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Takokak fruit is one of the plants that can be used to lower blood sugar levels. This study aims to identify the bioactive compounds of ethanol extract of takokak fruit and test the antidiabetic ethyl acetate fraction. Antidiabetic testing was carried out by in vivo testing using the Oral Glucose Tolerance Test (OGTT) method to see the decrease in blood glucose levels using white rats as test animals. The test results showed that takokak fruit contains flavonoids, steroids, and tannins. Fractionation is the process of extracting compounds from the extract using two types of solvents that do not mix with each other. The results of the antidiabetic test showed that the ethyl acetate fraction with glibenclamide as a comparator had the ability as an antidiabetic measured by the amount of difference in the decrease in blood glucose levels in the test animal group T₃₀ to T₁₂₀. From the results obtained, the average decrease in blood glucose levels in the negative control group (Na CMC) was 5.8 mg/dL, the positive control group (Glibenclamide) 21.03 mg/dL, and the fraction group 9.86 mg/dL. Takokak fruit has antidiabetic activity. Compounds that have antidiabetic activity are flavonoids, tannins, and steroids.

Background of the study: The Excessive of uric acid levels can cause the sedimentation process of uric acid crystals it can cause the gout. The antioxidant in soursop leaves is effective to slowdown and also prevent the gout. The purpose of this study is to find out the effect of soursop leaf decoction on reducing uric acid levels in the work area at UPTD Adow Health Centre. The research method use the Quasy Experiment, with a one group pre-post test method . The samples in this study taken 15 respondents by the total sampling techniques. The research instruments use an uric acid level checking and observation sheets. Then the data collected processed by Friedman's Statistical Test. Findings , the friedman statistical test results obtained a p value = 0.001 with a significance of < 0.05. The conclusion is giving soursop leaf decoction is effective on reducing uric acid levels in the working area at UPTD Adow Health Centre. It is hoped the decoction of soursop leaf can be useful as alternative medicine to lower  the uric acid levels.  

People with gout arthritis complain of pain in the joints, toes, hands, knees and have never used lemongrass water to reduce joint pain and choose analgesic drugs as pain relief. Lemongrass plant contains essential oil that has chemical properties and pharmacological effects, namely a spicy and warm taste as an anti- inflammatory and relieving analgesic pain.. The purpose of this research was to find out the effect of lemongrass (cymbopogon citratus) on the reduction of gout arthritis pain in The Community In The 1st Winenet Village, Bitung. This research used a pre experimental method with one group pretest-posttest design. The population were residents who suffered from gout arthritis and who experienced joint pain. Sampling using a purposive sampling technique with the number of samples were 12 respondents using the Lamesho formula. The instruments used in this research were observation sheets and pain intensity scale measurement sheets using the Numeric Rating Scale (NRS). The collected data was processed by running the computer program be analyzed by a Wilcoxon Signed Rank test with the significance level α = 0,05.The results of this research indicated that there are differences in pain intensity before and after giving lemongrass, with a ρ value (0,001) < (0,05), meaning that there is an effect of giving lemongrass on reducing gout arthritis pain.The conclusion of this research is that lemongrass can be used as a non- pharmacological therapy to reduce pain in gout arthritis. It is expected that the result of this research will be useful in reducing pain in patients with gout arthritis and can be used as an additional reference for further research.    

  Masyarakat di Kel. Kampung Jawa, Kec. Tondano Utara, Kab. Minahasa, Sulawesi Utara cukup banyak, namun berbagai sarana kesehatan yang minim membuat masyarakat kurang memperhatikan cara menggunakan, menyimpan, serta membuang obat yang baik dan benar. Masalah ini muncul dikarenakan pengetahuan masyarakat tentang obat masih sangat minim. Selama ini pemberdayaan masyarakat belum dioptimalkan sehingga penanganan terhadap masalah kesehatan dan pengobatan belum mendapat perhatian khusus. Tujuan kegiatan ini untuk meningkatkan pengetahuan dan keterampilan masyarakat dalam menggunakan, menyimpan, serta membuang obat yang baik dan benar. Metode pelaksanaan kegiatan dengan melakukan pelatihan Dagusibu dengan metode Cara Belajar Insan Aktif (CBIA) kepada Masyarakat Kel. Kampung Jawa, Kec. Tondano Utara, Kab. Minahasa, Sulawesi Utara. Materi terkait penyimpanan obat menekankan terhadap perlunya memperhatikan aturan pakai dan cara penyimpanan obat yang tertera pada etiket.Hasil yang diperoleh dari kegiatan ini, masyarakat Kel. Kampung Jawa, Kec. Tondano Utara, Kab. Minahasa, Sulawesi Utara memahami tentang cara mendapatkan obat, menggunakan obat, menyimpan obat dan membuang obat, mengetahui perbedaan klasifikasi obat (obat bebas, bebas terbatas, obat keras) dan bagaimana cara serta dimana tempat legal yang memiliki izin untuk menjual obat-obat tersebut, dan mengetahui cara menggunakan antibiotik dengan cerdas

