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Intan Nur’Aini; Karmila Nuralifah Kadir; Nadyya Dwi Wulandari; Aqila Fayyaza Ghafur; Farel Ananda Rizqi

Desentralisasi : Jurnal Hukum, Kebijakan Publik, dan Pemerintahan 2025 Asosiasi Peneliti dan Pengajar Ilmu Hukum Indonesia

Constitutional Court Decision Number 121/PUU-XXII/2024, which eliminates the Civil Service Commission (KASN) and transfers its duties to the National Civil Service Agency (BKN) as the new institution responsible for supervising the merit system, has generated significant concerns regarding the autonomy and effectiveness of internal bodies that are often viewed as underperforming. Based on a normative analysis grounded in relevant legal principles and theoretical frameworks, this ruling is seen as creating a gap in the oversight mechanism intended to safeguard the neutrality and integrity of the state civil apparatus. The shift in authority also introduces the potential for overlapping responsibilities that conflict with the fundamental doctrine of checks and balances. Such structural inconsistencies may weaken the supervision of civil service behavior and reduce the accountability expected from government institutions. Ultimately, these issues risk diminishing public confidence in the state apparatus, as the absence of an independent oversight body can hinder efforts to ensure professionalism, fairness, and ethical conduct within the ASN system.

Ojokoh, Promise; Agbolade, Olaide

Journal of Computing Theories and Applications 2025 Universitas Dian Nuswantoro

Power transformer theft, a pervasive issue disrupting critical infrastructure, necessitates the development of cost-effective and energy-autonomous security solutions. This paper presents the design and implementation of a detection-focused anti-theft framework that integrates a Raspberry Pi Zero W, camera module, and passive infrared (PIR) motion sensors powered by a solar system for continuous monitoring. The system is designed for remote, off-grid deployment, utilizing a headless Raspberry Pi powered by a 5V solar panel and power bank to ensure energy autonomy. Upon motion detection, captured images are processed on the edge device using OpenCV’s Haar Cascade classifier, optimized for upper-body detection to minimize false positives and verify human presence. Captured images are processed locally on the edge device using OpenCV’s Haar Cascade classifier to confirm human presence before an alert is sent to the mobile application, emphasizing real-time operation and low latency. Once an intrusion is confirmed, the images are saved locally and uploaded via the Secure File Transfer Protocol to a custom-developed Android application. The app provides a dedicated remote monitoring interface, enabling secure file transfer and system access, while providing users with immediate notifications and image management capabilities. The system emphasizes low power consumption, real-time operation, and low deployment cost. Tests over 200 triggered events under varied environmental conditions achieved 90% detection accuracy with an average latency of 4.5 s. Solar autonomy was maintained for approximately 24 h under normal operation. It is concluded that the integration of solar power, edge computing of images, and mobile monitoring provides a feasible, scalable, and financially viable framework for securing transformers, especially in resource-constrained environments.

Radina Dinova Ramadanis; Nasywa Natania Savira; Jihan Artika Prastiwi; Bening Zahwa Islamaya; Ratih Kusuma Dewi

Jurnal Riset Ilmu Farmasi dan Kesehatan 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

Hypothermia during surgery is a common occurrence among pediatric patients due to their immature thermoregulation system, higher body surface area-to-weight ratio, and thinner subcutaneous fat layer. This condition can lead to several complications, including increased bleeding, coagulation disorders, surgical wound infections, and delayed healing. Prevention strategies include active and passive warming methods. The purpose of this study is to evaluate the effectiveness of active and passive warming in preventing intraoperative hypothermia in pediatric patients. A scoping review approach was applied to interpret the evidence based on predetermined inclusion and exclusion criteria, followed by data exploration, analysis, and synthesis of findings. The results indicate that active warming methods—such as forced-air warming, blanket warming, and warmed intravenous fluids—are more effective than passive warming in maintaining normothermia during surgery. Moreover, combining both approaches provides optimal prevention against hypothermia. Overall, active warming plays a vital role in stabilizing body temperature and enhancing patient safety during pediatric surgery. Therefore, its implementation should be considered a standard practice in perioperative nursing care.

