies demonstrated that core stability training, either as a standalone intervention or combined with other modalities (e.g., treadmill training or balance training), resulted in significant improvements in both static and dynamic balance. These improvements are facilitated through the strengthening of deep trunk muscles (such as the multifidus, transversus abdominis, and rectus abdominis), which play a crucial role in proximal stabilization and force transfer to the extremities. In conclusion, core stability training is an effective and recommended intervention modality within physiotherapy rehabilitation programs to enhance the quality of life and motor independence of children with Down Syndrome.  

Inflammation is a physiological response to tissue injury, infection, or harmful stimuli, characterized by redness, swelling, heat, and pain. However, excessive or chronic inflammation may lead to tissue damage and degenerative diseases. Long-term use of non-steroidal anti-inflammatory drugs is associated with gastrointestinal and cardiovascular side effects, highlighting the need for safer natural alternatives. Taro leaves (Colocasia esculenta) are traditionally used to treat swelling and wounds and contain bioactive compounds such as flavonoids, alkaloids, tannins, saponins, and triterpenoids with potential anti-inflammatory effects. This study aimed to evaluate the anti-inflammatory activity of ethanol extract of taro leaves and determine the most effective dose. An experimental study was conducted using male white mice (Mus musculus) divided into five groups: negative control (Na-CMC), positive control (sodium diclofenac), and three treatment groups receiving extract doses of 25, 50, and 75 mg/kg BW. Inflammation was induced by 1% carrageenan injection. The extract significantly reduced inflammation, with the highest inhibition (84.13%) observed at 75 mg/kg BW, comparable to diclofenac.  

This study aims to examine the responses and levels of understanding of eleventh-grade students at SMA Negeri 4 Pasuruan City regarding trademark disputes, particularly the “Geprek Bensu” case. The research employs a descriptive quantitative approach, with data collected through questionnaires distributed to students as respondents. The questionnaire was designed to describe students’ understanding of the concept of trademarks, the benefits of trademark registration, and their views on the causes of trademark disputes. The results indicate that most students are familiar with the “Geprek Bensu” case and understand trademarks as a business identity and a means of product differentiation. The majority of respondents are also aware that trademark registration provides legal protection and exclusive rights to the trademark owner. However, students’ understanding of trademark law remains varied, as some respondents still associate trademark ownership with popularity alone. In addition, students demonstrate a positive attitude toward the importance of intellectual property education from an early stage through formal education. These findings emphasize the need to strengthen Intellectual Property Rights literacy at the secondary school level in order to enhance legal awareness and prevent trademark disputes in the future.  

Differences in students’ levels of learning interest are often associated with their understanding of religious values, one of which is the understanding of hadiths concerning the virtues of knowledge. Hadiths emphasizing the virtues of knowledge are believed to stimulate interest in the learning process. This study aims to examine the influence of students’ understanding of hadiths on the virtues of knowledge on their learning interest at STDI Imam Syafi’i Jember. This research employed a quantitative approach with a correlational design. A total of 130 students were selected as respondents using simple random sampling. The research instruments were tested for validity and reliability, yielding Cronbach’s alpha values of 0.838 for the variable of understanding the hadiths on the virtues of knowledge and 0.884 for the learning interest variable. The normality test using Shapiro–Wilk produced a value of 0.097, indicating that the data were normally distributed, while the heteroscedasticity test showed a significance value of 0.968, confirming that the regression model was appropriate for use. The regression analysis revealed a significance value of p = 0.001 and a coefficient of determination (R²) of 0.362. This indicates that understanding the hadiths on the virtues of knowledge has a positive influence of 36.2% on students’ learning interest, while the remaining 63.8% is influenced by other factors. These findings affirm that understanding the values contained in hadiths on the virtues of knowledge plays an important role in enhancing students’ learning interest.

This study aims to identify factors associated with fast food consumption behavior among adolescents based on the Social Cognitive Theory (SCT) through a literature review. A descriptive literature review was conducted using nine peer-reviewed articles published between 2021 and 2025, retrieved from Google Scholar, PubMed, and ScienceDirect. The findings indicate that adolescent fast food consumption behavior is influenced by two main components of SCT, namely personal factors and environmental factors. Personal factors were predominantly examined through the knowledge variable, which showed inconsistent associations with fast food consumption, while other personal variables, although mostly related, lacked consistent empirical support across studies. In contrast, environmental factors demonstrated more consistent associations, particularly peer influence, mass media exposure, parental influence, and pocket money, which were repeatedly identified as significant determinants of fast food consumption among adolescents. In conclusion, adolescent fast food consumption behavior is more strongly influenced by environmental factors than by personal factors, highlighting the importance of multi-level interventions that address social and environmental contexts in shaping healthy eating behaviors among adolescents.

