Formulation And Testing The Effectiveness Of Gel Extract Of Red Ginger (Zingiber officinale Var. Rubrum) As Antiinflamatory In White Male Rats (Rattus norvegicus).

Nurjannah Bachri ; Nielma Auliah ; Sri Wahyuningsih ; Husna Dewi
Proceeding International Conference Of Innovation... 📅 2024 Vol 3, No 1 🔗 DOI: 10.62951/icistech.v3i1.61
Abstract
Red Ginger is a type of rhizome that is widely used as an ingredient in traditional medicine in Indonesia. The efficacy of red ginger has been widely studied as an effective anti-inflammatory. One of the main components of red ginger is the gingerol class of compounds. This study aims to determine the anti-inflammatory effect that is applied to the red ginger extract gel (Zingiber officinale var. Ruburum) gel preparation with the HPMC gel-forming ingredient. The gel preparation was then tested for stability up to day 7 and evaluated for its anti-inflammatory power against white rats (Rattus norvegicus). The method used was the artificial inflammation ordering method, where the test was carried out by injection of carrageenan as a mediator for inflammation of the thighs of white rats, then topically giving Red Ginger extract gel with a concentration of 1%, 3% and 5%, HPMC as a negative control and diclofenac sodium as a Positive control. Measurements were carried out every 8 hours every day after being induced by carrageenan to use a caliper. The results showed that the reduction in inflammation to reduce the diameter of 1% after induction was 1.76 cm and decreased to 1.22 cm, the concentration of 3% after induction was 1.68 cm and decreased to 1.33 cm, the concentration of 5% after induction was 1 , 79 cm and decreased to 1.35 cm. Data were statistically analyzed using ANOVA showing that the negative HPMC controls did not show any anti-inflammatory effects. It can show that 1%, 3% and 5% Red Ginger ethanol extract gel has anti-inflammatory effects and the greatest effect is that the 5% concentration has an anti-inflammatory effect.
Keywords
Gel; Red Ginger; Anti-inflammatory; Carrageenan
How to Cite

Nurjannah Bachri, et al. (2024). Formulation And Testing The Effectiveness Of Gel Extract Of Red Ginger (Zingiber officinale Var. Rubrum) As Antiinflamatory In White Male Rats (Rattus norvegicus).. Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health, 3(1). https://doi.org/10.62951/icistech.v3i1.61

Nurjannah Bachri; Nielma Auliah; Sri Wahyuningsih; Husna Dewi, "Formulation And Testing The Effectiveness Of Gel Extract Of Red Ginger (Zingiber officinale Var. Rubrum) As Antiinflamatory In White Male Rats (Rattus norvegicus).," Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health, vol. 3, no. 1, 2024.

Nurjannah Bachri; Nielma Auliah; Sri Wahyuningsih; Husna Dewi. "Formulation And Testing The Effectiveness Of Gel Extract Of Red Ginger (Zingiber officinale Var. Rubrum) As Antiinflamatory In White Male Rats (Rattus norvegicus).." Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health, vol. 3, no. 1, 2024.

Nurjannah Bachri; Nielma Auliah; Sri Wahyuningsih; Husna Dewi. "Formulation And Testing The Effectiveness Of Gel Extract Of Red Ginger (Zingiber officinale Var. Rubrum) As Antiinflamatory In White Male Rats (Rattus norvegicus).." Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health 3, no. 1 (2024).

Nurjannah Bachri, et al. (2024) 'Formulation And Testing The Effectiveness Of Gel Extract Of Red Ginger (Zingiber officinale Var. Rubrum) As Antiinflamatory In White Male Rats (Rattus norvegicus).', Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health, 3(1). doi: 10.62951/icistech.v3i1.61.

Nurjannah Bachri; Nielma Auliah; Sri Wahyuningsih; Husna Dewi. Formulation And Testing The Effectiveness Of Gel Extract Of Red Ginger (Zingiber officinale Var. Rubrum) As Antiinflamatory In White Male Rats (Rattus norvegicus).. Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health. 2024;3(1).

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