Trisinta Trisinta; Suaib Suaib; Benny Harry L. Situmorang

Jurnal Siti Rufaidah 2025 PPNI UNIMMAN

Independence refers to the freedom to act and the ability to control one’s own or a group’s activities to protect oneself or others from various diseases or conditions. Among the elderly, the ability to perform Activities of Daily Living (ADL) often declines, which in turn reduces their independence in carrying out daily activities such as dressing, toileting, climbing stairs, or moving around. One of the common health problems affecting older adults is rheumatoid arthritis—an autoimmune disorder that causes inflammation and swelling in the joints, often affecting one or both sides of the body, making it difficult for the elderly to perform routine tasks. This study aims to determine the relationship between the level of independence and the incidence of rheumatoid arthritis among the elderly in the working area of Tinangkung Utara Public Health Center, Banggai Kepulauan Regency. This research employed a quantitative approach using the Chi-Square test. The study involved 50 respondents selected through a non-probability purposive sampling technique. The results of the Chi-Square analysis showed a p-value of 0.002 with a significance level of < 0.05, indicating that the research hypothesis was accepted. This finding means there is a significant relationship between the level of independence and the occurrence of rheumatoid arthritis among the elderly in the study area. In conclusion, the level of independence influences the occurrence of rheumatoid arthritis in older adults. Therefore, it is highly recommended that the elderly maintain active and independent movements as a way to keep their joints healthy and functional..

Ariyana Damayanti; Yurista Nirmalasari

Garina 2025 Akademi Kesejahteraan Sosial Ibu Kartini Semarang

Clothing is not only a primary clothing worn as body protection in everyday life, but has developed into clothing as a work of art. One of them is clothing designed for a big event with certain friends such as carnival or carnival clothing. Carnival costumes are designed to display creativity, joy, and cultural diversity. The design is often inspired by local cultural elements, such as mythology, flora, fauna, or traditional symbols. Carnival costumes are made of various materials, such as cloth, feathers, sequins, glitter, and others. This clothing is made to create a striking, beautiful, and eye-catching appearance. The author considers the historical background, mythology, architecture, and local culture related to temples in Indonesia, can produce carnival costumes that are not only visually appealing, but also rich in meaning and cultural values. The general objective of this study is to determine how the Development of Carnival Costumes with Prambanan Temple Architectural Inspiration. The method used is using the Research and Development (R&D) approach through the ADDIE development model. Each stage of ADDIE (Analysis, Design, Development, Implementation, and Evaluation) is used to systematically direct the costume creation process, from identifying needs to evaluating the final results. Determining factors such as measurements, errors, and weight of the clothing. Ergonomic design will allow carnival participants to move freely and comfortably.

Sarci Aurelia Tibultali; Yeftha Yerianto Sabaat; Diana S.A Natalia Tabun; Frans B.R Humau

Lembaga Pengembangan Kinerja Dosen 2025 Lembaga Pengembangan Kinerja Dosen

This study, entitled "Dynamics in Village Leadership (A Study of Village Apparatus Recruitment in Weseben Village, Malaka Regency)," aims to analyze the leadership style of village heads in the apparatus recruitment process, uncover the growing practices of patronage and clientelism, and examine their implications for the implementation of good governance principles at the village level. Theoretically, this research is based on village leadership theory, patronage-clientelism theory, and the concept of good governance, which emphasizes the values ​​of transparency, accountability, and public participation in village governance.The method used was a qualitative approach with a case study design. Data were collected through in-depth interviews with village heads, village officials, traditional leaders, members of the Village Consultative Body (BPD), and the community, and was supported by field observations and documentation studies. The results indicate that: (1) the leadership style of village heads in Weseben is dominant and personalistic, with the village head retaining full control over the apparatus recruitment process, (2) apparatus recruitment places greater emphasis on loyalty and personal closeness than on professional competence, (3) The practice of patronage and clientelism is strongly evident in the relationship between the village head as patron and village officials as clients, which is built through kinship ties and reciprocal interests, (4) decisions regarding the appointment of officials are often tinged with elements of nepotism and collusion to strengthen the village head's political support base, and (5) the recruitment system is not yet oriented towards the principle of a merit system, namely a selection system based on individual ability, achievement, and integrity, as implemented in professional governance.Thus, it can be concluded that the dynamics of village leadership in Weseben are still strongly influenced by the practice of patronage and clientelism, which hinders the realization of democratic, transparent, and accountable village governance.  

