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Takokak fruit contains bioactive compounds that can be used as antidiabetics. This study aims to identify bioactive compounds of ethanol extract of takokak fruit and antidiabetic test of n-Hexane fraction. The method used to obtain the extract is maceration using ethanol . Antidiabetic testing is carried out through in vivo testing with the Oral Glucose Tolerance Test (OGTT) method on white rats. Secondary metabolites are compounds contained in taakokak fruit that are identified as flavonoids, saponins, tannins, steroids and terpenoids . The results of the antidiabetic test showed that the n-Hexane fraction with glibencamide as a comparator has the ability as an antidiabetic in terms of the amount of difference in blood glucose levels in the test animal group from T 30 to T 120 . The average decrease in blood glucose levels in the negative control group (Na-CMC) was 108.67 mg/dL, the positive control group ( glibencamide ) 174.67 mg/dL, the 5% concentration fraction group 35.33 mg/dL, the 10% concentration fraction group 30.67 mg/dL, the 20% concentration fraction group 47.67 mg/dL.

Desa Bulutui adalah desa yang teletak di Kecamatan Likupang Barat Kabupaten Minahasa Utara yang sebagian besar masyarakatnya memiliki profesi nelayan. Berdasarkan hasil pendataan yang didapat dari pembagian kuisioner PIS-PK kepada 52 keluarga atau 25% dari total keluarga yang ada di desa Bulutui, salah satu masalah kesehatan dengan pesentasi tertinggi yang dialami oleh masyarakat di desa Bulutui adalah hipertensi atau tekanan darah tinggi yang  mencapai 84 %. Tujuan dilakukannya kegiatan pengabdian ini untuk meningkatkan pengetahuan dan keterampilan masyarakat desa Bulutui dalam mengolah dan memanfaatkan   tanaman yang memiliki potensi untuk penyakit khususnya teknik pembuatan jamu saintifik hipertensi. Metode yang digunakan meliputi pemaparan materi, tanya jawab, dan praktik langsung kepada masyarakat. Kegiatan pelatihan terlaksana dengan baik dan mendapatkan respon yang antusias dari pererintah dan khususnya dari masyarkat serta berharap pelatihan seperti ini dapat dilakukan kembali dikemudian hari.

Ternate Tanjung adalah Kelurahan yang teletak di Kecamatan Singkil Kota     Manado. Bagian utara berbatasan dengan Kelurahan Kombos Barat dan Timur, bagian barat berbatasan dengan kelurahan Ternate Baru dan Dendengan Luar Lingkungan III, bagian timur berbatasan dengan Keluarahan Pall Dua Lingkungan III dan bagian selatan berbatasan dengan Pall Dua Lingkungan II dan Kelurahan Dendengan Luar Lingkungan I. Berdasarkan hasil pendataan yang didapat dari  pembagian kuisioner kepada 125 keluarga atau 25% dari total keluarga yang ada di kelurahan Ternate Tanjung. Salah satu masalah kesehatan dalam kurun waktu satu tahun terakhir dengan pesentasi tertinggi yang dialami oleh adalah hipertensi atau tekanan darah tinggi yang  mencapai 8,1 % dimana dari pendataan masalah kesehatan ini merupakan penyakit riwayat keturunan.   Tujuan dilakukannya kegiatan pengabdian ini untuk meningkatkan pengetahuan dan keterampilan masyarakat Kelurahan Ternate Tanjung dalam mengolah dan memanfaatkan   tanaman yang memiliki potensi untuk penyakit khususnya teknik pembuatan jamu saintifik hipertensi. Metode yang digunakan meliputi pemaparan materi, tanya jawab, dan praktik langsung kepada masyarakat. Kegiatan pelatihan terlaksana dengan baik dan mendapatkan respon yang antusias dari pererintah dan khususnya dari masyarkat serta berharap pelatihan seperti ini dapat dilakukan kembali dikemudian hari.