Hypertension is an abnormal increase in blood pressure in the arteries continuously over a period of time. A person is said to be hypertensive if the systolic blood pressure is equal to or above 140 mmHg and/or the diastolic blood pressure is equal to or above 90 mmHg. The high prevalence of hypertension is one of the problems that affect public health status. The purpose of this study was to determine the effect of giving celery leaf decoction on blood pressure in hypertension patients in Mahawu, Manado This research design is a pre-experimental research design (one-group pre-post test design). The population in this study amounted to 53 patients with the sample used was 17 respondents. The sampling technique used is Accidental Sampling. Data collection using blood pressure observation sheet. The results of the study found that giving boiled celery leaves before giving boiled celery leaves were 12 respondents (70.6%). And after giving boiled celery leaves, 13 respondents (76.5%). The result of p value 0.000 (<0.05) so Ha is accepted. There is an effect of giving boiled celery leaves on blood pressure in hypertensive patients in Mahawu, Manado. The conclusion in this study is that there is an effect of giving celery leaf decoction on blood pressure in hypertension patients in Mahawu, Manado. Suggestions to respondents who often experience hypertension can do their own treatment when high blood pressure by boiling celery leaves.

Peraturan Menteri Kesehatan Tahun 2016 tentang Standar Pelayanan Kefarmasian di Puskesmas, menetapkan bahwa semua tenaga kefarmasian dalam melaksanakan tugas profesinya di puskesmas agar mengacu pada standar tersebut. Standar Pelayanan Kefarmasian ini dimaksudkan untuk meningkatkan mutu pelayanan kefarmasian, menjamin kepastian hukum bagi tenaga kefarmasian, dan melindungi pasien dan masyarakat dari penggunaan obat yang tidak rasional dalam rangka keselamatan pasien. Penelitian ini dilakukan untuk menganalisis standar pelayanan kefarmasian di puskesmas wawonasa kota manado yang mengacu pada Standar Pelayanan Kefarmasian di puskesmas menurut peraturan menteri kesehatan No 74 Tahun 2016. Jenis penelitian ini adalah penelitian deskriptif. Data dikumpulkan dengan melakukan wawancara kepada apoteker penanggung jawab apotek di puskesmas wawonasa dan dilakukan analisis menggunakan metode Conteks, Input, Proses, dan Produk (CIPP). Dalam penelitian ini Standar I adalah pengelolaan perbekalan farmasi, alat kesehatan, dan bahan medis habis pakai, dan standar II adalah pelayanan farmasi klinis. Berdasarkan hasil penelitian ini diketahui bahwa standar I dan II, masing-masing memiliki ketentuan yang belum terlaksana, untuk standar I ketentuan yang terlaksana sebesar 80% dan untuk standar II ketentuan yang terlaksana sebesar 72,72%, sehingga dapat dikategorikan bahwa pelaksanaan ketentuan untuk Standar I dan II oleh Puskesmas Wawonasa Kota Manado termasuk kategori sedang.  

Fever can be interpreted as a body temperature that is higher (>37°C) than normal temperature because of the temperature control center in the hypothalamus, the temperature control center balances temperature during health or fever by regulating the formation and release of heat. For this reason, the purpose of this study was to determine the antipyretic effectiveness of various concentrations of extracts. In this study, 5% peptone was used to induce fever in 15 white rats which were divided into 5 treatment groups. Groups 1 was given 1% NaCMC as a negative control, groups 2 was given paracetamol 9 mg/200gBB) as a positive control, groups 3 was given 10% lire leaf extract (2 mg/200gBB), groups 4 was given 20% lire leaf extract (4 mg/200gBB), and groups 5 was given 40% lire leaf extract (8 mg/200gBB). This results of this study obtained extract levels of 7,44% and there was a weak antipyretic effect at concentrations of 10% and 20% lire leaf extract, while the greatest antipyretic effect was found in 40% lire leaf extract, almost comparable to 9 mg paracetamol.

Pain is a defense mechanism of the body and caused by tissue damage to the body due to injury, accident or medical action. Traditionally, cashew leaves were used in curing inflammation, pain, toothache, wound healing, rheumatism as well as dysentery. This study aims to determine the effectiveness of analgetic power of cashew leaf ethanol extract (Anacardium occidentale L.) in white rats (Rattus norvegicus). The research conducted is experimental research, with chemical excitatory methods. The test animals were divided into 5 groups with each treatment of 3 mice. Group I Na CMC 1%, group II Paracetamol, group III cashew leaf ethanol extract 10%, group IV cashew leaf ethanol extract 20%, and group V cashew leaf ethanol extract 40% given orally. Pain inductors are 1% induced acetic acid intraperitonially. Observed the amount of mice geliat for 1 hour and calculated percent analgetic power. The results obtained in this study have properties as analgetics with analgetic power concentration of 10%: 82.73%, concentration of 20%: 84.89%, and concentration of 40%: 88.48%.