Rifky Verdiansyah; Guruh Taufan Hariyadi

Proceeding of the International Conference on Management, Entrepreneurship, and Business 2025 Asosiasi Riset Ilmu Manajemen Kewirausahaan dan Bisnis Indonesia

This study examines the influence of digital marketing strategies, including Content Marketing, Influencer Marketing, and Community Marketing, on Brand Awareness within the e-sports industry. Alongside the rapid growth of the e-sports sector both globally and in Indonesia, effective digital marketing has become essential for brands to enhance visibility and audience engagement. Employing a quantitative research design, data were collected through an online questionnaire distributed to 200 respondents and analyzed using SmartPLS version 4.1.1.2. The analysis results show that the research model achieved an Adjusted R-Square value of 0.752, indicating that the independent variables were able to explain 75.2% of the variance in Brand Awareness. The findings further reveal that Content Marketing, Influencer Marketing, and Community Marketing all have a significant positive effect on Brand Awareness, underscoring their critical role in shaping consumer perception and engagement. These results highlight the importance of integrated digital marketing strategies in building strong brand recognition, fostering community interaction, and enhancing consumer loyalty in the highly competitive e-sports landscape. By leveraging these strategies, companies can not only strengthen their market position but also create deeper relationships with e-sports fans. This study contributes to the growing body of literature on digital marketing within the creative economy and offers practical insights for marketers seeking to develop targeted and effective promotional strategies in the dynamic e-sports environment.

Ferlita Ferlita; Fauziah Fauziah; Mansuriza Mansuriza

Jurnal Ilmu Kesehatan 2025 Lembaga Pengembangan Kinerja Dosen

Research at Diponegoro University found that 66.7% of 63 respondents experienced neck pain due to using a laptop for more than 4 hours. Prolonged laptop use can negatively impact health from an ergonomic perspective, as the recommended maximum usage is 2 hours per day. However, students often maintain non-ergonomic positions for extended periods. This study aimed to determine the relationship between laptop use and neck pain among Diploma Three Nursing Students at Abulyatama University, Aceh. The research utilized an analytical, cross-sectional design, with a population of 556 students and a sample of 85 students, selected through purposive random sampling. The research was conducted at Abulyatama University from May 15 to June 2, 2025, and data was collected using a questionnaire with a Numeric Rating Scale. Analysis involved both univariate and bivariate methods using the Chi-Square test. The results showed that among 85 respondents, 44 (95.7%) experienced moderate pain, 8 (40.0%) had mild pain, and 8 (42.1%) reported severe pain. Statistical analysis indicated a significant correlation (p=0.000) between laptop use and neck pain. In conclusion, there is a strong relationship between laptop use and complaints of neck pain among university students. The research is expected to raise student awareness about the health risks associated with prolonged and improper laptop use, encourage better posture, and serve as a reference about limiting laptop use and improving ergonomics.

Gaeldrieno Gaeldrieno; Anom Zatmiko

Damai : Jurnal Pendidikan Agama Kristen dan Filsafat 2025 Asosiasi Riset Ilmu Pendidikan Agama dan Filsafat Indonesia

The doctrine of the Church, or ecclesiology, is an essential part of Christian theology that focuses on the understanding, function, and role of the Church as the body of Christ. The Church is not only understood as a physical institution but also as a community of faith that serves to glorify God, minister to others, and proclaim the Gospel. This study explains the importance of church doctrine as the foundation for forming congregational identity, spiritual growth, and as a guide in worship and ministry practices. Furthermore, this paper describes the positive impact of church doctrine on the spiritual development and social life of the congregation, as well as the challenges faced in the context of social, cultural, and technological change. The Church is expected to respond to these challenges through doctrinal education, community strengthening, and a contextual approach so that its teachings remain relevant and can be practically applied in the lives of believers.

R. Teguh Ady P; Dwi Retnaningsih

Jurnal Ilmu Kesehatan 2025 Lembaga Pengembangan Kinerja Dosen

Low Birth Weight (LBW) infants are among the leading causes of neonatal morbidity and mortality in Indonesia. This condition results from the immaturity of organ systems, including thermoregulation, making infants vulnerable to hypothermia. One non-pharmacological intervention to maintain body temperature stability is the nesting technique, which positions the baby in a flexed posture similar to the intrauterine condition using soft rolled cloths as a “nest.” This case study aimed to determine the effect of nesting on body temperature changes in LBW infants in the perinatology room of RSUD Batang. The study used a descriptive case study with a nursing process approach involving five LBW infants (<2500 g, spontaneous breathing). The intervention involved applying nesting for 30 minutes daily over three consecutive days. Body temperature was measured before and after the intervention using a digital thermometer. The results showed an increase in body temperature in all subjects. The average temperature before intervention was 35.9°C and increased to 36.6°C after three days of nesting therapy. This indicates that nesting effectively helps maintain body temperature stability in LBW infants by providing comfort, reducing stress, and conserving body energy. In conclusion, nesting is an effective evidence-based nursing intervention for improving body temperature in LBW infants and is recommended for perinatology care settings.