Turi (Sesbania grandiflora L) is native to Southeast Asia. This plant is used as a medicinal plant and also a vegetable. Turi (Sesbania grandiflora L) is a plant that is efficacious for the treatment of various diseases such as analgesic, antipyretic, diuretic and laxative. The purpose of this study was to identify the content of secondary metabolites in turi leaf extract extracted with ethanol, ethyl acetate and n-hexane as solvents. This research was conducted in two stages, namely extraction by maceration method using ethanol, ethyl acetate and n-hexane as solvents. And the identification stage of secondary metabolites consisting of identification of alkaloids, steroids, terpenoids, saponins and flavonoids. The results showed that the positive ethanol and ethyl acetate extracts contained flavonoids, saponins, terpenoids and steroids, while the negative n-hexane extract contained secondary metabolites.

Rosella (Hibiscus sabdariffal L.) contains anthocyanins which can be used as natural dyes and at the same time as an antioxidant that functions as an antidote to free radicals. The aim of this research was to formulate and test the physical characteristics of the blush on cream preparation from the essence of Rosella (Hibiscus sabdariffa L.) as a natural dye. This type of research is an experiment in the laboratory. The extract of Rosella calis flower is crushed and the filtrate is taken by extracting it. The extract is made into blush on cream preparations with a concentration of 20%, 40% and 60%. The organoleptic test results of blush on cream on the control were soft textured, white, smelled like cream, soft-textured F1, ivory white, Rosella flower-like smell, soft-textured F2, light cream colored, Roselle flower-like smell, and F3 small granular texture pink color, distinctive smell of Rosella flower, homogeneity test on homogeneous control, homogeneous F1, homogeneous F2, and not homogeneous F3, control pH test values: 6, F1: 6, F2: 6, F3: 4, control spreadability test: 6 , 3 cm, F1: 5.7 cm, F2: 5 cm, F3: 4.5 cm, control adhesion test: 4.42 seconds, F1: 4.21 seconds, F2: 4.19 seconds, F3: 4.12 seconds and emulsion type test on control: M / A, F1: M / A, F2 M / A, F3: M / A. The formulation and physical characteristics test of blush cream from the extract of Rosella flower petals (Hibiscus sabdariffa L.) cannot be formulated as a blush cream preparation and does not have good characteristics, one of which is the exposure to light and heating during the formulation.

Cork Fish (Channa striata) is used for traditional medicine and is one of the economically important fish in Indonesia so that it contains protein and albumin which are important for health. The purpose of this study was to determine the level of effectiveness of the snakehead fish extract ointment on the healing of burns in rabbits (Oryctolagus cuniculus). Then burns in rabbits were observed for up to 11 days. The data analysis used was using the Independent Sample t-test with the help of Microsoft Excel. Based on the results of the research formula one can be the t value count 4,666 and the table t value 2,085 and the second formula obtained is the t value count  of 2,185 and the table t value of 2,085 according totheresearch hypothesis is accept H1 then formula one dan formula two have an influence in the process of healing burns in rabbits (Oryctolagus cuniculus).

Bintaro (Cerbera manghas L.) is widely used as an analgesic, anticonvulsant, cardiotonic, and hypotensive activity. In Thailand bintaro is used as traditional medicine such as bark used as an antipyretic, laxative and in the treatment of dysuria. The flower part is applied to treat hemorrhoids. Secondary metabolites are chemical compounds contained in plants that can be drawn by a suitable solvent through extraction methods. The purpose of this study was to determine the content of secondary metabolites contained in bintaro leaf extract using ethanol, acetone, and n-Hexan solvents based on phytochemical screening. This research was carried out through two stages, namely extraction using maceration method using ethanol, acetone, n-Hexan and phytochemical screening solvents consisting of screening alkaloids, terpenoids, flavonoids, steroids, saponins, and tannins. The results showed that the bintaro leaf ethanol extract positively contained flavonoids, saponins, and tannins. The acetone extract of bintaro leaves positively contains, saponins and tannins. N-hexan daun bintaro extract positively contained steroids and alkaloids in testing with Dragendorft reagents, and was positive for Wagner reagents and negative for testing with Mayer reagents