Studi in Silico Seskuiterpen Hidrokarbon dari Resin Daemonorops Draco sebagai Kandidat Agen Antikanker

Nerdy N ; Nilsya F. Zebua ; Adelia Puspita R.N ; Titi K. Hulu ; Yulia Azzahra ; Azzahra T.M. Simatupang ; Nikasia G. Sitohang ; Chindy T. Manullang
Jurnal Kesehatan Amanah 📅 2026 Vol 10, No 1 🔗 DOI: 10.57214/jka.v10i1.1062
Abstract
Daemonorops draco is a rattan plant that produces resin traditionally used as medicine and is known to contain various bioactive compounds. Previous GC–MS analysis identified 42 active compounds in the resin of Daemonorops draco, including a group of sesquiterpene hydrocarbons suspected to contribute to its biological activities. This study aimed to evaluate the potential of six sesquiterpene hydrocarbons, namely α-cubebene, α-copaene, α-amorphene, δ-cadinene, aromadendrene, and viridiflorene, as anticancer candidates using an in silico approach. PASS Online prediction indicated that all compounds exhibit antineoplastic and apoptosis agonist activities with relatively high probability of activity (Pa) values and low probability of inactivity (Pi) values, particularly α-copaene, α-amorphene, and α-cubebene. Toxicity evaluation using ProTox 3.0 classified all compounds into Toxicity Class V with high LD₅₀ values, indicating low acute toxicity. ADMET analysis using pkCSM demonstrated favorable pharmacokinetic and safety profiles without major toxicity indications. Overall, sesquiterpene hydrocarbons from Daemonorops draco show potential as anticancer agents based on computational predictions.
Keywords
ADMET; Anticancer; Daemonorops Draco; In Silico; Sesquiterpene Hydrocarbons
How to Cite

Nerdy N, et al. (2026). Studi in Silico Seskuiterpen Hidrokarbon dari Resin Daemonorops Draco sebagai Kandidat Agen Antikanker. Jurnal Kesehatan Amanah, 10(1). https://doi.org/10.57214/jka.v10i1.1062

Nerdy N; Nilsya F. Zebua; Adelia Puspita R.N; Titi K. Hulu; Yulia Azzahra; Azzahra T.M. Simatupang; Nikasia G. Sitohang; Chindy T. Manullang, "Studi in Silico Seskuiterpen Hidrokarbon dari Resin Daemonorops Draco sebagai Kandidat Agen Antikanker," Jurnal Kesehatan Amanah, vol. 10, no. 1, 2026.

Nerdy N; Nilsya F. Zebua; Adelia Puspita R.N; Titi K. Hulu; Yulia Azzahra; Azzahra T.M. Simatupang; Nikasia G. Sitohang; Chindy T. Manullang. "Studi in Silico Seskuiterpen Hidrokarbon dari Resin Daemonorops Draco sebagai Kandidat Agen Antikanker." Jurnal Kesehatan Amanah, vol. 10, no. 1, 2026.

Nerdy N; Nilsya F. Zebua; Adelia Puspita R.N; Titi K. Hulu; Yulia Azzahra; Azzahra T.M. Simatupang; Nikasia G. Sitohang; Chindy T. Manullang. "Studi in Silico Seskuiterpen Hidrokarbon dari Resin Daemonorops Draco sebagai Kandidat Agen Antikanker." Jurnal Kesehatan Amanah 10, no. 1 (2026).

Nerdy N, et al. (2026) 'Studi in Silico Seskuiterpen Hidrokarbon dari Resin Daemonorops Draco sebagai Kandidat Agen Antikanker', Jurnal Kesehatan Amanah, 10(1). doi: 10.57214/jka.v10i1.1062.

Nerdy N; Nilsya F. Zebua; Adelia Puspita R.N; Titi K. Hulu; Yulia Azzahra; Azzahra T.M. Simatupang; Nikasia G. Sitohang; Chindy T. Manullang. Studi in Silico Seskuiterpen Hidrokarbon dari Resin Daemonorops Draco sebagai Kandidat Agen Antikanker. Jurnal Kesehatan Amanah. 2026;10(1).

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