Mardhatillah Syahrani Fauziah

Jurnal Publikasi Ilmu Psikologi. 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

Polycystic Ovary Syndrome (PCOS) is a chronic condition that not only impacts reproductive and metabolic functions, but also has a major impact on the mental health of women who experience it. This study aims to explore the factors that affect mental health in women with PCOS through a biopsychosocial approach. The method used was a review of the narrative literature on 11 scientific articles obtained through Google Scholar. The results of the study show that there are three main dimensions that are interrelated, namely biological factors (insulin resistance, obesity, hyperandrogenism, menstrual disorders, and infertility), psychological factors (neuroticism, coping style, and body image), and social factors (social stigma and social support). These three dimensions interact in a complex way and can contribute to the appearance of psychological disorders such as depression, anxiety, and low self-esteem. Therefore, a biopsychosocial approach is important to understand and treat the mental health of people with PCOS holistically. Interventions that are integrated between medical, psychological, and social aspects are needed to improve the emotional well-being and quality of life of women with PCOS in a sustainable manner.

Jonathan Octavianus; Hasanema Wau; Donalia Reynaldo

Anugerah : Jurnal Pendidikan Kristiani dan Kateketik Katolik 2025 Asosiasi Riset Ilmu Pendidikan Agama dan Filsafat Indonesia

The phenomena of stigmata and divine apparitions represent profound religious experiences that demonstrate the dynamic relationship between faith, body, and consciousness. Through a phenomenological-theological approach and literature review, this study examines how these extraordinary events reflect the spiritual and psychological dimensions of faith. The results demonstrate that stigmata and apparitions are not simply supernatural phenomena, but existential encounters that express human participation in the suffering and presence of Christ. Phenomenological reflection affirms that faith is lived through bodily awareness, not merely understood conceptually. This study emphasizes the importance of discernment and theological interpretation of the church so that extreme religious experiences deepen authentic spirituality, rather than giving rise to superstition. Understanding stigmata and apparitions as transcendental experiences that transcend worldly limitations requires an openness to assess these phenomena in light of the doctrines of Christian faith. Furthermore, this study explores how these experiences contribute to the development of personal and church community spirituality and open up space for deeper reflection on the human relationship with God. Ultimately, this study bridges phenomenology and theology, demonstrating that divine experiences enrich the Christian understanding of the incarnation, suffering, and grace of God present in human existence.

Catherine Mosiara Kenyatta; Rizky Parlika

International Journal of Economics and Management Sciences 2025 Asosiasi Riset Ekonomi dan Akuntansi Indonesia

Indubitably, digital accounting platforms have proven to be a key element in financial management, especially in the contemporary era. They not only promise but guarantee improved accuracy, analytical depth, and reduced delays. In Kenya, the popularity of cloud-based accounting, AI-powered analytics, and enterprise-resource modules is quickly growing, although adoption still remains uneven across organization sizes, regions, and sectors. This journal’s primary objective was to explore the numerous challenges Kenyan accountants encounter when implementing digital accounting platforms and the strategies they utilize to address and overcome these challenges. Regarding methodology, the paper reviews the existing body of literature, including expert reviews, policy documents, and professional reports, to evaluate six critical barriers: infrastructural limitations, change resistance, financial constraints, human capital shortages, ambiguities in ethical and regulatory areas and the challenges that impact technical integration. It also includes a discussion of the most practical plans of action that practitioners in the field of accounting can employ to adapt to the current and ever-evolving landscape. This thorough analysis concludes that the sustainable digitalization of the accounting sector in Kenya highly depends on a concerted effort from educational institutions, industry stakeholders, government agencies, and professional bodies. It provides pragmatic recommendations for policymakers and provides suggestions for areas of further research, with a deep emphasis on phased implementation, capacity building, across-the-board empirical research, boosted investment in critical and resilient infrastructure, and functional governance frameworks.