Food safety is a crucial aspect of public health, particularly for elementary school children who frequently consume street food or snacks sold within school environments. Food handlers play a key role in determining the level of hygiene and sanitation of the food served. This study aims to analyze the factors associated with food handlers’ hygiene behavior in elementary school canteens in Telanaipura District, Jambi City. This research employed a quantitative method with a cross-sectional approach involving 41 food handlers as respondents. Data were collected through structured interviews using questionnaires and direct observations based on hygiene and food sanitation standards in accordance with the Regulation of the Minister of Health No. 1096/Menkes/PER/VI/2011. Data were analyzed using univariate and bivariate methods with the Chi-Square test at a significance level of p < 0.05. The results showed that most food handlers exhibited poor hygiene behavior (61.0%). There were significant relationships between knowledge (p = 0.048), attitude (p = 0.000), and availability of facilities and infrastructure (p = 0.000) with hygiene behavior, while education level showed no significant association (p = 0.187). It can be concluded that improving hygiene behavior requires continuous training, supervision, and provision of adequate sanitation facilities to support food safety in school environments.

Psoriasis is a chronic inflammatory skin disease characterized by keratinocyte hyperproliferation, inflammation, and neoangiogenesis, largely driven by dominant T helper 1 (Th1) and T helper 17 (Th17) immune responses. Psoriasis is associated with metabolic, psychological, cardiovascular, and arthritic comorbidities. Vitamin D plays an important role in the management of psoriasis. Calcitriol (1,25(OH)₂D₃), regulates keratinocyte proliferation, differentiation, and apoptosis. Vitamin D supports the formation of the cornified envelope as well as epidermal lipid and ceramide production, also acts synergistically with the epidermal calcium gradient to maintain barrier function. In addition to its epidermal effects, vitamin D exerts immunomodulatory actions by enhancing regulatory T cells and anti-inflammatory cytokines (interleukin (IL)-10, IL-4, transforming growth factor-beta (TGF-β)), while suppressing Th1/Th17 activity and production of pro-inflammatory cytokines (IL-2, IL-17, tumor necrosis factor-alpha (TNF-α)). These mechanisms highlight its potential role in psoriasis therapy. Topical vitamin D₃ analogues are effective for mild to moderate disease due to the high expression of vitamin D receptors in psoriatic keratinocytes. Oral supplementation has also been explored for its systemic immunomodulatory effects, although findings remain inconsistent.  

The increasing use of digital devices among adolescents raises concerns regarding eye health, particularly myopia. Non-ergonomic postures, such as using gadgets in a lying position, may increase accommodative stress on the eyes and contribute to visual impairment. To analyze the association between the duration and viewing distance of gadget use in a lying position and the occurrence of myopia among eighth-grade students at SMPN 119 Central Jakarta. An observational analytic study with a cross-sectional design was conducted involving 74 eighth-grade students. Data on gadget use habits, including duration and viewing distance, were collected using a structured questionnaire. Visual acuity was assessed using a Snellen chart. Bivariate analysis was performed using the Chi-square test with a significance level of p < 0.05. Decreased visual acuity was found in 62.2% of respondents. There was no significant association between viewing distance and myopia (p = 0.080). However, a significant association was identified between gadget use duration exceeding two hours per day and the occurrence of myopia (p = 0.002). The duration of gadget use in a lying position was significantly associated with myopia, whereas viewing distance was not. Limiting the duration of gadget use may help prevent visual impairment among adolescents.

