Hubungan Kadar Alpha Fetoprotein (AFP) dengan Ukuran Tumor Hati Jenis Karsinoma Hepatoseluler di RSUD Abdul Wahab SJahranie Samarinda

Background: Hepatocellular carcinoma results from abnormal cell formation or malignant cell changes. Hepatocellular carcinoma can be diagnosed by measuring AFP levels in serum and performing examinations through radiology, FNAB, and histopathology. Pupose: The purpose of this study was to determine the relationship between AFP levels and liver tumor size of nodular-type hepatocellular carcinoma. Method: The sample of this study amounted to 55 samples of hepatocellular carcinoma patient data for the period 2020-2022 using a purposive sampling technique. This type of research is descriptive-analytic with a retrospective approach. Results: Data analysis was performed using the Chi-Square test. The results obtained data on the characteristics of the sex of hepatocellular carcinoma patients, namely men as many as 35 patients (63.6%) and women as many as 20 patients (36.4%), age characteristics at the most incidence of hepatocellular carcinoma occurred at the age of 50-59 years (30, 9%), with AFP levels in hepatocellular carcinoma patients with normal categories as many as 33 cases (60%) and increased categories as many as 22 cases (40%), and nodule sizes < 2 cm as many as 3 cases (5.5%), 2-5 cm as many as 9 cases (16.4%), and > 5 cm as many as 43 cases (78.2%). The data was then subjected to bivariate analysis, and the results of statistical calculation p value 0.017 (<0.05) which indicates a significant relationship between AFP levels and hepatocellular carcinoma nodule size. Conclusion: the higher the AFP level, the larger the nodule size.