Muhamad Afrizal; Arfa’i Arfa’i

Jurnal Hukum, Administrasi Publik dan Negara 2025 Asosiasi Peneliti Dan Pengajar Ilmu Sosial Indonesia

This study examines the role of the Village Consultative Body (BPD) in the formation of Mendalo Indah Village Regulation Number 02 of 2018 regarding Waste Collection, referring to Minister of Home Affairs Regulation Number 111 of 2014. Using an empirical juridical approach with a qualitative research method, the study was conducted in Mendalo Indah Village, Muaro Jambi Regency, Jambi Province. Data were collected through participatory observation, in-depth interviews with key stakeholders (including the Village Head, BPD Chair, and community leaders), and documentation. The findings indicate that while the BPD's role in forming village regulations is generally less than optimal, it has a more active role during the discussion and finalization of the draft regulations. However, the initial drafting and proposing stages are often initiated by the Village Head, with limited proactive involvement from the BPD. Key challenges identified include inadequate BPD human resources, limited understanding of their duties, and poor communication and coordination between the BPD, the Village Government, and other stakeholders. The study concludes that improving the BPD’s capacity, knowledge, and collaboration is essential for more effective participation in village regulation formation.

Ismanto, Arif; Kinasih, Dewi Sekar; Haris, Muh. Ichsan; Indana, Khoiru; Anindyasari, Dinar

JAPSI (Journal of Agriprecision and Social Impact) 2025 CV. Komunitas Dunia Peternakan

The addition of butterfly pea (Clitoria ternatea) extract which contains antioxidants into pasteurized milk is expected to increase the intake of antioxidants in the body. This research was conducted to evaluate the effect on pH, color, organoleptic chracteristic, and antioxidant activity of pasteurized milk. This study used a completely randomized design (CRD) with 5 treatments and 4 replications. The results of this study showed that increasing concentration of extract decreased pH, brightness, redness and yellowness. P3 was the most preferred treatment according to sensory evaluation. The antioxidant activity increased proportionally with extract concentration, reflected in decreasing IC50 values from 116.54 ppm (P0) to 19.06 ppm (P4). These findings indicate that the enrichment of pasteurized milk with butterfly pea extract effectively enhances its antioxidant capability while maintaining favorable sensory properties, particularly at moderate extract concentrations.

Amalina Nabila

Jurnal Riset Rumpun Ilmu Sosial, Politik dan Humaniora 2025 Pusat Riset dan Inovasi Nasional

Symbolic interactionism is an approach that examines how symbols and meanings are created through interactions between individuals within a learning context. This approach explores how individuals use symbols to communicate, interact, and understand the world around them. In the context of the learning process, symbolic interactionist analysis can provide a deep understanding of how learning occurs through interactions between teachers and students, as well as among students themselves. Through this analysis, we can observe how symbols such as language, gestures, and expressions are used to communicate ideas and concepts being taught in the classroom. Additionally, symbolic interactionist analysis can also help us understand how individuals construct their identities within the learning environment. In the modern era of education, the interaction between teachers and students has become one of the crucial aspects of the learning process. Through social interaction and the use of symbols, individuals can shape their perceptions of themselves and how they are viewed by others. This can affect their motivation and engagement in learning. Thus, symbolic interactionist analysis offers valuable insights into understanding the learning process and how interactions between individuals play a key role in the construction of meaning and understanding. Through this understanding, we can improve the quality of learning and provide more meaningful learning experiences for students. Communication does not only occur through words but also through nonverbal communication, including facial expressions, body movements, and other gestures. Therefore, this study aims to analyze how symbolic interactionism plays a role in learning and how nonverbal communication influences the dynamics of classroom interaction.

Cut Fitri Maqfirah; Fauziah Fauziah; Pasyamei Rembune Kala

Jurnal Ilmu Kesehatan 2025 Lembaga Pengembangan Kinerja Dosen

The teenage period is a crucial phase in developing self-esteem and body image, which play a significant role in shaping adolescent character. Adolescent girls often face social pressures related to physical appearance, which impacts on self-perception. This study aims to determine the correlation between body image and students’ self-esteem.  The study was conducted at MTsS Lam Ujong, Krueng Barona Jaya District, Aceh Besar on May 05th, 2025. This study used a quantitative approach with an analytical descriptive design. The sample consisted of 53 students selected by using a total sampling technique. The instruments used were the Multidimensional Body Self Relations Questionnaire (MBRSQ) with Cronbach Alpha 0.774 and the Rosenberg Self-Esteem Scale (RSES) with Cronbach Alpha 0,877. The univariate and bivariate data analysis using the Pearson Chi-Square test. The results showed that most respondents with negative body image had low self-esteem (94.1%), while respondents with positive body image showed variations in self-esteem. The Chi-Square test indicated a p-value of 0.001 (p < 0.05), indicating a significant correlation between body image and self-esteem. These findings indicate a significant correlation between body image and students’ self-esteem. This study suggests that schools and counselling teachers provide psychosocial education and mentoring to help students build a positive body image.