Introduction: Triglycerides are a lipids fractions that play an important role in energy metabolism, but high levels in the blood are strongly associated with increased risk of cardiovascular disease, metabolic syndrome, and type 2 diabetes. The prevalence of hypertriglyceridemia tends to increase, including in urban area such us West Jakarta which have high risk consumption patterns. This community service activity aimed to raise public awareness about the importance  lipid profile management with screen triglyceride levels in community of Kelurahan Kota Bambu. Method: The activity was conducted in June 2025, involving 168 adult participants. The method was used was health education on the role of triglycerides and their risk,, followed by laboratory testing using the Nesco BL-101 5in1 Lipid Panel Monitoring System. Triglyceride level was classified into normal, borderline, high, and very high categories according to the NCEP ATP III guidelines. Results: The average triglyceride level of the participants was 181.21 mg/dL, with a range of 47–830 mg/dL. The triglyceride levels of the majority of participants were in the normal category, but the proportion with high and very high triglyceride levels was significant, indicating the existence of a risk group that needs attention. Conclusion: This activity confirms that simple triglyceride testing at the community level can be an effective step in early detection, education, and prevention

The tradition of pregnant women hiding under the bed during a lunar eclipse is still found in some Muslim communities in Indonesia. This tradition is believed to serve as a means of protecting the fetus from the negative impacts of the eclipse, both physically and metaphysically. This study aims to examine this tradition from the perspective of Living Hadith, namely how the Prophet’s hadiths are understood, interpreted, and practiced within the social life of the community. This research employs a qualitative approach using field study methods, including observation, in-depth interviews, and documentation. The findings indicate that this tradition has no direct textual basis in the Prophet’s hadiths; rather, it has developed through processes of religious interpretation, local myths, and traditional knowledge that are associated with Islamic teachings. The community often relates this tradition to hadiths concerning eclipses as signs of God’s power and as moments to increase supplication and prayer. This tradition reflects a form of acculturation between Islamic values and local culture, while also demonstrating how hadiths are “lived” within the collective consciousness of the Muslim community, even when such practices do not fully align with the textual meanings of the hadiths.  

This study examines the implementation of the Manak Salah tradition in Padang Bulia Customary Village from the perspectives of legal certainty and human rights protection. Manak Salah is a customary practice associated with the birth of opposite-sex twins, which in Balinese Hindu cosmology is considered a sacred event that may disrupt the balance between the sekala and niskala realms, thereby requiring purification rituals. Although the contemporary practice of this tradition has become more humane and no longer involves social exclusion, its regulation remains unwritten and has not been formally codified in the village’s Awig-awig (customary law). This condition creates the risk of multiple interpretations, legal uncertainty, and insufficient protection of the rights of children and affected families. This research employs an empirical juridical method with a qualitative approach, using interviews with customary leaders, field observations, and document analysis of statutory regulations and customary legal sources. The findings reveal that the absence of written norms causes the implementation of Manak Salah to rely heavily on the discretion of customary authorities, leading to potential inconsistency and normative vulnerability. This study emphasizes the urgency of codifying the Manak Salah tradition into the Awig-awig as a form of customary law reform aimed at ensuring legal certainty, strengthening institutional accountability within customary villages, and harmonizing customary law with Bali Provincial Regulation No. 4 of 2019 and fundamental human rights principles.

Sleep quality is a crucial component of health and overall well-being among older adults, as the aging process is commonly associated with various physiological, psychological, and environmental changes that may significantly disrupt normal sleep patterns. Declining bodily functions, increased health problems, and changes in daily routines often contribute to sleep disturbances in later life. This literature review aims to analyze the factors influencing sleep quality in the elderly by synthesizing findings from relevant national and international studies published in recent years. Various factors were identified, including physiological conditions such as chronic diseases, pain, and hormonal changes; psychological factors such as anxiety, depression, stress, and cognitive decline; lifestyle-related factors such as levels of physical activity, dietary habits, medication use, and caffeine consumption; and environmental aspects including noise exposure, lighting conditions, temperature, and overall bedroom comfort. The reviewed literature consistently indicates that poor sleep quality is strongly associated with impaired physical health, reduced cognitive function, increased fatigue, and decreased emotional well-being in older adults. This review highlights the importance of comprehensive, multidisciplinary interventions that address both intrinsic and extrinsic determinants of sleep to effectively improve overall sleep quality among elderly populations.

