Modification and In Vitro Biological Evaluation of Ceftriaxone-Imine Derivatives: Possible Anticancer and Antimicrobial

Reem Alaulddin Jameel ; Balsam Mohammed Ahmed ; Raghad Haddad
Jurnal Riset Ilmu Farmasi dan Kesehatan 📅 2025 Vol 3, No 3 🔗 DOI: 10.61132/obat.v3i3.1393
Abstract
This research investigates the modification of ceftriaxone to synthesized imine derivatives (A-C), assessing their chemical and biological efficacy. This study underscores the notable antibacterial effectiveness of synthesized derivatives against Staphylococcus aureus and Escherichia coli, exhibiting a determined dose correlation. The synthesis procedure reacts ceftriaxone with different aldehydes, such as 2-Hydroxy-4-Methoxybenzaldehyde and 4-ethoxy-2-hydroxy-benzaldehyde, and 5-Chloro-2-hydroxybenzaldehyde yielding imines analyzed by various methods, such as FT-IR and 1H-NMR. The results indicate that imines may have implications in medical therapies, especially in addressing multidrug-resistant bacteria and a human breast cancer cell line MCF-7. Imine derivative C exhibits significant antibacterial efficacy, measuring 33 mm at 0.1 ppm against Staphylococcus aureus, while 30 mm at 0.1 as anti-Escherichia coli more activity from other synthesized derivatives. The derivative C recorded a value of 29.2441 after 24 hours as an inhibition MCF-7 cell line.
Keywords
Antibacterial; Imine; Ceftriaxone; Medical treatment; MCF
How to Cite

Reem Alaulddin Jameel, et al. (2025). Modification and In Vitro Biological Evaluation of Ceftriaxone-Imine Derivatives: Possible Anticancer and Antimicrobial. Jurnal Riset Ilmu Farmasi dan Kesehatan, 3(3). https://doi.org/10.61132/obat.v3i3.1393

Reem Alaulddin Jameel; Balsam Mohammed Ahmed; Raghad Haddad, "Modification and In Vitro Biological Evaluation of Ceftriaxone-Imine Derivatives: Possible Anticancer and Antimicrobial," Jurnal Riset Ilmu Farmasi dan Kesehatan, vol. 3, no. 3, 2025.

Reem Alaulddin Jameel; Balsam Mohammed Ahmed; Raghad Haddad. "Modification and In Vitro Biological Evaluation of Ceftriaxone-Imine Derivatives: Possible Anticancer and Antimicrobial." Jurnal Riset Ilmu Farmasi dan Kesehatan, vol. 3, no. 3, 2025.

Reem Alaulddin Jameel; Balsam Mohammed Ahmed; Raghad Haddad. "Modification and In Vitro Biological Evaluation of Ceftriaxone-Imine Derivatives: Possible Anticancer and Antimicrobial." Jurnal Riset Ilmu Farmasi dan Kesehatan 3, no. 3 (2025).

Reem Alaulddin Jameel, et al. (2025) 'Modification and In Vitro Biological Evaluation of Ceftriaxone-Imine Derivatives: Possible Anticancer and Antimicrobial', Jurnal Riset Ilmu Farmasi dan Kesehatan, 3(3). doi: 10.61132/obat.v3i3.1393.

Reem Alaulddin Jameel; Balsam Mohammed Ahmed; Raghad Haddad. Modification and In Vitro Biological Evaluation of Ceftriaxone-Imine Derivatives: Possible Anticancer and Antimicrobial. Jurnal Riset Ilmu Farmasi dan Kesehatan. 2025;3(3).

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