Studi in Silico Senyawa Aktif Rimpang Jahe (Zingiberis Officinalis Rhizoma) sebagai Antikanker Payudara terhadap Progesterone Receptor

Shafa Shaomi Maharani ; Ratnadani Amalia Safitri ; Khalisa Wahidani Aufhanggi ; Amira Hasna Azis ; Sasha Nurhalisa
Jurnal Kesehatan Amanah 📅 2025 Vol 9, No 1 🔗 DOI: 10.57214/jka.v9i1.840
Abstract
Breast cancer is one of the highest causes of death worldwide. Breast cancer is a malignant tumor that attacks the breast tissue which consists of the mammary glands (milk-making glands), glandular ducts (milk ducts), and breast supporting tissues. This study aims to look at the interaction of ginger compounds against progesterone receptors as anticancer of the breast. This research method includes Lipinski prediction, admetox prediction, pharmacophore screening, and molecular docking. Lipinski's prediction results show that of the 15 compounds tested, only 13 compounds were obtained that fulfilled the Lipinski rule. Admethox prediction results showed that the compounds with the best HIA, CaCO2, PPB, and BBB values were Zingiberene, beta-carotene, and Zingiberenol. The pharmacophore screening results showed model 8 as the best model with an AUC value of 100%, namely 0.71. From the results of molecular docking, it was found that Zingiberenol compound is the best drug candidate with the lowest binding energy value and KI value, namely -8.38 kcal/mol and 4.36 uM with van der waals bonds that occur in the Phe778 amino acid residue.
Keywords
Anticancer; Ginger; Molecular Docking; Progesterone Receptor
How to Cite

Shafa Shaomi Maharani, et al. (2025). Studi in Silico Senyawa Aktif Rimpang Jahe (Zingiberis Officinalis Rhizoma) sebagai Antikanker Payudara terhadap Progesterone Receptor. Jurnal Kesehatan Amanah, 9(1). https://doi.org/10.57214/jka.v9i1.840

Shafa Shaomi Maharani; Ratnadani Amalia Safitri; Khalisa Wahidani Aufhanggi; Amira Hasna Azis; Sasha Nurhalisa, "Studi in Silico Senyawa Aktif Rimpang Jahe (Zingiberis Officinalis Rhizoma) sebagai Antikanker Payudara terhadap Progesterone Receptor," Jurnal Kesehatan Amanah, vol. 9, no. 1, 2025.

Shafa Shaomi Maharani; Ratnadani Amalia Safitri; Khalisa Wahidani Aufhanggi; Amira Hasna Azis; Sasha Nurhalisa. "Studi in Silico Senyawa Aktif Rimpang Jahe (Zingiberis Officinalis Rhizoma) sebagai Antikanker Payudara terhadap Progesterone Receptor." Jurnal Kesehatan Amanah, vol. 9, no. 1, 2025.

Shafa Shaomi Maharani; Ratnadani Amalia Safitri; Khalisa Wahidani Aufhanggi; Amira Hasna Azis; Sasha Nurhalisa. "Studi in Silico Senyawa Aktif Rimpang Jahe (Zingiberis Officinalis Rhizoma) sebagai Antikanker Payudara terhadap Progesterone Receptor." Jurnal Kesehatan Amanah 9, no. 1 (2025).

Shafa Shaomi Maharani, et al. (2025) 'Studi in Silico Senyawa Aktif Rimpang Jahe (Zingiberis Officinalis Rhizoma) sebagai Antikanker Payudara terhadap Progesterone Receptor', Jurnal Kesehatan Amanah, 9(1). doi: 10.57214/jka.v9i1.840.

Shafa Shaomi Maharani; Ratnadani Amalia Safitri; Khalisa Wahidani Aufhanggi; Amira Hasna Azis; Sasha Nurhalisa. Studi in Silico Senyawa Aktif Rimpang Jahe (Zingiberis Officinalis Rhizoma) sebagai Antikanker Payudara terhadap Progesterone Receptor. Jurnal Kesehatan Amanah. 2025;9(1).

Artikel Terkait

Review Artikel: Analisis Drug Related Problems (DRP) pada Pasien Diabetes Melitus

Karlina Dwi Febrianingsih; Aulya Nur’ain

Perbandingan Prevalensi dan Kematian Ileus Paralitik dengan Kanker Usus Besar di Indonesia: Analisis Data Global Burden of Disease (GBD) Tahun 2019, 2021, dan 2023

Irma Nurvita Zerlinda; Vita Widyasari; Titik Kuntari

Trends In Ischemic Heart Disease In Indonesia From 2019–2023: A Global Burden Of Disease-Based Study with Gender Analysis (Male And Female)

Rizka Triadiati Ikhsantiningtyas Pratisti; Utami Utami; Vita Widyasari

Analisis Sanitasi Lingkungan dan Status Gizi terhadap Kejadian Infeksi Saluran Pernapasan Akut (ISPA) pada Balita Pasca Bencana Banjir di Wilayah Kerja Puskesmas Panteraja Kabupaten Pidie Jaya

Zakia Ulrahmah; Hafni Zahara; Martina Martina

Intensi Kehamilan, Komplikasi Kehamilan dan Berat Badan Lahir Rendah di Indonesia: Eviden dari Survei Demografi dan Kesehatan Indonesia 2012

Maulia Afidah Cahyani

The Impact of GNI Per Capita on the Prevalence and Incidence of Anxiety and Depressive Disorders: A Global Analysis Using GBD 2023 Data

Dede Efendy; Utami Utami; Vita Widyasari; Yoga Saputra; Yuni Asnaini
Tren Sitasi Jurnal