Breast cancer is a type of disease affecting the supporting tissue in the breast. In Indonesia, breast cancer is the leading cause of cancer death among women. Early detection of breast cancer is very important to be done as soon as possible through SADARI behavior because if an abnormality in the breast is detected early, clinical examination can be conducted promptly. Research objective: to identify the factors associated with SADARI behavior among female adolescents at SMAN 1 Tekarang. Research method: This study is quantitative with an analytical approach using a cross-sectional time approach. The study was conducted at SMAN 1 Tekarang from April 5, 2025, to May 21, 2025. The study population consisted of 217 female students at SMAN 1 Tekarang, while the sampling technique used was accidental sampling, resulting in 187 samples. The variables studied were the dependent variable of SADARI behavior and independent variables of attitude, health literacy, information exposure, and family health history with breast cancer. Data collection using a questionnaire. Analysis using the Chi Square test. The results of the analysis showed no relationship between attitudes (ρ value 0.073) and health lateracy (ρ value 0.959) with SADARI behavior, while there was a relationship between information exposure (ρ value 0.000) and family health history of breast cancer (ρ value 0.000) with SADARI behavior. Conclusion: There is a statistical relationship between information exposure and family health history with BSE behavior.  

Chronic kidney disease (CKD) is a growing global health concern that frequently remains undiagnosed until advanced stages. Early detection through simple laboratory screening is essential to prevent disease progression and associated cardiometabolic complications. This community service program aimed to assess kidney function using serum creatinine and estimated glomerular filtration rate (eGFR), while increasing public awareness regarding CKD prevention. A total of 59 participants were included, with a mean age of 39.15 ± 15.39 years (range 16–75 years), predominantly female (74.58%). The mean serum creatinine level was 1.0 ± 0.19 mg/dL, and the mean eGFR was 91.08 ± 20.53 mL/min/1.73 m². Most participants demonstrated normal kidney function (28.8%) or mild decline (21.6%). A progressive reduction in eGFR with increasing age was observed, reflecting the physiological decline in nephron mass and renal perfusion. The program also provided education on kidney-protective practices, including optimal blood pressure control, diabetes management, adequate hydration, and avoidance of nephrotoxic agents. This intervention improved participants’ understanding of CKD risk factors and the importance of regular screening. In conclusion, serum creatinine and eGFR evaluation offer simple, accurate, and practical tools for early CKD detection, supporting promotive–preventive strategies to slow disease progression and enhance quality of life in at-risk populations.

The rapid expansion of digital technology has intensified the circulation of pornographic content, making it increasingly accessible across various online platforms and posing significant risks to social, psychological, and moral stability. This study aims to examine the underlying factors contributing to the spread of pornographic content, its impact on individuals and society, and the urgency of strengthening regulatory and preventive measures. Using a qualitative approach supported by interviews and questionnaires distributed to university students in Jatinangor and Bandung, the research explores public perceptions, access patterns, and social responses regarding pornography in digital spaces. The findings reveal that most respondents consider pornography dissemination a deviant behavior, with economic motives and revenge-driven actions emerging as predominant driving factors. The study also shows that existing legal regulations are perceived as insufficient in mitigating the rapid growth of pornographic content online. These results highlight the importance of enhancing digital literacy, strengthening law enforcement, and promoting moral education to reduce the risks associated with pornography exposure. The study contributes to a deeper criminological understanding of deviant behavior in digital environments and underscores the need for collaborative societal efforts to address this phenomenon.

The development of digital technology has encouraged the government to modernize public services, including in the field of land affairs. Traditionally, land registration has been associated with long, complex procedures that are often prone to abuse of authority. To address these challenges, the Ministry of Agrarian Affairs and Spatial Planning/National Land Agency (ATR/BPN) has begun implementing a digital-based land registration system. However, its implementation raises an important question: is this digital system truly effective in improving the quality of services at the Land Office, or does it instead create new obstacles? This study aims to analyze the effectiveness of land registration digitalization, particularly in terms of accessibility, efficiency, transparency, and the challenges encountered during its implementation. The research employs an empirical juridical method with qualitative analysis. The juridical approach is used to examine the legal foundations of land registration digitalization, including Law No. 5 of 1960 on Basic Agrarian Principles, Government Regulation No. 24 of 1997 on Land Registration, and the Ministerial Regulation of ATR/BPN No. 1 of 2021 on Electronic Certificates. The empirical approach involves direct observation of service processes at the Land Office and interviews with employees and citizens utilizing digital services. The findings reveal that digitalization of land registration has generally improved the quality of services at the Land Office. Administrative processes have become faster, land data are stored more securely, and service transparency has increased, as the public can monitor the status of their registration online.