Sabrina Azzahro Putri; Qomariah Qomariah; Widya Mariyana

Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

Body shaming represents a global issue shaped by social constructions and media portrayals of the human body. Individuals who experience body shaming often feel humiliated and intimidated, leading to low self-image and diminished gratitude for their bodies. This study aimed to examine the effect of body shaming education on adolescents’ knowledge levels at SMP Futuhiyah Mranggen. The research employed a quasi-experimental design with a one-group pretest–posttest approach. The population included all 41 male and female seventh-grade students, selected through total sampling. Researchers used a validated knowledge questionnaire delivered through a PowerPoint presentation as the data collection instrument. Data analysis applied the Wilcoxon test. The conclusion of this study is that there is an influence of body shaming education on the level of knowledge of adolescents at SMP Futuhiyah Mranggen with a p-value of 0.000 because it is less than 0.05. The suggestion that will be put forward is that it is hoped that all adolescents can increase their understanding of body shaming, to find out the level of knowledge about body shaming in adolescents who are given intervention, and awareness of the impact of body shaming and handling of body shaming in adolescents at SMP Futuhiyah Mranggen, adolescents who are given education related to body shaming and surrounding adolescents.

I Kadek Restu Saputra

JURNAL RISET RUMPUN ILMU HEWANI 2025 Pusat riset dan Inovasi Nasional

Canine dwarfism is a growth disorder resulting from physiological dysfunction within the endocrine system, primarily due to growth hormone (GH) deficiency commonly caused by abnormal pituitary development. GH and Insulin-like Growth Factor 1 (IGF-1) play essential roles in regulating the growth of bones, muscles, skin, and internal organs through the hypothalamic–pituitary–liver axis. Under normal conditions, the hypothalamus controls GH secretion, which subsequently stimulates the liver to produce IGF-1 as the main mediator of growth. Genetic abnormalities such as LHX3 mutations can impair somatotroph cell differentiation and reduce GH production, ultimately leading to decreased IGF-1 levels. The deficiency of these hormones disrupts chondrocyte proliferation in the epiphyseal plates, decreases muscle protein synthesis, and negatively affects the development of tissues such as skin, hair, and reproductive organs. This study was conducted using a literature review method by searching scientific databases and selecting relevant publications addressing the physiological, clinical, and pathophysiological aspects of canine dwarfism. Literature analysis indicates that GH deficiency leads to clinical manifestations such as stunted body size, thin and easily shedding hair, dry and infection-prone skin, reduced muscle mass, metabolic disturbances, and delayed reproductive maturation. Diagnosis is established through clinical evaluation, IGF-1 measurement as an indicator of GH activity, and radiographic assessment of epiphyseal plate development. Overall, a comprehensive understanding of the relationship between physiological abnormalities and clinical signs is crucial for early detection and appropriate management of dwarfism, providing a strong scientific foundation for understanding the hormonal mechanisms disrupted in this condition.

Maslichah Mafruchati

JURNAL RISET RUMPUN ILMU HEWANI 2025 Pusat riset dan Inovasi Nasional

Hawthorn extract has been used for ameliorating cardiac disorders and pulmonary hypertension. The main chemical constituents of hawthorn flavonoid extract (HFE) include flavonoids (1-2%), oligomeric proanthocyanidins (1-3%), and other bioactive components (e.g., triterpene acids, organic acids, sterols, and cardioactive amines). These compounds are reported to have many pharmacological effects, including neuroprotective, hepatoprotective, cardioprotective, and nephroprotective effects. This study was aimed the analysis Crataegus oxyacantha based on a bioinformatic study and toxicity test on the chicken embryo. This method consisted of analysis of the three-dimensional structure of Crataegus oxyacantha Protein, Epitope and Allergen Proteins, Crataegus oxyacantha Proteins that were antigens and toxins and toxicity test on the chicken embryo. The results of research conducted on 3 three-dimensional structures of Crataegus oxyacantha protein, GQME value and QmeanDisCo value. In addition, this study also obtained the results of proteins that are epitope, antigenic, non-allergenic and non-toxic and toxicity test on the chicken embryo was 250 ng/egg..Morphological description of the embryo on the 21st day after injection, at a concentration of 250 ng of Crataegus oxyacantha /egg product, an abnormal embryological picture was obtained. Chicken Embryo Weight and Body Length Measurements were carried out in chicken embryos. Need research for other species of plant.